Insights into T cell recognition of antigen: significance of two-dimensional kinetic parameters

scientific article published on 20 April 2012

Insights into T cell recognition of antigen: significance of two-dimensional kinetic parameters is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FIMMU.2012.00086
P932PMC publication ID3342060
P698PubMed publication ID22566966
P5875ResearchGate publication ID224919354

P50authorBrian D EvavoldQ37370110
Veronika ZarnitsynaQ56766137
P2093author name stringCheng Zhu
Lindsay J Edwards
Jennifer D Hood
P2860cites workSyk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complexQ24678927
Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramersQ27480953
Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activationQ27642839
T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility ComplexQ27675661
Phenotypic analysis of antigen-specific T lymphocytesQ28290058
Late arrival: recruiting coreceptors to the T cell receptor complexQ28304099
Two-stage cooperative T cell receptor-peptide major histocompatibility complex-CD8 trimolecular interactions amplify antigen discriminationQ28728145
Memory in receptor-ligand-mediated cell adhesionQ30441797
Monitoring receptor-ligand interactions between surfaces by thermal fluctuationsQ30480925
The TCR triggering puzzleQ33335696
The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperationQ33652505
The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.Q34078621
Sensitive force technique to probe molecular adhesion and structural linkages at biological interfacesQ34129714
Measuring two-dimensional receptor-ligand binding kinetics by micropipetteQ34168986
Kinetic proofreading in T-cell receptor signal transductionQ34285825
Ex vivo analysis of tumor antigen specific CD8+ T cell responses using MHC/peptide tetramers in cancer patientsQ34311750
Identification of self through two-dimensional chemistry and synapses.Q34425148
The specificity of TCR/pMHC interactionQ34493013
High prevalence of low affinity peptide-MHC II tetramer-negative effectors during polyclonal CD4+ T cell responsesQ34501474
Two-dimensional kinetics regulation of alphaLbeta2-ICAM-1 interaction by conformational changes of the alphaL-inserted domainQ34666847
Interaction of streptavidin-based peptide-MHC oligomers (tetramers) with cell-surface TCRsQ35612835
TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.Q35739708
The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activationQ35876939
Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsivenessQ36009049
Measuring diffusion and binding kinetics by contact area FRAP.Q36737147
A coupled diffusion-kinetics model for analysis of contact-area FRAP experimentQ36737191
Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surfaceQ36740232
The actin cytoskeleton in T cell activationQ37096089
Replacing a lectin domain residue in L-selectin enhances binding to P-selectin glycoprotein ligand-1 but not to 6-sulfo-sialyl Lewis xQ38293878
Ultrasensitive detection and phenotyping of CD4+ T cells with optimized HLA class II tetramer stainingQ40354302
CD8 kinetically promotes ligand binding to the T-cell antigen receptor.Q40404578
Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligandsQ40487156
Receptor proximity, not intermolecular orientation, is critical for triggering T-cell activationQ40802102
The use of HLA A2.1/p53 peptide tetramers to visualize the impact of self tolerance on the TCR repertoireQ40908102
T-cell-receptor affinity and thymocyte positive selectionQ41192128
A kinase-independent function of Lck in potentiating antigen-specific T cell activationQ41533100
Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands.Q41612272
Expansion and functional maturation of human tumor antigen-specific CD8+ T cells after vaccination with antigenic peptide.Q43573563
HLA class II-restricted CD4+ T cell responses directed against influenza viral antigens postinfluenza vaccinationQ44460752
Immunogenicity and safety of a novel therapeutic hepatitis C virus (HCV) peptide vaccine: a randomized, placebo controlled trial for dose optimization in 128 healthy subjects.Q45418238
Ligand recognition by alpha beta T cell receptorsQ46222293
MHC variant peptide-mediated anergy of encephalitogenic T cells requires SHP-1.Q46266985
Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]Q46842083
Kinetics of MHC-CD8 interaction at the T cell membrane.Q46891783
Coreceptor CD8-driven modulation of T cell antigen receptor specificity.Q51905872
T cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TL.Q52126939
Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding PropertiesQ57372665
T cell receptor-MHC class I peptide interactions: affinity, kinetics, and specificityQ72112177
Increased vaccine-specific T cell frequency after peptide-based vaccination correlates with increased susceptibility to in vitro stimulation but does not lead to tumor regressionQ73202067
Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivoQ73263520
TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCRQ73827834
The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading modelQ74312259
Affinity and kinetic analysis of P-selectin binding to P-selectin glycoprotein ligand-1Q77604437
Induction or expansion of T-cell responses by a hepatitis B DNA vaccine administered to chronic HBV carriersQ80594566
P304page(s)86
P577publication date2012-04-20
P1433published inFrontiers in ImmunologyQ27723748
P1476titleInsights into T cell recognition of antigen: significance of two-dimensional kinetic parameters
P478volume3

Reverse relations

cites work (P2860)
Q581220652D Kinetic Analysis of TCR and CD8 Coreceptor for LCMV GP33 Epitopes
Q376148122D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system.
Q42290491A unifying mathematical framework for experimental TCR-pMHC kinetic constants
Q41051986Fluorescence Biomembrane Force Probe: Concurrent Quantitation of Receptor-ligand Kinetics and Binding-induced Intracellular Signaling on a Single Cell.
Q26774669Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens
Q36515364Insights from in situ analysis of TCR-pMHC recognition: response of an interaction network
Q64067638Is TCR/pMHC Affinity a Good Estimate of the T-cell Response? An Answer Based on Predictions From 12 Phenotypic Models
Q45191889Mathematical modelling and computational study of two-dimensional and three-dimensional dynamics of receptor-ligand interactions in signalling response mechanisms.
Q40092104Mechanosensing drives acuity of αβ T-cell recognition
Q36977064Monitoring the Dynamics of T Cell Clonal Diversity Using Recombinant Peptide:MHC Technology
Q38211020Receptor Pre-Clustering and T cell Responses: Insights into Molecular Mechanisms
Q36318694Resolving two-dimensional kinetics of the integrin αIIbβ3-fibrinogen interactions using binding-unbinding correlation spectroscopy
Q39305350Supported lipid bilayer platforms to probe cell mechanobiology
Q35935892Viral Escape Mutant Epitope Maintains TCR Affinity for Antigen yet Curtails CD8 T Cell Responses

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