Roles and post-translational regulation of cardiac class IIa histone deacetylase isoforms.

scientific article published on 25 November 2014

Roles and post-translational regulation of cardiac class IIa histone deacetylase isoforms. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1113/JPHYSIOL.2014.282442
P932PMC publication ID4405742
P698PubMed publication ID25362149

P50authorKate L WeeksQ54139861
Metin AvkiranQ30169436
P2093author name stringKate L Weeks
Metin Avkiran
P2860cites workThree proteins define a class of human histone deacetylases related to yeast Hda1pQ22009464
Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5Q22011186
Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressorQ22253464
Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localizationQ22254367
Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiationQ24290523
Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5Q24290618
Cloning and characterization of a histone deacetylase, HDAC9Q24291641
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoRQ24292197
CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophyQ24293269
PP2A regulates HDAC4 nuclear importQ24301735
New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylasesQ24303533
An expression screen reveals modulators of class II histone deacetylase phosphorylationQ24304114
AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5Q24306179
Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiationQ24307379
Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesisQ24309609
Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modificationsQ24324035
Sodium valproate, a histone deacetylase inhibitor, but not captopril, prevents right ventricular hypertrophy in rats.Q43140361
Agonist-induced nuclear export of GFP-HDAC5 in isolated adult rat ventricular myocytesQ45851266
Suppression of HDAC nuclear export and cardiomyocyte hypertrophy by novel irreversible inhibitors of CRM1.Q46026253
Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic bandingQ46870302
Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis.Q47860803
Neurohormonal regulation of cardiac histone deacetylase 5 nuclear localization by phosphorylation-dependent and phosphorylation-independent mechanisms.Q53169145
Valproate attenuates the risk of myocardial infarction in patients with epilepsy: a nationwide cohort studyQ57260389
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Treatment of chronic heart failure with β-adrenergic receptor antagonists: a convergence of receptor pharmacology and clinical cardiologyQ82242423
Caspase-dependent regulation of histone deacetylase 4 nuclear-cytoplasmic shuttling promotes apoptosisQ40568219
The CRM1 nuclear export receptor controls pathological cardiac gene expressionQ40586178
HDAC inhibition suppresses cardiac hypertrophy and fibrosis in DOCA-salt hypertensive rats via regulation of HDAC6/HDAC8 enzyme activityQ41166649
Transgenic overexpression of Hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophyQ41836714
Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription couplingQ41919774
HDAC4 controls histone methylation in response to elevated cardiac loadQ41992090
BET acetyl-lysine binding proteins control pathological cardiac hypertrophyQ42709887
Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failureQ42928039
Maintenance of cardiac energy metabolism by histone deacetylase 3 in miceQ43012174
Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factorsQ24519076
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Epigenetic control of skull morphogenesis by histone deacetylase 8Q24646214
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Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibersQ24673210
Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylasesQ24682791
Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein HopQ24682945
Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assemblyQ27666773
Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failureQ27865207
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylasesQ27934108
Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophyQ28219383
Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene familyQ28252866
A calcineurin-dependent transcriptional pathway for cardiac hypertrophyQ28269300
A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophyQ28504909
Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesisQ28505748
SUMO1-dependent modulation of SERCA2a in heart failureQ28508610
Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activityQ28508698
Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10Q28509194
The transcriptional corepressor MITR is a signal-responsive inhibitor of myogenesisQ28513025
Regulation of acetylation of histone deacetylase 2 by p300/CBP-associated factor/histone deacetylase 5 in the development of cardiac hypertrophyQ28573635
SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytesQ28590015
Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart developmentQ28592216
Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4Q28592681
Chemical phylogenetics of histone deacetylasesQ30977637
Isoform-selective HDAC inhibitors: Closing in on translational medicine for the heartQ33392979
Nuclear Import of Histone Deacetylase 5 by Requisite Nuclear Localization Signal PhosphorylationQ33748395
Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive ratsQ33772867
HDAC6 contributes to pathological responses of heart and skeletal muscle to chronic angiotensin-II signalingQ33913127
Targeted deletion of NF-kappaB p50 diminishes the cardioprotection of histone deacetylase inhibitionQ33917016
Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophyQ33929939
Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repressionQ34088777
HDAC Inhibition Attenuates Inflammatory, Hypertrophic, and Hypertensive Responses in Spontaneously Hypertensive RatsQ34099442
PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophyQ34100575
Essential role of sympathetic endothelin A receptors for adverse cardiac remodelingQ34217961
Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy.Q34319871
BET bromodomains mediate transcriptional pause release in heart failureQ34361491
Nuclear effects of G-protein receptor kinase 5 on histone deacetylase 5-regulated gene transcription in heart failureQ35228115
Spatiotemporally distinct protein kinase D activation in adult cardiomyocytes in response to phenylephrine and endothelinQ35312534
Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4.Q35503840
Back to your heart: ubiquitin proteasome system-regulated signal transductionQ35803035
Inhibition of histone deacetylases preserves myocardial performance and prevents cardiac remodeling through stimulation of endogenous angiomyogenesisQ35847709
Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractilityQ35893654
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylasesQ36141408
Requirement of protein kinase D1 for pathological cardiac remodelingQ36498485
Acute β-adrenergic activation triggers nuclear import of histone deacetylase 5 and delays G(q)-induced transcriptional activationQ36508570
Cardiac hypertrophy induced by sustained beta-adrenoreceptor activation: pathophysiological aspects.Q36771475
HDAC-dependent ventricular remodelingQ36945016
Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemiaQ37095364
The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overloadQ37114848
Defective sumoylation pathway directs congenital heart diseaseQ37273083
Quantitative control of adaptive cardiac hypertrophy by acetyltransferase p300.Q37303806
VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesisQ37353597
Histone deacetylase inhibition blunts ischemia/reperfusion injury by inducing cardiomyocyte autophagy.Q37700043
Inside HDAC with HDAC inhibitorsQ37707623
Therapeutic potential for HDAC inhibitors in the heartQ37937667
The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylasesQ39197659
Dephosphorylation at a conserved SP motif governs cAMP sensitivity and nuclear localization of class IIa histone deacetylasesQ39214537
Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failureQ39951451
Dephosphorylation and caspase processing generate distinct nuclear pools of histone deacetylase 4.Q40106235
Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiationQ40435172
Caspase-mediated specific cleavage of human histone deacetylase 4.Q40543725
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectregulation of gene expressionQ411391
isoformQ609809
human musculoskeletal systemQ726543
cellQ7868
post-translational protein modificationQ898362
cardiomegalyQ1729124
tissueQ40397
enzymeQ8047
circulatory systemQ11068
P304page(s)1785-1797
P577publication date2014-11-25
2015-04-15
P1433published inJournal of PhysiologyQ7743612
P1476titleRoles and post-translational regulation of cardiac class IIa histone deacetylase isoforms
P478volume593

