| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S1074-7613(01)00173-X |
| P698 | PubMed publication ID | 11485738 |
| P50 | author | Mark A Daniels | Q56427116 |
| P2093 | author name string | P J Travers | |
| C Rosette | |||
| P O Holman | |||
| S C Jameson | |||
| E Palmer | |||
| N R Gascoigne | |||
| S M Alam | |||
| G Werlen | |||
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| Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73 | Q42825163 | ||
| Naive CD8+ T cells do not require costimulation for proliferation and differentiation into cytotoxic effector cells. | Q44764971 | ||
| A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists | Q46121537 | ||
| Ligand recognition by alpha beta T cell receptors | Q46222293 | ||
| Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected] | Q46842083 | ||
| The duration of antigenic stimulation determines the fate of naive and effector T cells. | Q51099389 | ||
| Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: implications for TCR signaling. | Q55239901 | ||
| The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations | Q57275505 | ||
| Crippling of CD3-ζ ITAMs Does Not Impair T Cell Receptor Signaling | Q57275521 | ||
| Immobilization chemistries suitable for use in the BIAcore surface plasmon resonance detector | Q67586852 | ||
| Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy | Q71988127 | ||
| Modulation of calcium responses by altered peptide ligands in a human T cell clone | Q77714897 | ||
| High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling | Q77769114 | ||
| A functional hot spot for antigen recognition in a superagonist TCR/MHC complex | Q27622127 | ||
| Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition | Q27642083 | ||
| Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation | Q28277469 | ||
| Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells | Q28755947 | ||
| T cell receptor antagonist peptides induce positive selection | Q29618820 | ||
| The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation | Q33652505 | ||
| The role of T-cell receptor dimerization in T-cell activation. | Q33774239 | ||
| Selecting and maintaining a diverse T-cell repertoire | Q33783983 | ||
| T cell activation and the cytoskeleton | Q33932683 | ||
| Homeostatic T cell proliferation: how far can T cells be activated to self-ligands? | Q34010799 | ||
| Kinetic proofreading in T-cell receptor signal transduction | Q34285825 | ||
| Unexpected signals in a system subject to kinetic proofreading | Q36303085 | ||
| Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading | Q36303320 | ||
| Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells | Q36361774 | ||
| T cell affinity maturation by selective expansion during infection | Q36367796 | ||
| Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibility complex multimers | Q36375751 | ||
| Kinetics and extent of T cell activation as measured with the calcium signal | Q36377251 | ||
| Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells | Q36401236 | ||
| Kinetic discrimination in T-cell activation | Q37715642 | ||
| T cell receptor antagonists and partial agonists | Q40438235 | ||
| The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers | Q40831490 | ||
| A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity | Q40862851 | ||
| Essential flexibility in the T-cell recognition of antigen | Q40973329 | ||
| Peptide antagonism and T cell receptor interactions with peptide-MHC complexes | Q40996486 | ||
| Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology | Q41039639 | ||
| Mitogen-activated protein kinase cascades and regulation of gene expression | Q41102936 | ||
| Altered T cell receptor ligands trigger a subset of early T cell signals | Q41180292 | ||
| T-cell-receptor affinity and thymocyte positive selection | Q41192128 | ||
| Variant TCR ligands: new insights into the molecular basis of antigen-dependent signal transduction and T-cell activation | Q41214782 | ||
| Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists | Q41379043 | ||
| Differential signaling by lymphocyte antigen receptors. | Q41464265 | ||
| P433 | issue | 1 | |
| P921 | main subject | T cell activation | Q14863969 |
| P304 | page(s) | 59-70 | |
| P577 | publication date | 2001-07-01 | |
| P1433 | published in | Immunity | Q6005457 |
| P1476 | title | The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model | |
| P478 | volume | 15 |
| Q37614812 | 2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system. |
| Q37473160 | A deficiency in Drak2 results in a T cell hypersensitivity and an unexpected resistance to autoimmunity |
| Q33570532 | A multifactorial mechanism in the superior antimalarial activity of alpha-C-GalCer |
| Q34873201 | A role for CD8 in the developmental tuning of antigen recognition and CD3 conformational change |
| Q41965757 | A stochastic T cell response criterion |
| Q35016200 | A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding |
| Q42290491 | A unifying mathematical framework for experimental TCR-pMHC kinetic constants |
| Q79415991 | Activation of CD4+ CD25+ regulatory T cell suppressor function by analogs of the selecting peptide |
| Q27675301 | Affinity thresholds for naive CD8+ CTL activation by peptides and engineered influenza A viruses |
