MicroRNA-500 sustains nuclear factor-κB activation and induces gastric cancer cell proliferation and resistance to apoptosis

scientific article

MicroRNA-500 sustains nuclear factor-κB activation and induces gastric cancer cell proliferation and resistance to apoptosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.2800
P932PMC publication ID4385865
P698PubMed publication ID25595906
P5875ResearchGate publication ID271080083

P2093author name stringLiang Zhang
Jian Sun
Ya Ding
Shu Wu
Dongsheng Zhang
Su Li
Junling Liu
Zhongyu Yuan
Fangyong Lei
P2860cites workDe-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signallingQ24299573
Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human gastric carcinoma tissueQ77372895
Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activationQ24309469
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexesQ24312187
Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signalingQ24337661
Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activityQ24530708
Treatment of gastric cancerQ24602875
Global cancer statistics, 2002Q27860562
The functions of animal microRNAsQ27860621
MicroRNAs: genomics, biogenesis, mechanism, and functionQ27861070
Identification of the familial cylindromatosis tumour-suppressor geneQ28145560
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family membersQ28201693
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitinationQ28201717
Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activityQ28276063
Shaping the nuclear action of NF-kappaBQ29614600
Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa BQ29618210
Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMOQ29618712
Epidemiology of gastric cancerQ33788193
The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.Q34235332
Cyr61 induces gastric cancer cell motility/invasion via activation of the integrin/nuclear factor-kappaB/cyclooxygenase-2 signaling pathwayQ34444831
NF-kappaB as a therapeutic target in cancerQ34750172
International variationQ35868021
miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops.Q36596742
Phase II 2-arm trial of the proteasome inhibitor, PS-341 (bortezomib) in combination with irinotecan or PS-341 alone followed by the addition of irinotecan at time of progression in patients with locally recurrent or metastatic squamous cell carcinoQ36947423
NF-kappaB and cancer-identifying targets and mechanismsQ36984251
Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanomaQ37061845
CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processesQ37448141
The role of the kinases RIP1 and RIP3 in TNF-induced necrosisQ37721675
Phase I-II study of the farnesyl transferase inhibitor tipifarnib plus sequential weekly paclitaxel and doxorubicin-cyclophosphamide in HER2/neu-negative inflammatory carcinoma and non-inflammatory estrogen receptor-positive breast carcinomaQ37723277
Deubiquitinases in the regulation of NF-κB signalingQ37814068
Expanding role of ubiquitination in NF-κB signalingQ37816941
First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway.Q39393075
Inhibitor of kappaB kinase beta regulates gastric carcinogenesis via interleukin-1alpha expression.Q39721819
Reduced expression of CYLD in human colon and hepatocellular carcinomasQ40267883
NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signalingQ46820406
Gene expression profiling of paired ovarian tumors obtained prior to and following adjuvant chemotherapy: molecular signatures of chemoresistant tumors.Q53618136
Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer.Q54305213
Ubiquitination of RIP Is Required for Tumor Necrosis Factor α-induced NF-κB ActivationQ57372470
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectmicroRNAQ310899
P304page(s)2483-2495
P577publication date2015-02-01
P1433published inOncotargetQ1573155
P1476titleMicroRNA-500 sustains nuclear factor-κB activation and induces gastric cancer cell proliferation and resistance to apoptosis
P478volume6

Reverse relations

cites work (P2860)
Q26780293Dysregulation of non-coding RNAs in gastric cancer
Q92669327High expression of microRNA-500 is associated with poor prognosis in patients with acute myeloid leukemia receiving allogeneic hematopoietic stem cell transplantation
Q35927721Identification of a blood-borne miRNA signature of synovial sarcoma
Q38699763Inhibition of microRNA-500 has anti-cancer effect through its conditional downstream target of TFPI in human prostate cancer
Q38751308MiR-125b regulates proliferation and apoptosis of nasopharyngeal carcinoma by targeting A20/NF-κB signaling pathway
Q36413197MicroRNA-940 promotes tumor cell invasion and metastasis by downregulating ZNF24 in gastric cancer
Q50122609MicroRNA‑1288 promotes cell proliferation of human glioblastoma cells by repressing ubiquitin carboxyl‑terminal hydrolase CYLD expression
Q39204794NF-κB Signaling in Gastric Cancer.
Q51664715Noncoding RNAs Regulating NF-κB Signaling.
Q38824331Novel MicroRNA signatures in HPV-mediated cervical carcinogenesis in Indian women
Q90448135Plasma extracellular vesicle microRNAs for pulmonary ground-glass nodules
Q39237748Prognostic role of microRNAs in human gastrointestinal cancer: A systematic review and meta-analysis
Q41548169Prognostic value of microRNAs in gastric cancer: a meta-analysis
Q42367776The identification of molecular target of (20S) ginsenoside Rh2 for its anti-cancer activity
Q61797524The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer
Q64070295miR-500 promotes cell proliferation by directly targetting LRP1B in prostate cancer
Q44501687miR-500a-5p regulates oxidative stress response genes in breast cancer and predicts cancer survival

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