Central role of IL-17/Th17 immune responses and the gut microbiota in the pathogenesis of intestinal fibrosis

scientific article

Central role of IL-17/Th17 immune responses and the gut microbiota in the pathogenesis of intestinal fibrosis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1097/MOG.0000000000000119
P932PMC publication ID4512208
P698PubMed publication ID25255234

P2093author name stringShuvra Ray
Theresa T Pizarro
Carlo De Salvo
P2860cites workDeep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel diseaseQ24601772
Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel diseaseQ24646902
Increased expression of interleukin 17 in inflammatory bowel diseaseQ29622829
Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's diseaseQ30307038
Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitisQ30310728
Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel diseaseQ30311921
SAMP1/YitFc mouse strain: a spontaneous model of Crohn's disease-like ileitisQ30423660
Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammationQ30436253
Role of TL1A and its receptor DR3 in two models of chronic murine ileitisQ30440458
Commensal bacteria exacerbate intestinal inflammation but are not essential for the development of murine ileitisQ30442649
Interactions between the host innate immune system and microbes in inflammatory bowel diseaseQ33554402
The microbiome in inflammatory bowel disease: current status and the future aheadQ33664898
Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependentQ33730117
Airway remodeling in asthmaQ33753444
Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosisQ33802845
Nod/Ripk2 signaling in dendritic cells activates IL-17A-secreting innate lymphoid cells and drives colitis in T-bet-/-.Rag2-/- (TRUC) mice.Q33835084
Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cellsQ34150690
Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trialQ34275637
Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammationQ34327935
Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's diseaseQ34459129
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6Q34521302
IL-13 promotes collagen accumulation in Crohn's disease fibrosis by down-regulation of fibroblast MMP synthesis: a role for innate lymphoid cells?Q34540573
Angiotensin II is a new component involved in splenic T lymphocyte responses during Plasmodium berghei ANKA infectionQ34706971
Therapeutic effects of angiotensin II inhibition or blockade on the progression of chronic renal disease.Q35611798
Medical therapy for Crohn's disease stricturesQ35731494
Losartan reduces trinitrobenzene sulphonic acid-induced colorectal fibrosis in ratsQ35744613
Immunosuppressive treatment protects against angiotensin II-induced renal damageQ35747734
Fibrotic disease and the T(H)1/T(H)2 paradigmQ35852270
Interleukin-17A stimulates cardiac fibroblast proliferation and migration via negative regulation of the dual-specificity phosphatase MKP-1/DUSP-1.Q35920106
Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosisQ35951975
The use of angiotensin receptor blockers in the treatment of chronic heart failureQ35954136
Effects of six months losartan administration on liver fibrosis in chronic hepatitis C patients: a pilot studyQ36503291
TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune diseaseQ36639973
SUSTAINED TL1A (TNFSF15) EXPRESSION ON BOTH LYMPHOID AND MYELOID CELLS LEADS TO MILD SPONTANEOUS INTESTINAL INFLAMMATION AND FIBROSIS.Q36800644
TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation.Q37019308
The role of interleukin 17 in Crohn's disease-associated intestinal fibrosisQ37070931
Dysregulated NOD2 predisposes SAMP1/YitFc mice to chronic intestinal inflammationQ37240497
A protective function for interleukin 17A in T cell-mediated intestinal inflammationQ37260173
Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity.Q37329670
Combination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohn's diseaseQ37419668
Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids.Q37483138
Persistent infection with Crohn's disease-associated adherent-invasive Escherichia coli leads to chronic inflammation and intestinal fibrosis.Q37610002
Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategiesQ38013891
Mechanisms and models for intestinal fibrosis in IBD.Q38296801
Potential roles of interleukin-17A in the development of skin fibrosis in miceQ39308063
Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in miceQ39333394
IL-23/IL-17 immunity as a hallmark of Crohn's diseaseQ39977129
Angiotensin AT1 receptor antagonists exert anti-inflammatory effects in spontaneously hypertensive ratsQ40673218
Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1).Q42101278
Angiotensin converting enzyme-inhibitor reduces colitis severity in an IL-10 knockout modelQ42126346
Cellular and molecular mechanisms of intestinal fibrosisQ42252132
Angiotensinogen and transforming growth factor beta1: novel genes in the pathogenesis of Crohn's disease.Q43145801
IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activationQ43513541
Hemodynamic and antifibrotic effects of losartan in rats with liver fibrosis and/or portal hypertensionQ44225009
Increased levels of circulating Th17 cells in quiescent versus active Crohn's disease.Q44628467
Involvement of reactive oxygen species in angiotensin II-induced endothelin-1 gene expression in rat cardiac fibroblastsQ44671853
Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled studyQ44755697
Upregulation of circulating components of the alternative renin-angiotensin system in inflammatory bowel disease: A pilot studyQ45042350
Increased colonic mucosal angiotensin I and II concentrations in Crohn's colitisQ45286196
Secukinumab failure in Crohn's disease: the yeast connection?Q45370364
Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trialQ46911236
IL-17 contributes to cardiac fibrosis following experimental autoimmune myocarditis by a PKCβ/Erk1/2/NF-κB-dependent signaling pathway.Q50512444
Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II.Q54765190
Activation and suppression of renin–angiotensin system in human dendritic cellsQ57362707
Angiotensin II induces contraction and proliferation of human hepatic stellate cellsQ61576239
Role of oxygen-derived free radicals in acute angiotensin II--induced hypertensive vascular disease in the ratQ68715371
Immunohistochemical localization of angiotensin II receptor and local renin-angiotensin system in human colonic mucosaQ77513348
TNFSF15 polymorphisms are associated with susceptibility to inflammatory bowel disease in a new European cohortQ83252105
Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding studyQ86014195
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)531-538
P577publication date2014-11-01
P1433published inCurrent Opinion in GastroenterologyQ15758708
P1476titleCentral role of IL-17/Th17 immune responses and the gut microbiota in the pathogenesis of intestinal fibrosis
P478volume30

