| scholarly article | Q13442814 |
| P50 | author | J Chuck Harrell | Q74795342 |
| P2093 | author name string | Kathryn B Horwitz | |
| William P Schiemann | |||
| Dean Billheimer | |||
| Heide L Ford | |||
| Douglas S Micalizzi | |||
| Karen A Heichman | |||
| Alana L Welm | |||
| Anna E Barón | |||
| Paul Jedlicka | |||
| Ricardo D Coletta | |||
| Kimberly L Christensen | |||
| P2860 | cites work | Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma | Q24336272 |
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| A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes | Q24647928 | ||
| The epithelial-mesenchymal transition generates cells with properties of stem cells | Q24650786 | ||
| Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis | Q24679619 | ||
| The epithelial-mesenchymal transition: new insights in signaling, development, and disease | Q24683758 | ||
| Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro | Q24794867 | ||
| Effects of filtering by Present call on analysis of microarray experiments | Q25257108 | ||
| Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts | Q25257621 | ||
| Epithelial-mesenchymal transitions in tumour progression | Q27860487 | ||
| Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection | Q27860727 | ||
| A gene-expression signature as a predictor of survival in breast cancer | Q27860945 | ||
| TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis | Q46272247 | ||
| Gene expression profiling identifies molecular subtypes of gliomas | Q47719947 | ||
| Gene expression predictors of breast cancer outcomes | Q47912322 | ||
| Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy. | Q51596197 | ||
| Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer. | Q51929705 | ||
| Pharmacogenomic predictor of sensitivity to preoperative chemotherapy with paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide in breast cancer. | Q51935846 | ||
| A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. | Q51940347 | ||
| Six1 is not involved in limb tendon development, but is expressed in limb connective tissue under Shh regulation. | Q52053545 | ||
| Gene expression profiles associated with treatment response in oligodendrogliomas. | Q55470718 | ||
| Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease | Q57908314 | ||
| Distinct gene expression profiles determine molecular treatment response in childhood acute lymphoblastic leukemia | Q80607032 | ||
| A window on the dynamics of biological switches | Q81370890 | ||
| Cell cycle-regulated phosphorylation of the human SIX1 homeodomain protein | Q28143878 | ||
| Altered myogenesis in Six1-deficient mice | Q28187781 | ||
| ONCOMINE: a cancer microarray database and integrated data-mining platform | Q28255103 | ||
| ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells | Q28262414 | ||
| TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4 | Q28275478 | ||
| Six1 is required for the early organogenesis of mammalian kidney | Q28510085 | ||
| Beta-catenin is essential and sufficient for skeletal myogenesis in P19 cells | Q28511049 | ||
| Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney | Q28586205 | ||
| Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo | Q28593548 | ||
| Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer | Q29616379 | ||
| TGF-beta and epithelial-to-mesenchymal transitions | Q29616456 | ||
| Tumor metastasis: mechanistic insights and clinical challenges | Q29617676 | ||
| Molecular requirements for epithelial-mesenchymal transition during tumor progression | Q29618960 | ||
| An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival | Q33939753 | ||
| A molecular classification of papillary renal cell carcinoma | Q34558981 | ||
| Modelling breast cancer: one size does not fit all. | Q34667643 | ||
| Deregulated homeobox gene expression in cancer: cause or consequence? | Q34932292 | ||
| Classification and subtype prediction of adult soft tissue sarcoma by functional genomics | Q35791796 | ||
| Homeobox gene expression in cancer: insights from developmental regulation and deregulation | Q36274462 | ||
| Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways | Q36313178 | ||
| Transforming growth factor-beta in cancer and metastasis | Q36585129 | ||
| Breast cancer-derived factors facilitate osteolytic bone metastasis. | Q36596180 | ||
| Clinicopathological significance of homeoprotein Six1 in hepatocellular carcinoma | Q36612365 | ||
| Role of transforming growth factor-beta in cancer progression | Q36677493 | ||
| Notch2 is required for maintaining sustentacular cell function in the adult mouse main olfactory epithelium | Q38277144 | ||
| Gene expression profiling in cervical cancer: an exploration of intratumor heterogeneity | Q38308859 | ||
| ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells | Q38356519 | ||
| Epithelial to mesenchymal transition in human breast epithelial cells transformed by 17beta-estradiol | Q40040954 | ||
| Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival. | Q40149403 | ||
