Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL.

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Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M110.101964
P932PMC publication ID2934681
P698PubMed publication ID20558734

P50authorNicolas BonnetQ51535115
P2093author name stringDominique D Pierroz
Serge L Ferrari
Michael S Ominsky
Paul J Kostenuik
Paul A Baldock
Marina Stolina
P2860cites workOsteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
Osteoprotegerin: a novel secreted protein involved in the regulation of bone densityQ24313918
RANK is essential for osteoclast and lymph node developmentQ24598872
osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcificationQ24603266
Giant osteoclast formation and long-term oral bisphosphonate therapyQ24626459
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligandQ24653311
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
Cellular and molecular mechanisms of action of bisphosphonatesQ33970504
Effects of teriparatide, alendronate, or both on bone turnover in osteoporotic men.Q33995702
EphrinB2 regulation by PTH and PTHrP revealed by molecular profiling in differentiating osteoblastsQ34796085
beta-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female miceQ35062148
Osteoclast-derived activity in the coupling of bone formation to resorption.Q36032429
Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strengthQ36269835
Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesisQ36368706
Mechanisms involved in skeletal anabolic therapies.Q36532582
The use of parathyroid hormone in the treatment of osteoporosisQ36624534
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolismQ37108966
Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice.Q37166800
Osteoprotegerin abrogated cortical porosity and bone marrow fibrosis in a mouse model of constitutive activation of the PTH/PTHrP receptorQ37197357
Parathyroid hormone treatment for osteoporosisQ37312941
Local communication on and within bone controls bone remodeling.Q37433014
Hypothalamic control of bone formation: distinct actions of leptin and y2 receptor pathwaysQ38321099
Basic biomechanical measurements of bone: a tutorialQ40797364
The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosisQ44590934
The Effects of Parathyroid Hormone, Alendronate, or Both in Men with OsteoporosisQ44590937
OPG and PTH-(1-34) have additive effects on bone density and mechanical strength in osteopenic ovariectomized ratsQ46099755
One year of transgenic overexpression of osteoprotegerin in rats suppressed bone resorption and increased vertebral bone volume, density, and strengthQ46171552
RANKL inhibition with osteoprotegerin increases bone strength by improving cortical and trabecular bone architecture in ovariectomized ratsQ46212098
Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trialQ46393065
Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL.Q46459616
Daily and cyclic parathyroid hormone in women receiving alendronateQ46644473
A novel tetracycline labeling schedule for longitudinal evaluation of the short-term effects of anabolic therapy with a single iliac crest bone biopsy: early actions of teriparatideQ46954772
Teriparatide [PTH(1-34)] strengthens the proximal femur of ovariectomized nonhuman primates despite increasing porosityQ47988162
The effects of combination of alendronate and human parathyroid hormone(1-34) on bone strength are synergistic in the lumbar vertebra and additive in the femur of C57BL/6J mice.Q51750185
Bidirectional ephrinB2-EphB4 signaling controls bone homeostasisQ57675131
Trabecular and endocortical bone surfaces in the rat: modeling or remodeling?Q71697391
Early histomorphometric changes in response to parathyroid hormone therapy in osteoporosis: evidence for de novo bone formation on quiescent cancellous surfacesQ72908534
On the mechanism of cancellous bone preservation in postmenopausal women with mild primary hyperparathyroidismQ77738452
Co-treatment of PTH with osteoprotegerin or alendronate increases its anabolic effect on the skeleton of oophorectomized miceQ79171394
Pretreatment with anticatabolic agents blunts but does not eliminate the skeletal anabolic response to parathyroid hormone in oophorectomized miceQ80018761
Effects of daily treatment with parathyroid hormone 1-84 for 16 months on density, architecture and biomechanical properties of cortical bone in adult ovariectomized rhesus monkeysQ80487618
Mechanisms of the anabolic effects of teriparatide on bone: insight from the treatment of a patient with pycnodysostosisQ80779491
Bone response to intermittent parathyroid hormone is altered in mice null for {beta}-Arrestin2Q81391001
Teriparatide increases bone formation in modeling and remodeling osteons and enhances IGF-II immunoreactivity in postmenopausal women with osteoporosisQ83924332
P433issue36
P407language of work or nameEnglishQ1860
P304page(s)28164-28173
P577publication date2010-06-17
P1433published inJournal of Biological ChemistryQ867727
P1476titleAre osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL
P478volume285

