Association of ADIPOR2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study

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Association of ADIPOR2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1023880222
P356DOI10.1186/1475-2840-10-83
P932PMC publication ID3196906
P698PubMed publication ID21943112
P5875ResearchGate publication ID51670242

P50authorMatti UusitupaQ16991089
Jaakko TuomilehtoQ28050079
Jaana LindströmQ56947407
Pirjo Ilanne-ParikkaQ86871378
Leena PulkkinenQ117253180
Niina SiitonenQ117253193
Johan G. ErikssonQ37632234
Sirkka Keinänen-KiukaanniemiQ39201566
Marjukka KolehmainenQ42170406
P2093author name stringUrsula Schwab
P2860cites workNovel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectinQ22010955
Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophagesQ24290861
Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cellQ24299893
Cloning of adiponectin receptors that mediate antidiabetic metabolic effectsQ24304889
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinaseQ24309462
Statistical significance for genomewide studiesQ24681264
The International HapMap ProjectQ27860695
Haploview: analysis and visualization of LD and haplotype mapsQ27860955
Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)Q27860959
Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose toleranceQ28186874
Efficiency and power in genetic association studiesQ28278645
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesityQ28506782
Adipokines in inflammation and metabolic diseaseQ29620456
Ten-year mortality and cardiovascular morbidity in the Finnish Diabetes Prevention Study--secondary analysis of the randomized trialQ33455816
Genetic variation in the adiponectin receptor 2 (ADIPOR2) gene is associated with coronary artery disease and increased ADIPOR2 expression in peripheral monocytesQ33758866
Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: associations with metabolic parameters and insulin resistance and regulation by physical training.Q53631333
Hepatic adiponectin receptors (ADIPOR) 1 and 2 mRNA and their relation to insulin resistance in obese humans.Q53775867
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actionsQ57249776
Adiponectin and Coronary Heart DiseaseQ57416324
Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1interact with plasma saturated fatty acids to modulate insulin resistanceQ59607705
Adiponectin reduces atherosclerosis in apolipoprotein E-deficient miceQ64378290
Association of hypoadiponectinemia with coronary artery disease in menQ78780687
Common haplotypes at the adiponectin receptor 1 (ADIPOR1) locus are associated with increased risk of coronary artery disease in type 2 diabetesQ79143549
Variations in adiponectin receptor genes and susceptibility to type 2 diabetes in women: a tagging-single nucleotide polymorphism haplotype analysisQ80117562
Pattern of expression of adiponectin receptors in human adipose tissue depots and its relation to the metabolic stateQ80558968
Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian populationQ82676205
Intra-abdominal fat adiponectin receptors expression and cardiovascular metabolic risk factors in obesity and diabetesQ83935963
The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parentsQ33896882
Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemiaQ33946056
The International HapMap Project Web siteQ34206586
Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetesQ34315956
Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistanceQ34336221
Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolismQ34343566
Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order AmishQ34429449
Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention StudyQ34580894
Adiponectin levels and expression of adiponectin receptors in isolated monocytes from overweight patients with coronary artery diseaseQ34592893
Genomewide association studies and human diseaseQ34606556
Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndromeQ34695582
Adiponectin and its receptors in non-alcoholic steatohepatitis.Q35597147
Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populationsQ35629049
Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statementQ36342283
Adiponectin and adiponectin receptor gene variants in relation to type 2 diabetes and insulin resistance-related phenotypesQ36839329
Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosisQ38361016
Polymorphisms of ADIPOR1 and ADIPOR2 are associated with phenotypes of type 2 diabetes in Koreans.Q39984242
Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat.Q42484914
Decreased plasma adiponectin concentrations in women with dyslipidemiaQ44018162
Adiponectin stimulates production of nitric oxide in vascular endothelial cells.Q44565932
The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activityQ44666271
Pattern of expression of adiponectin receptors in human liver and its relation to nonalcoholic steatohepatitis.Q46314424
Association of ADIPOR2 with liver function tests in type 2 diabetic subjectsQ46417040
Expression of ghrelin gene in peripheral blood mononuclear cells and plasma ghrelin concentrations in patients with metabolic syndromeQ46685986
Opposing effects of adiponectin receptors 1 and 2 on energy metabolismQ48259094
Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland. Study design and 1-year interim report on the feasibility of the lifestyle intervention programme.Q50650486
Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts.Q51431569
Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans.Q51490522
P407language of work or nameEnglishQ1860
P921main subjectFinlandQ33
glucoseQ37525
cardiovascular diseaseQ389735
glycobiologyQ899224
type 2 diabetesQ3025883
P304page(s)83
P577publication date2011-09-24
P1433published inCardiovascular DiabetologyQ2468083
P1476titleAssociation of ADIPOR2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study
P478volume10

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cites work (P2860)
Q64094055Adiponectin Receptor gene Polymorphisms are Associated with Kidney Function in Elderly Japanese Populations
Q36288862Alterations of specific biomarkers of metabolic pathways in vascular tree from patients with Type 2 diabetes
Q35963270Association of serum adipocytokine levels with cardiac autonomic neuropathy in type 2 diabetic patients
Q36392003Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low.
Q27027840Cardiometabolic effects of adiponectin
Q38176765Cardiovascular risk in children and adolescents with type 2 diabetes mellitus
Q36828075Common variants in adiponectin gene are associated with coronary artery disease and angiographical severity of coronary atherosclerosis in type 2 diabetes
Q36521802Gly1057Asp polymorphism of insulin receptor substrate-2 is associated with coronary artery disease in the Taiwanese population
Q35451840Single nucleotide polymorphism-single nucleotide polymorphism interactions among inflammation genes in the genetic architecture of blood pressure in the Framingham Heart Study
Q34479338Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: a cross-sectional study
Q37363488Usefulness of metabolic syndrome score in the prediction of angiographic coronary artery disease severity according to the presence of diabetes mellitus: relation with inflammatory markers and adipokines.
Q49960522Variations in ADIPOR1 But Not ADIPOR2 are Associated With Hypertriglyceridemia and Diabetes in an Admixed Latin American Population.

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