Insights from in situ analysis of TCR-pMHC recognition: response of an interaction network

scientific article published on January 2013

Insights from in situ analysis of TCR-pMHC recognition: response of an interaction network is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/IMR.12016
P932PMC publication ID3539230
P698PubMed publication ID23278740
P5875ResearchGate publication ID234030337

P50authorBrian D EvavoldQ37370110
Ning JiangQ51089003
Veronika ZarnitsynaQ56766137
Cheng ZhuQ60964006
P2093author name stringJun Huang
P2860cites workT-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1Q24296288
Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signalingQ25257443
T cell antigen recognition at the cell membraneQ27022243
Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivityQ27333772
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Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based MotifQ27652912
T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility ComplexQ27675661
The immunological synapse: a molecular machine controlling T cell activationQ28139151
The molecular basis of TCR germline bias for MHC is surprisingly simpleQ28306893
Two-stage cooperative T cell receptor-peptide major histocompatibility complex-CD8 trimolecular interactions amplify antigen discriminationQ28728145
Models for the Specific Adhesion of Cells to CellsQ29616061
Force measurements of TCR/pMHC recognition at T cell surfaceQ30474720
Monitoring receptor-ligand interactions between surfaces by thermal fluctuationsQ30480925
Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch BondsQ30497295
Transforming binding affinities from three dimensions to two with application to cadherin clusteringQ30503964
T cell receptor triggering by forceQ33348048
Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement timeQ33821395
The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.Q34078621
Sensitive force technique to probe molecular adhesion and structural linkages at biological interfacesQ34129714
Measuring two-dimensional receptor-ligand binding kinetics by micropipetteQ34168986
Kinetic proofreading in T-cell receptor signal transductionQ34285825
Identification of self through two-dimensional chemistry and synapses.Q34425148
High prevalence of low affinity peptide-MHC II tetramer-negative effectors during polyclonal CD4+ T cell responsesQ34501474
Cell adhesion. Competition between nonspecific repulsion and specific bondingQ34535126
Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctionsQ34574696
Transport governs flow-enhanced cell tethering through L-selectin at threshold shear.Q35220087
Analysis of two-dimensional dissociation constant of laterally mobile cell adhesion moleculesQ35606770
Mechanosensing in T lymphocyte activationQ35679076
TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.Q35739705
TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.Q35739708
Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivoQ35925494
Insights into T cell recognition of antigen: significance of two-dimensional kinetic parametersQ35927615
Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsivenessQ36009049
Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptorQ36152482
Visualization of CD2 interaction with LFA-3 and determination of the two-dimensional dissociation constant for adhesion receptors in a contact area.Q36236485
Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of responseQ36402779
Measuring diffusion and binding kinetics by contact area FRAP.Q36737147
A coupled diffusion-kinetics model for analysis of contact-area FRAP experimentQ36737191
Evolutionarily conserved amino acids that control TCR-MHC interactionQ37096091
T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificityQ37363263
Measuring Receptor-Ligand Binding Kinetics on Cell Surfaces: From Adhesion Frequency to Thermal Fluctuation Methods.Q37408990
The alphabeta T cell receptor is an anisotropic mechanosensor.Q37431436
Structural alterations in peptide-MHC recognition by self-reactive T cell receptorsQ37456210
Kinetic discrimination in T-cell activationQ37715642
T cell triggering: insights from 2D kinetics analysis of molecular interactionsQ38032705
Replacing a lectin domain residue in L-selectin enhances binding to P-selectin glycoprotein ligand-1 but not to 6-sulfo-sialyl Lewis xQ38293878
Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligandsQ40487156
The immunological synapse and CD28-CD80 interactions.Q40767962
Peptide antagonism and T cell receptor interactions with peptide-MHC complexesQ40996486
Loss of division potential in vitro: aging or differentiation?Q41044517
CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexesQ41145528
T-cell-receptor affinity and thymocyte positive selectionQ41192128
Lack of strict correlation of functional sensitization with the apparent affinity of MHC/peptide complexes for the TCR.Q41325800
TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell SignalingQ41910808
The receptor deformation model of TCR triggeringQ42058124
TCR Signaling Emerges from the Sum of Many PartsQ42212300
A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonistsQ46121537
Ligand recognition by alpha beta T cell receptorsQ46222293
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.Q46793124
Kinetics of MHC-CD8 interaction at the T cell membrane.Q46891783
Quantification and modeling of tripartite CD2-, CD58FC chimera (alefacept)-, and CD16-mediated cell adhesion.Q51794352
Cutting Edge: mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling.Q54676899
Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: implications for TCR signaling.Q55239901
Low affinity interaction of human or rat T cell adhesion molecule CD2 with its ligand aligns adhering membranes to achieve high physiological affinityQ57962352
Measuring interactions of MHC class I molecules using surface plasmon resonanceQ71848145
T cell receptor-MHC class I peptide interactions: affinity, kinetics, and specificityQ72112177
Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activationQ73022474
The membrane anchor influences ligand binding two-dimensional kinetic rates and three-dimensional affinity of FcgammaRIII (CD16)Q73615825
The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading modelQ74312259
T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kineticsQ74595059
T-cell receptor binding kinetics in T-cell development and activationQ76384899
TCR binding to peptide-MHC stabilizes a flexible recognition interfaceQ77328526
Affinity and kinetic analysis of P-selectin binding to P-selectin glycoprotein ligand-1Q77604437
High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signalingQ77769114
Mechanical interactions between dendritic cells and T cells correlate with T cell responsivenessQ84217956
P433issue1
P304page(s)49-64
P577publication date2013-01-01
P1433published inImmunological ReviewsQ15724582
P1476titleInsights from in situ analysis of TCR-pMHC recognition: response of an interaction network
P478volume251

