TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis

scientific article published in November 1998

TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0960-9822(07)00533-7
P698PubMed publication ID9822576

P2093author name stringBeug H
Oft M
Heider KH
P2860cites workp15INK4B is a potential effector of TGF-beta-induced cell cycle arrestQ24319021
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instabilityQ24319995
TGF beta signals through a heteromeric protein kinase receptor complexQ24337608
CDC25 phosphatases as potential human oncogenesQ28116546
Lessons from hereditary colorectal cancerQ28131788
Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15Q28239045
Mechanism of activation of the TGF-beta receptorQ28245861
Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cellsQ28305879
Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell lineQ29547239
Production of high-titer helper-free retroviruses by transient transfectionQ29547802
Transforming growth factor β1 as a biomarker for prostate cancerQ35190856
Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitroQ35610349
Relationship of transforming growth factor beta 1 to extracellular matrix and stromal infiltrates in invasive breast carcinomaQ35979144
Cancer metastasis and angiogenesis: An imbalance of positive and negative regulationQ36618743
Transgenic models for the study of prostate cancerQ40873364
TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cellsQ41164260
Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinaseQ41639273
Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: implications for wound healing.Q42771319
Expression of mRNA for transforming growth factors-alpha and -beta and secretion of transforming growth factor-beta by renal cell carcinoma cell linesQ43940493
TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic miceQ45345227
Synergistic induction of mesoderm by FGF and TGF-beta and the identification of an mRNA coding for FGF in the early Xenopus embryo.Q45989344
Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency.Q47852627
Absence of mutations in the transforming growth factor-beta type II receptor in sporadic lung cancers with microsatellite instability and rare H-ras1 alleles.Q53442031
Genetic alterations in sporadic and Crohn's-associated adenocarcinomas of the small intestine.Q53442180
Analysis of the DPC4 gene in gastric carcinoma.Q55001846
MAD-related genes on 18q21.1, Smad2 and Smad4, are altered infrequently in esophageal squamous cell carcinoma.Q55410356
Expression of transforming growth factor-beta 1 in prostate cancer.Q64893650
Somatic alterations of the DPC4 gene in human colorectal cancers in vivoQ71739625
Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-betaQ71995235
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectneoplastic invasivenessQ112498967
P304page(s)1243-1252
P577publication date1998-11-01
P1433published inCurrent BiologyQ1144851
P1476titleTGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis
P478volume8

