Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis.

scholarly article

Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis. is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2004PNAS..10111064C
P356DOI10.1073/PNAS.0402455101
P932PMC publication ID503741
P698PubMed publication ID15263096
P5875ResearchGate publication ID8446669

P50authorGianluigi MancardiQ42463501
Angela PistorioQ56458832
Antonio UccelliQ57007173
Debora GiuntiQ73056631
P2093author name stringClaudio Gambini
Vito Pistoia
Anna Corcione
Elisa Ferretti
Simona Casazza
Emanuela Zappia
P2860cites workRecommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosisQ22252943
Transcriptional analysis of the B cell germinal center reactionQ24554209
Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating eventQ28186287
CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cellsQ28205502
CCL19 and CXCL12 trigger in vitro chemotaxis of human mantle cell lymphoma B cellsQ28244007
Germinal centersQ29616234
Pathways of fluid drainage from the brain--morphological aspects and immunological significance in rat and manQ30985026
Restricted use of VH4 germline segments in an acute multiple sclerosis brainQ32107477
The role of B cells and autoantibodies in multiple sclerosisQ33942290
Lymphoid neogenesis: de novo formation of lymphoid tissue in chronic inflammation through expression of homing chemokines.Q34191599
Combinatorial signals by inflammatory cytokines and chemokines mediate leukocyte interactions with extracellular matrixQ34280514
Analysis of somatic mutation in five B cell subsets of human tonsilQ34328629
Ectopic lymphoid organogenesis: a fast track for autoimmunityQ34363840
Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleenQ34488105
Three or more routes for leukocyte migration into the central nervous systemQ35183162
Memory B lymphocytes migrate to bone marrow in humansQ35905551
Ectopic LTαβ Directs Lymphoid Organ Neogenesis with Concomitant Expression of Peripheral Node Addressin and a HEV-restricted SulfotransferaseQ36370988
B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion.Q36400576
The Development of Rational Strategies for Selective Immunotherapy against Autoimmune Demyelinating DiseaseQ36665881
Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis.Q37385073
Immunoglobulin-containing cells in multiple-sclerosis plaquesQ39450637
Macrophages, lymphocytes, and plasma cells in the perivascular compartment in chronic multiple sclerosisQ40141450
TNF-alpha and IFN-gamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro.Q40647455
Regulation of CD27 expression in the course of germinal center B cell differentiation: the pivotal role of IL-10.Q40861806
Lymphotoxin alpha3 induces chemokines and adhesion molecules: insight into the role of LT alpha in inflammation and lymphoid organ developmentQ40986515
Germinal center developmentQ41583265
B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesionsQ41697260
Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cellsQ42108183
Germinal center founder cells display propensity for apoptosis before onset of somatic mutationQ42114332
Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patientsQ42619341
Identification of autoantibodies associated with myelin damage in multiple sclerosisQ46424597
Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis.Q47357498
Heterogeneity of tonsillar subepithelial B lymphocytes, the splenic marginal zone equivalentsQ47859763
MCP-1, MCP-2 and MCP-3 expression in multiple sclerosis lesions: an immunohistochemical and in situ hybridization studyQ47877446
Normal and clonal B lineage cells can be distinguished by their differential expression of B cell antigens and adhesion molecules in peripheral blood from multiple myeloma (MM) patients--diagnostic and clinical implications.Q47901564
Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS.Q48325664
Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis.Q51027456
Chemotaxis of human tonsil B lymphocytes to CC chemokine receptor (CCR) 1, CCR2 and CCR4 ligands is restricted to non-germinal center cells.Q52011406
Bm1-Bm5 classification of peripheral blood B cells reveals circulating germinal center founder cells in healthy individuals and disturbance in the B cell subpopulations in patients with primary Sjögren's syndrome.Q52017280
Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2.Q52054113
Macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta, and RANTES mRNA semiquantification and protein expression in active demyelinating multiple sclerosis (MS) lesionsQ73223366
Expression of the beta-chemokine receptors CCR2, CCR3 and CCR5 in multiple sclerosis central nervous system tissueQ74016845
Chemokines in inflammation and immunityQ74206737
Activation-dependent modulation of B lymphocyte migration to chemokinesQ74247915
Evolution of autoantibody responses via somatic hypermutation outside of germinal centersQ74813307
Functional B-cell response in intrahepatic lymphoid follicles in chronic hepatitis CQ77933533
P433issue30
P407language of work or nameEnglishQ1860
P921main subjectcell differentiationQ210861
patientQ181600
nervous systemQ9404
multiple sclerosisQ8277
P304page(s)11064-11069
P577publication date2004-07-19
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleRecapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis
P478volume101

Reverse relations

cites work (P2860)
Q47590508A Neuroprimer: Principles of Central Nervous System Immunity
Q37818921A case for regulatory B cells in controlling the severity of autoimmune-mediated inflammation in experimental autoimmune encephalomyelitis and multiple sclerosis
Q40530656Activated GL7+ B cells are maintained within the inflamed CNS in the absence of follicle formation during viral encephalomyelitis.
