| scholarly article | Q13442814 |
| P50 | author | Stephen Bunnell | Q58011905 |
| Julia R Kardon | Q89855393 | ||
| P2093 | author name string | C Jane McGlade | |
| Valarie A Barr | |||
| Tetsuo Yamazaki | |||
| Lawrence E Samelson | |||
| David I Hong | |||
| P2860 | cites work | Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton | Q22253423 |
| Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation | Q22254014 | ||
| LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation | Q24315021 | ||
| EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif | Q24320229 | ||
| Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation | Q24329121 | ||
| Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT | Q24550948 | ||
| Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells | Q24681319 | ||
| Rab11 regulates recycling through the pericentriolar recycling endosome | Q24681897 | ||
| The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors | Q28137592 | ||
| The immunological synapse: a molecular machine controlling T cell activation | Q28139151 | ||
| Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected] | Q46842083 | ||
| Membrane compartmentation is required for efficient T cell activation. | Q54132378 | ||
| Imaging antigen recognition by naive CD4+ T cells: compulsory cytoskeletal alterations for the triggering of an intracellular calcium response | Q74375728 | ||
| A receptor/cytoskeletal movement triggered by costimulation during T cell activation | Q77696385 | ||
| TCR signaling induces selective exclusion of CD43 from the T cell-antigen-presenting cell contact site | Q77715944 | ||
| Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade | Q28142714 | ||
| Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases | Q28143793 | ||
| T cell receptor signaling precedes immunological synapse formation | Q28203073 | ||
| Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin | Q28208110 | ||
| The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner | Q28238101 | ||
| LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation | Q28281516 | ||
| Three-dimensional segregation of supramolecular activation clusters in T cells | Q28282528 | ||
| LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway | Q28290956 | ||
| ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse | Q28507578 | ||
| Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76 | Q28647329 | ||
| Membrane transport in the endocytic pathway | Q29616400 | ||
| Role of Grb2 in EGF-stimulated EGFR internalization. | Q30165476 | ||
| A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation | Q30491549 | ||
| The ubiquitin-proteasome system and endocytosis. | Q33598928 | ||
| Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition | Q33867251 | ||
| Interactions between Fc(epsilon)RI and lipid raft components are regulated by the actin cytoskeleton. | Q33890829 | ||
| The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling. | Q33958592 | ||
| Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins | Q34115639 | ||
| Information transfer at the immunological synapse. | Q34117443 | ||
| Mechanisms of signaling by the hematopoietic-specific adaptor proteins, SLP-76 and LAT and their B cell counterpart, BLNK/SLP-65. | Q34419552 | ||
| Dynamics of the immunological synapse: finding, establishing and solidifying a connection | Q34493020 | ||
| Positive and negative regulation of T-cell activation by adaptor proteins | Q34572179 | ||
| ZAP-70 association with T cell receptor zeta (TCRzeta): fluorescence imaging of dynamic changes upon cellular stimulation | Q36288209 | ||
| Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor | Q36326042 | ||
| Selective accumulation of raft-associated membrane protein LAT in T cell receptor signaling assemblies | Q36366952 | ||
| High resolution mapping of mast cell membranes reveals primary and secondary domains of Fc(epsilon)RI and LAT. | Q36377574 | ||
| T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells | Q36400875 | ||
| Distinct compartmentalization of TGN46 and beta 1,4-galactosyltransferase in HeLa cells. | Q36851941 | ||
| Characterization of ochratoxin A transport by human organic anion transporters | Q40773388 | ||
| Multicolour imaging of post-Golgi sorting and trafficking in live cells | Q40827648 | ||
| Differential clustering of CD4 and CD3zeta during T cell recognition | Q40859028 | ||
| Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line | Q40949941 | ||
| Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell | Q41024970 | ||
| Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. | Q41066099 | ||
