A net +1 frameshift permits synthesis of thymidine kinase from a drug-resistant herpes simplex virus mutant

scientific article

A net +1 frameshift permits synthesis of thymidine kinase from a drug-resistant herpes simplex virus mutant is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1994PNAS...91.5461H
P356DOI10.1073/PNAS.91.12.5461
P932PMC publication ID44015
P698PubMed publication ID8202508
P5875ResearchGate publication ID14995775

P50authorPaul DigardQ40060981
P2093author name stringD M Coen
S Roberts
E Pelosi
B Horsburgh
C B Hwang
P2860cites workThe nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase geneQ24632148
Permissible amino acid substitutions within the putative nucleoside binding site of herpes simplex virus type 1 encoded thymidine kinase established by random sequence mutagenesis [corrected]Q31160273
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Nucleotide sequence changes in thymidine kinase gene of herpes simplex virus type 2 clones from an isolate of a patient treated with acyclovirQ35542181
Increased ribosomal accuracy increases a programmed translational frameshift in Escherichia coliQ36167381
Open reading frame cloning: identification, cloning, and expression of open reading frame DNA.Q36318880
Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1Q36365046
The extreme C terminus of herpes simplex virus DNA polymerase is crucial for functional interaction with processivity factor UL42 and for viral replication.Q36639684
Herpes simplex virus thymidine kinase and specific stages of latency in murine trigeminal gangliaQ36654762
Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutantsQ36782886
Isolation and characterization of herpes simplex virus mutants containing engineered mutations at the DNA polymerase locusQ36805852
Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locusQ36897832
Establishment of latency in mice by herpes simplex virus 1 recombinants that carry insertions affecting regulation of the thymidine kinase geneQ36903318
Towards a genetic dissection of the basis of triplet decoding, and its natural subversion: programmed reading frame shifts and hopsQ37041849
The promoter of the latency-associated transcripts of herpes simplex virus type 1 contains a functional cAMP-response element: role of the latency-associated transcripts and cAMP in reactivation of viral latencyQ37357752
Ribosome gymnastics--degree of difficulty 9.5, style 10.0.Q37944676
The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1.Q39232644
Plaque autoradiography assay for the detection and quantitation of thymidine kinase-deficient and thymidine kinase-altered mutants of herpes simplex virus in clinical isolatesQ39850127
Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanineQ40189782
Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity?Q41213814
A novel functional domain of an alpha-like DNA polymerase. The binding site on the herpes simplex virus polymerase for the viral UL42 proteinQ42083798
The herpes simplex virus type I DNA polymerase. Polypeptide structure and antigenic domainsQ42638790
Characterization of an efficient coronavirus ribosomal frameshifting signal: requirement for an RNA pseudoknotQ42646008
Two thymidine kinase deficient herpes simplex viruses exhibit unexpected virulence propertiesQ43503714
Acyclovir-resistant herpes simplex virus causing pneumonia after marrow transplantationQ43904839
Analysis of the thymidine kinase gene from clinically isolated acyclovir-resistant herpes simplex virusesQ44266191
Herpes simplex virus type 2 meningoencephalitis resistant to acyclovir in a patient with AIDS.Q44295406
The role of herpes simplex virus type 1 thymidine kinase in pathogenesisQ44549973
Successful treatment with foscarnet of an acyclovir-resistant mucocutaneous infection with herpes simplex virus in a patient with acquired immunodeficiency syndromeQ45281990
A low thymidine kinase-producing mutant of herpes simplex virus type 1 causes latent trigeminal ganglia infections in miceQ45798323
Evidence that the 'active centre' of the herpes simplex virus thymidine kinase involves an interaction between three distinct regions of the polypeptideQ45837075
Low levels of herpes simplex virus thymidine- thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse modelQ45846379
Effect of an amber mutation in the herpes simplex virus thymidine kinase gene on polypeptide synthesis and stabilityQ45846382
Acyclovir-resistant herpes simplex virus infections in patients with the acquired immunodeficiency syndrome.Q45846461
Expression of the Rous sarcoma virus pol gene by ribosomal frameshiftingQ45848547
Altered sensitivity to antiviral drugs of herpes simplex virus isolates from a patient with the acquired immunodeficiency syndromeQ45851060
Herpes simplex virus resistant to acyclovir. A study in a tertiary care centerQ45851795
A controlled trial comparing foscarnet with vidarabine for acyclovir-resistant mucocutaneous herpes simplex in the acquired immunodeficiency syndrome. The AIDS Clinical Trials GroupQ46117817
Resistance to antiviral drugs: the end of innocence.Q54360000
Acyclovir-resistant herpes in AIDS treated with foscarnet.Q54378545
Characterization of acyclovir-resistant and -sensitive herpes simplex viruses isolated from a patient with an acquired immune deficiency.Q54422091
Ribosomal frameshifting in the yeast retrotransposon Ty: tRNAs induce slippage on a 7 nucleotide minimal siteQ68468601
A genetic approach to promoter recognition during trans induction of viral gene expressionQ70147104
Genetic analysis of temperature-sensitive mutants of HSV-1: The combined use of complementation and physical mapping for cistron assignmentQ70178006
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)5461-5465
P577publication date1994-06-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleA net +1 frameshift permits synthesis of thymidine kinase from a drug-resistant herpes simplex virus mutant
P478volume91

