Affinity thresholds for naive CD8+ CTL activation by peptides and engineered influenza A viruses

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Affinity thresholds for naive CD8+ CTL activation by peptides and engineered influenza A viruses is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1003937
P3181OpenCitations bibliographic resource ID4277631
P698PubMed publication ID22039305
P5875ResearchGate publication ID51753875

P50authorPeter C. DohertyQ309814
Jamie RossjohnQ28036336
Stephanie GrasQ28355141
Carole GuillonneauQ28355651
Justine D. MinternQ39631810
Philip D HodgkinQ42698266
David JacksonQ42889647
Alice E. DentonQ45408437
Stephen J. TurnerQ47502192
Matthew R. OlsonQ51022230
P2093author name stringWeiguang Zeng
Robb Wesselingh
P2860cites workClonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding propertiesQ80991133
The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivityQ27631051
The crystal structure of human phosphoglucose isomerase at 1.6 A resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemiaQ27631906
Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptabilityQ27661747
Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding grooveQ27729958
XDSQ27860472
Coot: model-building tools for molecular graphicsQ27860505
The CCP4 suite: programs for protein crystallographyQ27861090
A cellular calculus for signal integration by T cellsQ28145380
T cell receptor antagonist peptides induce positive selectionQ29618820
A DNA transfection system for generation of influenza A virus from eight plasmidsQ29642855
Stimulation of naive CD8+ T cells by a variant viral epitope induces activation and enhanced apoptosisQ30433067
Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement timeQ33821395
Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansionQ33882912
Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cellsQ34003618
Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell deathQ34015840
When Toll-like receptor and T-cell receptor signals collide: a mechanism for enhanced CD8 T-cell effector functionQ34310528
T cell anergyQ35019694
TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.Q35739708
Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cellsQ36361774
T cells compete for access to antigen-bearing antigen-presenting cellsQ36376071
Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude.Q36383089
T-cell receptor bias and immunityQ37061390
Relative immunogenicity of the cold-adapted influenza virus A/Ann Arbor/6/60 (A/AA/6/60-ca), recombinants of A/AA/6/60-ca, and parental strains with similar surface antigensQ37098316
The fidelity, occasional promiscuity, and versatility of T cell receptor recognitionQ37110406
Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative responseQ37376774
A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responsesQ37585518
The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded stateQ38360444
Thymic selection threshold defined by compartmentalization of Ras/MAPK signallingQ39773899
Rapid production of TNF-alpha following TCR engagement of naive CD8 T cellsQ40364726
T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptideQ40368484
Signals and signs for lymphocyte responsesQ40620206
T-cell-receptor affinity and thymocyte positive selectionQ41192128
Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands.Q41612272
Complete but curtailed T-cell response to very low-affinity antigenQ41902378
Altered hapten ligands antagonize trinitrophenyl-specific cytotoxic T cells and block internalization of hapten-specific receptorsQ41903218
Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonistQ42032626
Recruitment of antigen-specific CD8+ T cells in response to infection is markedly efficientQ43281147
Dissection of major histocompatibility complex (MHC) and T cell receptor contact residues in a Kb-restricted ovalbumin peptide and an assessment of the predictive power of MHC-binding motifsQ43409344
Highly immunogenic and totally synthetic lipopeptides as self-adjuvanting immunocontraceptive vaccines.Q44187641
The context of epitope presentation can influence functional quality of recalled influenza A virus-specific memory CD8+ T cellsQ45401359
Addition of a prominent epitope affects influenza A virus-specific CD8+ T cell immunodominance hierarchies when antigen is limitingQ45413199
Hierarchies in cytokine expression profiles for acute and resolving influenza virus-specific CD8+ T cell responses: correlation of cytokine profile and TCR avidityQ45649608
Ligand recognition by alpha beta T cell receptorsQ46222293
Synthesis of toll-like receptor-2 targeting lipopeptides as self-adjuvanting vaccinesQ46411811
A kinetic window constricts the T cell receptor repertoire in the thymus.Q52930208
Universal primer set for the full-length amplification of all influenza A virusesQ57202943
Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cellsQ60181797
An Essential Role for TNF in Modulating Thresholds for Survival, Activation, and Tolerance of CD8+ T CellsQ60651246
TCR Affinity Promotes CD8+ T Cell Expansion by Regulating SurvivalQ61853669
T cell fitness determined by signal strengthQ73134915
Enhanced antigen-specific antitumor immunity with altered peptide ligands that stabilize the MHC-peptide-TCR complexQ73168752
CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleenQ73520530
TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCRQ73827834
The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading modelQ74312259
Immunodominance in TCD8+ responses to viruses: cell biology, cellular immunology, and mathematical modelsQ80444901
CD8+ T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rateQ80819638
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)5733-44
P577publication date2011-12-01
P1433published inJournal of ImmunologyQ3521441
P1476titleAffinity thresholds for naive CD8+ CTL activation by peptides and engineered influenza A viruses
P478volume187

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cites work (P2860)
Q33835059Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses
Q34241366Antigen-specific inhibition of high-avidity T cell target lysis by low-avidity T cells via trogocytosis.
Q55421143Brucella Peptide Cross-Reactive Major Histocompatibility Complex Class I Presentation Activates SIINFEKL-Specific T Cell Receptor-Expressing T Cells.
Q91761205CD4+ T help promotes influenza virus-specific CD8+ T cell memory by limiting metabolic dysfunction
Q91638872CTL-Derived Exosomes Enhance the Activation of CTLs Stimulated by Low-Affinity Peptides
Q30430651Conserved epitopes dominate cross-CD8+ T-cell responses against influenza A H1N1 virus among Asian populations
Q38619883Contractile actomyosin arcs promote the activation of primary mouse T cells in a ligand-dependent manner
Q90390406Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity
Q34082904Fibroblastic reticular cells of the lymph node are required for retention of resting but not activated CD8+ T cells
Q48283531Hyaluronan-binding by CD44 reduces the memory potential of activated murine CD8 T cells.
Q37374912Interferon regulatory factor 4 sustains CD8(+) T cell expansion and effector differentiation
Q39181825Mini-intronic plasmid vaccination elicits tolerant LAG3+ CD8+ T cells and inferior antitumor responses.
Q92483991Opposing T cell responses in experimental autoimmune encephalomyelitis
Q35453691Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing.
Q37162518Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1.
Q94932167Stimulation strength controls the rate of initiation but not the molecular organization of TCR-induced signalling
Q57235281T cell cytolytic capacity is independent of initial stimulation strength
Q37682074TCRβ repertoire of CD4+ and CD8+ T cells is distinct in richness, distribution, and CDR3 amino acid composition.
Q52337645The partial dissociation of MHC class I bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1.
Q88956155Vaccine Adjuvant Incorporation Strategy Dictates Peptide Amphiphile Micelle Immunostimulatory Capacity

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