| Polarity of T cell shape, motility, and sensitivity to antigen | Q41202887 | ||
| Making the T cell receptor go the distance: a topological view of T cell activation | Q41457016 | ||
| Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. | Q43566798 | ||
| Distinct patterns of membrane microdomain partitioning in Th1 and th2 cells. | Q43812081 | ||
| Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse | Q43968748 | ||
| Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selection | Q43968754 | ||
| P433 | issue | 7 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1263-1275 | |
| P577 | publication date | 2002-09-01 | |
| P1433 | published in | Journal of Cell Biology | Q1524550 |
| P1476 | title | T cell receptor ligation induces the formation of dynamically regulated signaling assemblies | |
| P478 | volume | 158 |
| Q83231407 | A composition-dependent molecular clutch between T cell signaling condensates and actin |
| Q55209436 | A correlative and quantitative imaging approach enabling characterization of primary cell-cell communication: Case of human CD4+ T cell-macrophage immunological synapses. |
| Q33852715 | A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli |
| Q37150264 | A mechanism for SRC kinase-dependent signaling by noncatalytic receptors |
| Q64084600 | A micropatterning platform for quantifying interaction kinetics between the T cell receptor and an intracellular binding protein |
| Q28471992 | A novel ZAP-70 dependent FRET based biosensor reveals kinase activity at both the immunological synapse and the antisynapse |
| Q36267208 | A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76. |
| Q30009227 | A peptide-functionalized polymer as a minimal scaffold protein to enhance cluster formation in early T cell signal transduction. |
| Q35036951 | A quantitative assessment of costimulation and phosphatase activity on microclusters in early T cell signaling. |
| Q30946361 | A role for rebinding in rapid and reliable T cell responses to antigen |
| Q90316475 | A signaling hub of insulin receptor, dystrophin glycoprotein complex and plakoglobin regulates muscle size |
| Q30654313 | A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interaction |
| Q57284504 | ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters |
| Q25257443 | Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling |
| Q35165479 | Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway |
| Q30829566 | Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability |
| Q34522338 | Actin-bundling protein L-plastin regulates T cell activation. |
| Q26751049 | Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse |
| Q37604357 | Activated PLC-γ1 is catalytically induced at LAT but activated PLC-γ1 is localized at both LAT- and TCR-containing complexes. |
| Q52575193 | Activation of Human Natural Killer Cells by Graphene Oxide-Templated Antibody Nanoclusters. |
| Q47607418 | Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse; involvement of SNARE complexes. |
| Q34998171 | Adaptation dynamics in densely clustered chemoreceptors |
| Q35055629 | Adaptors as central mediators of signal transduction in immune cells |
| Q53301798 | Adhesion-dependent modulation of actin dynamics in Jurkat T cells. |
| Q37263238 | Aggregation of membrane proteins by cytosolic cross-linkers: theory and simulation of the LAT-Grb2-SOS1 system |
| Q27322644 | Altered actin centripetal retrograde flow in physically restricted immunological synapses |
| Q54866372 | An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics. |
| Q37385303 | An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor. |
| Q34014654 | An enigmatic tail of CD28 signaling |
| Q35076666 | An evolutionary and structural perspective on T cell antigen receptor function |
| Q33390368 | An experimental and computational study of effects of microtubule stabilization on T-cell polarity |
| Q35884077 | Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells |
| Q39143836 | Are rafts involved in T-cell receptor signalling? Introduction to the Talking Point on the involvement of lipid rafts in T-cell activation |
| Q40437451 | Artificially lipid-anchored proteins can elicit clustering-induced intracellular signaling events in Jurkat T-lymphocytes independent of lipid raft association |
| Q57816679 | Biophysical Characterization of CD6-TCR/CD3 Interplay in T Cells |
| Q30519567 | Biophysical mechanism of T-cell receptor triggering in a reconstituted system |
| Q92556937 | Bridging the Gap: Modulatory Roles of the Grb2-Family Adaptor, Gads, in Cellular and Allergic Immune Responses |
