Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing.

scientific article

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1000934935
P356DOI10.1038/NATURE14001
P698PubMed publication ID25428506
P5875ResearchGate publication ID268874261

P50authorZora ModrusanQ30582818
Jens FritscheQ80489820
P2093author name stringIra Mellman
Lélia Delamarre
Patrick Lupardus
Toni Weinschenk
Jennie R Lill
Qui T Phung
Tommy K Cheung
Suchit Jhunjhunwala
Christian Franci
Mahesh Yadav
Joshua Tanguay
Stephanie Bumbaca
P2860cites workMutational heterogeneity in cancer and the search for new cancer-associated genesQ24606956
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancerQ24616117
How H13 histocompatibility peptides differing by a single methyl group and lacking conventional MHC binding anchor motifs determine self-nonself discriminationQ27636980
Peptidic termini play a significant role in TCR recognitionQ27639611
Structural and biological basis of CTL escape in coronavirus-infected miceQ27649999
Affinity thresholds for naive CD8+ CTL activation by peptides and engineered influenza A virusesQ27675301
The three-dimensional structure of H-2Db at 2.4 A resolution: implications for antigen-determinant selectionQ27729346
Structural evidence of T cell xeno-reactivity in the absence of molecular mimicryQ27766708
Coot: model-building tools for molecular graphicsQ27860505
A framework for variation discovery and genotyping using next-generation DNA sequencing dataQ29547262
Deriving the consequences of genomic variants with the Ensembl API and SNP Effect PredictorQ29614870
GMAP: a genomic mapping and alignment program for mRNA and EST sequencesQ29616836
How TCRs bind MHCs, peptides, and coreceptorsQ29619572
T cell exhaustionQ29620463
Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survivalQ33564510
Fast and SNP-tolerant detection of complex variants and splicing in short readsQ33751343
MED12 and HMGA2 mutations: two independent genetic events in uterine leiomyoma and leiomyosarcomaQ33844725
Oncology meets immunology: the cancer-immunity cycleQ34037625
Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infectionQ34093225
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patientsQ34161579
Rosetta FlexPepDock web server--high resolution modeling of peptide-protein interactionsQ35075670
CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1.Q35783166
Expression of tumour-specific antigens underlies cancer immunoeditingQ35785378
The MHC class I peptide repertoire is molded by the transcriptome.Q36509857
Functions of the proteasome: from protein degradation and immune surveillance to cancer therapyQ36703005
NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11Q36749382
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoeditingQ37418530
PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumorsQ37726682
Role of PD-1 in Regulating T-Cell ImmunityQ37808145
T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironmentQ38072512
Exploiting the mutanome for tumor vaccination.Q39413641
Oncolytic virus-initiated protective immunity against prostate cancerQ39606073
The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopesQ41411510
Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanomaQ42874163
MHC I-associated peptides preferentially derive from transcripts bearing miRNA response elementsQ44073800
Surveillance of the tumor mutanome by T cells during progression from primary to recurrent ovarian cancer.Q54464932
Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC moleculesQ55042699
Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancerQ57152489
P433issue7528
P407language of work or nameEnglishQ1860
P304page(s)572-576
P577publication date2014-11-01
P1433published inNatureQ180445
P1476titlePredicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing
P478volume515

