L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin

scientific article

L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M111.235473
P932PMC publication ID3186417
P698PubMed publication ID21841000

P2093author name stringKuniaki Saito
Ekihiro Seki
Masato Hoshi
Hisataka Moriwaki
Atsushi Suetsugu
Yosuke Osawa
Masahito Nagaki
Hiromitsu Kanamori
Hiroyasu Ito
Mitsuru Seishima
Hirofumi Ohtaki
Yoichi Yasuda
P2860cites workSerotonin promotes tumor growth in human hepatocellular cancerQ24297176
Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolismQ27334776
Fatty liver induced by injection of L-tryptophanQ28237468
Autophagy regulates lipid metabolismQ29547421
Nonalcoholic fatty liver diseaseQ29619354
Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulinQ30434199
Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradationQ33540082
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesisQ33734679
Autophagy in health and disease. 2. Regulation of lipid metabolism and storage by autophagy: pathophysiological implicationsQ33840453
Immunohistochemical localization of tryptophan hydroxylase in the human and rat gastrointestinal tractsQ33869202
Proteolytic and lipolytic responses to starvationQ33997322
L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications.Q34011523
The target of rapamycin (TOR) proteinsQ34287448
Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alphaQ34425224
Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppressionQ34682367
Differential effects of long-term leucine infusion on tissue protein synthesis in neonatal pigsQ35114398
Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]Q36604703
Role of serotonin in the hepato-gastroIntestinal tract: an old molecule for new perspectives.Q37031956
Mammalian target of rapamycin (mTOR) pathway signalling in lymphomasQ37074284
An emerging role of mTOR in lipid biosynthesis.Q37641438
The role of fructose in the pathogenesis of NAFLD and the metabolic syndromeQ37724585
L-Tryptophan: Biochemical, nutritional and pharmacological aspectsQ38157695
Rat liver is not damaged by high dose tryptophan treatmentQ38565402
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.Q40480010
Immunocytochemical demonstration of 5-hydroxytryptamine in gastrointestinal endocrine cellsQ41019873
Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in miceQ43263378
Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in ratsQ44129339
Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): a population based studyQ44451078
Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR.Q44482073
Identification of the aromatic L-amino acid decarboxylase gene expression in various mice tissues and its modulation by immobilization stress in stellate gangliaQ44944608
The mTOR signaling pathway mediates control of ribosomal protein mRNA translation in rat liverQ45020034
Tryptophan loading induces oxidative stressQ45204042
Aggravation of viral hepatitis by platelet-derived serotoninQ45218233
Rapamycin protects against high fat diet-induced obesity in C57BL/6J miceQ46047957
Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liverQ46827700
Promotion of oxidative stress by L-tryptophan in cerebral cortex of ratsQ46960043
Ultrastructural changes of the liver following L-tryptophan ingestion in ratsQ49011144
The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid.Q53579178
Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis.Q55044281
Subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant miceQ58045882
Tryptophan and the control of triglyceride and carbohydrate metabolism in the ratQ71206529
The Absence of IDO Upregulates Type I IFN Production, Resulting in Suppression of Viral Replication in the Retrovirus-Infected MouseQ84698033
P4510describes a project that usesImageJQ1659584
P433issue40
P407language of work or nameEnglishQ1860
P921main subjectsirolimusQ32089
liver diseaseQ929737
metabolic dysfunction–associated steatotic liver diseaseQ1546498
fatty liver diseaseQ6058862
P304page(s)34800-34808
P577publication date2011-08-12
P1433published inJournal of Biological ChemistryQ867727
P1476titleL-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin
P478volume286

Reverse relations

cites work (P2860)
Q48032403Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease
Q47548477Cardioprotective effects of dietary rapamycin on adult female C57BLKS/J-Leprdb mice
Q42504789Dietary Tryptophan Enhanced the Expression of Tight Junction Protein ZO-1 in Intestine.
Q37385498Effective treatment with combination of peripheral 5-hydroxytryptamine synthetic inhibitor and 5-hydroxytryptamine 2 receptor antagonist on glucocorticoid-induced whole-body insulin resistance with hyperglycemia
Q34988970Effects of indoleamine 2,3-dioxygenase deficiency on high-fat diet-induced hepatic inflammation
Q41200837Identification of key metabolic changes during liver fibrosis progression in rats using a urine and serum metabolomics approach
Q38799136Important role of 5-hydroxytryptamine in glucocorticoid-induced insulin resistance in liver and intra-abdominal adipose tissue of rats
Q37059599Induction of TDO2 and IDO2 in Liver by High-Fat Feeding in Mice: Discrepancies with Human Obesity
Q55387515Inhibition of Serotonin Synthesis Induces Negative Hepatic Lipid Balance.
Q37106900L-tryptophan metabolism in pregnant mice fed a high L-tryptophan diet and the effect on maternal, placental, and fetal growth
Q97516977LC-MS-Based Metabolomic Study of Oleanolic Acid-Induced Hepatotoxicity in Mice
Q90602682Liver ASK1 protects from non-alcoholic fatty liver disease and fibrosis
Q36534056Long-term Stress with Hyperglucocorticoidemia-induced Hepatic Steatosis with VLDL Overproduction Is Dependent on both 5-HT2 Receptor and 5-HT Synthesis in Liver
Q92129602Maternally Inherited Differences within Mitochondrial Complex I Control Murine Healthspan
Q31044588Metabolomics Coupled with Multivariate Data and Pathway Analysis on Potential Biomarkers in Cholestasis and Intervention Effect of Paeonia lactiflora Pall
Q92635722Pathogens MenTORing Macrophages and Dendritic Cells: Manipulation of mTOR and Cellular Metabolism to Promote Immune Escape
Q38652774Redox Properties of Tryptophan Metabolism and the Concept of Tryptophan Use in Pregnancy
Q33645106Role of serotonin in fatty acid-induced non-alcoholic fatty liver disease in mice
Q42091299Sake lees extract improves hepatic lipid accumulation in high fat diet-fed mice
Q58577645Serotonin induced hepatic steatosis is associated with modulation of autophagy and notch signaling pathway
Q59136627Serotonin signals through a gut-liver axis to regulate hepatic steatosis
Q41176544Serum serotonin reduced the expression of hepatic transporter Mrp2 and P-gp via regulating nuclear receptor CAR in PI-IBS rats
Q43099927Severe everolimus-induced steatohepatis: a case report
Q37309756Subanesthetic doses of ketamine transiently decrease serotonin transporter activity: a PET study in conscious monkeys
Q89114871The gut microbiota metabolite indole alleviates liver inflammation in mice
Q38081396The mTOR pathway in hepatic malignancies
Q38886658l-Tryptophan Activates Mammalian Target of Rapamycin and Enhances Expression of Tight Junction Proteins in Intestinal Porcine Epithelial Cells

Search more.