Development of dual-acting pyrimidinediones as novel and highly potent topical anti-HIV microbicides

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Development of dual-acting pyrimidinediones as novel and highly potent topical anti-HIV microbicides is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.05237-11
P8608Fatcat IDrelease_4gvcyqkhg5ctfgxsenxisndyoq
P932PMC publication ID3195032
P698PubMed publication ID21896906

P50authorRobert W BuckheitQ114435506
P2093author name stringLu Yang
Karen Watson Buckheit
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Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in womenQ24629582
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Highly potent oxathiin carboxanilide derivatives with efficacy against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus isolatesQ28379523
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Comparative evaluation of virus transmission inhibition by dual-acting pyrimidinedione microbicides using the microbicide transmission and sterilization assayQ36803970
Inhibition of human immunodeficiency virus type 1 infection by the candidate microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitorQ37072072
Microbicide delivery: formulation technologies and strategies.Q37447846
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Simple, rapid, quantitative, syncytium-forming microassay for the detection of human immunodeficiency virus neutralizing antibodyQ38476940
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Primary human immunodeficiency virus type 2 (HIV-2) isolates, like HIV-1 isolates, frequently use CCR5 but show promiscuity in coreceptor usage.Q39551934
Inhibition of replication and cytopathic effect of human T cell lymphotropic virus type III/lymphadenopathy-associated virus by 3'-azido-3'-deoxythymidine in vitroQ39851761
The structure-activity relationships of 2,4(1H,3H)-pyrimidinedione derivatives as potent HIV type 1 and type 2 inhibitorsQ40042904
Comparative evaluation of the inhibitory activities of a series of pyrimidinedione congeners that inhibit human immunodeficiency virus types 1 and 2.Q40060575
Inhibition of human immunodeficiency virus replication by the sulfonated stilbene dye resobeneQ41148915
An assay for HIV infection of cultured human cervix-derived cellsQ41364806
Characterization of an HIV-1 Isolate Displaying an Apparent Absence of Virion-Associated Reverse Transcriptase ActivityQ41691433
Anti-HIV activity of adefovir (PMEA) and PMPA in combination with antiretroviral compounds: in vitro analysesQ42545418
Approaches to improve the stability of the antiviral agent UC781 in aqueous solutionsQ43051081
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)5243-5254
P577publication date2011-09-06
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleDevelopment of dual-acting pyrimidinediones as novel and highly potent topical anti-HIV microbicides
P478volume55

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cites work (P2860)
Q39152233"Fusion and binding inhibition" key target for HIV-1 treatment and pre-exposure prophylaxis: targets, drug delivery and nanotechnology approaches.
Q47678273A Dose Ranging Pharmacokinetic Evaluation of IQP-0528 Released from Intravaginal Rings in Non-Human Primates
Q48130430A Search for Dual Action HIV-1 Reverse Transcriptase, Bacterial RNA Polymerase Inhibitors.
Q37980177A novel vaginal microbicide containing the rationally designed anti-HIV compound HI-443 (N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea]).
Q28545757Current and emerging formulation strategies for the effective transdermal delivery of HIV inhibitors
Q41040182Double Variational Binding--(SMILES) Conformational Analysis by Docking Mechanisms for Anti-HIV Pyrimidine Ligands.
Q28533587In vitro and ex vivo evaluations on transdermal delivery of the HIV inhibitor IQP-0410
Q36644657Pharmacokinetic and Pharmacodynamic Evaluation following Vaginal Application of IQB3002, a Dual-Chamber Microbicide Gel Containing the Nonnucleoside Reverse Transcriptase Inhibitor IQP-0528 in Rhesus Macaques
Q35844509Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase
Q28538105Quantitative analysis of microbicide concentrations in fluids, gels and tissues using confocal Raman spectroscopy
Q36409617Safety and efficacy of tenofovir/IQP-0528 combination gels - a dual compartment microbicide for HIV-1 prevention
Q35518190Vaginal film drug delivery of the pyrimidinedione IQP-0528 for the prevention of HIV infection

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