| Q89830743 | Bypassing ubiquitination enables LAT recycling to the cell surface and enhanced signaling in T cells |
| Q63408317 | CD19 is essential for B cell activation by promoting B cell receptor–antigen microcluster formation in response to membrane-bound ligand |
| Q28244243 | CD28 and CTLA-4 coreceptor expression and signal transduction |
| Q44605241 | CD38 signaling in T cells is initiated within a subset of membrane rafts containing Lck and the CD3-zeta subunit of the T cell antigen receptor |
| Q24670421 | CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76 |
| Q35632815 | CD8αα and -αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I. |
| Q41591286 | CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization |
| Q38682962 | Ca2+ Microdomains in T-Lymphocytes |
| Q37748608 | Cbl-b in T-cell activation |
| Q45215158 | Chemical inhibitors when timing is critical: a pharmacological concept for the maturation of T cell contacts |
| Q28269352 | Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance |
| Q26767452 | Comparative Anatomy of Phagocytic and Immunological Synapses |
| Q36365512 | Compartmentalization in T-cell signalling: membrane microdomains and polarity orchestrate signalling and morphology. |
| Q36877284 | Compartmentalization of ITAM and integrin signaling by adapter molecules |
| Q36296177 | Comprehensive Analysis of Immunological Synapse Phenotypes Using Supported Lipid Bilayers |
| Q36320347 | Condensation of the plasma membrane at the site of T lymphocyte activation |
| Q42679142 | Conformational states of the kinase Lck regulate clustering in early T cell signaling |
| Q30616951 | Contact-induced mitochondrial polarization supports HIV-1 virological synapse formation |
| Q46556005 | Continuous T cell receptor signaling required for synapse maintenance and full effector potential |
| Q35856744 | Control of immune responses by trafficking cell surface proteins, vesicles and lipid rafts to and from the immunological synapse |
| Q27021661 | Controversy and consensus regarding myosin II function at the immunological synapse |
| Q90226429 | Cooperative assembly of a four-molecule signaling complex formed upon T cell antigen receptor activation |
| Q24323631 | Cooperative interactions at the SLP-76 complex are critical for actin polymerization |
| Q37298815 | Coordinate control of cytoskeletal remodeling and calcium mobilization during T-cell activation |
| Q51905872 | Coreceptor CD8-driven modulation of T cell antigen receptor specificity. |
| Q24305190 | Crystal structure of the C-terminal SH3 domain of the adaptor protein GADS in complex with SLP-76 motif peptide reveals a unique SH3-SH3 interaction |
| Q37160464 | Cytometry of raft and caveola membrane microdomains: from flow and imaging techniques to high throughput screening assays. |
| Q41074693 | Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation |
| Q64120090 | Cytoskeletal actin patterns shape mast cell activation |
| Q37786677 | Cytoskeletal cross‐talk in the control of T cell antigen receptor signaling |
| Q30620298 | Cytoskeletal forces during signaling activation in Jurkat T-cells |
| Q37445559 | Cytoskeleton-membrane interactions in membrane raft structure |
| Q46460661 | Development of nanoscale structure in LAT-based signaling complexes. |
| Q49605860 | Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics |
| Q36983760 | Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells |
| Q30477116 | Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells |
| Q37805565 | Diversity in immunological synapse structure |
| Q38120024 | Do signalling endosomes play a role in T cell activation? |
| Q26742164 | Dynamic Regulation of TCR-Microclusters and the Microsynapse for T Cell Activation |
| Q38735074 | Dynamic analysis of immune and cancer cell interactions at single cell level in microfluidic droplets |
| Q34973782 | Dynamic cortical actin remodeling by ERM proteins controls BCR microcluster organization and integrity |
| Q45159091 | Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton. |
| Q30482508 | Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps |
| Q33779818 | Dynamic palmitoylation and the role of DHHC proteins in T cell activation and anergy |
| Q37812670 | Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters |
| Q46427556 | Dynamic regulation of Tec kinase localization in membrane-proximal vesicles of a T cell clone revealed by total internal reflection fluorescence and confocal microscopy |
| Q36561604 | Dynamics in the plasma membrane: how to combine fluidity and order. |
