Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer

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Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1029544380
P356DOI10.1186/S12943-015-0310-8
P932PMC publication ID4392793
P698PubMed publication ID25889301

P50authorEmily HamsQ54378130
Derek J. RichardQ55163299
Kathy GatelyQ58895237
Steven G GrayQ38325510
Martin BarrQ42762920
Padraic G. FallonQ42944857
P2093author name stringAnthony Mitchell Davies
Graham P Pidgeon
Kenneth J O'Byrne
P2860cites workBlocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growthQ24293042
Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factorQ24321564
Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effectQ24564247
Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activityQ24677555
Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1Q28140309
Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cellsQ28203964
Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cellsQ28209907
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancerQ28278736
VEGF165 mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor bindingQ28646414
A peptide corresponding to the neuropilin-1-binding site on VEGF165 induces apoptosis of neuropilin-1-expressing breast tumour cellsQ29543360
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesisQ29620559
Targeting neuropilin 1 as an antitumor strategy in lung cancer.Q30833416
Identification of circulating neuropilin-1 and dose-dependent elevation following anti-neuropilin-1 antibody administrationQ33523441
Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexesQ33940345
Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinomaQ34157370
Non-angiogenic functions of VEGF in breast cancerQ34559451
A vascular niche and a VEGF–Nrp1 loop regulate the initiation and stemness of skin tumoursQ59059617
cAMP-responsive element-binding protein regulates vascular endothelial growth factor expression: implication in human prostate cancer bone metastasisQ79801048
Neuropilin-1 expression in cancer and developmentQ82183407
Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a biomarker evaluation from the AVAGAST randomized phase III trialQ84078596
Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growthQ35826030
Overexpression of neuropilin-1 promotes constitutive MAPK signalling and chemoresistance in pancreatic cancer cellsQ36615085
Neuropilin-1 upholds dedifferentiation and propagation phenotypes of renal cell carcinoma cells by activating Akt and sonic hedgehog axesQ37661416
Systematic review and meta-analysis of randomised, phase II/III trials adding bevacizumab to platinum-based chemotherapy as first-line treatment in patients with advanced non-small-cell lung cancerQ38062459
Neuropilin-1 promotes unlimited growth of ovarian cancer by evading contact inhibition.Q40155967
Expression of neuropilin-1 in high-grade dysplasia, invasive cancer, and metastases of the human gastrointestinal tractQ40563679
Vascular endothelial growth factor, platelet-derived endothelial cell growth factor and angiogenesis in non-small-cell lung cancerQ43202368
Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting.Q45934563
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P2507corrigendum / erratumCorrection to: Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancerQ92972114
P921main subjectlung cancerQ47912
endotheliumQ111140
P304page(s)45
P577publication date2015-02-20
P1433published inMolecular CancerQ15724585
P1476titleVascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer
P478volume14

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cites work (P2860)
Q39794263A small interfering RNA targeting vascular endothelial growth factor efficiently inhibits growth of VX2 cells and VX2 tumor model of hepatocellular carcinoma in rabbit by transarterial embolization-mediated siRNA delivery
Q38621453Antifibrotic role of vascular endothelial growth factor in pulmonary fibrosis.
Q40979902Bevacizumab counteracts VEGF-dependent resistance to erlotinib in an EGFR-mutated NSCLC xenograft model
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Q92972114Correction to: Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer
Q94471894Correlation of gene polymorphisms of vascular endothelial growth factor with grade and prognosis of lung cancer
Q42374239Genetic status of KRAS modulates the role of Neuropilin-1 in tumorigenesis
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Q37671418MicroRNA-29c functions as a tumor suppressor by targeting VEGFA in lung adenocarcinoma
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