Distinct TRAIL resistance mechanisms can be overcome by proteasome inhibition but not generally by synergizing agents.

scientific article published on March 2011

Distinct TRAIL resistance mechanisms can be overcome by proteasome inhibition but not generally by synergizing agents. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/0008-5472.CAN-10-2252
P932PMC publication ID3250348
P698PubMed publication ID21363923

P50authorKian BehbakhtQ56332429
P2093author name stringAndrew Thorburn
Jacqueline Thorburn
Heide L Ford
Lianghua Bin
Christina Menke
P2860cites workThe Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1Q24564859
Rare loss-of-function mutation of a death receptor gene in head and neck cancerQ28281058
Quantitative analysis of pathways controlling extrinsic apoptosis in single cellsQ33807797
Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2.Q33999606
Enhancement of therapeutic potential of TRAIL by cancer chemotherapy and irradiation: mechanisms and clinical implicationsQ35781710
NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cellsQ35850681
TRAIL receptor-targeted therapeutics: resistance mechanisms and strategies to avoid them.Q36731174
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) pathway signaling.Q36839047
To kill a tumor cell: the potential of proapoptotic receptor agonistsQ37181734
The TRAIL apoptotic pathway in cancer onset, progression and therapyQ37278043
The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signalingQ37328463
Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibodyQ37367298
Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturationQ39698787
Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand bindingQ40100090
The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cellsQ40131236
Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival.Q40149403
Gene amplification is a mechanism of Six1 overexpression in breast cancerQ40439862
Differential induction of apoptosis by tumor necrosis factor-related apoptosis-inducing ligand in human ovarian carcinoma cellsQ40545469
Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.Q40975748
Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia.Q44165080
The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cellsQ44539646
Bortezomib sensitizes primary human astrocytoma cells of WHO grades I to IV for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.Q48148098
Mutation analysis and mRNA expression of trail-receptors in human breast cancer.Q53386106
A matter of life and deathQ63408384
TRAIL-R2 is not correlated with p53 status and is rarely mutated in non-small cell lung cancerQ73505532
Somatic mutations of TRAIL-receptor 1 and TRAIL-receptor 2 genes in non-Hodgkin's lymphomaQ73787515
Extensive regions of the FADD death domain are required for binding to the TRAIL receptor DR5Q80346249
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1883-1892
P577publication date2011-03-01
P1433published inCancer ResearchQ326097
P1476titleDistinct TRAIL resistance mechanisms can be overcome by proteasome inhibition but not generally by synergizing agents
P478volume71

Reverse relations

cites work (P2860)
Q51176917A Genome-Wide Loss-of-Function Screen Identifies SLC26A2 as a Novel Mediator of TRAIL Resistance.
Q37299291Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5.
Q38945539Bortezomib sensitises TRAIL-resistant HPV-positive head and neck cancer cells to TRAIL through a caspase-dependent, E6-independent mechanism.
Q37003894Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes
Q35327231Combination of TRAIL with bortezomib shifted apoptotic signaling from DR4 to DR5 death receptor by selective internalization and degradation of DR4.
Q35561369Genetic and Pharmacological Screens Converge in Identifying FLIP, BCL2, and IAP Proteins as Key Regulators of Sensitivity to the TRAIL-Inducing Anticancer Agent ONC201/TIC10.
Q39400148Histone deacetylase inhibitor-mediated sensitization to TRAIL-induced apoptosis in childhood malignancies is not associated with upregulation of TRAIL receptor expression, but with potentiated caspase-8 activation
Q92756792Importance of TRAIL Molecular Anatomy in Receptor Oligomerization and Signaling. Implications for Cancer Therapy
Q38726186Non-cell-autonomous Effects of Autophagy Inhibition in Tumor Cells Promote Growth of Drug-resistant Cells
Q35853714On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics
Q36992161Overcoming resistance to TRAIL-induced apoptosis in solid tumor cells by simultaneously targeting death receptors, c-FLIP and IAPs
Q33695003Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells
Q36579619Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis
Q97901404TRAIL of Hope Meeting Resistance in Cancer
Q35609438Targeted ovarian cancer treatment: the TRAILs of resistance.
Q43468001The plant alkaloid and anti-leukemia drug homoharringtonine sensitizes resistant human colorectal carcinoma cells to TRAIL-induced apoptosis via multiple mechanisms.
Q38861356Using natural products to promote caspase-8-dependent cancer cell death
Q35501202Verticillin A overcomes apoptosis resistance in human colon carcinoma through DNA methylation-dependent upregulation of BNIP3.
Q36347307Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation

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