| Q37470914 | Dynamics of membrane trafficking downstream of B and T cell receptor engagement: impact on immune synapses |
| Q33203351 | Dynamics of putative raft-associated proteins at the cell surface |
| Q34480890 | Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways |
| Q24293524 | Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif |
| Q35110287 | Endocytic events in TCR signaling: focus on adapters in microclusters |
| Q34583014 | Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation |
| Q39434675 | Essential role of the adaptor protein Nck1 in Jurkat T cell activation and function |
| Q30495533 | Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster |
| Q34522144 | Examining multiprotein signaling complexes from all angles |
| Q36572135 | Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec |
| Q48728903 | Expression of multiple Src family kinases in sea urchin eggs and their function in Ca2+ release at fertilization |
| Q36379032 | Ezrin and moesin function together to promote T cell activation. |
| Q24321953 | Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse. |
| Q30515819 | F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation |
| Q51994109 | Feedback control of T-cell receptor activation. |
| Q34513225 | Fluorescence-quenching and resonance energy transfer studies of lipid microdomains in model and biological membranes |
| Q37398394 | Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor. |
| Q41681613 | Force and affinity in ligand discrimination by the TCR. |
| Q35153208 | Formation of functional cell membrane domains: the interplay of lipid- and protein-mediated interactions |
| Q26770383 | Function and Dynamics of Tetraspanins during Antigen Recognition and Immunological Synapse Formation |
| Q37646737 | Functional anatomy of T cell activation and synapse formation |
| Q30502363 | Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization |
| Q33338433 | Functional implications of plasma membrane condensation for T cell activation |
| Q64939214 | Functional link between plasma membrane spatiotemporal dynamics, cancer biology, and dietary membrane-altering agents. |
| Q35577665 | Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor |
| Q36467652 | Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells |
| Q37125223 | Glycerol Monolaurate (GML) inhibits human T cell signaling and function by disrupting lipid dynamics. |
| Q54223596 | Glycerol monolaurate induces filopodia formation by disrupting the association between LAT and SLP-76 microclusters. |
| Q55513488 | Gp41 dynamically interacts with the TCR in the immune synapse and promotes early T cell activation. |
| Q33306697 | HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling |
| Q34316824 | HIV-1 Nef: a multifaceted modulator of T cell receptor signaling |
| Q36719318 | Have we become overly reliant on lipid rafts? Talking Point on the involvement of lipid rafts in T-cell activation |
| Q27336137 | Hierarchical nanostructure and synergy of multimolecular signalling complexes |
| Q37407904 | High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells |
| Q30484408 | High-speed high-resolution imaging of intercellular immune synapses using optical tweezers |
| Q41870258 | How membrane structures control T cell signaling |
| Q37977320 | How the TCR balances sensitivity and specificity for the recognition of self and pathogens. |
| Q36169347 | Human Serum Albumin (HSA) Suppresses the Effects of Glycerol Monolaurate (GML) on Human T Cell Activation and Function. |
| Q30483680 | Human immunodeficiency virus type 1 envelope gp120 induces a stop signal and virological synapse formation in noninfected CD4+ T cells |
| Q80238794 | Identification of individual protein-ligand NOEs in the limit of intermediate exchange |
| Q46007271 | Imaging Spatiotemporal Activities of ZAP-70 in Live T Cells Using a FRET-Based Biosensor. |
| Q36111834 | Imaging techniques for assaying lymphocyte activation in action |
| Q37626146 | Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells |
| Q36149269 | Immune synapse formation requires ZAP-70 recruitment by ezrin and CD43 removal by moesin |
| Q33773066 | In vitro membrane reconstitution of the T-cell receptor proximal signaling network |
| Q30156865 | In vivo significance of ITK-SLP-76 interaction in cytokine production |
| Q97424442 | Inefficient CAR-proximal signaling blunts antigen sensitivity |
| Q38241273 | Integrative biology of T cell activation |
| Q27314180 | Integrins Influence the Size and Dynamics of Signaling Microclusters in a Pyk2-dependent Manner |