Reverse relations

cites work (P2860)
Q39642251Accumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus.
Q42627168Acyclovir resistance in herpes simplex virus isolates from keratitis cases: an analysis from a developing country
Q33892430An unusual internal ribosome entry site in the herpes simplex virus thymidine kinase gene
Q40132856Analysis of Herpes Simplex Virus ICP0 Promoter Function in Sensory Neurons during Acute Infection, Establishment of Latency, and Reactivation In Vivo
Q34464221Biological aspects of DNA/RNA quadruplexes
Q74489912Current and potential therapies for the treatment of herpesvirus infections
Q43782944Detection of mutations within the thymidine kinase gene of herpes simplex virus type 1 by denaturing gradient gel electrophoresis
Q30831284Diverse herpes simplex virus type 1 thymidine kinase mutants in individual human neurons and Ganglia
Q35895966Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity.
Q45751135Emergence of resistance to acyclovir and penciclovir in varicella-zoster virus and genetic analysis of acyclovir-resistant variants
Q35947601Expression of extremely low levels of thymidine kinase from an acyclovir-resistant herpes simplex virus mutant supports reactivation from latently infected mouse trigeminal ganglia
Q34579981Herpes simplex virus resistance to acyclovir and penciclovir after two decades of antiviral therapy
Q34531396Herpes simplex virus resistance to antiviral drugs
Q34467256High-frequency phenotypic reversion and pathogenicity of an acyclovir-resistant herpes simplex virus mutant
Q39879440Homopolymer mutational hot spots mediate herpes simplex virus resistance to acyclovir
Q34383861Human DNA tumor viruses generate alternative reading frame proteins through repeat sequence recoding
Q33783612Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant
Q37138530Identification and characterization of a -1 reading frameshift in the heavy chain constant region of an IgG1 recombinant monoclonal antibody produced in CHO cells
Q40988373In situ detection of frameshift mutations in mouse cells
Q34716802Low-level expression and reversion both contribute to reactivation of herpes simplex virus drug-resistant mutants with mutations on homopolymeric sequences in thymidine kinase
Q40407340Mutation hot spots in the canine herpesvirus thymidine kinase gene
Q39686714Mutation spectra of herpes simplex virus type 1 thymidine kinase mutants
Q36236198Net -1 frameshifting on a noncanonical sequence in a herpes simplex virus drug-resistant mutant is stimulated by nonstop mRNA.
Q39652814Penciclovir susceptibilities of herpes simplex virus isolates from patients using penciclovir cream for treatment of recurrent herpes labialis
Q35868002Quantification and analysis of thymidine kinase expression from acyclovir-resistant G-string insertion and deletion mutants in herpes simplex virus-infected cells
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Q34149904Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management
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Q36401203Ribosomal frameshifting used in influenza A virus expression occurs within the sequence UCC_UUU_CGU and is in the +1 direction
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Q30329370Susceptibility testing. Viral pathogens.
Q34861045Translational compensation of a frameshift mutation affecting herpes simplex virus thymidine kinase is sufficient to permit reactivation from latency
Q44381148Translational recoding induced by G-rich mRNA sequences that form unusual structures

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