TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion.

scientific article

TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E14-05-1015
P932PMC publication ID4230614
P698PubMed publication ID25143398

P50authorKarthikeyan MythreyeQ42775830
Richard SuperfineQ55815944
Gerard C BlobeQ112122504
P2093author name stringTam How
George Z Li
E Tim O'Brien
Lukas D Osborne
P2860cites workCellular traction stresses increase with increasing metastatic potentialQ21134747
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticityQ24297858
SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7Q24299813
Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanismQ24600173
Matrix crosslinking forces tumor progression by enhancing integrin signalingQ24646370
MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoAQ24648090
From mechanical force to RhoA activationQ26824081
MicroRNAs: small RNAs with a big role in gene regulationQ27860896
Tensional homeostasis and the malignant phenotypeQ27860932
Regulation of cell polarity and protrusion formation by targeting RhoA for degradationQ28189565
TGFβ signalling in contextQ28275410
Rac activation and inactivation control plasticity of tumor cell movementQ28299776
Force fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migrationQ28508256
Tumour-cell invasion and migration: diversity and escape mechanismsQ29547894
Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysisQ29615193
Many roads to maturity: microRNA biogenesis pathways and their regulationQ29615469
TGF-beta-induced epithelial to mesenchymal transitionQ29619820
The RhoA activator GEF-H1/Lfc is a transforming growth factor-beta target gene and effector that regulates alpha-smooth muscle actin expression and cell migrationQ30436035
Integrin-dependent actomyosin contraction regulates epithelial cell scattering.Q30443410
Substrate rigidity regulates the formation and maintenance of tissuesQ30476924
Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edgeQ30490189
The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins.Q30500836
Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathwayQ30540604
Thin-foil magnetic force system for high-numerical-aperture microscopy.Q33251301
Expression profiling of genes regulated by TGF-beta: differential regulation in normal and tumour cells.Q33281716
TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responsesQ34089674
Mechanotransduction Across the Cell Surface and Through the CytoskeletonQ34306171
Cell stiffness is a biomarker of the metastatic potential of ovarian cancer cellsQ34441724
Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitroQ34928535
RhoA and RhoC have distinct roles in migration and invasion by acting through different targetsQ35196063
Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines.Q35563976
The physics of cancer: the role of physical interactions and mechanical forces in metastasisQ35684114
Overexpressed hPTTG1 promotes breast cancer cell invasion and metastasis by regulating GEF-H1/RhoA signallingQ36053060
Microtubules regulate GEF-H1 in response to extracellular matrix stiffnessQ36066653
Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria.Q36479378
Regulation of focal adhesion kinase activation, breast cancer cell motility, and amoeboid invasion by the RhoA guanine nucleotide exchange factor Net1.Q36978333
The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cellsQ37040558
Bone morphogenetic proteins induce pancreatic cancer cell invasiveness through a Smad1-dependent mechanism that involves matrix metalloproteinase-2.Q37090431
A tense situation: forcing tumour progressionQ37112264
Guiding cell migration by tuggingQ37307604
High throughput system for magnetic manipulation of cells, polymers, and biomaterials.Q37356808
EMT, the cytoskeleton, and cancer cell invasionQ37377630
The plasticity of cytoskeletal dynamics underlying neoplastic cell migrationQ37786738
Guanine nucleotide exchange factors for RhoGTPases: good therapeutic targets for cancer therapy?Q37806397
Induction of epithelial-mesenchymal transition by transforming growth factor β.Q38006771
Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cellsQ38302139
Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinomaQ40277150
TGFbeta-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN.Q40362946
Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinomaQ40485731
Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein.Q40560477
TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cellsQ40915568
The role of actin-binding protein 280 in integrin-dependent mechanoprotectionQ41069999
RhoA and microtubule dynamics control cell-basement membrane interaction in EMT during gastrulationQ42437398
Cytoskeletal rearrangement and signal transduction in TGF-beta1-stimulated mesangial cell collagen accumulationQ42444937
Regulation of actin organisation by TGF-beta in H-ras-transformed fibroblasts.Q42818111
TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasisQ46272247
Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channelsQ46917020
Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-β and miR-24: role in epithelial-to-mesenchymal transition.Q52617207
The nanomechanical signature of breast cancerQ58463870
P433issue22
P304page(s)3528-3540
P577publication date2014-08-20
P1433published inMolecular Biology of the CellQ2338259
P1476titleTGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion
P478volume25

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cites work (P2860)
Q35130924A high throughput array microscope for the mechanical characterization of biomaterials
Q30844674A new strategy to measure intercellular adhesion forces in mature cell-cell contacts
Q27345323An Automated High-throughput Array Microscope for Cancer Cell Mechanics
Q42315790An oncogenic KRAS transcription program activates the RHOGEF ARHGEF2 to mediate transformed phenotypes in pancreatic cancer.
Q38864912Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads.
Q28079722Biophysical Approach to Mechanisms of Cancer Prevention and Treatment with Green Tea Catechins
Q47233500Cell softening in malignant progression of human lung cancer cells by activation of receptor tyrosine kinase AXL.
Q61798258Cisplatin enhances cell stiffness and decreases invasiveness rate in prostate cancer cells by actin accumulation
Q94483867Context specificity of the EMT transcriptional response
Q59792835Epithelial-Mesenchymal Transition and Metastasis under the Control of Transforming Growth Factor β
Q49499717Go with the flow: GEF-H1 mediated shear stress mechanotransduction in neutrophils.
Q38851702Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix
Q26745545Mechanisms of TGFβ-Induced Epithelial-Mesenchymal Transition
Q54108549Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer.
Q102141796Metastasis: crosstalk between tissue mechanics and tumour cell plasticity
Q45030327Overexpression of tumor suppressor gene ZNF750 inhibits oral squamous cell carcinoma metastasis
Q30657060RalB regulates contractility-driven cancer dissemination upon TGFβ stimulation via the RhoGEF GEF-H1
Q28817018TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis
Q38846822The role of small GTPases of the Rho/Rac family in TGF-β-induced EMT and cell motility in cancer
Q42109031Three-Dimensional Breast Cancer Models Mimic Hallmarks of Size-Induced Tumor Progression.
Q37684429c-Abl inhibits breast cancer tumorigenesis through reactivation of p53-mediated p21 expression

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