The plant alkaloid and anti-leukemia drug homoharringtonine sensitizes resistant human colorectal carcinoma cells to TRAIL-induced apoptosis via multiple mechanisms.

scientific article published in June 2013

The plant alkaloid and anti-leukemia drug homoharringtonine sensitizes resistant human colorectal carcinoma cells to TRAIL-induced apoptosis via multiple mechanisms. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10495-013-0823-9
P698PubMed publication ID23456623
P5875ResearchGate publication ID235777632

P50authorAntónio R PombinhoQ56480104
Petr BartůněkQ59689457
Magdalena KlánováQ39185457
Pavel KlenerQ39185479
Jan MolinskyQ43704022
P2093author name stringLadislav Andera
Michal Koc
Jarmila Spegarova
Lenka Beranova
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DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADDQ24316876
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Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cellsQ28215810
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complexQ28221276
Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivityQ28729760
Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and BortezomibQ33906039
Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL.Q34018500
New insights into apoptosis signaling by Apo2L/TRAIL.Q34022690
Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL.Q34069986
Homoharringtonine: history, current research, and future directionQ34105271
Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax.Q34488880
Molecular modes of action of cephalotaxine and homoharringtonine from the coniferous tree Cephalotaxus hainanensis in human tumor cell linesQ44343089
Translation inhibitors sensitize prostate cancer cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by activating c-Jun N-terminal kinaseQ44381498
TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB.Q44482351
Homoharringtonine inhibits the AKT pathway and induces in vitro and in vivo cytotoxicity in human multiple myeloma cellsQ46298902
Leukemia-initiating cells of patient-derived acute lymphoblastic leukemia xenografts are sensitive toward TRAIL.Q48032022
MADD/DENN splice variant of the IG20 gene is a negative regulator of caspase-8 activation. Knockdown enhances TRAIL-induced apoptosis of cancer cellsQ50337127
Omacetaxine mepesuccinate for the treatment of leukemia.Q52892987
Omacetaxine mepesuccinate prevents cytokine-dependent resistance to nilotinib in vitro: potential role of the common β-subunit c of cytokine receptors.Q54326636
The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis.Q54694804
Homoharringtonine reduced Mcl-1 expression and induced apoptosis in chronic lymphocytic leukemiaQ34568840
The role of TRADD in TRAIL-induced apoptosis and signalingQ34682495
Conscripts of the infinite armada: systemic cancer therapy using nanomaterials.Q35545342
Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin's lymphoma B cellsQ35643014
Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expressionQ35643815
Synergistic TRAIL sensitizers from Barleria alluaudii and Diospyros maritimaQ35850815
On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeuticsQ35853714
Mechanisms of resistance to TRAIL-induced apoptosis in cancerQ35954258
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptorsQ36852093
Synthesis of antiproliferative Cephalotaxus esters and their evaluation against several human hematopoietic and solid tumor cell lines: uncovering differential susceptibilities to multidrug resistanceQ37074659
Mcl-1: a gateway to TRAIL sensitization.Q37125357
Current constructs and targets in clinical development for antibody-based cancer therapyQ37387364
Cellular FLICE-inhibitory protein (c-FLIP) signalling: a key regulator of receptor-mediated apoptosis in physiologic context and in cancerQ37637257
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TRAIL receptor signaling and therapeutics.Q37785559
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State of art and recent developments of anti-cancer strategies based on TRAIL.Q37960569
The therapeutic potential of TRAIL receptor signalling in cancer cells.Q37962655
Histone deacetylase (HDAC) inhibitors and regulation of TRAIL-induced apoptosisQ37988252
Thapsigargin sensitizes human melanoma cells to TRAIL-induced apoptosis by up-regulation of TRAIL-R2 through the unfolded protein response.Q38299743
Targeting FLIP and Mcl-1 using a combination of aspirin and sorafenib sensitizes colon cancer cells to TRAIL.Q39248620
Distinct TRAIL resistance mechanisms can be overcome by proteasome inhibition but not generally by synergizing agents.Q39583729
FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificityQ39694237
Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death.Q40110911
TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window.Q40165924
Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis.Q40448034
Tipping the Noxa/Mcl-1 balance overcomes ABT-737 resistance in chronic lymphocytic leukemiaQ42802658
Identification of c-FLIP(L) and c-FLIP(S) as critical regulators of death receptor-induced apoptosis in pancreatic cancer cellsQ42874678
P433issue6
P921main subjectmultiple drug resistanceQ643839
(-)-homoharringtonineQ7089373
colorectal carcinomaQ25493920
P304page(s)739-750
P577publication date2013-06-01
P1433published inApoptosisQ15749546
P1476titleThe plant alkaloid and anti-leukemia drug homoharringtonine sensitizes resistant human colorectal carcinoma cells to TRAIL-induced apoptosis via multiple mechanisms
P478volume18

Reverse relations

cites work (P2860)
Q35882493Bay 61-3606 Sensitizes TRAIL-Induced Apoptosis by Downregulating Mcl-1 in Breast Cancer Cells
Q46316687Cephalotaxus Alkaloids
Q36260575Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death.
Q35600313Efficient drug delivery and induction of apoptosis in colorectal tumors using a death receptor 5-targeted nanomedicine
Q98499791Homoharringtonine suppresses tumor proliferation and migration by regulating EphB4-mediated β-catenin loss in hepatocellular carcinoma
Q38880884Homoharringtonine, a clinically approved anti-leukemia drug, sensitizes tumor cells for TRAIL-induced necroptosis
Q64230629Human Embryonic Stem Cells Acquire Responsiveness to TRAIL upon Exposure to Cisplatin
Q42915261Human embryonic and induced pluripotent stem cells express TRAIL receptors and can be sensitized to TRAIL-induced apoptosis.
Q58759678Liposomal Co-Delivery of Omacetaxine Mepesuccinate and Doxorubicin for Synergistic Potentiation of Antitumor Activity
Q38760939Nucleostemin dysregulation contributes to ischemic vulnerability of diabetic hearts: Role of ribosomal biogenesis
Q38789476Omacetaxine mepesuccinate induces apoptosis and cell cycle arrest, promotes cell differentiation, and reduces telomerase activity in diffuse large B‑cell lymphoma cells

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