| Cell adhesion molecule L1 disrupts E-cadherin-containing adherens junctions and increases scattering and motility of MCF7 breast carcinoma cells | Q40200773 | ||
| Estrogen receptor positive breast cancer metastasis: altered hormonal sensitivity and tumor aggressiveness in lymphatic vessels and lymph nodes. | Q40230408 | ||
| Identification of expressed genes characterizing long-term survival in malignant glioma patients | Q40284703 | ||
| Identification and classification of differentially expressed genes in renal cell carcinoma by expression profiling on a global human 31,500-element cDNA array | Q40415541 | ||
| Gene amplification is a mechanism of Six1 overexpression in breast cancer | Q40439862 | ||
| TGF-beta in mammary gland development and breast cancer. | Q40448992 | ||
| Identifying superficial, muscle-invasive, and metastasizing transitional cell carcinoma of the bladder: use of cDNA array analysis of gene expression profiles | Q40552177 | ||
| Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators | Q40602477 | ||
| Expression profiling of epithelial plasticity in tumor progression | Q40625666 | ||
| Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways | Q40757186 | ||
| Quantitative demonstration of spontaneous metastasis by MCF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and LacZ. | Q41555475 | ||
| Six1 overexpression in mammary cells induces genomic instability and is sufficient for malignant transformation | Q42814954 | ||
| Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning | Q45728735 | ||
| Gene expression profiling of gliomas strongly predicts survival | Q46043661 | ||
| P433 | issue | 9 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 2678-2690 | |
| P577 | publication date | 2009-08-24 | |
| P1433 | published in | Journal of Clinical Investigation | Q3186904 |
| P1476 | title | The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling | |
| P478 | volume | 119 |
| Q33997141 | An RNA interference phenotypic screen identifies a role for FGF signals in colon cancer progression |
| Q64279774 | An integrated analysis to predict micro-RNAs targeting both stemness and metastasis in breast cancer stem cells |
| Q34570526 | Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer |
| Q26851620 | Breast cancer epithelial-to-mesenchymal transition: examining the functional consequences of plasticity |
| Q91890919 | CLDN6 promotes tumor progression through the YAP1-snail1 axis in gastric cancer |
| Q41216714 | Cancer stem cells: repair gone awry? |
| Q34503221 | Cell fate determination factor Dachshund reprograms breast cancer stem cell function |
| Q94547499 | Cellular Plasticity in Breast Cancer Progression and Therapy |
| Q33523907 | Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis |
| Q34374689 | DACH1 inhibits cyclin D1 expression, cellular proliferation and tumor growth of renal cancer cells |
| Q53662194 | DNA methylation is a key factor in understanding differentiation phenotype in esophageal squamous cell carcinoma. |
| Q37328411 | Defining a role for the homeoprotein Six1 in EMT and mammary tumorigenesis |
| Q24304311 | Direct role of Bardet-Biedl syndrome proteins in transcriptional regulation |
| Q39583729 | Distinct TRAIL resistance mechanisms can be overcome by proteasome inhibition but not generally by synergizing agents. |
| Q35775160 | ELL Protein-associated Factor 2 (EAF2) Inhibits Transforming Growth Factor β Signaling through a Direct Interaction with Smad3 |
| Q33804808 | EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells |
| Q37762478 | Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer |
| Q28662207 | Epithelial-mesenchymal transition and tumor suppression are controlled by a reciprocal feedback loop between ZEB1 and Grainyhead-like-2 |
| Q24633875 | Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression |
| Q35747467 | Epithelial-mesenchymal transition in cervical carcinoma. |
| Q37620379 | Epithelial-mesenchymal transition in development and cancer |
| Q41552614 | Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer |
| Q36924443 | Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signal-regulated kinase and transforming growth factor-beta signaling pathways. |
| Q37328021 | Expression profile of SIX family members correlates with clinic-pathological features and prognosis of breast cancer: A systematic review and meta-analysis |
| Q35243673 | Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell properties |
| Q88660937 | Eya3 promotes breast tumor-associated immune suppression via threonine phosphatase-mediated PD-L1 upregulation |
| Q28547302 | Fighting the force: Potential of homeobox genes for tumor microenvironment regulation |
| Q35133195 | Gasdermin-B promotes invasion and metastasis in breast cancer cells |
| Q35683564 | Generation of tumor-initiating cells by exogenous delivery of OCT4 transcription factor. |
| Q38874118 | Glabridin inhibits cancer stem cell-like properties of human breast cancer cells: An epigenetic regulation of miR-148a/SMAd2 signaling |
| Q104475857 | HPV-inactive cell populations arise from HPV16-transformed human keratinocytes after p53 knockout |
