Mutations in pneumococcal cpsE generated via in vitro serial passaging reveal a potential mechanism of reduced encapsulation utilized by a conjunctival isolate

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Mutations in pneumococcal cpsE generated via in vitro serial passaging reveal a potential mechanism of reduced encapsulation utilized by a conjunctival isolate is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JB.02602-14
P932PMC publication ID4402401
P698PubMed publication ID25777672

P2093author name stringAndrew Camilli
Michael S Gilmore
Mara G Shainheit
Michael D Valentino
P2860cites workGenetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypesQ25256120
Gene splicing and mutagenesis by PCR-driven overlap extensionQ29615338
Characterization of nontypable Streptococcus pneumoniae-like organisms isolated from outbreaks of conjunctivitis.Q30451614
Quorum sensing and biofilm formation in Streptococcal infectionsQ33630399
Relationship between cell surface carbohydrates and intrastrain variation on opsonophagocytosis of Streptococcus pneumoniae.Q33867105
Illustration of pneumococcal polysaccharide capsule during adherence and invasion of epithelial cellsQ33946696
The type 2 capsule locus of Streptococcus pneumoniaeQ33991837
Virulence factors and the pathogenesis of disease caused by Streptococcus pneumoniae.Q34015618
Is the Ami-AliA/B oligopeptide permease of Streptococcus pneumoniae involved in sensing environmental conditions?Q34015652
Streptococcus pneumoniae in biofilms are unable to cause invasive disease due to altered virulence determinant productionQ34103322
CpsE from type 2 Streptococcus pneumoniae catalyzes the reversible addition of glucose-1-phosphate to a polyprenyl phosphate acceptor, initiating type 2 capsule repeat unit formationQ34110012
Phosphorylcholine allows for evasion of bactericidal antibody by Haemophilus influenzaeQ34186951
Capsule type of Streptococcus pneumoniae determines growth phenotypeQ34192851
A homologue of aliB is found in the capsule region of nonencapsulated Streptococcus pneumoniaeQ34350570
Streptococcus pneumoniae resistance to complement-mediated immunity is dependent on the capsular serotypeQ42040636
Simple sequence repeats and genome plasticity in Streptococcus agalactiaeQ42576675
Capsular polysaccharide synthesis in Streptococcus pneumoniae serotype 14: molecular analysis of the complete cps locus and identification of genes encoding glycosyltransferases required for the biosynthesis of the tetrasaccharide subunitQ42668248
Spontaneous sequence duplication within an open reading frame of the pneumococcal type 3 capsule locus causes high-frequency phase variationQ42671880
Simple sequence repeats in the Helicobacter pylori genomeQ42676800
Tts, a processive beta-glucosyltransferase of Streptococcus pneumoniae, directs the synthesis of the branched type 37 capsular polysaccharide in Pneumococcus and other gram-positive speciesQ43551071
Mismatch repair and the regulation of phase variation in Neisseria meningitidisQ43612705
CpsB is a modulator of capsule-associated tyrosine kinase activity in Streptococcus pneumoniaeQ43770495
Spontaneous sequence duplications within capsule genes cap8E and tts control phase variation in Streptococcus pneumoniae serotypes 8 and 37.Q44353953
Streptococcus pneumoniae ocular infections, prominent role of unencapsulated isolates in conjunctivitisQ44796990
The diversity within an expanded and redefined repertoire of phase-variable genes in Helicobacter pyloriQ47792946
Tyrosine phosphorylation of CpsD negatively regulates capsular polysaccharide biosynthesis in streptococcus pneumoniaeQ47870346
An outbreak of conjunctivitis due to atypical Streptococcus pneumoniaeQ48024791
Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniaeQ48040381
Three highly homologous membrane-bound lipoproteins participate in oligopeptide transport by the Ami system of the gram-positive Streptococcus pneumoniaeQ48080082
The glucosyl-1-phosphate transferase WchA (Cap8E) primes the capsular polysaccharide repeat unit biosynthesis of Streptococcus pneumoniae serotype 8.Q50094029
Repeat-associated phase variable genes in the complete genome sequence of Neisseria meningitidis strain MC58Q57976193
Versatility of the capsular genes during biofilm formation byStreptococcus pneumoniaeQ59261556
Pathogenesis of Pneumococcal InfectionQ59647738
Capsule and D-alanylated lipoteichoic acids protect Streptococcus pneumoniae against neutrophil extracellular trapsQ64129446
Association of intrastrain phase variation in quantity of capsular polysaccharide and teichoic acid with the virulence of Streptococcus pneumoniaeQ74184782
Phase variation in colony opacity by Streptococcus pneumoniaeQ74745253
Transformation of a type 4 encapsulated strain of Streptococcus pneumoniaeQ77208657
Unencapsulated Streptococcus pneumoniae from conjunctivitis encode variant traits and belong to a distinct phylogenetic clusterQ34509050
Phenotypic characterization of Streptococcus pneumoniae biofilm developmentQ34514309
A point mutation in cpsE renders Streptococcus pneumoniae nonencapsulated and enhances its growth, adherence and competenceQ34570325
Mutational analysis of the carboxy-terminal (YGX)4 repeat domain of CpsD, an autophosphorylating tyrosine kinase required for capsule biosynthesis in Streptococcus pneumoniaeQ34977456
