Conserved molecular signatures in gp120 are associated with the genetic bottleneck during simian immunodeficiency virus (SIV), SIV-human immunodeficiency virus (SHIV), and HIV type 1 (HIV-1) transmission

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Conserved molecular signatures in gp120 are associated with the genetic bottleneck during simian immunodeficiency virus (SIV), SIV-human immunodeficiency virus (SHIV), and HIV type 1 (HIV-1) transmission is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.03235-14
P8608Fatcat IDrelease_iyw7cl5wojc7zhdomwckljsx3i
P932PMC publication ID4403421
P698PubMed publication ID25589663

P50authorGeorge K. LewisQ91710020
John L SpougeQ92400517
Anthony L DeVicoQ114780410
P2093author name stringMileidy W Gonzalez
P2860cites workStructure and immune recognition of trimeric pre-fusion HIV-1 Env.Q35142291
Lineage-specific differences between human and simian immunodeficiency virus regulation of gp120 trimer association and CD4 bindingQ36155019
HIV transmissionQ36526615
Exploration of antigenic variation in gp120 from clades A through F of human immunodeficiency virus type 1 by using monoclonal antibodiesQ36638240
Selection for specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary infectionQ36647820
Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG.Q36895518
Neutralizing IgG at the portal of infection mediates protection against vaginal simian/human immunodeficiency virus challengeQ37252676
Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1.Q37273086
Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infectionQ37273158
Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.Q37625296
Interaction with cellular CD4 exposes HIV-1 envelope epitopes targeted by antibody-dependent cell-mediated cytotoxicityQ37644079
HIV-1 genomic RNA diversification following sexual and parenteral virus transmissionQ45873185
Retrieval and on-the-fly alignment of sequence fragments from the HIV database.Q48679004
Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 InfectionQ27640572
Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobilityQ27658989
Diverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 bindingQ27675486
Crystal Structure of a Soluble Cleaved HIV-1 Envelope TrimerQ27680496
Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope TrimerQ27680497
MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and UsabilityQ27860817
Effect of breastfeeding and formula feeding on transmission of HIV-1: a randomized clinical trialQ28137803
Human immunodeficiency virus type 1 gp120 envelope glycoprotein regions important for association with the gp41 transmembrane glycoproteinQ28646759
Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trialQ28972526
Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and diseaseQ29616432
Immune-correlates analysis of an HIV-1 vaccine efficacy trialQ29617377
Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infectionQ29619510
A modified Bonferroni method for discrete dataQ30620985
High Multiplicity Infection by HIV-1 in Men Who Have Sex with Men.Q33582135
Tetherin antagonism by Vpu protects HIV-infected cells from antibody-dependent cell-mediated cytotoxicity.Q33674461
Characterization of human immunodeficiency virus type 1 (HIV-1) envelope variation and neutralizing antibody responses during transmission of HIV-1 subtype B.Q33780595
Selection for human immunodeficiency virus type 1 envelope glycosylation variants with shorter V1-V2 loop sequences occurs during transmission of certain genetic subtypes and may impact viral RNA levelsQ33780649
Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitionsQ33789251
Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus type 1 infectionQ33825654
Epitope target structures of Fc-mediated effector function during HIV-1 acquisitionQ33924272
Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infectionsQ34042642
Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infantQ34301874
Phenotypic properties of transmitted founder HIV-1Q34336058
HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2.Q34402446
Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trialQ34648825
Immune escape from HIV-specific antibody-dependent cellular cytotoxicity (ADCC) pressureQ34937296
An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serumQ35077677
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectHIVQ15787
Simian immunodeficiency virusQ1890246
HIV transmissionQ49029021
P304page(s)3619-3629
P577publication date2015-01-14
P1433published inJournal of VirologyQ1251128
P1476titleConserved molecular signatures in gp120 are associated with the genetic bottleneck during simian immunodeficiency virus (SIV), SIV-human immunodeficiency virus (SHIV), and HIV type 1 (HIV-1) transmission
P478volume89

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cites work (P2860)
Q33780980Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys
Q47548907Alterations of HIV-1 envelope phenotype and antibody-mediated neutralization by signal peptide mutations.
Q40393973Characterization of founder viruses in very early SIV rectal transmission
Q59357154Characterization of the Plasmacytoid Dendritic Cell Response to Transmitted/Founder and Nontransmitted Variants of HIV-1
Q36288959Conserved signatures indicate HIV-1 transmission is under strong selection and thus is not a "stochastic" process
Q36022372HIV-1 Genetic Variation Resulting in the Development of New Quasispecies Continues to Be Encountered in the Peripheral Blood of Well-Suppressed Patients
Q47552258High-Resolution Sequencing of Viral Populations During Early SIV Infection Reveals Evolutionary Strategies for Rapid Escape from Emerging Env-Specific Antibody Responses.
Q37182674Human Th17 Cells Lack HIV-Inhibitory RNases and Are Highly Permissive to Productive HIV Infection
Q37642937Partial HIV C2V3 envelope sequence analysis reveals association of coreceptor tropism, envelope glycosylation and viral genotypic variability among Kenyan patients on HAART.
Q47109778Patterns of conserved gp120 epitope presentation on attached HIV-1 virions
Q40320261Reply to correspondence 'Conserved signatures indicate HIV-1 transmission is under strong selection and thus is not a "stochastic" process' by Gonzalez et al., Retrovirology 2017.
Q49790276Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120.
Q36523998Signatures in Simian Immunodeficiency Virus SIVsmE660 Envelope gp120 Are Associated with Mucosal Transmission but Not Vaccination Breakthrough in Rhesus Macaques
Q30238730Survivors Remorse: antibody-mediated protection against HIV-1.
Q40697873The V1 region of gp120 is preferentially selected during SIV/HIV transmission and is indispensable for envelope function and virus infection

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