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cites work (P2860)
Q46907891A Novel, Direct NO Donor Regulates Osteoblast and Osteoclast Functions and Increases Bone Mass in Ovariectomized Mice
Q37679606A closer look at the immediate trabecula response to combined parathyroid hormone and alendronate treatment.
Q38047183Advances in osteoimmunology: pathophysiologic concepts and treatment opportunities
Q44216694An experimental therapy to improve skeletal growth and prevent bone loss in a mouse model overexpressing IL-6.
Q37673469Bone biology and anabolic therapies for bone: current status and future prospects
Q27025688Bone health and associated metabolic complications in neuromuscular diseases
Q36524611Denosumab-associated osteonecrosis of the jaw affects osteoclast formation and differentiation: Pathological features of two cases
Q91768602Effect of parathyroid hormone on the structural, densitometric and failure behaviors of mouse tibia in the spatiotemporal space
Q46583319Effects of morning vs. evening teriparatide injection on bone mineral density and bone turnover markers in postmenopausal osteoporosis
Q34182919Emerging therapies in metastatic bone pain
Q37370284Enhanced individual trabecular repair and its mechanical implications in parathyroid hormone and alendronate treated rat tibial bone.
Q38661460Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells
Q38183262Implications of osteoblast-osteoclast interactions in the management of osteoporosis by antiresorptive agents denosumab and odanacatib.
Q35378487Increased bone mass in mice after single injection of anti-receptor activator of nuclear factor-kappaB ligand-neutralizing antibody: evidence for bone anabolic effect of parathyroid hormone in mice with few osteoclasts
Q37720404Individual and combining effects of anti-RANKL monoclonal antibody and teriparatide in ovariectomized mice
Q36647074Intermittent PTH administration and mechanical loading are anabolic for periprosthetic cancellous bone.
Q46977608Is it time to combine osteoporosis therapies?
Q26741146Longitudinal imaging of the ageing mouse
Q37414413Mechanisms of osteoclast-dependent bone formation
Q64081065Molecular understanding of pharmacological treatment of osteoporosis
Q37110385Monocyte chemoattractant protein-1 is a mediator of the anabolic action of parathyroid hormone on bone.
Q38205860Novel techniques in the development of osteoporosis drug therapy: the osteoclast ruffled-border vacuolar H(+)-ATPase as an emerging target
Q39283452One Year of Abaloparatide, a Selective Activator of the PTH1 Receptor, Increased Bone Formation and Bone Mass in Osteopenic Ovariectomized Rats Without Increasing Bone Resorption
Q33993757Osteoclasts: more than 'bone eaters'.
Q38230277Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption-formation cycles?
Q38257484Osteoporosis therapy: a novel insight from natural homeostatic system in the skeleton
Q51703751Overexpression of Gα11 in Osteoblast Lineage Cells Suppresses the Osteoanabolic Response to Intermittent PTH and Exercise.
Q37661167Parathyroid Hormone (1-34) Might Not Improve Early Bone Healing after Sinus Augmentation in Healthy Rabbits.
Q57217564Parathyroid hormone changes following denosumab treatment in postmenopausal osteoporosis
Q57976931Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation
Q48986728Pharmacologically Inactive Bisphosphonates as an Alternative Strategy for Targeting Osteoclasts: In Vivo Assessment of 5-Fluorodeoxyuridine-Alendronate in a Preclinical Model of Breast Cancer Bone Metastases
Q54228752RANKL blockade prevents and treats aggressive osteosarcomas.
Q36236285Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin
Q37385579Release of bone markers in immediately loaded and nonloaded dental implants: a randomized clinical trial
Q30455154Role of denosumab in prostate cancer
Q34551704Soluble guanylate cyclase as a novel treatment target for osteoporosis
Q54229745Suppression of p38α MAPK Signaling in Osteoblast Lineage Cells Impairs Bone Anabolic Action of Parathyroid Hormone.
Q35165694Teriparatide Therapy as an Adjuvant for Tissue Engineering and Integration of Biomaterials
Q30627873Teriparatide and denosumab, alone or combined, in women with postmenopausal osteoporosis: the DATA study randomised trial.
Q46851946The effect of etidronate on the periodontium of ovariectomized rats
Q34079954The effects of PTH, loading and surgical insult on cancellous bone at the bone-implant interface in the rabbit.
Q41989650The inhibitory effects of a RANKL-binding peptide on articular and periarticular bone loss in a murine model of collagen-induced arthritis: a bone histomorphometric study.
Q38827517The skeletal impact of the chemotherapeutic agent etoposide
Q39324421Three-dimensional image registration improves the long-term precision of in vivo micro-computed tomographic measurements in anabolic and catabolic mouse models
Q35108947μCT-based, in vivo dynamic bone histomorphometry allows 3D evaluation of the early responses of bone resorption and formation to PTH and alendronate combination therapy

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