Pluronic F127 polymeric micelles for co-delivery of paclitaxel and lapatinib against metastatic breast cancer: preparation, optimization and in vitro evaluation

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Pluronic F127 polymeric micelles for co-delivery of paclitaxel and lapatinib against metastatic breast cancer: preparation, optimization and in vitro evaluation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3109/10837450.2014.965323
P698PubMed publication ID25265388

P50authorHossein AkbariQ43096206
P2093author name stringEbrahim Saadat
Fatemeh Ravar
Farid Dorkoosh
Pooya Dehghan Kelishady
P2860cites workMultidrug resistance in cancer: role of ATP-dependent transportersQ28208049
Therapeutic nanoparticles for drug delivery in cancerQ28271255
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a reviewQ29617388
Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulationQ33182379
Paclitaxel-loaded Pluronic P123/F127 mixed polymeric micelles: formulation, optimization and in vitro characterizationQ33437962
Dual targeting folate-conjugated hyaluronic acid polymeric micelles for paclitaxel deliveryQ34029905
Abraxane in the treatment of ovarian cancer: the absence of hypersensitivity reactionsQ34459821
Pluronic block copolymers as novel polymer therapeutics for drug and gene deliveryQ34783697
Methods to assess in vitro drug release from injectable polymeric particulate systemsQ36363768
Taxol induces the assembly of free microtubules in living cells and blocks the organizing capacity of the centrosomes and kinetochoresQ36368107
Lapatinib in breast cancerQ36860184
Preclinical evaluation of Genexol-PM, a nanoparticle formulation of paclitaxel, as a novel radiosensitizer for the treatment of non-small cell lung cancerQ37113921
Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancerQ37117151
Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2Q37119716
Lapatinib: a dual inhibitor of human epidermal growth factor receptor tyrosine kinasesQ37274044
Delivery of paclitaxel across cellular barriers using a dendrimer-based nanocarrier.Q39254937
Antitumor activity and molecular dynamics simulations of paclitaxel-laden triazine dendrimersQ39409812
Paclitaxel in tyrosine-derived nanospheres as a potential anti-cancer agent: in vivo evaluation of toxicity and efficacy in comparison with paclitaxel in CremophorQ39430827
Lapatinib/Paclitaxel polyelectrolyte nanocapsules for overcoming multidrug resistance in ovarian cancerQ39440238
Multifunctional Pluronic P123/F127 mixed polymeric micelles loaded with paclitaxel for the treatment of multidrug resistant tumors.Q39604391
A synergistic interaction between lapatinib and chemotherapy agents in a panel of cell lines is due to the inhibition of the efflux pump BCRP.Q39648670
Polymeric micelles for the pH-dependent controlled, continuous low dose release of paclitaxel.Q39767302
Differential metabolic responses to pluronic in MDR and non-MDR cells: a novel pathway for chemosensitization of drug resistant cancers.Q39789933
Aerosol delivery of liposomal formulated paclitaxel and vitamin E analog reduces murine mammary tumor burden and metastasesQ39816322
Tyrosine kinase inhibitors potentiate the cytotoxicity of MDR-substrate anticancer agents independent of growth factor receptor status in lung cancer cell lines.Q39842390
Enhanced cytotoxicity of a polymer-drug conjugate with triple payload of paclitaxelQ39844935
Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistanceQ39866484
Difunctional Pluronic copolymer micelles for paclitaxel delivery: synergistic effect of folate-mediated targeting and Pluronic-mediated overcoming multidrug resistance in tumor cell linesQ40173111
Simultaneous delivery of doxorubicin and GG918 (Elacridar) by new polymer-lipid hybrid nanoparticles (PLN) for enhanced treatment of multidrug-resistant breast cancerQ40209779
Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53.Q40811036
ABC transporters in cancer: more than just drug efflux pumps.Q43193922
BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agentsQ43761469
Effects of ethylene glycol-based graft, star-shaped, and dendritic polymers on solubilization and controlled release of paclitaxelQ44668176
Paclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluationQ46297662
Pyrene absorption can be a convenient method for probing critical micellar concentration (cmc) and indexing micellar polarityQ46660282
Dual agents loaded PLGA nanoparticles: systematic study of particle size and drug entrapment efficiencyQ46675585
PLGA nanoparticles simultaneously loaded with vincristine sulfate and verapamil hydrochloride: systematic study of particle size and drug entrapment efficiencyQ46969189
PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug.Q51475804
Discovery of a potent dual EGFR/HER-2 inhibitor L-2 (selatinib) for the treatment of cancer.Q54768529
P921main subjectmicellesQ421110
paclitaxelQ423762
metastatic breast cancerQ12859063
P304page(s)1-9
P577publication date2014-09-29
P1433published inPharmaceutical Development and TechnologyQ7180729
P1476titlePluronic F127 polymeric micelles for co-delivery of paclitaxel and lapatinib against metastatic breast cancer: preparation, optimization and in vitro evaluation

Reverse relations

cites work (P2860)
Q42094444Development and Validation of a Rapid RP-HPLC-DAD Analysis Method for the Simultaneous Quantitation of Paclitaxel and Lapatinib in a Polymeric Micelle Formulation
Q38735063In vitro and in vivo evaluation of paclitaxel-lapatinib-loaded F127 pluronic micelles.
Q38844243Liposomal formulation for co-delivery of paclitaxel and lapatinib, preparation, characterization and optimization
Q42215950Pluronic F127 and D-α-Tocopheryl Polyethylene Glycol Succinate (TPGS) Mixed Micelles for Targeting Drug Delivery across The Blood Brain Barrier
Q33553597Redox-sensitive Pluronic F127-tocopherol micelles: synthesis, characterization, and cytotoxicity evaluation

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