Q80767685Analysis of cerebrospinal fluid cell populations with monoclonal antibodies
Q36484465Anti-B-Cell Therapies in Autoimmune Neurological Diseases: Rationale and Efficacy Trials
Q35891689Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein
Q33745475Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid
Q35758506Antigen microarrays identify CNS-produced autoantibodies in RRMS.
Q42665157Astrocytes produce dendritic cell-attracting chemokines in vitro and in multiple sclerosis lesions
Q24628925Atacicept: targeting B cells in multiple sclerosis
Q26770852B Cells in the Multiple Sclerosis Central Nervous System: Trafficking and Contribution to CNS-Compartmentalized Inflammation
Q37093281B Lymphocytes in Multiple Sclerosis: Bregs and BTLA/CD272 Expressing-CD19+ Lymphocytes Modulate Disease Severity
Q37400354B cell characterization and reactivity analysis in multiple sclerosis
Q36091161B cell proliferation, somatic hypermutation, class switch recombination, and autoantibody production in ectopic lymphoid tissue in murine lupus
Q36220292B cell repertoire expansion occurs in meningeal ectopic lymphoid tissue.
Q38050398B cells and antibodies in multiple sclerosis pathogenesis and therapy
Q42249555B cells as a target of immune modulation
Q34544062B cells move to centre stage: novel opportunities for autoimmune disease treatment
Q51033051B-cell subsets up-regulate α4 integrin and accumulate in the cerebrospinal fluid in clinically isolated syndrome suggestive of multiple sclerosis onset
Q36981274B-cells and humoral immunity in multiple sclerosis. Implications for therapy
Q24646563BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma
Q27496017Biomarkers in Multiple Sclerosis: An Up-to-Date Overview
Q46275246CNS viral infection diverts homing of antibody-secreting cells from lymphoid organs to the CNS.
Q37990784CXCL12 in control of neuroinflammation.
Q92238833CXCL13 and Its Receptor CXCR5 in Cancer: Inflammation, Immune Response, and Beyond
Q35086918CXCL13 antibody for the treatment of autoimmune disorders
Q36788638CXCL13 promotes isotype-switched B cell accumulation to the central nervous system during viral encephalomyelitis
Q30498100Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue
Q47356888Cerebrospinal Fluid Cytokine Expression Profile in Multiple Sclerosis and Chronic Inflammatory Demyelinating Polyneuropathy.
Q41255081Cerebrospinal fluid B cells and disease progression in multiple sclerosis - A longitudinal prospective study.
Q21144285Cerebrospinal fluid B cells correlate with early brain inflammation in multiple sclerosis
Q36082102Cerebrospinal fluid B cells from multiple sclerosis patients are subject to normal germinal center selection.
Q35947260Chemokine signatures in the skin disorders of Lyme borreliosis in Europe: predominance of CXCL9 and CXCL10 in erythema migrans and acrodermatitis and CXCL13 in lymphocytoma
Q48701331Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment
Q92538902Chronic Inflammation: A Common Promoter in Tertiary Lymphoid Organ Neogenesis
Q36086261Chronic hepatitis C virus infection breaks tolerance and drives polyclonal expansion of autoreactive B cells
Q47935420Clonal relationships of CSF B cells in treatment-naive multiple sclerosis patients.
Q36827362Current concepts of the cellular and molecular pathophysiology of multiple sclerosis
Q37111883DNA-based vaccines: the future of multiple sclerosis therapy?
Q40619934Demyelinating strain of mouse hepatitis virus infection bridging innate and adaptive immune response in the induction of demyelination
Q36097325Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases
Q37867728Development of anti-CD20 therapy for multiple sclerosis.
