The relevance of the TGF-β Paradox to EMT-MET programs

scientific article published on 05 March 2013

The relevance of the TGF-β Paradox to EMT-MET programs is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CANLET.2013.02.048
P932PMC publication ID3752409
P698PubMed publication ID23474494
P5875ResearchGate publication ID235895063

P2093author name stringWilliam P Schiemann
Jenny G Parvani
Chevaun D Morrison
P2860cites workNF-kappaB activation, dependent on acetylation/deacetylation, contributes to HIF-1 activity and migration of bone metastatic breast carcinoma cells.Q39813889
TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switchQ39903519
Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cellsQ39939949
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Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancerQ40079491
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Human epithelial basal cells are cells of origin of prostate cancer, independent of CD133 status.Q42506512
Epithelial-mesenchymal transition induced by growth suppressor p12CDK2-AP1 promotes tumor cell local invasion but suppresses distant colony growthQ43225336
A phase II trial of imatinib mesylate monotherapy in patients with metastatic breast cancer.Q43487632
Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticityQ45405811
Imaging transforming growth factor-beta signaling dynamics and therapeutic response in breast cancer bone metastasis.Q52594636
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High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-beta1Q79643431
Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasionQ80171744
To differentiate or not--routes towards metastasisQ84106913
Cancer stem cellsQ84976114
Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signalingQ24298472
The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent mannerQ24308947
A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progressionQ24314451
ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicingQ24321530
Epithelial-mesenchymal transition-derived cells exhibit multilineage differentiation potential similar to mesenchymal stem cellsQ24599620
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic nicheQ24606366
miR-21 and miR-31 Converge on TIAM1 to Regulate Migration and Invasion of Colon Carcinoma CellsQ24613084
Matrix crosslinking forces tumor progression by enhancing integrin signalingQ24646370
MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoAQ24648090
The epithelial-mesenchymal transition generates cells with properties of stem cellsQ24650786
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An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotypeQ27339197
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Tensional homeostasis and the malignant phenotypeQ27860932
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1Q27861068
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miR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasisQ28236600
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Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motilityQ28261746
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TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transitionQ28512991
Type II Transforming Growth Factor-β Receptor Recycling Is Dependent upon the Clathrin Adaptor Protein Dab2Q28588905
Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristicsQ28751743
SMAD proteins control DROSHA-mediated microRNA maturationQ28941771
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Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signalingQ37371663
X-linked inhibitor of apoptosis protein and its E3 ligase activity promote transforming growth factor-{beta}-mediated nuclear factor-{kappa}B activation during breast cancer progressionQ37372003
beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epitheliumQ37460431
Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasisQ37467183
MicroRNAs: novel regulators in the hallmarks of human cancerQ37493501
Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer.Q37721840
Endoplasmic reticulum protein 29 (ERp29): An emerging role in cancerQ37797638
Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating-cancer stem cells: distinct, overlapping or same populationsQ37885165
Mechanism of the mesenchymal-epithelial transition and its relationship with metastatic tumor formationQ37917310
MicroRNAs: critical regulators of epithelial to mesenchymal (EMT) and mesenchymal to epithelial transition (MET) in cancer progressionQ37970478
Induction of epithelial-mesenchymal transition by transforming growth factor β.Q38006771
TGF-β-induced epithelial-mesenchymal transition: a link between cancer and inflammationQ38012975
Regulation of EMT by TGFβ in cancer.Q38019712
Endoplasmic reticulum protein 29 regulates epithelial cell integrity during the mesenchymal-epithelial transition in breast cancer cellsQ39356840
Suppression of the epithelial-mesenchymal transition by Grainyhead-like-2.Q39387840
TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP.Q39451094
The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formationQ39458532
Targets of the tumor suppressor miR-200 in regulation of the epithelial-mesenchymal transition in cancer.Q39460209
TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer.Q39532727
Altered TGF-β signaling in a subpopulation of human stromal cells promotes prostatic carcinogenesis.Q39595827
Balancing the activation state of the endothelium via two distinct TGF-beta type I receptorsQ39646992
An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transitionQ39667327
Exon-based clustering of murine breast tumor transcriptomes reveals alternative exons whose expression is associated with metastasisQ39747555
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumorsQ29615393
TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epitheliaQ29618875
Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancerQ29619481
Generation of breast cancer stem cells through epithelial-mesenchymal transitionQ29619717
Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating featuresQ29620020
uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cellsQ30443804
Down-regulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer.Q30502431
TGF-beta receptor 2 downregulation in tumour-associated stroma worsens prognosis and high-grade tumours show more tumour-associated macrophages and lower TGF-beta1 expression in colon carcinoma: a retrospective studyQ33293871
p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity.Q33553472
Activated Abl kinase inhibits oncogenic transforming growth factor-beta signaling and tumorigenesis in mammary tumorsQ33613286
ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migrationQ33705264
PGE2 receptor EP2 mediates the antagonistic effect of COX-2 on TGF-beta signaling during mammary tumorigenesisQ33752909
Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression?Q33755906
Role of integrins in cancer: survey of expression patternsQ33774941
Mechanisms of the epithelial-mesenchymal transition by TGF-betaQ33804105
Roles for the type III TGF-beta receptor in human cancerQ33872593
miR-10b targets Tiam1: implications for Rac activation and carcinoma migrationQ33966873
Smad proteins bind a conserved RNA sequence to promote microRNA maturation by DroshaQ34065396
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypesQ34100400
The organization of tight junctions in epithelia: implications for mammary gland biology and breast tumorigenesisQ34103481
A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblastsQ34125363
Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formationQ34174349
Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomasQ34197948
Non-Smad TGF-beta signalsQ34443708
Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungsQ34608570
Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenationQ34613520
Homeoprotein Six1 Increases TGF-β Type I Receptor and Converts TGF-β Signaling from Suppressive to Supportive for Tumor GrowthQ34768886
Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networksQ34781947
p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs.Q34787898
Transforming growth factor-β and the hallmarks of cancerQ34789300
Lysyl oxidase contributes to mechanotransduction-mediated regulation of transforming growth factor-β signaling in breast cancer cellsQ34887552
The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasisQ34933986
An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transitionQ34977307
TGFbeta/TNF(alpha)-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotypeQ35085542
Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cellsQ35134466
Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonizationQ35204515
Epithelial-Mesenchymal Transition in tumor microenvironmentQ35230386
Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell propertiesQ35243673
Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cellsQ35605733
Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators.Q35778924
Matrix rigidity regulates a switch between TGF-β1-induced apoptosis and epithelial-mesenchymal transitionQ35790882
The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer.Q35928749
Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cellsQ36006612
Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environmentQ36215812
A phase II study of imatinib mesylate and capecitabine in metastatic breast cancer: Southwest Oncology Group Study 0338Q36435548
Differential cadherin expression: potential markers for epithelial to mesenchymal transformation during tumor progressionQ36847939
Mesenchymal to epithelial transition in development and disease.Q36857740
Transforming growth factor-beta and microRNA:mRNA regulatory networks in epithelial plasticityQ36857841
Treatment for chronic myelogenous leukemia: the long road to imatinibQ36900105
Applying the discovery of the Philadelphia chromosomeQ36900109
Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton.Q36922699
Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanismsQ36959011
The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cellsQ37040558
TGF-β stimulates Pyk2 expression as part of an epithelial-mesenchymal transition program required for metastatic outgrowth of breast cancerQ37040574
Grb2 binding to Tyr284 in TbetaR-II is essential for mammary tumor growth and metastasis stimulated by TGF-betaQ37041510
Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progressionQ37041538
Noncanonical TGF-β signaling during mammary tumorigenesisQ37044600
Role of TGF-β and the tumor microenvironment during mammary tumorigenesisQ37044604
Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progressionQ37044614
TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-betaQ37052635
Three-dimensional context regulation of metastasisQ37111021
Cancer-associated transforming growth factor beta type II receptor gene mutant causes activation of bone morphogenic protein-Smads and invasive phenotypeQ37155797
The TGF-beta paradox in human cancer: an updateQ37261631
Role of TGF-beta in the tumor stromaQ37264582
MicroRNAs as regulators of epithelial-mesenchymal transition.Q37300965
Imatinib mesylate (Gleevec) in advanced breast cancer-expressing C-Kit or PDGFR-beta: clinical activity and biological correlationsQ37326191
The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signalingQ37328463
Roles of TGF-beta family signaling in stem cell renewal and differentiationQ37359959
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)30-40
P577publication date2013-03-05
P1433published inCancer LettersQ326372
P1476titleThe relevance of the TGF-β Paradox to EMT-MET programs
P478volume341

Reverse relations

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