TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

scientific article published in August 1996

TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0092-8674(00)80127-0
P698PubMed publication ID8752208
P5875ResearchGate publication ID14450791

P50authorWei CuiQ41903793
P2093author name stringAkhurst RJ
Balmain A
Ireland H
Bryson S
Fowlis DJ
Duffie E
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Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitroQ35610349
Carcinosarcoma of the lung; review of the literature and report of two cases treated by pneumonectomyQ35661885
Recombinant latent transforming growth factor beta 1 has a longer plasma half-life in rats than active transforming growth factor beta 1, and a different tissue distributionQ35817740
Concerted action of TGF-beta 1 and its type II receptor in control of epidermal homeostasis in transgenic miceQ72297295
Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinomaQ72801082
In situ end-labelling detects DNA strand breaks in apoptosis and other physiological and pathological statesQ72818153
Transforming growth factor-beta 1 as a signal for induction of cell death by apoptosisQ35975984
Stimulatory role of transforming growth factors in multistage skin carcinogenesis: possible explanation for the tumor-inducing effect of wounding in initiated NMRI mouse skinQ36009391
Distribution and modulation of the cellular receptor for transforming growth factor-betaQ36217344
Transforming growth factor-beta 1: histochemical localization with antibodies to different epitopesQ36220190
Integrin heterodimer and receptor complexity in avian and mammalian cellsQ36220327
TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptorsQ36235100
Cell death by apoptosis and its protective role against diseaseQ36327633
Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic miceQ36345330
Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversionQ36392971
TGF-beta 1 is an autocrine-negative growth regulator of human colon carcinoma FET cells in vivo as revealed by transfection of an antisense expression vectorQ36530713
Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor beta 1Q36531643
Transforming growth factor-beta 3 is required for secondary palate fusionQ37373842
Secreted or nonsecreted forms of acidic fibroblast growth factor produced by transfected epithelial cells influence cell morphology, motility, and invasive potentialQ37467404
Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cellsQ37486376
Escape from transforming growth factor beta control and oncogene cooperation in skin tumor developmentQ37611617
A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillanceQ37699443
Mesoderm induction in Xenopus caused by activation of MAP kinaseQ38293549
Spindle cell squamous carcinomas and sarcoma-like tumors of the skin: a comparative study of 38 casesQ40361204
Transgenic Approaches to the Analysis of ras and p53 Function in Multistage CarcinogenesisQ40431247
Autocrine transforming growth factor beta 1 modulates the expression of integrin alpha 5 beta 1 in human colon carcinoma FET cellsQ41335793
Complex patterns of expression suggest extensive roles for the α2β1 integrin in murine developmentQ41478595
Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities.Q41552765
Expression of alpha 6 beta 4 integrin increases during malignant conversion of mouse epidermal keratinocytes: association of beta 4 subunit to the cytokeratin fractionQ41611433
Regulation of human colon-carcinoma cell adhesion to extracellular matrix by transforming growth factor beta 1Q41631134
TGF-beta 1 and skin carcinogenesis: antiproliferative effect in vitro and TGF-beta 1 mRNA expression during epidermal hyperproliferation and multistage tumorigenesisQ41706662
The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive eventQ42218126
Involvement of p21ras in Xenopus mesoderm inductionQ42819317
Induction of papillomas with a high probability of conversion to malignancyQ44144119
Mediation of wound-related Rous sarcoma virus tumorigenesis by TGF-betaQ44225473
Changes in response to, and production of, transforming growth factor type beta during neoplastic progression in cultured rat tracheal epithelial cellsQ44751226
Spindle cell carcinoma.Ultrastructural evidence of squamous origin and collagen production by the tumor cellsQ44962271
Synergistic induction of mesoderm by FGF and TGF-beta and the identification of an mRNA coding for FGF in the early Xenopus embryo.Q45989344
Aberrant expression during two-stage mouse skin carcinogenesis of a type I 47-kDa keratin, K13, normally associated with terminal differentiation of internal stratified epithelia.Q53524991
Keratins as markers of malignancy in mouse epidermal tumorsQ53577413
Localized production of TGF-β mRNA in tumour promoter-stimulated mouse epidermisQ59068394
Differential expression of genes encoding TGFs β1, β2, and β3 during murine palate formationQ67672314
Immunolocalization of epidermal growth factor (EGF), EGF receptor and transforming growth factor alpha (TGF alpha) during murine palatogenesis in vivo and in vitroQ68026026
Multistage chemical carcinogenesis protocols produce spindle cell carcinomas of the mouse skinQ69108506
Epithelial-mesenchymal cell transformation in the embryonic heart can be mediated, in part, by transforming growth factor betaQ69650317
Sarcomatoid squamous cell carcinoma of the mucous membranes of the head and neck: a clinicopathologic study of 20 casesQ70902588
Expression pattern of the cell adhesion molecules. E-cadherin, P-cadherin and alpha 6 beta 4 intergrin is altered in pre-malignant skin tumors of p53-deficient miceQ70913851
Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancerQ71601446
Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human lung carcinoma cells of different histotypesQ71604126
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)531-542
P577publication date1996-08-01
P1433published inCellQ655814
P1476titleTGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
P478volume86

Reverse relations

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