Q30598338Diagnostic biomarkers in multiple sclerosis.
Q50860736Differential effects of fingolimod on B-cell populations in multiple sclerosis.
Q37328280Disease-modifying agents for multiple sclerosis: recent advances and future prospects
Q38198016Does disease-irrelevant intrathecal synthesis in multiple sclerosis make sense in the light of tertiary lymphoid organs?
Q21261385Early B-cell Factor gene association with multiple sclerosis in the Spanish population
Q37075235Ectopic lymphoid tissues and local immunity
Q35099828Effect of met-enkephalin on chromosomal aberrations in the lymphocytes of the peripheral blood of patients with multiple sclerosis
Q38091729Effects of CXCL13 inhibition on lymphoid follicles in models of autoimmune disease
Q37778622Emerging concepts in autoimmune encephalomyelitis beyond the CD4/TH1 paradigm
Q26830464Epstein-Barr virus in systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis—association and causation
Q35231795Evidence for the role of B cells and immunoglobulins in the pathogenesis of multiple sclerosis
Q35077861Expansion of CD27high plasmablasts in transverse myelitis patients that utilize VH4 and JH6 genes and undergo extensive somatic hypermutation.
Q34449329Extensive grey matter pathology in the cerebellum in multiple sclerosis is linked to inflammation in the subarachnoid space
Q34742821Factors supporting intrathecal humoral responses following viral encephalomyelitis.
Q37875022Flow cytometric characterization of cerebrospinal fluid cells
Q36302329Follicular B helper T cells in antibody responses and autoimmunity.
Q36919822Glial cell activation, recruitment, and survival of B-lineage cells following MCMV brain infection
Q36778303High-Density Peptide Microarray Analysis of IgG Autoantibody Reactivities in Serum and Cerebrospinal Fluid of Multiple Sclerosis Patients.
Q28750403IgG antibodies against measles, rubella, and varicella zoster virus predict conversion to multiple sclerosis in clinically isolated syndrome
Q42259604Immune cell subtyping in the cerebrospinal fluid of patients with neurological diseases
Q34251673Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis.
Q36577275Immunopathogenesis and immunotherapy of multiple sclerosis
Q55039421Immunophenotypic characterization of CSF B cells in virus-associated neuroinflammatory diseases.
Q36286321In situ single cell detection via microfluidic magnetic bead assay
Q37655201Increased cortical lesion load and intrathecal inflammation is associated with oligoclonal bands in multiple sclerosis patients: a combined CSF and MRI study.
Q35764685Inflammatory cortical demyelination in early multiple sclerosis
Q37354974Inhibition of LTi cell development by CD25 blockade is associated with decreased intrathecal inflammation in multiple sclerosis
Q92642889Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis
Q42232853Intrahepatic B-cell follicles of chronically hepatitis C virus-infected individuals lack signs of an ectopic germinal center reaction.
Q59355260Intrathecal B Cells in MS Have Significantly Greater Lymphangiogenic Potential Compared to B Cells Derived From Non-MS Subjects
Q36142794Intrathecal IgM production at clinical onset correlates with a more severe disease course in multiple sclerosis
Q40272576Intrathecal chitotriosidase and the outcome of multiple sclerosis
Q38084075Intrathecal humoral immunity to encephalitic RNA viruses.
Q44681284Intrathecal somatic hypermutation of IgM in multiple sclerosis and neuroinflammation
Q33565842Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS.
Q37523986Kv1.3 potassium channels as a therapeutic target in multiple sclerosis
Q44121733Leukocyte entry into the CNS of Leishmania chagasi naturally infected dogs.
Q64066412Longitudinally persistent cerebrospinal fluid B cells can resist treatment in multiple sclerosis
Q35563291Loureirin B, an essential component of Sanguis Draxonis, inhibits Kv1.3 channel and suppresses cytokine release from Jurkat T cells
Q37186200Lymphoid chemokines in chronic neuroinflammation
Q34020894Lymphoid chemokines in the CNS.
Q36405080Lymphoid neogenesis in chronic inflammatory diseases.