Reverse relations

cites work (P2860)
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Q36119302Force-Regulated In Situ TCR-Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+ T Cells.
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Q64067638Is TCR/pMHC Affinity a Good Estimate of the T-cell Response? An Answer Based on Predictions From 12 Phenotypic Models
Q27002652Linking form to function: Biophysical aspects of artificial antigen presenting cell design
Q50963377Lipid rafts enhance the binding constant of membrane-anchored receptors and ligands.
Q26781296Lower Affinity T Cells are Critical Components and Active Participants of the Immune Response
Q90168597Mechanosensing through immunoreceptors
Q36977064Monitoring the Dynamics of T Cell Clonal Diversity Using Recombinant Peptide:MHC Technology
Q38626628Normalized Synergy Predicts That CD8 Co-Receptor Contribution to T Cell Receptor (TCR) and pMHC Binding Decreases As TCR Affinity Increases in Human Viral-Specific T Cells
Q37637869Potentiation of T Cell Stimulatory Activity by Chemical Fixation of a Weak Peptide-MHC Complex
Q47625174Receptor-mediated cell mechanosensing.
Q38169708Strict Major Histocompatibility Complex Molecule Class-Specific Binding by Co-Receptors Enforces MHC-Restricted αβ TCR Recognition during T Lineage Subset Commitment
Q37030688Structural and biophysical insights into the role of CD4 and CD8 in T cell activation
Q38671405TCR-ligand dissociation rate is a robust and stable biomarker of CD8+ T cell potency
Q51371514Tension-compression asymmetry in the binding affinity of membrane-anchored receptors and ligands.
Q40972761The cellular environment regulates in situ kinetics of T-cell receptor interaction with peptide major histocompatibility complex
Q41447071The contribution of major histocompatibility complex contacts to the affinity and kinetics of T cell receptor binding
Q51361915The glycocalyx promotes cooperative binding and clustering of adhesion receptors.
Q35333646Transport regulation of two-dimensional receptor-ligand association
Q40310220Two-Dimensional Analysis of Cross-Junctional Molecular Interaction by Force Probes.

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