| Q90408578 | Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation |
| Q24338926 | Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function |
| Q37585149 | Interference with Ca(2+) release activated Ca(2+) (CRAC) channel function delays T-cell arrest in vivo |
| Q33836812 | Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases. |
| Q26825315 | Investigative and clinical applications of synthetic immune synapses |
| Q35642470 | Itk controls the spatiotemporal organization of T cell activation |
| Q36891447 | Keeping the (kinase) party going: SLP-76 and ITK dance to the beat |
| Q36995467 | Kinetic proofreading of ligand-FcepsilonRI interactions may persist beyond LAT phosphorylation |
| Q41013111 | LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation |
| Q27308133 | Ligand mobility modulates immunological synapse formation and T cell activation |
| Q34628896 | Ligand-mediated friction determines morphodynamics of spreading T cells |
| Q27002652 | Linking form to function: Biophysical aspects of artificial antigen presenting cell design |
| Q35061351 | Lipid Raft is required for PSGL-1 ligation induced HL-60 cell adhesion on ICAM-1 |
| Q57369571 | Lipid raft proteins have a random distribution during localized activation of the T-cell receptor |
| Q33973937 | Lipid rafts: elusive or illusive? |
| Q57961804 | Liquidity in immune cell signaling |
| Q36478261 | Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain |
| Q35145754 | Lymphocyte lipid rafts: structure and function. |
| Q54977289 | Lymphocyte-specific protein tyrosine kinase (LCK) is involved in the aryl hydrocarbon receptor (AHR)-mediated impairment of immunoglobulin secretion in human primary B cells. |
| Q24299345 | Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation |
| Q36629861 | Maintenance and modulation of T cell polarity |
| Q64958454 | Mapping the stochastic sequence of individual ligand-receptor binding events to cellular activation: T cells act on the rare events. |
| Q34358916 | Markers for detergent-resistant lipid rafts occupy distinct and dynamic domains in native membranes. |
| Q33778625 | Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human natural killer cells |
| Q35790365 | Mathematical and computational models of immune-receptor signalling |
| Q30010016 | Mechanism and function of Vav1 localisation in TCR signalling. |
| Q37553914 | Mechanisms and functions for the duration of intercellular contacts made by lymphocytes |
| Q34625569 | Mechanisms for T cell receptor triggering |
| Q30480910 | Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells |
| Q53099215 | Mechanosensing in the immune response. |
| Q37779419 | Mediation of T-cell activation by actin meshworks |
| Q57492028 | Membrane Ultrastructure and T Cell Activation |
| Q35696789 | Membrane domains in lymphocytes - from lipid rafts to protein scaffolds |
| Q35866776 | Membrane dynamics correlate with formation of signaling clusters during cell spreading |
| Q36306854 | Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages. |
| Q35723346 | Membranes as messengers in T cell adhesion signaling |
| Q97692681 | Metabolic signaling in T cells |
| Q30799250 | Micro-adhesion rings surrounding TCR microclusters are essential for T cell activation |
| Q82043851 | Microclusters initiate and sustain T cell signaling |
| Q36118221 | Microclusters of inhibitory killer immunoglobulin-like receptor signaling at natural killer cell immunological synapses |
| Q38038563 | Microfabricated platforms to modulate and monitor T cell synapse assembly |
| Q30482179 | Micropatterning of costimulatory ligands enhances CD4+ T cell function |
| Q38056851 | Microspectroscopy reveals mechanisms of lymphocyte activation |
| Q37323143 | Microvilli set the stage for T-cell activation |
| Q34187060 | Modeling and simulation of aggregation of membrane protein LAT with molecular variability in the number of binding sites for cytosolic Grb2-SOS1-Grb2. |
| Q37672286 | Modular design of immunological synapses and kinapses |
| Q37766483 | Modulation of CTLA-4 and GITR for cancer immunotherapy |
| Q38093572 | Modulation of tumor immunity by soluble and membrane-bound molecules at the immunological synapse. |
| Q37264992 | Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells. |
| Q28480563 | Myosin IIA modulates T cell receptor transport and CasL phosphorylation during early immunological synapse formation |
| Q50231177 | Nano-clustering of ligands on surrogate antigen presenting cells modulates T cell membrane adhesion and organization. |
