| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1019205749 |
| P356 | DOI | 10.1038/CDDIS.2015.38 |
| P932 | PMC publication ID | 4669816 |
| P698 | PubMed publication ID | 25719250 |
| P5875 | ResearchGate publication ID | 272836903 |
| P2093 | author name string | J B McMahon | |
| A D Brooks | |||
| C J Henrich | |||
| C L Thomas | |||
| C R Thompson | |||
| H R Bokesch | |||
| K L Erickson | |||
| K R Gustafson | |||
| P Tewary | |||
| R J Pompei | |||
| T J Sayers | |||
| P2860 | cites work | Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP | Q24302531 |
| Getting TRAIL back on track for cancer therapy | Q27027460 | ||
| Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5 | Q27649718 | ||
| Targeting the dynamic HSP90 complex in cancer | Q28288602 | ||
| c-FLIP, a master anti-apoptotic regulator | Q28391119 | ||
| Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies | Q33345317 | ||
| Withaferin A inhibits experimental epithelial-mesenchymal transition in MCF-10A cells and suppresses vimentin protein level in vivo in breast tumors | Q33690570 | ||
| An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells | Q33798802 | ||
| Bortezomib sensitizes human renal cell carcinomas to TRAIL apoptosis through increased activation of caspase-8 in the death-inducing signaling complex. | Q33862527 | ||
| Utilization of the cellular stress response to sensitize cancer cells to TRAIL-mediated apoptosis | Q34286028 | ||
| Molecular insight in the multifunctional activities of Withaferin A. | Q34299843 | ||
| Withanolides-induced breast cancer cell death is correlated with their ability to inhibit heat protein 90 | Q34305025 | ||
| Withaferin A induces proteasome inhibition, endoplasmic reticulum stress, the heat shock response and acquisition of thermotolerance | Q34316709 | ||
| Clerodane Diterpenes from Casearia arguta That Act As Synergistic TRAIL Sensitizers | Q34683833 | ||
| Steroidal lactones from Withania somnifera, an ancient plant for novel medicine | Q34994211 | ||
| Withaferin A targets heat shock protein 90 in pancreatic cancer cells | Q35004306 | ||
| Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic cell death of human myeloid leukemia HL-60 cells by a dietary compound withaferin A with concomitant protection by N-acetyl cysteine. | Q53527360 | ||
| Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo. | Q54579220 | ||
| Suppression of cFLIP is sufficient to sensitize human melanoma cells to TRAIL- and CD95L-mediated apoptosis | Q80210089 | ||
| Isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from Physalis angulata | Q80503888 | ||
| Expression of c-FLIP in malignant melanoma, and its relationship with the clinicopathological features of the disease | Q82610583 | ||
| Structure-activity relationships for withanolides as inducers of the cellular heat-shock response | Q87434263 | ||
| Anti-proliferative withanolides from the Solanaceae: a structure-activity study | Q35008723 | ||
| A cell-based high-throughput screen to identify synergistic TRAIL sensitizers | Q35200982 | ||
| c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis | Q35735269 | ||
| Synergistic TRAIL sensitizers from Barleria alluaudii and Diospyros maritima | Q35850815 | ||
| On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics | Q35853714 | ||
| Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone | Q37148287 | ||
| Mitochondria: gatekeepers of response to chemotherapy | Q37347485 | ||
| Structure-activity relationship (SAR) of withanolides to inhibit Hsp90 for its activity in pancreatic cancer cells | Q37397036 | ||
| Growth arrest by the antitumor steroidal lactone withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of β-tubulin | Q37488585 | ||
| Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. | Q37494492 | ||
| Natural withanolides: an overview | Q37846112 | ||
| Targeting the extrinsic apoptosis signaling pathway for cancer therapy | Q37882480 | ||
| Targeting the Apo2L/TRAIL system for the therapy of autoimmune diseases and cancer. | Q37974383 | ||
| TRAIL signaling and synergy mechanisms used in TRAIL-based combination therapies | Q37974875 | ||
| Cellular FLICE-like inhibitory proteins (c-FLIPs): fine-tuners of life and death decisions | Q37981778 | ||
| Bortezomib and TRAIL: a perfect match for apoptotic elimination of tumour cells? | Q38040227 | ||
| Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family | Q38098380 | ||
| Death receptors as targets in cancer | Q38103591 | ||
| Tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL). | Q38227049 | ||
| Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells | Q39330257 | ||
| ER stress sensitizes cells to TRAIL through down-regulation of FLIP and Mcl-1 and PERK-dependent up-regulation of TRAIL-R2. | Q39445601 | ||
| Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2. | Q39516815 | ||
| Distinct TRAIL resistance mechanisms can be overcome by proteasome inhibition but not generally by synergizing agents. | Q39583729 | ||
| Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase. | Q39656557 | ||
| Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis. | Q40448034 | ||
| Defining characteristics of Types I and II apoptotic cells in response to TRAIL. | Q41687820 | ||
| The HSP90 inhibitor ganetespib synergizes with the MET kinase inhibitor crizotinib in both crizotinib-sensitive and -resistant MET-driven tumor models | Q42811812 | ||
| Heat shock protein 90alpha recruits FLIPS to the death-inducing signaling complex and contributes to TRAIL resistance in human glioma | Q44155968 | ||
| The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP. | Q44361998 | ||
| Cellular FLICE-like inhibitory protein secures intestinal epithelial cell survival and immune homeostasis by regulating caspase-8. | Q44465192 | ||
| Cellular FLICE/caspase-8-inhibitory protein as a principal regulator of cell death and survival in human hepatocellular carcinoma | Q44513297 | ||
| Reduction of the antiapoptotic protein cFLIP enhances the susceptibility of human renal cancer cells to TRAIL apoptosis | Q45198192 | ||
| cFLIP regulates skin homeostasis and protects against TNF-induced keratinocyte apoptosis | Q45844877 | ||
| Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP. | Q46061571 | ||
| Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB-regulated gene expression | Q47197772 | ||
| Bortezomib sensitizes primary human astrocytoma cells of WHO grades I to IV for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. | Q48148098 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P921 | main subject | apoptotic process | Q14599311 |
| renal carcinoma | Q18556333 | ||
| P304 | page(s) | e1666 | |
| P577 | publication date | 2015-02-26 | |
| P1433 | published in | Cell Death and Disease | Q2197222 |
| P1476 | title | Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation | |
| P478 | volume | 6 |
| Q36296924 | 17β-Hydroxywithanolides as Sensitizers of Renal Carcinoma Cells to Tumor Necrosis Factor-α Related Apoptosis Inducing Ligand (TRAIL) Mediated Apoptosis: Structure-Activity Relationships. |
| Q36332681 | A promising "TRAIL" of tanshinones for cancer therapy |
| Q36378038 | Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity |
| Q64284731 | Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells |
| Q38828394 | Down-Regulating Receptor Interacting Protein Kinase 1 (RIP1) Promotes Oxaliplatin-Induced Tca8113 Cell Apoptosis. |
| Q37676951 | Importance of ROS-mediated autophagy in determining apoptotic cell death induced by physapubescin B. |
| Q45491251 | Increased cFLIP expression in thymic epithelial tumors blocks autophagy via NF-κB signalling. |
| Q42336210 | Is immunity in cancer the key to improving clinical outcome?: Report on the International Symposium on Immunotherapy, The Royal Society, London, UK, 12-13 May 2017. |
| Q43196527 | Kaempferol Sensitizes Human Ovarian Cancer Cells-OVCAR-3 and SKOV-3 to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis via JNK/ERK-CHOP Pathway and Up-Regulation of Death Receptors 4 and 5. |
| Q38981459 | Metabolite Profiling in Withania somnifera Roots Hydroalcoholic Extract Using LC/MS, GC/MS and NMR Spectroscopy |
| Q38965226 | Natural Withanolides in the Treatment of Chronic Diseases |
| Q38772848 | New Frontiers in Promoting TRAIL-Mediated Cell Death: Focus on Natural Sensitizers, miRNAs, and Nanotechnological Advancements |
| Q37393983 | New withanolides with TRAIL-sensitizing effect from Physalis pubescens L. |
| Q89040090 | Pharmacological Targeting of Cell Cycle, Apoptotic and Cell Adhesion Signaling Pathways Implicated in Chemoresistance of Cancer Cells |
| Q37223809 | Physapubescin selectively induces apoptosis in VHL-null renal cell carcinoma cells through down-regulation of HIF-2α and inhibits tumor growth |
| Q59799448 | Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs |
| Q51760860 | Should We Keep Walking along the Trail for Pancreatic Cancer Treatment? Revisiting TNF-Related Apoptosis-Inducing Ligand for Anticancer Therapy. |
| Q42709967 | Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy |
| Q55457033 | Synergistic effect of TRAIL and irradiation in elimination of glioblastoma stem-like cells. |
| Q38861356 | Using natural products to promote caspase-8-dependent cancer cell death |
| Q38849089 | Withaferin-A Reduces Acetaminophen-Induced Liver Injury in Mice |
| Q38700280 | Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells. |
| Q48158098 | c-FLIP is a target of the E3 ligase deltex1 in gastric cancer. |
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