| Q92700052 | HPV16-transformed human keratinocytes depend on SIX1 expression for proliferation and HPV E6/E7 gene expression |
| Q34768886 | Homeoprotein Six1 Increases TGF-β Type I Receptor and Converts TGF-β Signaling from Suppressive to Supportive for Tumor Growth |
| Q34717946 | Homeoprotein Six2 promotes breast cancer metastasis via transcriptional and epigenetic control of E-cadherin expression |
| Q38011246 | Human HAD phosphatases: structure, mechanism, and roles in health and disease |
| Q34347238 | Identification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity |
| Q34701472 | Identification of an mRNP complex regulating tumorigenesis at the translational elongation step |
| Q42503675 | Immunization against HIF-1α Inhibits the Growth of Basal Mammary Tumors and Targets Mammary Stem Cells In Vivo |
| Q50695266 | Immunohistochemical expression of homeoproteins Six1 and Pax3 in breast phyllodes tumours correlates with histological grade and clinical outcome. |
| Q91682971 | Increased Six1 expression in macrophages promotes hepatocellular carcinoma growth and invasion by regulating MMP-9 |
| Q33684857 | Increased Six1 expression is associated with poor prognosis in patients with osteosarcoma |
| Q41175001 | Increased expression of Six1 correlates with progression and prognosis of prostate cancer |
| Q36340248 | Inhibition of Six1 affects tumour invasion and the expression of cancer stem cell markers in pancreatic cancer |
| Q38949050 | Inhibition of the cancer stem cells-like properties by arsenic trioxide, involved in the attenuation of endogenous transforming growth factor beta signal |
| Q28088611 | Interplay of retinal determination gene network with TGF-β signaling pathway in epithelial-mesenchymal transition |
| Q91705819 | LOXL 2 Promotes The Epithelial-Mesenchymal Transition And Malignant Progression Of Cervical Cancer |
| Q89944672 | Lung Cancer (LC) in HIV Positive Patients: Pathogenic Features and Implications for Treatment |
| Q39063008 | Lymph Nodes and Cancer Metastasis: New Perspectives on the Role of Intranodal Lymphatic Sinuses |
| Q37783809 | Making senses development of vertebrate cranial placodes |
| Q26745545 | Mechanisms of TGFβ-Induced Epithelial-Mesenchymal Transition |
| Q34516160 | Meta-analysis of gene expression signatures defining the epithelial to mesenchymal transition during cancer progression |
| Q38832381 | MiR-204-5p/Six1 feedback loop promotes epithelial-mesenchymal transition in breast cancer |
| Q58709397 | Mice doubly deficient in and show ventral body wall defects reproducing human omphalocele |
| Q38675837 | MicroRNA-30a functions as tumor suppressor and inhibits the proliferation and invasion of prostate cancer cells by down-regulation of SIX1. |
| Q33613370 | MicroRNA-30a regulates zebrafish myogenesis through targeting the transcription factor Six1 |
| Q58769228 | Molecular Changes of Lung Malignancy in HIV Infection |
| Q91519389 | Molecular pathogenesis of triple-negative breast cancer based on microRNA expression signatures: antitumor miR-204-5p targets AP1S3 |
| Q37711271 | Molecular signaling of the epithelial to mesenchymal transition in generating and maintaining cancer stem cells |
| Q35853714 | On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics |
| Q38215948 | Oncogenic roles of EMT-inducing transcription factors |
| Q41755749 | Overexpression of SIX1 is an independent prognostic marker in stage I-III colorectal cancer |
| Q39256753 | Overexpression of Six1 leads to retardation of myogenic differentiation in C2C12 myoblasts |
| Q37282604 | POU2F2-oriented network promotes human gastric cancer metastasis |
| Q33738694 | Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis. |
| Q38492153 | Protein kinase CK2 in breast cancer: the CK2β regulatory subunit takes center stage in epithelial plasticity |
| Q91639511 | Roles of the Phosphorylation of Transcriptional Factors in Epithelial-Mesenchymal Transition |
| Q33814892 | SFRP1 reduction results in an increased sensitivity to TGF-β signaling |
| Q33891236 | SHOX2 is a direct miR-375 target and a novel epithelial-to-mesenchymal transition inducer in breast cancer cells |
| Q92542107 | SIX1 Activates STAT3 Signaling to Promote the Proliferation of Thyroid Carcinoma via EYA1 |
| Q41105036 | SIX1 Oncoprotein as a Biomarker in a Model of Hormonal Carcinogenesis and in Human Endometrial Cancer. |
| Q37106448 | SIX1 coordinates with TGFβ signals to induce epithelial-mesenchymal transition in cervical cancer |
| Q35913687 | SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer |
| Q37670690 | SIX1 maintains tumor basal cells via transforming growth factor-β pathway and associates with poor prognosis in esophageal cancer |
| Q38328202 | SIX1 promotes epithelial-mesenchymal transition in colorectal cancer through ZEB1 activation |
| Q35556501 | Short-Form Ron Promotes Spontaneous Breast Cancer Metastasis through Interaction with Phosphoinositide 3-Kinase |
| Q48258004 | Signaling pathways and mesenchymal transition in pediatric high-grade glioma. |
