Mmp15 is a direct target of Snai1 during endothelial to mesenchymal transformation and endocardial cushion development

scientific article

Mmp15 is a direct target of Snai1 during endothelial to mesenchymal transformation and endocardial cushion development is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YDBIO.2011.08.022
P932PMC publication ID3202673
P698PubMed publication ID21920357
P5875ResearchGate publication ID51645135

P2093author name stringThomas Gridley
Joy Lincoln
Ge Tao
Agata K Levay
P2860cites workHeart Disease and Stroke Statistics--2010 Update: A Report From the American Heart AssociationQ22306345
Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.Q24301606
Slug is a direct Notch target required for initiation of cardiac cushion cellularizationQ24318449
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The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cellsQ28143877
Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by SnailQ28187811
Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expressionQ28216833
Sox9 is required for precursor cell expansion and extracellular matrix organization during mouse heart valve developmentQ28504526
Reduced sox9 function promotes heart valve calcification phenotypes in vivoQ28506607
Multiple functions of Snail family genes during palate development in miceQ28507025
Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heartQ28507415
Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecanQ28507492
The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transitionQ28594539
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expressionQ28595042
The incidence of congenital heart diseaseQ29614195
Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivoQ29620373
Hearts and bones: shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development.Q30354085
Matrix metalloproteinase 2-integrin alpha(v)beta3 binding is required for mesenchymal cell invasive activity but not epithelial locomotion: a computational time-lapse study.Q30484821
Epiblast-specific Snai1 deletion results in embryonic lethality due to multiple vascular defectsQ30859157
Heart valve development: endothelial cell signaling and differentiationQ33607338
Snail: More than EMTQ33977450
Cell biology of cardiac cushion development.Q36083465
The Snail genes as inducers of cell movement and survival: implications in development and cancer.Q36177031
Regulation of cell invasion and morphogenesis in a three-dimensional type I collagen matrix by membrane-type matrix metalloproteinases 1, 2, and 3.Q36328263
Leptin affects endocardial cushion formation by modulating EMT and migration via Akt signaling cascadesQ36562949
BMP-2 induces cell migration and periostin expression during atrioventricular valvulogenesisQ36816511
Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programsQ37106719
MT2-MMP-dependent release of collagen IV NC1 domains regulates submandibular gland branching morphogenesis.Q37401941
Heart valve development: regulatory networks in development and diseaseQ37421779
Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1.Q37453552
Regulation of membrane-type 4 matrix metalloproteinase by SLUG contributes to hypoxia-mediated metastasisQ37478659
A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions.Q38301815
SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cellsQ38334630
Common regulation of growth arrest and differentiation of osteoblasts by helix-loop-helix factorsQ39528734
Slug is a downstream mediator of transforming growth factor-beta1-induced matrix metalloproteinase-9 expression and invasion of oral cancer cellsQ39812740
The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells.Q40360748
Snail regulates p21(WAF/CIP1) expression in cooperation with E2A and TwistQ40489885
Snail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties in vivoQ40550757
The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressorsQ40680001
Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouseQ41831039
Temporal and spatial expression of collagens during murine atrioventricular heart valve development and maintenanceQ41873955
Akt promotes endocardial-mesenchyme transitionQ41874128
Tbx20 regulation of endocardial cushion cell proliferation and extracellular matrix gene expressionQ42132732
Expression and activity of matrix metalloproteinase-2 in calcific aortic stenosisQ42457227
Degradation of type IV collagen by matrix metalloproteinases is an important step in the epithelial-mesenchymal transformation of the endocardial cushionsQ42495701
Lineage and morphogenetic analysis of the cardiac valves.Q44228444
Development of heart valve leaflets and supporting apparatus in chicken and mouse embryosQ44910199
The Slug gene is not essential for mesoderm or neural crest development in miceQ47862704
Epithelial-Mesenchymal Transitions in development and disease: old views and new perspectives.Q51795587
BMP and FGF regulatory pathways control cell lineage diversification of heart valve precursor cells.Q52018487
Expression patterns of Tgfbeta1-3 associate with myocardialisation of the outflow tract and the development of the epicardium and the fibrous heart skeleton.Q52103919
Extracellular Matrix Remodeling and Organization in Developing and Diseased Aortic ValvesQ63341951
Myocardial specificity for initiating endothelial-mesenchymal cell transition in embryonic chick heart correlates with a particulate distribution of fibronectinQ68922758
Migratory behavior of cardiac cushion tissue cells in a collagen-lattice culture systemQ70400076
Invasion of mesenchyme into three-dimensional collagen gels: a regional and temporal analysis of interaction in embryonic heart tissueQ71664314
Congenital heart defects: trapping the genetic culpritsQ73783699
Expression of MMP2, MMP9, MT1-MMP, TIMP1, and TIMP2 mRNA in valvular lesions of the heartQ74002697
Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valvesQ77198147
Slug is a mediator of epithelial-mesenchymal cell transformation in the developing chicken heartQ78038736
Generation of a Snail1 (Snai1) conditional null alleleQ82196217
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
P304page(s)209-221
P577publication date2011-09-05
P1433published inDevelopmental BiologyQ3025402
P1476titleMmp15 is a direct target of Snai1 during endothelial to mesenchymal transformation and endocardial cushion development
P478volume359

Reverse relations

cites work (P2860)
Q33736954A Snail1/Notch1 signalling axis controls embryonic vascular development.
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Q46310764Breaking down barriers: the evolution of cell invasion
Q38226670Etiology of valvular heart disease-genetic and developmental origins
Q42679119FoxM1 promotes epithelial-mesenchymal transition of hepatocellular carcinoma by targeting Snai1.
Q42776614HAND2 Target Gene Regulatory Networks Control Atrioventricular Canal and Cardiac Valve Development
Q35405508Increased MT2-MMP expression in gastric cancer patients is associated with poor prognosis
Q36593590Isolation of murine valve endothelial cells
Q33898816MT2-MMP expression associates with tumor progression and angiogenesis in human lung cancer
Q42523572MT2-MMP expression during early avian morphogenesis
Q36510078Maternal DNA Methylation Regulates Early Trophoblast Development
Q52575478Neural crest delamination and migration: Looking forward to the next 150 years.
Q38086222Signaling and transcriptional networks in heart development and regeneration
Q41266029Snai1 is important for avian epicardial cell transformation and motility
Q37663653Snail modulates the assembly of fibronectin via α5 integrin for myocardial migration in zebrafish embryos
Q37682494Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice
Q30541198Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis.
Q39007418Transcriptional Control of Cell Lineage Development in Epicardium-Derived Cells.

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