| scholarly article | Q13442814 |
| P50 | author | James P. Allison | Q6140731 |
| P2093 | author name string | Emily Corse | |
| Rachel A Gottschalk | |||
| Michelle Krogsgaard | |||
| P2860 | cites work | Quantitative challenges in understanding ligand discrimination by alphabeta T cells | Q24684195 |
| Modeling T cell antigen discrimination based on feedback control of digital ERK responses | Q24814731 | ||
| Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation | Q27642839 | ||
| Lineage relationship and protective immunity of memory CD8 T cell subsets | Q28206693 | ||
| miR-181a is an intrinsic modulator of T cell sensitivity and selection | Q28294631 | ||
| Central memory and effector memory T cell subsets: function, generation, and maintenance | Q29615097 | ||
| Immunogenicity. I. Use of peptide libraries to identify epitopes that activate clonotypic CD4+ T cells and induce T cell responses to native peptide ligands | Q30823267 | ||
| Relating TCR-peptide-MHC affinity to immunogenicity for the design of tumor vaccines | Q33255244 | ||
| The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation | Q33652505 | ||
| Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time | Q33821395 | ||
| TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo | Q34044406 | ||
| Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. | Q34504134 | ||
| Preferential localization of effector memory cells in nonlymphoid tissue | Q34514330 | ||
| The CD28 signaling pathway regulates glucose metabolism | Q34525357 | ||
| T cells like a firm molecular handshake | Q34574614 | ||
| Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctions | Q34574696 | ||
| CTLA-4: new insights into its biological function and use in tumor immunotherapy | Q34711491 | ||
| Molecular interactions mediating T cell antigen recognition | Q35077424 | ||
| Dynamics of Cell Surface Molecules During T Cell Recognition | Q35550692 | ||
| Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness | Q36009049 | ||
| How T cells 'see' antigen | Q36045188 | ||
| Recent advances in the protein kinase B signaling pathway | Q36076055 | ||
| Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands | Q36369018 | ||
| T cells compete for access to antigen-bearing antigen-presenting cells | Q36376071 | ||
| Negative selection during the peripheral immune response to antigen | Q36376090 | ||
| Sensory adaptation in naive peripheral CD4 T cells | Q36376411 | ||
| Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. | Q36383089 | ||
| CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity | Q36401360 | ||
| Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma | Q36853440 | ||
| Decoding the dynamics of T cell-dendritic cell interactions in vivo. | Q37084896 | ||
| New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation | Q37133882 | ||
| Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines | Q37140636 | ||
| T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation | Q37233655 | ||
| New insights into the regulation and function of serine/threonine kinases in T lymphocytes | Q37416272 | ||
| Naive and memory CD4+ T cell survival controlled by clonal abundance | Q38510919 | ||
| Vaccine adjuvants alter TCR-based selection thresholds. | Q40096549 | ||
| Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide | Q40220156 | ||
| Altered T cell receptor ligands trigger a subset of early T cell signals | Q41180292 | ||
| A kinetic basis for T cell receptor repertoire selection during an immune response | Q41649927 | ||
| The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse | Q41762464 | ||
| Complete but curtailed T-cell response to very low-affinity antigen | Q41902378 | ||
| Peptide dose, affinity, and time of differentiation can contribute to the Th1/Th2 cytokine balance. | Q42058318 | ||
| Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103). | Q42068640 | ||
| Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex | Q44255903 | ||
| TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways | Q44308973 | ||
| CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse | Q44973640 | ||
| Ligand recognition by alpha beta T cell receptors | Q46222293 | ||
| Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity | Q46681223 | ||
| Positive selection as a developmental progression initiated by alpha beta TCR signals that fix TCR specificity prior to lineage commitment. | Q51090801 | ||
| Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity. | Q52034176 | ||
| Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes | Q57962178 | ||
| Low affinity interaction of human or rat T cell adhesion molecule CD2 with its ligand aligns adhering membranes to achieve high physiological affinity | Q57962352 | ||
| Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation | Q73022474 | ||
| Induction of IL-4-producing CD4+ T cells by antigenic peptides altered for TCR binding | Q73287537 | ||
| The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model | Q74312259 | ||
| T cell clonal conditioning: a phase occurring early after antigen presentation but before clonal expansion is impacted by Toll-like receptor stimulation | Q75197411 | ||
| High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling | Q77769114 | ||
