Surgical method for virally mediated gene delivery to the mouse inner ear through the round window membrane

scientific article

Surgical method for virally mediated gene delivery to the mouse inner ear through the round window membrane is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3791/52187
P932PMC publication ID4401361
P698PubMed publication ID25867531
P5875ResearchGate publication ID273896858

P2093author name stringLawrence R Lustig
Omar Akil
Dylan K Chan
Stephanie L Rouse
P2860cites workStructure of Adeno-Associated Virus Serotype 8, a Gene Therapy VectorQ27647639
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Adenovector-mediated hair cell regeneration is affected by promoter type.Q30364969
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Gene transfer in human vestibular epithelia and the prospects for inner ear gene therapyQ30440245
Gene therapy and stem cell transplantation: strategies for hearing restorationQ30448504
Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy.Q30451780
Inner ear gene transfection in neonatal mice using adeno-associated viral vector: a comparison of two approachesQ30464591
Adeno-associated virus-mediated gene delivery into the scala media of the normal and deafened adult mouse ear.Q30472510
Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell deathQ30578611
Kv7-type channel currents in spiral ganglion neurons: involvement in sensorineural hearing lossQ34251255
Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammalsQ34394494
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Mouse models to study inner ear development and hereditary hearing lossQ36950147
Gap junctions and connexins in the inner ear: their roles in homeostasis and deafnessQ37271371
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Hearing loss: mechanisms revealed by genetics and cell biologyQ37582921
How the genetics of deafness illuminates auditory physiologyQ37809076
Mouse Cochlear Whole Mount ImmunofluorescenceQ39467632
A surgical approach appropriate for targeted cochlear gene therapy in the mouseQ40734130
Green fluorescent protein as a reporter for gene transfer studies in the cochleaQ40871576
Development of in vivo gene therapy for hearing disorders: introduction of adeno-associated virus into the cochlea of the guinea pig.Q40934948
Adenoviral vectors for improved gene delivery to the inner ear.Q42109130
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brainQ42280576
Hearing preservation after inner ear gene therapy: the effect of vector and surgical approach.Q42451504
Gene transfer into guinea pig cochlea using adeno-associated virus vectorsQ42525743
Long-term in vivo cochlear transgene expression mediated by recombinant adeno-associated virusQ44136141
Efficient and specific transduction of cochlear supporting cells by adeno-associated virus serotype 5.Q44705948
The functional and structural outcome of inner ear gene transfer via the vestibular and cochlear fluids in miceQ45071652
Noninvasive in vivo delivery of transgene via adeno-associated virus into supporting cells of the neonatal mouse cochleaQ45395514
The effect of cochleostomy and intracochlear infusion on auditory brain stem response threshold in the guinea pig.Q45855751
Inner ear transgene expression after adenoviral vector inoculation in the endolymphatic sac.Q45857676
AAV-mediated delivery of the caspase inhibitor XIAP protects against cisplatin ototoxicityQ45859205
Viral-mediated gene transfer in the cochleaQ45883103
Cochlear microinjection and its effects upon auditory function in the guinea pig.Q46100531
Progressive deafness and altered cochlear innervation in knock-out mice lacking prosaposin.Q46425316
Cochlear gene delivery through an intact round window membrane in mouseQ46630707
Adenoviral-mediated gene transfer into guinea pig cochlear cells in vivo.Q50515400
Interaction of cisplatin and noise on the peripheral auditory system.Q50548304
P433issue97
P407language of work or nameEnglishQ1860
P577publication date2015-03-16
P1433published inJournal of Visualized ExperimentsQ954500
P1476titleSurgical method for virally mediated gene delivery to the mouse inner ear through the round window membrane

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cites work (P2860)
Q52649043A Surgical Procedure for the Administration of Drugs to the Inner Ear in a Non-Human Primate Common Marmoset (Callithrix jacchus).
Q61118468AAV2.7m8 is a powerful viral vector for inner ear gene therapy
Q64986345Anatomical and Surgical Evaluation of the Common Marmoset as an Animal Model in Hearing Research.
Q93016803Antisense Oligonucleotides for the Treatment of Inner Ear Dysfunction
Q59359281Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice
Q38783334Challenges for the application of optical stimulation in the cochlea for the study and treatment of hearing loss
Q30359095Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction.
Q90505891Genetic Therapies for Hearing Loss: Accomplishments and Remaining Challenges
Q45863463Hearing Loss after Round Window Surgery in Mice Is due to Middle Ear Effusion.
Q50312575It's All in the Delivery: Improving AAV Transfection Efficiency with Exosomes
Q36413770Rhesus Cochlear and Vestibular Functions Are Preserved After Inner Ear Injection of Saline Volume Sufficient for Gene Therapy Delivery
Q92127585Viral Transfer of Mini-Otoferlins Partially Restores the Fast Component of Exocytosis and Uncovers Ultrafast Endocytosis in Auditory Hair Cells of Otoferlin Knock-Out Mice
Q59353271Virally Mediated Overexpression of Glial-Derived Neurotrophic Factor Elicits Age- and Dose-Dependent Neuronal Toxicity and Hearing Loss

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