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Q60948122Recent Development and Clinical Application of Cancer Vaccine: Targeting Neoantigens
Q28067217Recent advances in understanding antitumor immunity
Q90426278Recombinant Listeria promotes tumor rejection by CD8+ T cell-dependent remodeling of the tumor microenvironment
Q90639891Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer
Q89538412Research Progress Evaluating the Function and Mechanism of Anti-Tumor Peptides
Q38731119STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment.
Q38704265Sarcoma Eradication by Doxorubicin and Targeted TNF Relies upon CD8+ T-cell Recognition of a Retroviral Antigen
Q39438407Secreted tumor antigens - immune biomarkers for diagnosis and therapy.
Q96137394Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination
Q93101149Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood
Q55008935Serine Proteases Enhance Immunogenic Antigen Presentation on Lung Cancer Cells.
Q40104793Sharpening the Edge for Precision Cancer Immunotherapy: Targeting Tumor Antigens through Oncolytic Vaccines
Q36159205Simul-seq: combined DNA and RNA sequencing for whole-genome and transcriptome profiling
Q41325257Soluble HLA-associated peptide from PSF1 has a cancer vaccine potency
Q88764273Structural basis for ADP-dependent glucokinase inhibition by 8-bromo-substituted adenosine nucleotide
Q98513865Structural dissimilarity from self drives neoepitope escape from immune tolerance
Q90290722Structure Based Prediction of Neoantigen Immunogenicity
Q55046482Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap.
Q47145915Synergistic anticancer activity of a novel oral chemotherapeutic agent containing trifluridine and tipiracil in combination with anti-PD-1 blockade in microsatellite stable-type murine colorectal cancer cells
Q41035371Synthetic melanin bound to subunit vaccine antigens significantly enhances CD8+ T-cell responses
Q58587953Systematically benchmarking peptide-MHC binding predictors: From synthetic to naturally processed epitopes
Q95310618T Cell Receptor Engineered Lymphocytes for Cancer Therapy
Q48247566T cell receptor β-chain repertoire analysis reveals the association between neoantigens and tumour-infiltrating lymphocytes in multifocal papillary thyroid carcinoma.
Q50861629T-Cell Epitope Discovery for Therapeutic Cancer Vaccines.
Q90176790T-Cell Immunotherapies Targeting Histocompatibility and Tumor Antigens in Hematological Malignancies
Q39160959TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy
Q30668579TAPBPR alters MHC class I peptide presentation by functioning as a peptide exchange catalyst
Q35377746TCR contact residue hydrophobicity is a hallmark of immunogenic CD8+ T cell epitopes.
Q27316403TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection
Q38855909TIL 2.0: More effective and predictive T-cell products by enrichment for defined antigen specificities
Q50116964TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer
Q50130464Targeting Neoantigens in Glioblastoma: An Overview of Cancer Immunogenomics and Translational Implications.
Q38366556Targeting cancer-specific mutations by T cell receptor gene therapy
Q36618620Targeting human melanoma neoantigens by T cell receptor gene therapy
Q47433391Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution.
Q37223669Targeting neoantigens for cancer immunotherapy
Q39149196Targeting neoantigens to augment antitumour immunity
Q34677333Targeting of cancer neoantigens with donor-derived T cell receptor repertoires
Q36316627Targeting the undruggable: immunotherapy meets personalized oncology in the genomic era.
Q91799734The Case for Proteomics and Phospho-Proteomics in Personalized Cancer Medicine
Q38768283The Damaging Effect of Passenger Mutations on Cancer Progression
Q91711253The Graft-Versus-Leukemia Effect in AML
Q91343733The Human Immunopeptidome Project: A Roadmap to Predict and Treat Immune Diseases
Q38807692The Human Vaccines Project: A roadmap for cancer vaccine development
Q41189810The Long and Winding Road: From the High-Affinity Choline Uptake Site to Clinical Trials for Malignant Brain Tumors
Q38753386The Role of Neoantigens in Naturally Occurring and Therapeutically Induced Immune Responses to Cancer
Q42204343The Role of Next-Generation Sequencing in Enabling Personalized Oncology Therapy.
Q47678849The diverse functions of the PD1 inhibitory pathway
Q91520697The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy
Q38829558The future of immunotherapy for sarcoma
Q48461416The immunocheckpoints in modern oncology: the next 15 years.
Q97067351The impact of PD-L1 N-linked glycosylation on cancer therapy and clinical diagnosis
Q102211076The intrinsic immunogenic properties of cancer cell lines, immunogenic cell death, and how these influence host antitumor immune responses
Q55001351The perfect personalized cancer therapy: cancer vaccines against neoantigens.
Q34528638The present status and future prospects of peptide-based cancer vaccines
Q39427595The role of MHC genes in contagious cancer: the story of Tasmanian devils
Q47190955The role of mass spectrometry and proteogenomics in the advancement of HLA epitope prediction
Q90481320The role of proteomics in the age of immunotherapies
Q58924840The swinging pendulum of cancer immunotherapy personalization
Q39828989The therapeutic promise of disrupting the PD-1/PD-L1 immune checkpoint in cancer: unleashing the CD8 T cell mediated anti-tumor activity results in significant, unprecedented clinical efficacy in various solid tumors
Q40728648Therapeutic Cancer Vaccines
Q50988785Therapeutic cancer vaccines.
Q90339758Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells
Q38650013Tools to define the melanoma-associated immunopeptidome.
Q96641056Towards new horizons: characterization, classification and implications of the tumour antigenic repertoire
Q47789519Towards personalized, tumour-specific, therapeutic vaccines for cancer.
Q37660771Transient Treg depletion enhances therapeutic anti-cancer vaccination.
Q38878056Translational value of mouse models in oncology drug development
Q56893452Trial watch: DNA-based vaccines for oncological indications
Q56594845Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics
Q37422116Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures
Q89525448Tumor immune microenvironment in head and neck cancers
Q92579646Tumor mutation burden: from comprehensive mutational screening to the clinic
Q91895975Tumor mutational burden quantification from targeted gene panels: major advancements and challenges
Q28082704Tumor neoantigens: building a framework for personalized cancer immunotherapy
Q93157712Tumor neoantigens: from basic research to clinical applications
Q92757018Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity
Q37660698Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice
Q58927160Tumour mutations harnessed to build cancer vaccine
Q38787035Unmasking targets of antitumor immunity via high-throughput antigen profiling
Q30391717Unsupervised HLA Peptidome Deconvolution Improves Ligand Prediction Accuracy and Predicts Cooperative Effects in Peptide-HLA Interactions
Q57050167Utilizing TAPBPR to promote exogenous peptide loading onto cell surface MHC I molecules
Q50222492Vaccination with High-Affinity Epitopes Impairs Antitumor Efficacy by Increasing PD-1 Expression on CD8+ T Cells
Q39791206Viral Infection of Tumors Overcomes Resistance to PD-1-immunotherapy by Broadening Neoantigenome-directed T-cell Responses.
Q37035972Viral infection causes a shift in the self peptide repertoire presented by human MHC class I molecules
Q89850600dbPepNeo: a manually curated database for human tumor neoantigen peptides
Q39013357mRNA Cancer Vaccines
Q37202382sNebula, a network-based algorithm to predict binding between human leukocyte antigens and peptides
Q26861133αβ TCR-mediated recognition: relevance to tumor-antigen discovery and cancer immunotherapy