| CD8+ T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rate | Q80819638 | ||
| Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties | Q80991133 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 9 | |
| P407 | language of work or name | English | Q1860 |
| P577 | publication date | 2010-09-14 | |
| P1433 | published in | PLOS Biology | Q1771695 |
| P1476 | title | Attenuated T cell responses to a high-potency ligand in vivo | |
| P478 | volume | 8 |
| Q37614812 | 2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system. |
| Q34086610 | Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation |
| Q37379865 | Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose |
| Q27681832 | Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor |
| Q36717167 | Control of T cell antigen reactivity via programmed TCR downregulation. |
| Q56888747 | Cutting Edge: CTLA-4 on Effector T Cells Inhibits In Trans |
| Q51142505 | DNA vaccines for prostate cancer. |
| Q34439729 | Design of T-cell receptor libraries with diverse binding properties to examine adoptive T-cell responses |
| Q42212744 | Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity |
| Q36983760 | Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells |
| Q30504688 | Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses |
| Q45737915 | Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination |
| Q37610961 | Fbw7-dependent cyclin E regulation ensures terminal maturation of bone marrow erythroid cells by restraining oxidative metabolism. |
| Q47113506 | Fine-Tuning of Optimal TCR Signaling in Tumor-Redirected CD8 T Cells by Distinct TCR Affinity-Mediated Mechanisms. |
| Q36710561 | Functional evidence for TCR-intrinsic specificity for MHCII. |
| Q92861845 | High Peptide Dose Vaccination Promotes the Early Selection of Tumor Antigen-Specific CD8 T-Cells of Enhanced Functional Competence |
| Q35724710 | Identification of human leukemia antigen A*0201-restricted epitopes derived from epidermal growth factor pathway substrate number 8 |
| Q26774669 | Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens |
| Q90928077 | Improving T Cell Receptor On-Target Specificity via Structure-Guided Design |
| Q37634253 | Improving T cell responses to modified peptides in tumor vaccines |
| Q34440919 | Increased synapse formation obtained by T cell epitopes containing a CxxC motif in flanking residues convert CD4+ T cells into cytolytic effectors |
| Q27012849 | Indoctrinating T cells to attack pathogens through homeschooling |
| Q36080586 | Interplay between T cell receptor binding kinetics and the level of cognate peptide presented by major histocompatibility complexes governs CD8+ T cell responsiveness |
| Q39290133 | MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR. |
| Q64958454 | Mapping the stochastic sequence of individual ligand-receptor binding events to cellular activation: T cells act on the rare events. |
| Q47127214 | Micromolar affinity CAR T cells to ICAM-1 achieves rapid tumor elimination while avoiding systemic toxicity |
| Q38117139 | Molecular insights for optimizing T cell receptor specificity against cancer |
| Q36977064 | Monitoring the Dynamics of T Cell Clonal Diversity Using Recombinant Peptide:MHC Technology |
| Q37844539 | Peptidomimetics: modifying peptides in the pursuit of better vaccines |
| Q30728815 | Pharmacogenomic characterization of gemcitabine response--a framework for data integration to enable personalized medicine |
| Q46214811 | Phenotypic models of T cell activation |
| Q34643623 | Piecing together the family portrait of TCR-CD3 complexes |
| Q36951735 | Public T cell receptors confer high-avidity CD4 responses to HIV controllers |
| Q28080312 | Recent advances in T-cell engineering for use in immunotherapy |
| Q49547293 | Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex |
| Q36638160 | SHP-1 phosphatase activity counteracts increased T cell receptor affinity |
| Q34383054 | Specific increase in potency via structure-based design of a TCR. |
| Q37866944 | Strength of TCR-peptide/MHC interactions and in vivo T cell responses |
| Q64896944 | Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro. |
| Q27667507 | Structural Basis of Specificity and Cross-Reactivity in T Cell Receptors Specific for Cytochrome c-I-E |
| Q34115960 | T cell avidity and tumor immunity: problems and solutions |
| Q37693754 | T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks |
| Q36799229 | T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy |
| Q42212300 | TCR Signaling Emerges from the Sum of Many Parts |
| Q26772341 | TCR Signaling in T Cell Memory |
| Q34044406 | TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo |
| Q90149902 | TCR-pMHC bond conformation controls TCR ligand discrimination |
| Q46003771 | The IRF4 Gene Regulatory Module Functions as a Read-Write Integrator to Dynamically Coordinate T Helper Cell Fate. |
| Q38113623 | The role of CARMA1 in T cells. |
| Q36218880 | Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity |
| Q50222492 | Vaccination with High-Affinity Epitopes Impairs Antitumor Efficacy by Increasing PD-1 Expression on CD8+ T Cells |
| Q36512323 | Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection |
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