| Q36211172 | Nanoscale Relationship Between CD4 and CD25 of T Cells Visualized with NSOM/QD-Based Dual-Color Imaging System |
| Q37929550 | New insights into the T cell synapse from single molecule techniques |
| Q46793124 | Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. |
| Q38050488 | Non-catalytic tyrosine-phosphorylated receptors |
| Q30009442 | Non-overlapping functions of Nck1 and Nck2 adaptor proteins in T cell activation |
| Q54218745 | Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis. |
| Q42568353 | Numbers matter: quantitative and dynamic analysis of the formation of an immunological synapse using imaging flow cytometry |
| Q24299715 | Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1 |
| Q34967410 | On the issue of peptide recognition in T cell development |
| Q38151848 | Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapses. |
| Q92111174 | Orchestration of Immunological Synapse Assembly by Vesicular Trafficking |
| Q33753888 | Organization of proximal signal initiation at the TCR:CD3 complex |
| Q28587297 | POLKADOTS are foci of functional interactions in T-Cell receptor-mediated signaling to NF-kappaB. |
| Q40507314 | PTEN permits acute increases in D3-phosphoinositide levels following TCR stimulation but inhibits distal signaling events by reducing the basal activity of Akt. |
| Q37435788 | Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells. |
| Q40240283 | Peptide-MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices |
| Q30478068 | Persistence of cooperatively stabilized signaling clusters drives T-cell activation |
| Q33849372 | Perspectives for computer modeling in the study of T cell activation |
| Q34248094 | Phase coexistence and connectivity in the apical membrane of polarized epithelial cells |
| Q42742423 | Phase separation of signaling molecules promotes T cell receptor signal transduction |
| Q34317431 | Phosphatase CD45 both positively and negatively regulates T cell receptor phosphorylation in reconstituted membrane protein clusters |
| Q59791606 | Phosphatase of Regenerating Liver-1 (PRL-1) Regulates Actin Dynamics During Immunological Synapse Assembly and T Cell Effector Function |
| Q27313688 | Phosphatidylinositol (4,5) bisphosphate controls T cell activation by regulating T cell rigidity and organization |
| Q36537936 | Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen |
| Q55008738 | Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation. |
| Q35809659 | Plasma membrane microdomains: organization, function and trafficking |
| Q37592327 | Plasma membrane rafts engaged in T cell signalling: new developments in an old concept |
| Q44846647 | Pre-existing clusters of the adaptor Lat do not participate in early T cell signaling events |
| Q33525562 | Preferential transfer of certain plasma membrane proteins onto T and B cells by trogocytosis |
| Q30515733 | Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. |
| Q34413684 | Protein clusters on the T cell surface may suppress spurious early signaling events. |
| Q28477483 | Quantifying intramolecular binding in multivalent interactions: a structure-based synergistic study on Grb2-Sos1 complex |
| Q92686032 | Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy |
| Q35128943 | Quantitative analysis of the role of receptor recycling in T cell polarization |
| Q51327142 | Ratiometric Tension Probes for Mapping Receptor Forces and Clustering at Intermembrane Junctions. |
| Q43024047 | Real-time GPU-based 3D Deconvolution |
| Q46406249 | Reconstitution of TCR Signaling Using Supported Lipid Bilayers |
| Q24304214 | Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains |
| Q51273623 | Recruitment of calcineurin to the TCR positively regulates T cell activation. |
| Q30009151 | Regions outside of conserved PxxPxR motifs drive the high affinity interaction of GRB2 with SH3 domain ligands |
| Q37474900 | Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells |
| Q37895965 | Regulation of NF-κB induction by TCR/CD28. |
| Q37270535 | Regulation of T cell integrin function by adapter proteins |
| Q36720943 | Regulation of T-cell activation by the cytoskeleton |
| Q26852312 | Regulation of T-cell receptor signaling by the actin cytoskeleton and poroelastic cytoplasm |
| Q35670715 | Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation |
| Q41061434 | Resolving mixed mechanisms of protein subdiffusion at the T cell plasma membrane. |
| Q37235232 | Retractile processes in T lymphocyte orientation on a stimulatory substrate: morphology and dynamics. |
| Q48152533 | Rewiring T-cell responses to soluble factors with chimeric antigen receptors. |