| Q36376674 | Allelic variation of MHC structure alters peptide ligands to induce atypical partial agonistic CD8+ T cell function |
| Q57363751 | Allogeneic and syngeneic class I MHC complexes drive the association of CD8 and TCR on 2C T cells |
| Q98177732 | An Unusual MHC Molecule Generates Protective CD8+ T Cell Responses to Chronic Infection |
| Q35076666 | An evolutionary and structural perspective on T cell antigen receptor function |
| Q33698019 | Attenuated T cell responses to a high-potency ligand in vivo |
| Q91638872 | CTL-Derived Exosomes Enhance the Activation of CTLs Stimulated by Low-Affinity Peptides |
| Q34160870 | Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules |
| Q37644276 | Co-receptors and recognition of self at the immunological synapse |
| Q41440201 | Competition between T cells maintains clonal dominance during memory inflation induced by MCMV. |
| Q34388307 | Computational analysis of T cell receptor signaling and ligand discrimination – Past, present, and future |
| Q28469243 | Computational investigations into the origins of short-term biochemical memory in T cell activation |
| Q38619883 | Contractile actomyosin arcs promote the activation of primary mouse T cells in a ligand-dependent manner |
| Q34895271 | Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation. |
| Q39349502 | Dendritic cells matured by inflammation induce CD86-dependent priming of naive CD8+ T cells in the absence of their cognate peptide antigen. |
| Q41772561 | Destabilization of peptide:MHC interaction induces IL-2 resistant anergy in diabetogenic T cells |
| Q30504688 | Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses |
| Q57275451 | Distinct orientation of the alloreactive monoclonal CD8 T cell activation program by three different peptide/MHC complexes |
| Q38734283 | Distinct patterns of cytolytic T-cell activation by different tumour cells revealed by Ca2+ signalling and granule mobilization |
| Q42088119 | Dynamic changes during the immune response in T cell-antigen-presenting cell clusters isolated from lymph nodes. |
| Q35022798 | Effect of preexisting immunity to adenovirus on transgene product-specific genital T cell responses on vaccination of mice with a homologous vector |
| Q27331858 | Epitope flexibility and dynamic footprint revealed by molecular dynamics of a pMHC-TCR complex |
| Q37518497 | Functional implications of T cell receptor diversity |
| Q36012164 | Gads regulates the expansion phase of CD8+ T cell-mediated immunity |
| Q37773428 | Generation of effector CD8+ T cells and their conversion to memory T cells |
| Q34612531 | Homeostasis of naïve, effector and memory CD8 T cells |
| Q36432686 | How much of virus-specific CD8 T cell reactivity is detected with a peptide pool when compared to individual peptides? |
| Q46768284 | IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level |
| Q26774669 | Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens |
| Q36515364 | Insights from in situ analysis of TCR-pMHC recognition: response of an interaction network |
| Q35927615 | Insights into T cell recognition of antigen: significance of two-dimensional kinetic parameters |
| Q36740232 | Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface |
| Q35612835 | Interaction of streptavidin-based peptide-MHC oligomers (tetramers) with cell-surface TCRs |
| Q36080586 | Interplay between T cell receptor binding kinetics and the level of cognate peptide presented by major histocompatibility complexes governs CD8+ T cell responsiveness |
| Q28512242 | Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement |
| Q40170834 | JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response |
| Q35076704 | Kinetic perspectives of T cell antigen receptor signaling. A two-tier model for T cell full activation |
| Q36995467 | Kinetic proofreading of ligand-FcepsilonRI interactions may persist beyond LAT phosphorylation |
| Q64955683 | LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling. |
| Q64052753 | Live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance |
| Q51983937 | Long-lived memory CD8+ T cells are programmed by prolonged antigen exposure and low levels of cellular activation. |
| Q34193211 | Low 2-dimensional CD4 T cell receptor affinity for myelin sets in motion delayed response kinetics |
| Q37486804 | Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression |
| Q33838467 | Manipulating antigenic ligand strength to selectively target myelin-reactive CD4+ T cells in EAE. |
| Q35790365 | Mathematical and computational models of immune-receptor signalling |
| Q27016079 | Mechanical regulation of T-cell functions |
| Q36891310 | Mobilizing the low-avidity T cell repertoire to kill tumors |
| Q24814731 | Modeling T cell antigen discrimination based on feedback control of digital ERK responses |
| Q34916448 | Models of self-peptide sampling by developing T cells identify candidate mechanisms of thymic selection |
| Q36977064 | Monitoring the Dynamics of T Cell Clonal Diversity Using Recombinant Peptide:MHC Technology |
| Q38857800 | Of the multiple mechanisms leading to type 1 diabetes, T cell receptor revision may play a prominent role (is type 1 diabetes more than a single disease?). |
| Q92267475 | PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance |
| Q36074247 | Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis |
| Q37637869 | Potentiation of T Cell Stimulatory Activity by Chemical Fixation of a Weak Peptide-MHC Complex |
| Q34815668 | Probing T cell membrane organization using dimeric MHC-Ig complexes |
| Q42942958 | Protein-protein interaction investigated by steered molecular dynamics: the TCR-pMHC complex |
| Q73022474 | Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation |
| Q24684195 | Quantitative challenges in understanding ligand discrimination by alphabeta T cells |
| Q33255244 | Relating TCR-peptide-MHC affinity to immunogenicity for the design of tumor vaccines |
| Q90606946 | Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection |
| Q37107843 | Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies |
| Q36231103 | Role of the LAT adaptor in T-cell development and Th2 differentiation |
| Q37377422 | Self-class I MHC molecules support survival of naive CD8 T cells, but depress their functional sensitivity through regulation of CD8 expression levels |
| Q33992835 | Sequential immunization with heterologous chimeric flaviviruses induces broad-spectrum cross-reactive CD8+ T cell responses |
| Q34778134 | Signaling in thymic selection |
| Q90704129 | Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination |
| Q94932167 | Stimulation strength controls the rate of initiation but not the molecular organization of TCR-induced signalling |
| Q37866944 | Strength of TCR-peptide/MHC interactions and in vivo T cell responses |
| Q37951560 | Structural and biophysical determinants of αβ T-cell antigen recognition |
| Q37651126 | Suboptimal engagement of the T-cell receptor by a variety of peptide-MHC ligands triggers T-cell anergy |
| Q26765917 | T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells |
| Q27022243 | T cell antigen recognition at the cell membrane |
| Q57235281 | T cell cytolytic capacity is independent of initial stimulation strength |
| Q24297041 | T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice |
| Q37823023 | T cell receptor signaling kinetics takes the stage |
| Q43810167 | T cell receptor-mediated signal transduction controlled by the beta chain transmembrane domain: apoptosis-deficient cells display unbalanced mitogen-activated protein kinases activities upon T cell receptor engagement. |
| Q24626152 | T cell recognition of weak ligands: roles of signaling, receptor number, and affinity |
| Q30492783 | T-cell antagonism by short half-life pMHC ligands can be mediated by an efficient trapping of T-cell polarization toward the APC |
| Q37363263 | T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity |
| Q38009792 | TCR Nanoclusters as the Framework for Transmission of Conformational Changes and Cooperativity |
| Q57184989 | TCR affinity and negative regulation limit autoimmunity |
| Q40264104 | TCR ligand avidity determines the mode of B-Raf/Raf-1/ERK activation leading to the activation of human CD4+ T cell clone. |
| Q34044406 | TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo |
| Q37252710 | Tailoring T-cell receptor signals by proximal negative feedback mechanisms |
| Q36656068 | Temporal cross-talk between TCR and STAT signals for CD8 T cell effector differentiation. |
| Q35076682 | The Ras/MAPK cascade and the control of positive selection |
| Q33351190 | The SCHOOL of nature: I. Transmembrane signaling |
| Q34612495 | The T-cell receptor signalosome: a dynamic structure with expanding complexity |
| Q40972761 | The cellular environment regulates in situ kinetics of T-cell receptor interaction with peptide major histocompatibility complex |
| Q39819950 | The duration of TCR/pMHC interactions regulates CTL effector function and tumor-killing capacity. |
| Q50073563 | The half-life of the T-cell receptor/peptide-major histocompatibility complex interaction can modulate T-cell activation in response to bacterial challenge |
| Q33737674 | The impact of TCR-binding properties and antigen presentation format on T cell responsiveness |
| Q34078621 | The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness. |
| Q43149205 | The proline-rich sequence of CD3epsilon as an amplifier of low-avidity TCR signaling |
| Q37468145 | The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse |
| Q37687058 | Themis sets the signal threshold for positive and negative selection in T-cell development |
| Q58570417 | Themis-associated phosphatase activity controls signaling in T cell development |
| Q37170396 | Thermodynamics of T-cell receptor-peptide/MHC interactions: progress and opportunities |
| Q39773899 | Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling |
| Q44625252 | Thymocyte Sensitivity and Supramolecular Activation Cluster Formation Are Developmentally Regulated: A Partial Role for Sialylation |
| Q36018570 | Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells |
| Q34507271 | Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns |
| Q36218880 | Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity |
| Q84736367 | Variability of CD3 membrane expression and T cell activation capacity |
| Q36512323 | Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection |
| Q37517305 | Visualizing intermolecular interactions in T cells |
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