Simultaneous application of bevacizumab and anti-CTGF antibody effectively suppresses proangiogenic and profibrotic factors in human RPE cells

scientific article

Simultaneous application of bevacizumab and anti-CTGF antibody effectively suppresses proangiogenic and profibrotic factors in human RPE cells is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID4392827
P698PubMed publication ID25883524

P50authorZahra-Soheila SoheiliQ40211284
P2093author name stringNader Sheibani
Hamid Ahmadieh
Mozhgan Rezaei Kanavi
Shahram Samiei
Azam Mohammadian
Abouzar Bagheri
Shamila Darvishalipour Astaneh
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VEGF 165 b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy.Q40001026
VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expressionQ40497297
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Secreted proteome profiling in human RPE cell cultures derived from donors with age related macular degeneration and age matched healthy donors.Q42502356
Antifibrotic activity of bevacizumab on human Tenon's fibroblasts in vitroQ43007261
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VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinomaQ44068637
Modulation of matrix metalloproteinase and TIMP-1 expression by cytokines in human RPE cells.Q44082604
AAV-mediated expression of vascular endothelial growth factor induces choroidal neovascularization in rat.Q44295605
VEGF164Is Proinflammatory in the Diabetic RetinaQ44417311
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MMP-2 and MMP-9 secretion by rpe is stimulated by angiogenic molecules found in choroidal neovascular membranesQ46163874
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Diabetic retinopathy is associated with a switch in splicing from anti- to pro-angiogenic isoforms of vascular endothelial growth factor.Q46727452
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Production and Activation of Matrix Metalloproteinase-2 in Proliferative Diabetic RetinopathyQ47952325
PlGF gene knockdown in human retinal pigment epithelial cells.Q54400583
TGF-β1 induces lens cells to accumulate α-smooth muscle actin, a marker for subcapsular cataractsQ61927877
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Synthesis and secretion of vascular permeability factor/vascular endothelial growth factor by human retinal pigment epithelial cellsQ70764129
Basic fibroblast growth factor and vascular endothelial growth factor are present in epiretinal and choroidal neovascular membranesQ71506583
Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cellsQ73038409
Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitroQ74214063
Transforming growth factor-beta 1 promotes contraction of collagen gel by bovine corneal fibroblasts through differentiation of myofibroblastsQ74431998
Involvement of CTGF, a hypertrophic chondrocyte-specific gene product, in tumor angiogenesisQ77226536
P921main subjectbevacizumabQ413299
P304page(s)378-390
P577publication date2015-04-10
P1433published inMolecular VisionQ6895981
P1476titleSimultaneous application of bevacizumab and anti-CTGF antibody effectively suppresses proangiogenic and profibrotic factors in human RPE cells
P478volume21

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cites work (P2860)
Q55078147CTGF Contributes to the Development of Posterior Capsule Opacification: an in vitro and in vivo study.
Q47096952Clinical and experimental study on angiopoietin-like protein 8 associated with proliferative diabetic retinopathy
Q41808036Effect of bevacizumab on the expression of fibrosis-related inflammatory mediators in ARPE-19 cells
Q64234996Extremely low frequency-pulsed electromagnetic fields affect proangiogenic-related gene expression in retinal pigment epithelial cells
Q49503028Involvement of the ubiquitin-proteasome system in the expression of extracellular matrix genes in retinal pigment epithelial cells.
Q50145564Regulation and bioactivity of the CCN family of genes and proteins in obesity and diabetes.

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