| Q36231103 | Role of the LAT adaptor in T-cell development and Th2 differentiation |
| Q40599629 | Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function. |
| Q30495049 | SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering |
| Q37226140 | SLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation |
| Q28298645 | SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond |
| Q55119821 | Sailing to and Docking at the Immune Synapse: Role of Tubulin Dynamics and Molecular Motors. |
| Q37465020 | Shine a light: imaging the immune system |
| Q37084879 | Signal initiation in T-cell receptor microclusters |
| Q36990598 | Signaling clusters in the cell membrane |
| Q37802003 | Signaling microdomains in T cells |
| Q35837361 | Single Molecule Fluorescence Microscopy on Planar Supported Bilayers. |
| Q30493983 | Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells |
| Q37495024 | Size-dependent protein segregation at membrane interfaces |
| Q34009424 | Spatial association of signaling proteins and F-actin effects on cluster assembly analyzed via photoactivation localization microscopy in T cells |
| Q36957644 | Spatial organization and signal transduction at intercellular junctions |
| Q30488141 | Spatiotemporal patterning during T cell activation is highly diverse |
| Q39964480 | Stimulus dependence of the action of small-molecule inhibitors in the CD3/CD28 signalling network |
| Q36762518 | Stochasticity and spatial heterogeneity in T-cell activation |
| Q30493744 | Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes. |
| Q89400695 | Super-resolution Analysis of TCR-Dependent Signaling: Single-Molecule Localization Microscopy |
| Q27015450 | Super-resolution characterization of TCR-dependent signaling clusters |
| Q37065031 | Superresolution imaging reveals nanometer- and micrometer-scale spatial distributions of T-cell receptors in lymph nodes |
| Q37509382 | Supported bilayers at the vanguard of immune cell activation studies |
| Q58785757 | Synaptic Interactions in Germinal Centers |
| Q24298128 | Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains |
| Q35189593 | Systems biology in immunology: a computational modeling perspective. |
| Q98771671 | T Cell Membrane Heterogeneity Aids Antigen Recognition and T Cell Activation |
| Q57073714 | T Cells on Engineered Substrates: The Impact of TCR Clustering Is Enhanced by LFA-1 Engagement |
| Q30524213 | T Lymphocyte Myosin IIA is Required for Maturation of the Immunological Synapse |
| Q26774645 | T Lymphocyte-Endothelial Interactions: Emerging Understanding of Trafficking and Antigen-Specific Immunity |
| Q24658051 | T cell activation |
| Q37172527 | T cell activation and the cytoskeleton: you can't have one without the other |
| Q37308616 | T cell activation is determined by the number of presented antigens |
| Q28828763 | T cell activation requires force generation |
| Q30489233 | T cell antigen receptor signaling and immunological synapse stability require myosin IIA |
| Q37267531 | T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes |
| Q41809472 | T cell receptor dwell times control the kinase activity of Zap70. |
| Q37823023 | T cell receptor signaling kinetics takes the stage |
| Q38092568 | T cell receptor signalling networks: branched, diversified and bounded |
| Q29617556 | T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster |
| Q57374307 | T-Cell Antigen Receptor-Induced Signaling Complexes: Internalization Via a Cholesterol-Dependent Endocytic Pathway |
| Q41198902 | T-cell receptor early signalling complex activation in response to interferon-alpha receptor stimulation |
| Q34648944 | T-cell receptor signaling to integrins |
| Q46522042 | T-cell-antigen recognition and the immunological synapse |
| Q52332859 | TAGLN2 polymerizes G-actin in a low ionic state but blocks Arp2/3-nucleated actin branching in physiological conditions. |
| Q33895792 | TCR Microclusters pre-exist and contain molecules necessary for TCR signal transduction |
| Q35739705 | TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation. |
| Q60907554 | TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps |
| Q50867366 | Temporal dynamics in an immunological synapse: Role of thermal fluctuations in signaling. |
| Q40964647 | The Affinity of Elongated Membrane-Tethered Ligands Determines Potency of T Cell Receptor Triggering. |
| Q37806867 | The Cytoskeleton Coordinates the Early Events of B-cell Activation |
| Q43756172 | The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity |
| Q38839497 | The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells. |
