Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice

scientific article published in January 2010

Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/HEP.23262
P698PubMed publication ID19821528
P5875ResearchGate publication ID26887271

P2093author name stringEkihiro Seki
Hisataka Moriwaki
Atsushi Suetsugu
Yosuke Osawa
Masahito Nagaki
Hiroyasu Ito
Mitsuru Seishima
Masayuki Adachi
P2860cites workHepatocyte growth factor gene therapy of liver cirrhosis in ratsQ44406096
Kupffer cell-depleted rats have a diminished acute-phase response following major liver resection.Q44913978
Fumonisin B1 hepatotoxicity in mice is attenuated by depletion of Kupffer cells by gadolinium chlorideQ45181857
Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liverQ46827700
Analysis of the lung pathology and alveolar macrophage function in the acid sphingomyelinase--deficient mouse model of Niemann-Pick diseaseQ49240068
Severe impairment in early host defense against Listeria monocytogenes in mice deficient in acid sphingomyelinaseQ50105214
SMAD and p38 MAPK signaling pathways independently regulate alpha1(I) collagen gene expression in unstimulated and transforming growth factor-beta-stimulated hepatic stellate cells.Q50781080
Acid sphingomyelinase inhibition suppresses lipopolysaccharide-mediated release of inflammatory cytokines from macrophages and protects against disease pathology in dextran sulphate sodium-induced colitis in mice.Q51020334
Altered Kupffer cell function in biliary obstruction.Q51841407
Kupffer Cell-Expressed Membrane-Bound TNF Mediates Melphalan Hepatotoxicity via Activation of Both TNF ReceptorsQ58858794
Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activationQ73229802
Inflammation in response to hepatocellular apoptosisQ77823653
Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expressionQ79209033
Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligationQ79219306
Mannose-conjugated alendronate selectively depletes Kupffer cells and inhibits endotoxemic shock in the miceQ79860542
Akt-mediated liver growth promotes induction of cyclin E through a novel translational mechanism and a p21-mediated cell cycle arrestQ80367693
Liver fibrosisQ29547449
TLR4 enhances TGF-beta signaling and hepatic fibrosisQ29620016
Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout miceQ30881683
Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transitionQ32075959
Kupffer cells abrogate cholestatic liver injury in miceQ33236130
Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alphaQ34425224
Bile acid regulation of hepatic physiology: IV. Bile acids and death receptorsQ35102867
Ceramide-enriched membrane domainsQ36286893
"Let there be bile"--understanding hepatic injury in cholestasisQ36526816
Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesisQ36661322
Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitisQ37058328
Inflammatory pathways in liver homeostasis and liver injuryQ37207091
Fas enhances fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosis.Q39632325
Functions of ceramide in coordinating cellular responses to stressQ41243489
Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators.Q42435405
Protective role of Kupffer cells in acetaminophen-induced hepatic injury in miceQ44249123
Liver regeneration in heparin-binding EGF-like growth factor transgenic mice after partial hepatectomyQ44337885
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)237-245
P577publication date2010-01-01
P1433published inHepatologyQ15724398
P1476titleRole of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice
P478volume51

Reverse relations

cites work (P2860)
Q34086900Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis
Q55110755Cellular Mechanisms of Hepatoprotection Mediated by M2-Like Macrophages.
Q36517945Contrasting responses of Kupffer cells and inflammatory mononuclear phagocytes to biliary obstruction in a mouse model of cholestatic liver injury
Q89497645Crosstalk Between Acid Sphingomyelinase and Inflammasome Signaling and Their Emerging Roles in Tissue Injury and Fibrosis
Q100517651Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities
Q36541005Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice.
Q46331739Isofraxidin, a coumarin component improves high-fat diet induced hepatic lipid homeostasis disorder and macrophage inflammation in mice
Q35235774Kupffer cells influence parenchymal invasion and phenotypic orientation, but not the proliferation, of liver progenitor cells in a murine model of liver injury
Q35266698L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin
Q34796252Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice.
Q64946007Liver Macrophages: Old Dogmas and New Insights.
Q36580354Liver acid sphingomyelinase inhibits growth of metastatic colon cancer
Q33740461M2-like Kupffer cells in fibrotic liver may protect against acute insult
Q41620915M2-like macrophages in the fibrotic liver protect mice against lethal insults through conferring apoptosis resistance to hepatocytes
Q39367594Mechanisms of bile acid mediated inflammation in the liver
Q38906942Pathogenesis of Kupffer Cells in Cholestatic Liver Injury
Q91897717Phenotypic switch of human and mouse macrophages and resultant effects on apoptosis resistance in hepatocytes
Q64111310Role of macrophages in experimental liver injury and repair in mice
Q34766246Tumor necrosis factor-α promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells
Q52605838Tumor necrosis factor-α-mediated hepatocyte apoptosis stimulates fibrosis in the steatotic liver in mice.
Q57478274Wnt/β-Catenin Signaling as a Potential Target for the Treatment of Liver Cirrhosis Using Antifibrotic Drugs
Q36442343β-Arrestin 2 Promotes Hepatocyte Apoptosis by Inhibiting Akt Protein

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