Increased bone mass in mice after single injection of anti-receptor activator of nuclear factor-kappaB ligand-neutralizing antibody: evidence for bone anabolic effect of parathyroid hormone in mice with few osteoclasts

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Increased bone mass in mice after single injection of anti-receptor activator of nuclear factor-kappaB ligand-neutralizing antibody: evidence for bone anabolic effect of parathyroid hormone in mice with few osteoclasts is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M111.246280
P932PMC publication ID3196100
P698PubMed publication ID21862583

P2093author name stringKaoru Mori
Sakae Tanaka
Naoyuki Takahashi
Nobuyuki Udagawa
Hisataka Yasuda
Tadashi Ninomiya
Yuriko Furuya
Yoshiya Tomimori
Kohji Uchida
P2860cites workOsteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
Osteoprotegerin: a novel secreted protein involved in the regulation of bone densityQ24313918
TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cellsQ24315251
Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesisQ24324701
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell functionQ24336057
RANK is essential for osteoclast and lymph node developmentQ24598872
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligandQ24653311
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLQ24682139
Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptorQ28142274
Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling systemQ28283972
RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesisQ28293009
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature CommitteeQ29616160
A novel molecular mechanism modulating osteoclast differentiation and functionQ30643494
The RANKL inhibitor OPG-Fc increases cortical and trabecular bone mass in young gonad-intact cynomolgus monkeysQ33279942
Comparison of effects of the bisphosphonate alendronate versus the RANKL inhibitor denosumab on murine fracture healing.Q33385262
Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL.Q34107428
Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitroQ34459310
Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL.Q34469691
Role of RANK ligand in mediating increased bone resorption in early postmenopausal womenQ34912769
Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repressionQ35169193
Regulation of cancer cell migration and bone metastasis by RANKL.Q40298349
Control of mammary stem cell function by steroid hormone signalling.Q43103606
Prevention of glucocorticoid-induced bone loss in mice by inhibition of RANKL.Q46030946
OPG and PTH-(1-34) have additive effects on bone density and mechanical strength in osteopenic ovariectomized ratsQ46099755
A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal womenQ46133598
Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL.Q46459616
Cells of the osteoclast lineage as mediators of the anabolic actions of parathyroid hormone in boneQ46635832
Sustained antiresorptive effects after a single treatment with human recombinant osteoprotegerin (OPG): a pharmacodynamic and pharmacokinetic analysis in rats.Q46699294
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.Q51949099
Therapeutic efficacy of a soluble receptor activator of nuclear factor kappaB-IgG Fc fusion protein in suppressing bone resorption and hypercalcemia in a model of humoral hypercalcemia of malignancy.Q52542731
Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibodyQ79826358
P433issue42
P407language of work or nameEnglishQ1860
P304page(s)37023-37031
P577publication date2011-08-23
P1433published inJournal of Biological ChemistryQ867727
P1476titleIncreased bone mass in mice after single injection of anti-receptor activator of nuclear factor-kappaB ligand-neutralizing antibody: evidence for bone anabolic effect of parathyroid hormone in mice with few osteoclasts
P478volume286