| Q37770817 | The LAT story: a tale of cooperativity, coordination, and choreography |
| Q30009507 | The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms |
| Q37682609 | The Role of SH2 Domain-containing Leukocyte Phosphoprotein of 76 kDa in the Regulation of Immune Cell Development and Function |
| Q42144611 | The T Cell Plasma Membrane Lipid Bilayer Stages TCR-proximal Signaling Events |
| Q42137002 | The T cell receptor resides in ordered plasma membrane nanodomains that aggregate upon patching of the receptor |
| Q35096688 | The TCR ADAPts to integrin-mediated cell adhesion |
| Q38151850 | The actin-driven spatiotemporal organization of T-cell signaling at the system scale |
| Q30490766 | The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells |
| Q38059682 | The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation. |
| Q37446125 | The cellular context of T cell signaling |
| Q38151853 | The central role of the cytoskeleton in mechanisms and functions of the NK cell immune synapse. |
| Q43729111 | The chemokine CXCL12 generates costimulatory signals in T cells to enhance phosphorylation and clustering of the adaptor protein SLP-76. |
| Q37237643 | The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells |
| Q35280445 | The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck |
| Q35145749 | The diversity of immunological synapses. |
| Q38070786 | The function of sub-synaptic vesicles during T-cell activation |
| Q39710320 | The immune molecule CD3zeta and its downstream effectors ZAP-70/Syk mediate ephrin signaling in neurons to regulate early neuritogenesis |
| Q57961866 | The immunological synapse |
| Q37883459 | The immunological synapse: a cause or consequence of T-cell receptor triggering? |
| Q37262507 | The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation |
| Q41754563 | The integration of signaling and the spatial organization of the T cell synapse |
| Q36541612 | The kinetic-segregation model: TCR triggering and beyond |
| Q36873274 | The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor |
| Q36283658 | The linker for activation of T cells (LAT) signaling hub: from signaling complexes to microclusters |
| Q37941546 | The myosin family: unconventional roles of actin-dependent molecular motors in immune cells. |
| Q36877356 | The role of integrins and coreceptors in refining thresholds for B-cell responses |
| Q37408300 | The spatial structure of cell signaling systems |
| Q24314787 | The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling |
| Q34601866 | The who, how and where of antigen presentation to B cells |
| Q37323186 | Three-dimensional localization of T-cell receptors in relation to microvilli using a combination of superresolution microscopies |
| Q90691557 | Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8+ T Cell Expansion and Differentiation |
| Q47895648 | To cluster or not to cluster: FRETting over rafts |
| Q37392111 | Two pathways of costimulation through CD28. |
| Q37802005 | Understanding signal integration through targeted mutations of an adapter protein |
| Q37789101 | Understanding the structure and function of the immunological synapse |
| Q38789324 | Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCβ Kinase Activity |
| Q33492741 | Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity |
| Q35810320 | Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation |
| Q36003933 | Vav1 oncogenic mutation inhibits T cell receptor-induced calcium mobilization through inhibition of phospholipase Cγ1 activation |
| Q37387352 | Vav1-mediated scaffolding interactions stabilize SLP-76 microclusters and contribute to antigen-dependent T cell responses |
| Q37535266 | Visualization of plasma membrane compartmentalization with patterned lipid bilayers. |
| Q46308696 | Visualizing dynamic microvillar search and stabilization during ligand detection by T cells. |
| Q27314779 | WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site |
| Q38151844 | Wiskott-Aldrich syndrome protein--dynamic regulation of actin homeostasis: from activation through function and signal termination in T lymphocytes |
| Q30480971 | c-Cbl-mediated regulation of LAT-nucleated signaling complexes |
| Q36342273 | eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1. |
| Q92482629 | mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse |
| Q37573289 | madSTORM: a superresolution technique for large-scale multiplexing at single-molecule accuracy |
| Q56884990 | αβ T Cell Receptor Mechanosensing Forces out Serial Engagement |
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