| Q61807849 | Sine oculis homeobox 1 promotes proliferation and migration of human colorectal cancer cells through activation of Wnt/β-catenin signaling |
| Q38991070 | Sineoculis homeobox homolog 1 protein as an independent biomarker for gastric adenocarcinoma |
| Q38971678 | Sineoculis homeobox homolog 1 protein is associated with breast cancer progression and survival outcome |
| Q37328450 | Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition |
| Q33597712 | Six1 expression is associated with a poor prognosis in patients with glioma |
| Q34657109 | Six1 overexpression at early stages of HPV16-mediated transformation of human keratinocytes promotes differentiation resistance and EMT. |
| Q38716404 | Six1 promotes colorectal cancer growth and metastasis by stimulating angiogenesis and recruiting tumor-associated macrophages. |
| Q33705247 | Six1 promotes epithelial-mesenchymal transition and malignant conversion in human papillomavirus type 16-immortalized human keratinocytes. |
| Q34634833 | Six1 promotes proliferation of pancreatic cancer cells via upregulation of cyclin D1 expression |
| Q38184513 | Six1: a critical transcription factor in tumorigenesis |
| Q33596982 | Smad4-mediated TGF-beta signaling in tumorigenesis |
| Q36714078 | Specificity and prognostic validation of a polyclonal antibody to detect Six1 homeoprotein in ovarian cancer |
| Q27676610 | Structure-function analyses of the human SIX1–EYA2 complex reveal insights into metastasis and BOR syndrome |
| Q28079488 | Switching Roles of TGF-β in Cancer Development: Implications for Therapeutic Target and Biomarker Studies |
| Q34985004 | TGF-β signaling in breast cancer cell invasion and bone metastasis |
| Q36497263 | TGF-β upregulates miR-181a expression to promote breast cancer metastasis |
| Q35273414 | TGF-β1 induces epigenetic silence of TIP30 to promote tumor metastasis in esophageal carcinoma |
| Q33802751 | TRAIL receptor signaling regulation of chemosensitivity in vivo but not in vitro |
| Q35562945 | TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation |
| Q36462348 | Targeting the TGFβ signalling pathway in disease |
| Q27021750 | Targeting the Transforming Growth Factor-β Signaling in Cancer Therapy |
| Q90069521 | Targeting transcription factors in cancer - from undruggable to reality |
| Q28263832 | The DACH/EYA/SIX gene network and its role in tumor initiation and progression |
| Q36985643 | The Dual Role of TGFβ in Human Cancer: From Tumor Suppression to Cancer Metastasis |
| Q42516196 | The Epithelial-to-Mesenchymal Transition in Breast Cancer: Focus on Basal-Like Carcinomas |
| Q47832015 | The Eya phosphatase: Its unique role in cancer |
| Q34766011 | The PI3K/Akt signal hyperactivates Eya1 via the SUMOylation pathway. |
| Q35107900 | The SIX1-EYA transcriptional complex as a therapeutic target in cancer |
| Q36437988 | The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p. |
| Q36109766 | The T box transcription factor TBX2 promotes epithelial-mesenchymal transition and invasion of normal and malignant breast epithelial cells |
| Q39002239 | The canonical wnt signal restricts the glycogen synthase kinase 3/fbw7-dependent ubiquitination and degradation of eya1 phosphatase. |
| Q36462328 | The complexities of TGF-β action during mammary and squamous cell carcinogenesis |
| Q28078421 | The dual regulatory role of miR-204 in cancer |
| Q52584557 | The miR-106b-25 cluster mediates breast tumor initiation through activation of NOTCH1 via direct repression of NEDD4L. |
| Q35928749 | The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer. |
| Q35864968 | The molecular biology of brain metastasis |
| Q37040558 | The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells |
| Q33842051 | The prognostic impact of TGF-β1, fascin, NF-κB and PKC-ζ expression in soft tissue sarcomas |
| Q57483942 | The regulation of cytokine signaling by retinal determination gene network pathway in cancer |
| Q37118399 | The relevance of the TGF-β Paradox to EMT-MET programs |
| Q26747218 | The retinal determination gene network: from developmental regulator to cancer therapeutic target |
| Q39145031 | Transcriptional differences between normal and glioma-derived glial progenitor cells identify a core set of dysregulated genes. |
| Q35819975 | Transcriptional profiles of pilocytic astrocytoma are related to their three different locations, but not to radiological tumor features |
| Q38431922 | Transcriptome profiling of cancer and normal tissues from cervical squamous cancer patients by deep sequencing |
| Q37918451 | Transforming growth factor-β signaling in tumor initiation, progression and therapy in breast cancer: an update |
| Q34789337 | Transforming growth factor-β-induced epithelial-mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression |
| Q49729843 | miR-204-5p suppresses hepatocellular cancer proliferation by regulating homeoprotein SIX1 expression. |
| Q39018756 | miR-30b regulates migration and invasion of human colorectal cancer via SIX1. |
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