Molecular understanding of pharmacological treatment of osteoporosis

scientific article published on 29 April 2019

Molecular understanding of pharmacological treatment of osteoporosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1302/2058-5241.4.180018
P932PMC publication ID6491949
P698PubMed publication ID31057953

P50authorSakae TanakaQ39065998
P2093author name stringSakae Tanaka
P2860cites workRisks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trialQ27860743
Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human boneQ28241025
Denosumab for prevention of fractures in postmenopausal women with osteoporosisQ28254528
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Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumabQ28265584
Romosozumab Treatment in Postmenopausal Women with OsteoporosisQ28278665
NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy, March 7-29, 2000: highlights of the conferenceQ74145388
Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling systemQ28283972
WNT signaling in bone homeostasis and disease: from human mutations to treatmentsQ28285090
The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical boneQ28393372
Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL.Q34107428
Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patientsQ34346682
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Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodelingQ34384039
Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis: A Randomized Clinical TrialQ34537630
Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclastsQ34679499
Parathyroid hormone (PTH)-induced bone gain is blunted in SOST overexpressing and deficient miceQ35156214
Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading.Q35635751
New simulation model for bone formation markers in osteoporosis patients treated with once-weekly teriparatideQ35755175
Effects of Deletion of ERα in Osteoblast-Lineage Cells on Bone Mass and Adaptation to Mechanical Loading Differ in Female and Male MiceQ35864023
Binding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream SignalingQ36431762
Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrualQ36497298
Mechanisms of anabolic therapies for osteoporosisQ36924676
HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosisQ37236532
Adverse effects of bisphosphonates: implications for osteoporosis managementQ37246255
Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFQ37432186
Profile of changes in bone turnover markers during once-weekly teriparatide administration for 24 weeks in postmenopausal women with osteoporosisQ37581507
New knowledge on critical osteoclast formation and activation pathways from study of rare genetic diseases of osteoclasts: focus on the RANK/RANKL axis.Q37748586
Biochemical and molecular mechanisms of action of bisphosphonates.Q37812800
Efficacy and safety of currently marketed anti-osteoporosis medications.Q38272390
Short-term and long-term effects of osteoporosis therapies.Q38473594
Role and mechanism of action of sclerostin in boneQ38807230
Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells.Q40004851
Remodeling- and Modeling-Based Bone Formation with Teriparatide versus Denosumab: A Longitudinal Analysis from Baseline to 3 Months in the AVA StudyQ42696517
Antiapoptotic molecule Bcl-2 is essential for the anabolic activity of parathyroid hormone in boneQ46296752
The anti-tumor effect of RANKL inhibition in malignant solid tumors - A systematic review.Q47386961
The effect of switching from teriparatide to anti-RANKL antibody on cancellous and cortical bone in ovariectomized miceQ47595884
Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis.Q47823018
RANKL: A therapeutic target for bone destruction in rheumatoid arthritisQ50207113
Distinguishing the proapoptotic and antiresorptive functions of risedronate in murine osteoclasts: role of the Akt pathway and the ERK/Bim axis.Q54562620
Elimination and biochemical responses to intravenous alendronate in postmenopausal osteoporosisQ73794664
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectteriparatideQ411781
RomosozumabQ7363297
P304page(s)158-164
P577publication date2019-04-29
P1433published inEFORT Open ReviewsQ39053387
P1476titleMolecular understanding of pharmacological treatment of osteoporosis
P478volume4

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Q90152614The Antiosteoporosis Effects of Yishen Bugu Ye Based on Its Regulation on the Differentiation of Osteoblast and Osteoclastcites workP2860

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