The Streptococcus pneumoniae capsule inhibits complement activity and neutrophil phagocytosis by multiple mechanismsQ35015208
Identification of Streptococcus pneumoniae Cps2C residues that affect capsular polysaccharide polymerization, cell wall ligation, and Cps2D phosphorylationQ35095863
Population-based analysis of invasive nontypeable pneumococci reveals that most have defective capsule synthesis genes.Q35169266
Infectious conjunctivitisQ35577565
Capsule enhances pneumococcal colonization by limiting mucus-mediated clearance.Q35689073
Mutations blocking side chain assembly, polymerization, or transport of a Wzy-dependent Streptococcus pneumoniae capsule are lethal in the absence of suppressor mutations and can affect polymer transfer to the cell wallQ35759822
Phase variation in pneumococcal opacity: relationship between colonial morphology and nasopharyngeal colonizationQ35782997
Nontypeable pneumococci can be divided into multiple cps types, including one type expressing the novel gene pspKQ35924482
Biochemical, genetic, and serological characterization of two capsule subtypes among Streptococcus pneumoniae Serotype 20 strains: discovery of a new pneumococcal serotypeQ36201961
Adherence molecules of pathogenic pneumococciQ36336197
Characterization of the cassette containing genes for type 3 capsular polysaccharide biosynthesis in Streptococcus pneumoniaeQ36364598
Positive Correlation between Tyrosine Phosphorylation of CpsD and Capsular Polysaccharide Production inStreptococcus pneumoniaeQ36474326
PspK of Streptococcus pneumoniae increases adherence to epithelial cells and enhances nasopharyngeal colonizationQ36506030
Streptococcus pneumoniae capsular serotype invasiveness correlates with the degree of factor H binding and opsonization with C3b/iC3bQ36506103
Variation at the capsule locus, cps, of mistyped and non-typable Streptococcus pneumoniae isolates.Q36523162
Bacterial contingency loci: the role of simple sequence DNA repeats in bacterial adaptationQ36649037
Isolation of Streptococcus pneumoniae biofilm mutants and their characterization during nasopharyngeal colonizationQ36949951
The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and diseaseQ37109940
DNA repeats identify novel virulence genes in Haemophilus influenzaeQ37312114
Biochemical activities of Streptococcus pneumoniae serotype 2 capsular glycosyltransferases and significance of suppressor mutations affecting the initiating glycosyltransferase Cps2E.Q37469690
The core promoter of the capsule operon of Streptococcus pneumoniae is necessary for colonization and invasive diseaseQ37546517
Pneumococcal biofilms.Q37604205
The pneumococcus: why a commensal misbehavesQ37629673
Phase variation: how to create and coordinate population diversity.Q37835537
Capsules of Streptococcus pneumoniae and other bacteria: paradigms for polysaccharide biosynthesis and regulationQ37896640
Genetic relatedness among nontypeable pneumococci implicated in sporadic cases of conjunctivitisQ39453939
Changes in availability of oxygen accentuate differences in capsular polysaccharide expression by phenotypic variants and clinical isolates of Streptococcus pneumoniae.Q39521835
Short-sequence tandem and nontandem DNA repeats and endogenous hydrogen peroxide production contribute to genetic instability of Streptococcus pneumoniaeQ39679924
Relationship between phase variation in colony morphology, intrastrain variation in cell wall physiology, and nasopharyngeal colonization by Streptococcus pneumoniae.Q39825198
Adherence of nontypeable Streptococcus pneumoniae to human conjunctival epithelial cellsQ40067764
The high level streptomycin resistance gene from Streptococcus pneumoniae is a homologue of the ribosomal protein S12 gene from Escherichia coliQ40535698
A new pneumococcal serotype, 11E, has a variably inactivated wcjE geneQ40880240
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)1781-1791
P577publication date2015-03-16
P1433published inJournal of BacteriologyQ478419
P1476titleMutations in pneumococcal cpsE generated via in vitro serial passaging reveal a potential mechanism of reduced encapsulation utilized by a conjunctival isolate
P478volume197

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cites work (P2860)
Q37134767Allelic Variation of the Capsule Promoter Diversifies Encapsulation and Virulence In Streptococcus pneumoniae
Q37211042Experimental single-strain mobilomics reveals events that shape pathogen emergence
Q36349117Human milk oligosaccharides inhibit growth of group B Streptococcus
Q40186334Integrated proteomic and metabolomic analysis reveals that rhodomyrtone reduces the capsule in Streptococcus pneumoniae.
Q52620569Interplay Between Capsule Expression and Uracil Metabolism in Streptococcus pneumoniae D39.
Q30829175ManLMN is a glucose transporter and central metabolic regulator in Streptococcus pneumoniae
Q46341953Molecular Cloning, Expression and Characterization of Oenococcus oeni Priming Glycosyltransferases
Q90664151Pneumococci Can Become Virulent by Acquiring a New Capsule From Oral Streptococci
Q92282164The Best of All Worlds: Streptococcus pneumoniae Conjunctivitis through the Lens of Community Ecology and Microbial Biogeography
Q36061279Two cases of serotypeable and non-serotypeable variants of Streptococcus pneumoniae detected simultaneously during invasive disease

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