Update on the autoimmune pathology of multiple sclerosis: B-cells as disease-drivers and therapeutic targets

scientific article

Update on the autoimmune pathology of multiple sclerosis: B-cells as disease-drivers and therapeutic targets is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1159/000377675
P932PMC publication ID4401636
P698PubMed publication ID25824054
P5875ResearchGate publication ID274317276

P50authorHans-Christian von BüdingenQ73517832
P2093author name stringScott S Zamvil
Arumugam Palanichamy
Klaus Lehmann-Horn
Brady A Michel
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Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosisQ34538912
Memory B cells from a subset of treatment‐naïve relapsing‐remitting multiple sclerosis patients elicit CD4+ T‐cell proliferation and IFN‐γ production in response to myelin basic protein and myelin oligodendrocyte glycoproteinQ34773444
Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progressionQ34831296
Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulinQ34960518
B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodesQ35298764
Anti-CD20 B-cell depletion enhances monocyte reactivity in neuroimmunological disordersQ35544312
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Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluid.Q54759503
Intrathecal IgM synthesis predicts the onset of new relapses and a worse disease course in MS.Q55036043
Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?Q57041523
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Lymphocyte Subpopulations in the Cerebrospinal Fluid and Peripheral Blood in Patients with Multiple SclerosisQ66881982
A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune diseaseQ68834759
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Occurrence of oligoclonal IgM bands in the cerebrospinal fluid of neurological patients: an immunoaffinity-mediated capillary blot studyQ72816132
B cells are critical to induction of experimental allergic encephalomyelitis by protein but not by a short encephalitogenic peptideQ73170385
Critical role of antigen-specific antibody in experimental autoimmune encephalomyelitis induced by recombinant myelin oligodendrocyte glycoproteinQ74456215
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Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapyQ81235564
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B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunityQ36034499
Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions.Q36385029
B cell exchange across the blood-brain barrier in multiple sclerosisQ36498036
The neurobiology of multiple sclerosis: genes, inflammation, and neurodegenerationQ36610350
Specific peripheral B cell tolerance defects in patients with multiple sclerosisQ36890946
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligationQ36977531
The relation between inflammation and neurodegeneration in multiple sclerosis brains.Q37181308
Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis.Q37285430
Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis.Q37385073
MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodiesQ37397820
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In multiple sclerosis, oligoclonal bands connect to peripheral B-cell responses.Q37652977
New Anti-CD20 Monoclonal Antibodies for the Treatment of B-Cell Lymphoid MalignanciesQ37810901
The potential risk of infections during (prolonged) rituximab therapy in rheumatoid arthritis.Q37852715
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Induction of persistently demyelinated lesions in the rat following the repeated adoptive transfer of encephalitogenic T cells and demyelinating antibodyQ41601127
B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesionsQ41697260
Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patientsQ42619341
A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis.Q42847184
B-cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibodyQ42982096
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B cells undergo unique compartmentalized redistribution in multiple sclerosisQ44463732
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The risk of relapses in multiple sclerosis during systemic infectionsQ46129279
Comparative analysis of the CD19+ and CD138+ cell antibody repertoires in the cerebrospinal fluid of patients with multiple sclerosisQ47309556
Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis.Q47357498
Clonally expanded plasma cells in the cerebrospinal fluid of patients with central nervous system autoimmune demyelination produce "oligoclonal bands".Q48412765
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Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitmentQ48701331
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination.Q48819558
Short-lived plasma blasts are the main B cell effector subset during the course of multiple sclerosisQ48949365
Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosisQ48949792
Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis.Q51027456
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Immunological memory: contribution of memory B cells expressing costimulatory molecules in the resting state.Q52016419
Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis.Q53555780
P433issue3-4
P921main subjectmultiple sclerosisQ8277
P304page(s)238-246
P577publication date2015-03-25
P1433published inEuropean NeurologyQ1376833
P1476titleUpdate on the autoimmune pathology of multiple sclerosis: B-cells as disease-drivers and therapeutic targets
P478volume73

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cites work (P2860)
Q39458392A B Cell-Driven Autoimmune Pathway Leading to Pathological Hallmarks of Progressive Multiple Sclerosis in the Marmoset Experimental Autoimmune Encephalomyelitis Model
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Q90393310Efficacy and safety of autologous hematopoietic stem-cell transplantation in multiple sclerosis: a systematic review and meta-analysis
Q61817102Enduring Clinical Value of Copaxone® (Glatiramer Acetate) in Multiple Sclerosis after 20 Years of Use
Q89942990Experimental autoimmune encephalomyelitis in the common marmoset: a translationally relevant model for the cause and course of multiple sclerosis
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Q64968463Multiple Sclerosis: B Cells Take Center Stage.
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Q96306924[Ocrelizumab for treatment of multiple sclerosis]

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