The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling

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The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.200303040
P932PMC publication ID2173795
P698PubMed publication ID12913111
P5875ResearchGate publication ID10618385

P50authorArthur WeissQ25939202
P2093author name stringJoseph Lin
P2860cites workNegative regulation of human T cell activation by the receptor-type protein tyrosine phosphatase CD148Q22003980
Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signalingQ22254087
Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylationQ24290951
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activationQ24315021
Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2Q24676628
Essential role of LAT in T cell developmentQ28141618
T cell receptor signaling precedes immunological synapse formationQ28203073
Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesinQ28208110
Three-dimensional segregation of supramolecular activation clusters in T cellsQ28282528
A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contactsQ28282813
CD148: a receptor-type protein tyrosine phosphatase involved in the regulation of human T cell activationQ28284339
LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathwayQ28290956
Generation of destabilized green fluorescent protein as a transcription reporterQ28291771
CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signalingQ28567160
A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activationQ30491549
Understanding the mechanism of action of bacterial superantigens from a decade of research.Q33683420
CD148, a new membrane tyrosine phosphatase involved in leukocyte functionQ33856335
Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognitionQ33867251
Signal transduction by the TCR for antigenQ33898927
Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell lineQ34054993
Lymphocytes with a complex: adapter proteins in antigen receptor signalingQ34091330
Ligand-receptor interactions required for commitment to the activation of the interleukin 2 geneQ34166130
The immunological synapse.Q34178149
Formation and function of the immunological synapseQ34612487
Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanismQ36276679
T cell receptor ligation induces the formation of dynamically regulated signaling assembliesQ36324026
Selective accumulation of raft-associated membrane protein LAT in T cell receptor signaling assembliesQ36366952
Dynamic changes in the mobility of LAT in aggregated lipid rafts upon T cell activationQ42037813
c-rel regulation of IL-2 gene expression may be mediated through activation of AP-1.Q42943858
Dependence of T cell antigen recognition on the dimensions of an accessory receptor-ligand complexQ42946982
Identification of the minimal tyrosine residues required for linker for activation of T cell functionQ43632117
Rat protein tyrosine phosphatase eta physically interacts with the PDZ domains of synteninQ43660018
T cell receptor signallingQ46629952
The duration of antigenic stimulation determines the fate of naive and effector T cells.Q51099389
The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activationQ77307336
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
negative regulation of T cell receptor signaling pathwayQ14881245
Protein tyrosine phosphatase receptor type JQ21108488
Protein tyrosine phosphatase, receptor type, JQ21986313
P304page(s)673-82
P577publication date2003-08-18
P1433published inJournal of Cell BiologyQ1524550
P1476titleThe tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling
P478volume162

Reverse relations

cites work (P2860)
Q42723848Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'.
Q36979111Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane.
Q41411382Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells
Q28588890CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages
Q34963679CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells
Q34724853Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production
Q64096913Design and analysis of stably integrated reporters for inducible transgene expression in human T cells and CAR NK-cell lines
Q37689769Differential expression of CD148 on leukocyte subsets in inflammatory arthritis.
Q34345106Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumors
Q42372128Gene Expression Profiles of Human Phosphotyrosine Phosphatases Consequent to Th1 Polarisation and Effector Function
Q55223802High-Affinity Ligands Can Trigger T Cell Receptor Signaling Without CD45 Segregation.
Q35082927Inhibition of T-cell activation by syndecan-4 is mediated by CD148 through protein tyrosine phosphatase activity
Q37580455Insights into the initiation of TCR signaling
Q42278090Ligand detection and discrimination by spatial relocalization: A kinase-phosphatase segregation model of TCR activation
Q47231597Maintenance of murine platelet homeostasis by the kinase Csk and the phosphatase CD148.
Q33778625Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human natural killer cells
Q34625569Mechanisms for T cell receptor triggering
Q35696789Membrane domains in lymphocytes - from lipid rafts to protein scaffolds
Q35307025Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding
Q44441578Modulation of T-cell receptor functional sensitivity via the opposing actions of protein tyrosine kinases and phosphatases: a mathematical model
Q38050488Non-catalytic tyrosine-phosphorylated receptors
Q38003542Protein tyrosine phosphatases in lymphocyte activation and autoimmunity
Q91811501Regulation of CD4+ T Cell Signaling and Immunological Synapse by Protein Tyrosine Phosphatases: Molecular Mechanisms in Autoimmunity
Q35063027Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148.
Q38031978Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity
Q27330599Remote control of therapeutic T cells through a small molecule-gated chimeric receptor.
Q30436912SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels
Q36762518Stochasticity and spatial heterogeneity in T-cell activation
Q28510998T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases
Q33824896T cell signal regulation by the actin cytoskeleton
Q40392458T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.
Q36541612The kinetic-segregation model: TCR triggering and beyond
Q36873274The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor
Q24339248The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarization
Q28509969The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis

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