KCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 orthologue.

scientific article published on November 2011

KCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 orthologue. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1085/JGP.201110677
P932PMC publication ID3206303
P698PubMed publication ID22042987
P5875ResearchGate publication ID51760313

P50authorAtsuo NishinoQ42291343
Koichi NakajoQ56736214
P2093author name stringYoshihiro Kubo
Yasushi Okamura
P2860cites workIon channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordatesQ21145023
A constitutively open potassium channel formed by KCNQ1 and KCNE3Q22011154
The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interactionQ24305236
Regulation of the Kv2.1 potassium channel by MinK and MiRP1Q24311239
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channelQ24318271
Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunitsQ24336294
Intracellular domains interactions and gated motions of I(KS) potassium channel subunitsQ24337820
KCNQ1 gain-of-function mutation in familial atrial fibrillationQ24338486
Interaction of KCNE subunits with the KCNQ1 K+ channel poreQ24548322
Voltage-dependent inactivation of the human K+ channel KvLQT1 is eliminated by association with minimal K+ channel (minK) subunitsQ24653858
Structure of KCNE1 and Implications for How It Modulates the KCNQ1 Potassium Channel † ‡Q27651069
Structural determinants of KvLQT1 control by the KCNE family of proteinsQ28139369
A single transmembrane site in the KCNE-encoded proteins controls the specificity of KvLQT1 channel gatingQ28216718
KCNE1 and KCNE3 stabilize and/or slow voltage sensing S4 segment of KCNQ1 channelQ28240701
Functional modulation of the transient outward current Ito by KCNE beta-subunits and regional distribution in human non-failing and failing heartsQ28254884
Crystal structure of a mammalian voltage-dependent Shaker family K+ channelQ28260421
The conduction pore of a cardiac potassium channelQ28262167
The MinK-related peptidesQ28291767
Cloning of a membrane protein that induces a slow voltage-gated potassium currentQ28292630
K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium currentQ28295470
KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gateQ28300574
Stoichiometry of the KCNQ1 - KCNE1 ion channel complex.Q28583726
KCNE1 constrains the voltage sensor of Kv7.1 K+ channelsQ33327366
Functional interactions between KCNE1 C-terminus and the KCNQ1 channelQ33425857
State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activationQ33922794
Identification of a protein-protein interaction between KCNE1 and the activation gate machinery of KCNQ1Q33922814
Activation and inactivation of homomeric KvLQT1 potassium channels.Q34168644
Neuronal KCNQ potassium channels: physiology and role in disease.Q34185467
KCNE1 remodels the voltage sensor of Kv7.1 to modulate channel functionQ34388706
Expression of multiple KCNE genes in human heart may enable variable modulation of I(Ks).Q34392041
Comprehensive analysis of the ascidian genome reveals novel insights into the molecular evolution of ion channel genesQ34421194
In vitro molecular interactions and distribution of KCNE family with KCNQ1 in the human heartQ34436223
KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activityQ35021903
Secondary structure of a KCNE cytoplasmic domainQ36295930
The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexesQ36299677
KCNE peptides differently affect voltage sensor equilibrium and equilibration rates in KCNQ1 K+ channelsQ36325866
Gating of IsK expressed in Xenopus oocytes depends on the amount of mRNA injectedQ36435283
Counting membrane-embedded KCNE beta-subunits in functioning K+ channel complexesQ36446328
KCNQ1 and KCNE1 in the IKs channel complex make state-dependent contacts in their extracellular domainsQ36667897
Location of KCNE1 relative to KCNQ1 in the I(KS) potassium channel by disulfide cross-linking of substituted cysteinesQ37070508
Gating-related molecular motions in the extracellular domain of the IKs channel: implications for IKs channelopathyQ37486999
Nano-environmental changes by KCNE proteins modify KCNQ channel functionQ37886520
KCNE1 binds to the KCNQ1 pore to regulate potassium channel activityQ40543524
TEA(+)-sensitive KCNQ1 constructs reveal pore-independent access to KCNE1 in assembled I(Ks) channelsQ41949170
Structural models for the KCNQ1 voltage-gated potassium channelQ42001843
Location and orientation of minK within the I(Ks) potassium channel complexQ43691940
Primary structure, functional characterization and developmental expression of the ascidian Kv4-class potassium channel.Q44266739
The transmembrane beta-subunits KCNE1, KCNE2, and DPP6 modify pharmacological effects of the antiarrhythmic agent tedisamil on the transient outward current Ito.Q46157083
Short QT syndrome and atrial fibrillation caused by mutation in KCNH2.Q46436523
Voltage sensor of Kv1.2: structural basis of electromechanical couplingQ46588794
Mechanisms by which atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of IKs channelsQ48745779
MinK residues line a potassium channel poreQ49018055
Alteration of channel activities and gating by mutations of slow ISK potassium channel.Q50796495
Charybdotoxin Binding in the IKs Pore Demonstrates Two MinK Subunits in Each Channel ComplexQ58482877
MinK-KvLQT1 fusion proteins, evidence for multiple stoichiometries of the assembled IsK channelQ77677778
Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testingQ81666361
P433issue5
P304page(s)521-535
P577publication date2011-11-01
P1433published inThe Journal of General PhysiologyQ1092259
P1476titleKCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 orthologue
P478volume138

Reverse relations

cites work (P2860)
Q42291315AMPA glutamate receptors are required for sensory-organ formation and morphogenesis in the basal chordate
Q38854252Cardiac Delayed Rectifier Potassium Channels in Health and Disease
Q47928241KCNE1 and KCNE3 modulate KCNQ1 channels by affecting different gating transitions.
Q27027928KCNQ1 channel modulation by KCNE proteins via the voltage-sensing domain
Q35893721Regulation of Voltage-Activated K(+) Channel Gating by Transmembrane β Subunits
Q53042866Steric hindrance between S4 and S5 of the KCNQ1/KCNE1 channel hampers pore opening.
Q37245582Structural basis for KCNE3 modulation of potassium recycling in epithelia
Q38033161The KCNE Tango - How KCNE1 Interacts with Kv7.1.
Q38690407Voltage-Dependent Gating: Novel Insights from KCNQ1 Channels

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