Reverse relations

cites work (P2860)
Q90193726Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis
Q40288354CD90(+) stromal cells are the major source of IL-6, which supports cancer stem-like cells and inflammation in colorectal cancer
Q27027429Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease
Q89986846Controversial Contribution of Th17/IL-17 Toward the Immune Response in Intestinal Fibrosis
Q89425548Effect of Homocysteine on the Differentiation of CD4+ T Cells into Th17 Cells
Q38695350Genetic Adjuvantation of a Cell-Based Therapeutic Vaccine for Amelioration of Chagasic Cardiomyopathy
Q55190074Heat shock protein 70 protects mouse against post-infection irritable bowel syndrome via up-regulating intestinal γδ T cell's Th17 response.
Q39182623IL-17 mediates neutrophil infiltration and renal fibrosis following recovery from ischemia reperfusion: compensatory role of natural killer cells in athymic rats
Q53222506IL-17-driven intestinal fibrosis is inhibited by Itch-mediated ubiquitination of HIC-5.
Q42369863Immunity and Fibrogenesis: The Role of Th17/IL-17 Axis in HBV and HCV-induced Chronic Hepatitis and Progression to Cirrhosis.
Q58541796Interleukin-17A and B-cell activating factor in chronic hepatitis C patients with or without asymptomatic mixed cryoglobulinemia: effects of antiviral treatment and correlations with vitamin D
Q26770666Osteoimmune Interactions in Inflammatory Bowel Disease: Central Role of Bone Marrow Th17 TNFα Cells in Osteoclastogenesis
Q93075393Pathogenesis of fibrostenosing Crohn's disease
Q36373253Reversibility of Stricturing Crohn's Disease-Fact or Fiction?
Q38853672The Lung Microbiome, Immunity, and the Pathogenesis of Chronic Lung Disease

Search more.