Streptococcus pneumoniae in biofilms are unable to cause invasive disease due to altered virulence determinant production

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Streptococcus pneumoniae in biofilms are unable to cause invasive disease due to altered virulence determinant production is …
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scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...628738S
P356DOI10.1371/JOURNAL.PONE.0028738
P932PMC publication ID3234282
P698PubMed publication ID22174882
P5875ResearchGate publication ID51884840

P50authorCarlos J OrihuelaQ59689126
P2093author name stringHervé Tettelin
Julie C Dunning Hotopp
Nikhil Kumar
Carlos J Sanchez
Pooja Shivshankar
James H Jorgensen
Anel Lizcano
P2860cites workGenome of the Bacterium Streptococcus pneumoniae Strain R6Q22065464
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Interaction of pneumococcal phase variation, host and pressure/gas composition: virulence expression of NanA, HylA, PspA and CbpA in simulated otitis mediaQ42473415
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Contribution of serotype and genetic background to biofilm formation by Streptococcus pneumoniaeQ45056811
Tissue-specific contributions of pneumococcal virulence factors to pathogenesisQ45101885
An accessory sec locus of Streptococcus gordonii is required for export of the surface protein GspB and for normal levels of binding to human platelets.Q45947385
Determinants of the streptococcal surface glycoprotein GspB that facilitate export by the accessory Sec system.Q45992753
Sialic acid: a preventable signal for pneumococcal biofilm formation, colonization, and invasion of the host.Q46037892
Biofilm formation byStreptococcus pneumoniaeisolates from paediatric patientsQ57589183
Differences in biofilm development and antibiotic susceptibility among Streptococcus pneumoniae isolates from cystic fibrosis samples and blood culturesQ61410340
Association of intrastrain phase variation in quantity of capsular polysaccharide and teichoic acid with the virulence of Streptococcus pneumoniaeQ74184782
Early biofilm formation on microtiter plates is not correlated with the invasive disease potential of Streptococcus pneumoniaeQ33712535
The impact of the competence quorum sensing system on Streptococcus pneumoniae biofilms varies depending on the experimental modelQ33872802
Extracellular matrix formation enhances the ability of Streptococcus pneumoniae to cause invasive diseaseQ33911080
Illustration of pneumococcal polysaccharide capsule during adherence and invasion of epithelial cellsQ33946696
Vaccine development in Staphylococcus aureus: taking the biofilm phenotype into considerationQ34113328
Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumoniaQ34193667
The two variants of the Streptococcus pneumoniae pilus 1 RrgA adhesin retain the same function and elicit cross-protection in vivoQ34309687
Both family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniaeQ34530684
Transcriptional regulation in the Streptococcus pneumoniae rlrA pathogenicity islet by RlrA.Q34580930
Streptococcus pyogenes pili promote pharyngeal cell adhesion and biofilm formationQ34628182
Historical comparisons of morbidity and mortality for vaccine-preventable diseases in the United StatesQ34655381
The physiology and collective recalcitrance of microbial biofilm communities.Q34695138
Mechanisms of antibiotic resistance in bacterial biofilmsQ34796493
Identification of a Candidate Streptococcus pneumoniae core genome and regions of diversity correlated with invasive pneumococcal diseaseQ34975633
The Streptococcus gordonii platelet binding protein GspB undergoes glycosylation independently of exportQ35546776
Characterization of colony morphology variants isolated from Streptococcus pneumoniae biofilmsQ35759418
Phase variation in pneumococcal opacity: relationship between colonial morphology and nasopharyngeal colonizationQ35782997
Infection Caused by Streptococcus pneumoniae in Children with Sickle Cell Disease: Epidemiology, Immunologic Mechanisms, Prophylaxis, and VaccinationQ36184870
Variation in the group B Streptococcus CsrRS regulon and effects on pathogenicityQ36483768
Genetic relationships between respiratory pathogens isolated from dental plaque and bronchoalveolar lavage fluid from patients in the intensive care unit undergoing mechanical ventilationQ36637809
Prevention measures for ventilator-associated pneumonia: a new focus on the endotracheal tubeQ36819167
Pyruvate oxidase, as a determinant of virulence in Streptococcus pneumoniaeQ36821393
Formation of Streptococcus pneumoniae non-phase-variable colony variants is due to increased mutation frequency present under biofilm growth conditionsQ36933242
Isolation of Streptococcus pneumoniae biofilm mutants and their characterization during nasopharyngeal colonizationQ36949951
Strong association between capsular type and virulence for mice among human isolates of Streptococcus pneumoniaeQ36953957
Dual role for pilus in adherence to epithelial cells and biofilm formation in Streptococcus agalactiaeQ37173651
The Streptococcus pneumoniae adhesin PsrP binds to Keratin 10 on lung cellsQ37366269
Phase variable desialylation of host proteins that bind to Streptococcus pneumoniae in vivo and protect the airwayQ38335915
Streptococcus pneumoniae surface protein PcpA elicits protection against lung infection and fatal sepsisQ39023214
Relationship between phase variation in colony morphology, intrastrain variation in cell wall physiology, and nasopharyngeal colonization by Streptococcus pneumoniae.Q39825198
Antibodies against PsrP, a novel Streptococcus pneumoniae adhesin, block adhesion and protect mice against pneumococcal challengeQ39977826
The acute-phase reactant C-reactive protein binds to phosphorylcholine-expressing Neisseria meningitidis and increases uptake by human phagocytesQ40025165
Infections in sickle cell anemia: pathogenesis and control.Q40323000
A neuraminidase from Streptococcus pneumoniae has the features of a surface proteinQ40375144
The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cellsQ40849349
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PAf receptor anchors Streptococcus pneumoniae to activated human endothelial cellsQ41455460
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectStreptococcus pneumoniaeQ221179
biofilmQ467410
invasive diseaseQ111796726
P304page(s)e28738
P577publication date2011-12-08
P1433published inPLOS OneQ564954
P1476titleStreptococcus pneumoniae in biofilms are unable to cause invasive disease due to altered virulence determinant production
P478volume6

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