Reverse relations

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Q34136526TGF-beta and colorectal carcinogenesis
Q29616456TGF-beta and epithelial-to-mesenchymal transitions
Q39957865TGF-beta has paradoxical and context dependent effects on proliferation and anoikis in human colorectal cancer cell lines
Q34421804TGF-beta signaling in cancer--a double-edged sword
Q29615427TGF-beta signaling in tumor suppression and cancer progression
Q36001319TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression.
Q40727835TGF-beta(1) and Smad4 overexpression induce a less invasive phenotype in highly invasive spindle carcinoma cells
Q29619820TGF-beta-induced epithelial to mesenchymal transition
Q37693902TGF-β autocrine pathway and MAPK signaling promote cell invasiveness and in vivo mammary adenocarcinoma tumor progression
Q46183468TGF-β inhibits metastasis in late stage human squamous cell carcinoma of the skin by a mechanism that does not involve Id1
Q30597668TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion.
Q37492534TGF-β regulation of gene expression at early and late stages of HPV16-mediated transformation of human keratinocytes
Q92377249TGF-β signaling promotes tube-structure-forming growth in pancreatic duct adenocarcinoma
Q37641591TGF-β1 stimulates migration of type II endometrial cancer cells by down-regulating PTEN via activation of SMAD and ERK1/2 signaling pathways.
Q39103885TGF-β2: A Novel Target of CD44-Promoted Breast Cancer Invasion
Q45364293TGFBR3 polymorphisms and its haplotypes associated with chronic hepatitis B virus infection and age of hepatocellular carcinoma occurrence
Q35589431TGFbeta induces morphological and molecular changes similar to human anterior subcapsular cataract
Q28142605TGFbeta signaling in growth control, cancer, and heritable disorders
Q33980127TGFbeta signaling supports survival and metastasis of endometrial cancer cells.
Q36619111TGFbeta-mediated signaling and transcriptional regulation in pancreatic development and cancer.
Q35079908TGFbeta-regulated transcriptional mechanisms in cancer
Q39903519TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch
Q28589847TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development
Q28083107TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis
Q48577765TGFβ can stimulate the p(38)/β-catenin/PPARγ signaling pathway to promote the EMT, invasion and migration of non-small cell lung cancer (H460 cells).
Q33648775TMPRSS2:ERG gene fusion variants induce TGF-β signaling and epithelial to mesenchymal transition in human prostate cancer cells
Q46256864Tamoxifen decreases extracellular TGF-beta1 secreted from breast cancer cells--a post-translational regulation involving matrix metalloproteinase activity
Q28067219Targeting microenvironment in cancer therapeutics
Q35042977Targeting of α(v)-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer
Q35169582Targeting the TGF beta signaling network in human neoplasia
Q40717397Targets of transcriptional regulation by transforming growth factor-beta: expression profile analysis using oligonucleotide arrays
Q41711662Tartrate-resistant acid phosphatase (TRAP/ACP5) promotes metastasis-related properties via TGFβ2/TβR and CD44 in MDA-MB-231 breast cancer cells.
Q34356297Tgf-beta signaling pathway in lung adenocarcinoma invasion.
Q59355701The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers
Q34278562The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion.
Q42009631The Misregulation of Cell Adhesion Components during Tumorigenesis: Overview and Commentary
Q33784365The PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression
Q36522719The Role of TGFβ Signaling in Squamous Cell Cancer: Lessons from Mouse Models
Q57816901The Role of the Extracellular Matrix and Its Molecular and Cellular Regulators in Cancer Cell Plasticity
Q37328463The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling
Q33800658The Smads.
Q28207920The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation
Q36429644The alphaVbeta6 integrin as a novel molecular target for colorectal cancer
Q44159142The atypical chemokine receptor CCX-CKR regulates metastasis of mammary carcinoma via an effect on EMT.
Q24652992The basics of epithelial-mesenchymal transition
Q37780777The crosstalk of RAS with the TGF-β family during carcinoma progression and its implications for targeted cancer therapy
Q34295021The early steps of neural crest development
Q34310378The epigenetics of epithelial-mesenchymal plasticity in cancer
Q36547739The evolving portrait of cancer metastasis.
Q34989790The genetic pathogenesis of colorectal cancer
Q34483637The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway
Q39372971The iron chelators Dp44mT and DFO inhibit TGF-β-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1).
Q33860861The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter
Q28254798The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it
Q24801456The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion.
Q40626766The proto-oncoprotein c-Fos negatively regulates hepatocellular tumorigenesis.
Q36241260The role of TGF-beta and Wnt signaling in gastrointestinal stem cells and cancer
Q35969342The role of TGF-beta in epithelial malignancy and its relevance to the pathogenesis of oral cancer (part II).
Q26997815The role of the myofibroblast in tumor stroma remodeling
Q36677504The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis
Q28216843The snail superfamily of zinc-finger transcription factors
Q33607396The tale of transforming growth factor-beta (TGFbeta) signaling: a soigné enigma.
Q37157489The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha
Q36964339The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway
Q37112272The type I TGF-beta receptor is covalently modified and regulated by sumoylation
Q21195231The use of cystatin C to inhibit epithelial-mesenchymal transition and morphological transformation stimulated by transforming growth factor-beta
Q73855680There is no increase in frequency of somatic mutations in metastases compared with primary colorectal carcinomas with microsatellite instability
Q33806990Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction
Q35591715Transcription factor Dlx2 protects from TGFβ-induced cell-cycle arrest and apoptosis
Q33731789Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma
Q36279142Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma
Q36897816Transformation by oncogenic Ras expands the early genomic response to transforming growth factor beta in intestinal epithelial cells
Q43850094Transforming growth factor beta 1 induces proliferation in colon carcinoma cells by Ras-dependent, smad-independent down-regulation of p21cip1.
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Q24793229Transforming growth factor-beta and breast cancer: Lessons learned from genetically altered mouse models
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Q24793319Transforming growth factor-beta and breast cancer: Tumor promoting effects of transforming growth factor-beta
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Q37219226Transforming growth factor-beta signaling: emerging stem cell target in metastatic breast cancer?
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Q74615795Transforming growth factor-beta-induced upregulation of transforming growth factor-beta receptor expression in pancreatic regeneration
Q44508741Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways
Q24600173Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
Q35747461Transforming growth factor-beta1 triggers hepatocellular carcinoma invasiveness via alpha3beta1 integrin
Q38315881Transforming growth factor-beta1 upregulates transcription of alpha3 integrin gene in hepatocellular carcinoma cells via Ets-transcription factor-binding motif in the promoter region
Q39447639Transforming growth factor-β1 activates ΔNp63/c-Myc to promote oral squamous cell carcinoma
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Q24791032Transforming growth factors-beta are not good biomarkers of chemopreventive efficacy in a preclinical breast cancer model system.
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Q40469680Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase.
Q44792812Visualization of the post-Golgi vesicle-mediated transportation of TGF-β receptor II by quasi-TIRFM.

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