Reverse relations

cites work (P2860)
Q37218059A class of their own: exploring the nondeacetylase roles of class IIa HDACs in cardiovascular disease
Q47567230A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway.
Q53182665Activating transcription factor 3 SUMOylation is involved in angiotensin II-induced endothelial cell inflammation and dysfunction.
Q52689351Bidirectional regulation of HDAC5 by mAKAPβ signalosomes in cardiac myocytes.
Q88453278Epigenetics of Aberrant Cardiac Wound Healing
Q64261117HDAC inhibitors and cardioprotection: Homing in on a mechanism of action
Q93056448Histone deacetylases in cardiovascular and metabolic diseases
Q38974621How cardiomyocytes sense pathophysiological stresses for cardiac remodeling.
Q55625734Inflammation leads through PGE/EP3 signaling to HDAC5/MEF2-dependent transcription in cardiac myocytes.
Q39034552MicroRNA-1 overexpression blunts cardiomyocyte hypertrophy elicited by thyroid hormone.
Q90290390Novel Insight Into the Epigenetic and Post-transcriptional Control of Cardiac Gene Expression by Thyroid Hormone
Q90627698Nucleoporins in cardiovascular disease
Q35541203Promiscuous actions of small molecule inhibitors of the protein kinase D-class IIa HDAC axis in striated muscle
Q50233552Serine/Threonine Kinase 40 (Stk40) Functions as a Novel Regulator of Skeletal Muscle Differentiation
Q87111225Transcriptome and proteome dynamics in the cardiovascular system
Q49917356Understanding Key Mechanisms of Exercise-Induced Cardiac Protection to Mitigate Disease: Current Knowledge and Emerging Concepts
Q41165926β-Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55α-PP2A-Mediated Dephosphorylation.

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