Q48489792Magnetic resonance evidence of cortical onset of multiple sclerosis
Q35755470Measles virus-specific plasma cells are prominent in subacute sclerosing panencephalitis CSF
Q36097332Meningeal Infiltration of the Spinal Cord by Non-Classically Activated B Cells is Associated with Chronic Disease Course in a Spontaneous B Cell-Dependent Model of CNS Autoimmune Disease
Q48949792Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis
Q36572543Multiple roles of chemokine CXCL12 in the central nervous system: a migration from immunology to neurobiology
Q35756367N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3.
Q44938493Natalizumab treatment decreases serum IgM and IgG levels in multiple sclerosis patients
Q36991434New insights into adaptive immunity in chronic neuroinflammation
Q37313911Novel therapeutic strategies for multiple sclerosis--a multifaceted adversary
Q42566452Pathogenic antibodies are active participants in spinal cord injury
Q24642165Pathological expression of CXCL12 at the blood-brain barrier correlates with severity of multiple sclerosis
Q42264060Phenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis
Q28281365Potassium channels, memory T cells, and multiple sclerosis
Q90429566Potential Biomarker and Therapeutic LncRNAs in Multiple Sclerosis Through Targeting Memory B Cells
Q39084950Potential importance of B cells in aging and aging-associated neurodegenerative diseases
Q64249132Presence of intragraft B cells during acute renal allograft rejection is accompanied by changes in peripheral blood B cell subsets
Q34059107Progression from IgD+ IgM+ to isotype-switched B cells is site specific during coronavirus-induced encephalomyelitis.
Q35126686Proliferating brain cells are a target of neurotoxic CSF in systemic autoimmune disease.
Q41933450Protective Humoral Immunity in the CNS Requires Peripheral CD19-Dependent Germinal Center Formation Following Coronavirus Encephalomyelitis.
Q37019872Recent Advances in Monoclonal Antibody Therapies for Multiple Sclerosis
Q36607157Recruitment and retention of B cells in the central nervous system in response to alphavirus encephalomyelitis
Q36832863Role of B cells in pathogenesis of multiple sclerosis
Q57825775Role of CXCL13 in the formation of the meningeal tertiary lymphoid organ in multiple sclerosis
Q38530157Role of T Follicular Helper cells in Multiple Sclerosis
Q52657141Role of TFH Cells in Promoting T Helper 17-Induced Neuroinflammation.
Q33264770Screening random peptide libraries with subacute sclerosing panencephalitis brain-derived recombinant antibodies identifies multiple epitopes in the C-terminal region of the measles virus nucleocapsid protein
Q42373792Selective intrathecal enrichment of G1m1-positive B cells in multiple sclerosis
Q38690022Targeting B cells in relapsing-remitting multiple sclerosis: from pathophysiology to optimal clinical management.
Q28303760Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases
Q51976995Tertiary lymphoid tissues generate effector and memory T cells that lead to allograft rejection.
Q36474316The B cell response in multiple sclerosis
Q26776542The Ins and Outs of B Cells in Multiple Sclerosis
Q36216025The Role of Latently Infected B Cells in CNS Autoimmunity
Q90050404The Role of the CXCL12/CXCR4/ACKR3 Axis in Autoimmune Diseases
Q82719617The SDF-1 3'a genetic variation of the chemokine SDF-1α (CXCL12) in parallel with its increased circulating levels is associated with susceptibility to MS: a study on Iranian multiple sclerosis patients
Q47116115The chronically inflamed central nervous system provides niches for long-lived plasma cells
Q92213495The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis
Q35155753The double-edged sword of autoimmunity: lessons from multiple sclerosis
Q37818131The potential role of B cell-targeted therapies in multiple sclerosis
Q38092972The utility of cerebrospinal fluid analysis in patients with multiple sclerosis
Q38560936Thyroid Hormone Potentially Benefits Multiple Sclerosis via Facilitating Remyelination.
Q36492380Toward biomarkers in multiple sclerosis: new advances.
Q46927946Unaltered levels of transplant arteriosclerosis in the absence of the B cell homing chemokine receptor CXCR5.
Q35463552Update on the autoimmune pathology of multiple sclerosis: B-cells as disease-drivers and therapeutic targets
Q40053831Use of rituximab in multiple sclerosis: current progress and future perspectives
Q57001708Viruses and multiple sclerosis
Q83274218[Rituximab in treatment for neuroimmunological diseases]
Q51958899[Targeting B cells in multiple sclerosis. Current concepts and strategies].

Search more.