A polyketide synthase acyltransferase domain structure suggests a recognition mechanism for its hydroxymalonyl-acyl carrier protein substrate

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A polyketide synthase acyltransferase domain structure suggests a recognition mechanism for its hydroxymalonyl-acyl carrier protein substrate is …
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scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...9k0965P
P356DOI10.1371/JOURNAL.PONE.0110965
P932PMC publication ID4207774
P698PubMed publication ID25340352
P5875ResearchGate publication ID267625998

P50authorKatrina T. ForestQ89722501
P2093author name stringDavid H Dyer
Hyunjun Park
Michael G Thomas
Brian M Kevany
P2860cites workA natural prodrug activation mechanism in nonribosomal peptide synthesis.Q53218701
Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthasesQ60301917
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Asymmetric synthesis of diastereomeric diaminoheptanetetraols. A proposal for the configuration of (+)-zwittermicin aQ24648995
Processing of X-ray diffraction data collected in oscillation modeQ26778468
Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylaseQ27640455
A tylosin ketoreductase reveals how chirality is determined in polyketidesQ27647542
Structural and Mechanistic Analysis of Protein Interactions in Module 3 of the 6-Deoxyerythronolide B SynthaseQ27647550
Structure and malonyl CoA-ACP transacylase binding of streptomyces coelicolor fatty acid synthase acyl carrier proteinQ27656251
Structure and Mechanism of the trans -Acting Acyltransferase from the Disorazole SynthaseQ27670570
Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne BiosynthesisQ27679103
REFMAC5 for the refinement of macromolecular crystal structuresQ27860905
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Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.Q30329267
Kappa-alpha plot derived structural alphabet and BLOSUM-like substitution matrix for rapid search of protein structure database.Q30360136
Formation and characterization of acyl carrier protein-linked polyketide synthase extender unitsQ33429442
Recognition of (2S)-aminomalonyl-acyl carrier protein (ACP) and (2R)-hydroxymalonyl-ACP by acyltransferases in zwittermicin A biosynthesisQ33547618
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Polyketide and nonribosomal peptide antibiotics: modularity and versatilityQ33976771
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Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallographyQ34525718
Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender unitsQ35080629
The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.Q35131209
Biological activities of two fungistatic antibiotics produced by Bacillus cereus UW85Q36056183
The type I fatty acid and polyketide synthases: a tale of two megasynthasesQ36489362
Acyltransferases in bacteriaQ36890367
Characterization of the complete zwittermicin A biosynthesis gene cluster from Bacillus cereusQ37099333
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(+)-Zwittermicin A: assignment of its complete configuration by total synthesis of the enantiomer and implication of D-serine in its biosynthesisQ37642790
Structure of a modular polyketide synthaseQ41608053
On the combination of molecular replacement and single-wavelength anomalous diffraction phasing for automated structure determinationQ42575593
Biological Control of Damping-Off of Alfalfa Seedlings with Bacillus cereus UW85.Q42926193
4-[2-(2-amino-2-oxoethyl)-2,7-dihydroxy-4-oxochroman-5-yl]-3-hydroxybut-2-enoic acidQ43394722
In vivo evidence for a prodrug activation mechanism during colibactin maturation.Q44140961
Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthasesQ44507378
A prodrug resistance mechanism is involved in colibactin biosynthesis and cytotoxicityQ45678137
The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender unitsQ47850876
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.Q48118274
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)e110965
P577publication date2014-10-23
P1433published inPLOS OneQ564954
P1476titleA polyketide synthase acyltransferase domain structure suggests a recognition mechanism for its hydroxymalonyl-acyl carrier protein substrate
P478volume9

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cites work (P2860)
Q64897732Acyltransferases as Tools for Polyketide Synthase Engineering.
Q28081578Architecture of the polyketide synthase module: surprises from electron cryo-microscopy
Q28828730Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis
Q37707960Biosynthetic origin of butyrolactol A, an antifungal polyketide produced by a marine-derived Streptomyces
Q93363943Extender Unit Promiscuity and Orthogonal Protein Interactions of an Aminomalonyl-ACP Utilizing Trans-Acyltransferase from Zwittermicin Biosynthesis
Q37672851Polyketide stereocontrol: a study in chemical biology
Q26766621Recent Advances in Understanding and Engineering Polyketide Synthesis
Q38264066Recent advances in the biosynthesis of unusual polyketide synthase substrates
Q47579285Structure and function of polyketide biosynthetic enzymes: various strategies for production of structurally diverse polyketides
Q36607621Structure-based analysis of the molecular interactions between acyltransferase and acyl carrier protein in vicenistatin biosynthesis.

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