Force-Regulated In Situ TCR-Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+ T Cells.

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Force-Regulated In Situ TCR-Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+ T Cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1501407
P932PMC publication ID4592802
P698PubMed publication ID26336148

P50authorBrian D EvavoldQ37370110
Cheng ZhuQ60964006
P2093author name stringPaul M Allen
Jinsung Hong
Stephen P Persaud
Stephen Horvath
P2860cites workMechanical regulation of T-cell functionsQ27016079
A functional hot spot for antigen recognition in a superagonist TCR/MHC complexQ27622127
T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility ComplexQ27675661
Two-stage cooperative T cell receptor-peptide major histocompatibility complex-CD8 trimolecular interactions amplify antigen discriminationQ28728145
Models for the Specific Adhesion of Cells to CellsQ29616061
Monitoring receptor-ligand interactions between surfaces by thermal fluctuationsQ30480925
Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch BondsQ30497295
Transforming binding affinities from three dimensions to two with application to cadherin clusteringQ30503964
High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics.Q33814783
Accumulation of serial forces on TCR and CD8 frequently applied by agonist antigenic peptides embedded in MHC molecules triggers calcium in T cellsQ33874701
The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.Q34078621
Measuring two-dimensional receptor-ligand binding kinetics by micropipetteQ34168986
Low 2-dimensional CD4 T cell receptor affinity for myelin sets in motion delayed response kineticsQ34193211
Direct observation of catch bonds involving cell-adhesion moleculesQ34195515
Progression of relapsing-remitting demyelinating disease does not require increased TCR affinity or epitope spreadQ34364686
Identification of self through two-dimensional chemistry and synapses.Q34425148
High prevalence of low affinity peptide-MHC II tetramer-negative effectors during polyclonal CD4+ T cell responsesQ34501474
Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptorQ34589911
Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetimeQ35062603
TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.Q35739708
Determination of interaction kinetics between the T cell receptor and peptide-loaded MHC class II via single-molecule diffusion measurementsQ36105328
Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligandsQ36367500
An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4Q36402496
Insights from in situ analysis of TCR-pMHC recognition: response of an interaction networkQ36515364
Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cellsQ36983760
T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificityQ37363263
Measuring Receptor-Ligand Binding Kinetics on Cell Surfaces: From Adhesion Frequency to Thermal Fluctuation Methods.Q37408990
2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system.Q37614812
How the TCR balances sensitivity and specificity for the recognition of self and pathogens.Q37977320
Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligandsQ40487156
The cellular environment regulates in situ kinetics of T-cell receptor interaction with peptide major histocompatibility complexQ40972761
Accumulation of dynamic catch bonds between TCR and agonist peptide-MHC triggers T cell signaling.Q41769969
Production of soluble MHC class II proteins with covalently bound single peptidesQ42068482
Ligand recognition by alpha beta T cell receptorsQ46222293
Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivityQ46681223
Kinetics of MHC-CD8 interaction at the T cell membrane.Q46891783
TCR transgenic mice in which usage of transgenic alpha- and beta-chains is highly dependent on the level of selecting ligand.Q47817299
Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexesQ47877315
T-cell receptor binding kinetics in T-cell development and activationQ76384899
Kinetic measurements of cell surface E-selectin/carbohydrate ligand interactionsQ77489965
High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signalingQ77769114
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)3557-3564
P577publication date2015-09-02
P1433published inJournal of ImmunologyQ3521441
P1476titleForce-Regulated In Situ TCR-Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+ T Cells
P478volume195

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cites work (P2860)
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