Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells

scientific article published on 03 July 2013

Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.7554/ELIFE.00778
P932PMC publication ID3701909
P698PubMed publication ID23840928
P5875ResearchGate publication ID248385195

P50authorJay T GrovesQ89422757
P2093author name stringRafal M Pielak
Jenny J Lin
Geoff P O'Donoghue
Alexander A Smoligovets
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The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.Q34078621
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T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clustersQ35022108
TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.Q35739708
EphA2 receptor activation by monomeric Ephrin-A1 on supported membranesQ35815919
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Determination of interaction kinetics between the T cell receptor and peptide-loaded MHC class II via single-molecule diffusion measurementsQ36105328
Synaptic pattern formation during cellular recognitionQ36225863
T cell receptor ligation induces the formation of dynamically regulated signaling assembliesQ36324026
A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complexQ36369989
Insights from in situ analysis of TCR-pMHC recognition: response of an interaction networkQ36515364
Patterned two-photon photoactivation illuminates spatial reorganization in live cellsQ36765585
A mechanism for SRC kinase-dependent signaling by noncatalytic receptorsQ37150264
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Receptor signaling clusters in the immune synapseQ37725089
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Serial triggering of many T-cell receptors by a few peptide-MHC complexesQ41346263
Making the T cell receptor go the distance: a topological view of T cell activationQ41457016
Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonistQ42032626
Bayesian detection of intensity changes in single molecule and molecular dynamics trajectoriesQ43850734
TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathwaysQ44308973
Direct observation of ligand recognition by T cells.Q46020608
Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptorQ46155874
Supported membrane formation, characterization, functionalization, and patterning for application in biological science and technologyQ46269577
Kinetic control of histidine-tagged protein surface density on supported lipid bilayersQ46455172
Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivityQ46681223
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.Q46793124
Feedback control of T-cell receptor activation.Q51994109
CD8+ T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rateQ80819638
Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipperQ83200613
P407language of work or nameEnglishQ1860
P304page(s)e00778
P577publication date2013-07-03
P1433published ineLifeQ2000008
P1476titleDirect single molecule measurement of TCR triggering by agonist pMHC in living primary T cells
P478volume2

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