Flavonoids: A versatile source of anticancer drugs

scientific article published on January 2011

Flavonoids: A versatile source of anticancer drugs is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4103/0973-7847.79093
P932PMC publication ID3210013
P698PubMed publication ID22096313

P2093author name stringMahabeer P Dobhal
Neelu Sharma
Yogesh C Joshi
Maheep K Chahar
P2860cites workSignal transduction by receptors with tyrosine kinase activityQ27860624
Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase IIQ28253570
Inhibition of aromatase activity by flavonoidsQ28369087
Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofenQ28377754
The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancerQ29617123
Cancer chemoprevention with dietary phytochemicalsQ29617743
Genistein, a specific inhibitor of tyrosine-specific protein kinasesQ29618097
Oxidative stress, caloric restriction, and agingQ29618229
Cytotoxic flavonoids with isoprenoid groups from Morus mongolicaQ30663344
Cytotoxic mechanism of flavonoid from Temu Kunci (Kaempferia pandurata) in cell culture of human mammary carcinoma.Q30665653
Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines.Q31431628
Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cellsQ31512518
Detrimental effect of cancer preventive phytochemicals silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human prostate carcinoma DU145 cellsQ31912935
Biological properties of citrus flavonoids pertaining to cancer and inflammationQ31922880
Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignanciesQ32173424
Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell linesQ33178761
Topoisomerase I poisons and suppressors as anticancer drugsQ33179504
Dietary flavone is a potent apoptosis inducer in human colon carcinoma cellsQ33180798
Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trialsQ33832656
Tea and tea polyphenols in cancer preventionQ33866238
Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonucleaseQ33957385
Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agentsQ34047187
The therapeutic potential of flavonoidsQ34075072
Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current statusQ34090992
Flavonoids: structural requirements for antiproliferative activity on breast cancer cellsQ34103052
Cancer chemoprevention and apoptosis mechanisms induced by dietary polyphenolicsQ34153260
Receptors for epidermal growth factor and other polypeptide mitogensQ34163558
Growth factor receptor tyrosine kinasesQ34164164
Inhibition of carcinogenesis by dietary polyphenolic compoundsQ34262930
Silymarin: a review of its clinical properties in the management of hepatic disordersQ34344965
Inhibitory effects of flavonoids on xanthine oxidase.Q34348882
Aromatase, aromatase inhibitors, and breast cancerQ34364140
Modulation of pro-epidermal growth factor, pro-transforming growth factor alpha and epidermal growth factor receptor gene expression in human renal carcinomasQ68817821
Genistein arrests cell cycle progression at G2-MQ70586651
In vitro bioassays of non-steroidal phytoestrogensQ70731013
Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cellsQ71725485
Serotonin involvement in the antitumour and host effects of flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acidQ72678276
Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cellsQ73033886
Silibinin up-regulates insulin-like growth factor-binding protein 3 expression and inhibits proliferation of androgen-independent prostate cancer cellsQ73144122
Flavonoid constituents of Chorizanthe diffusa with potential cancer chemopreventive activityQ73187932
Intake of flavonoids and lung cancerQ73365478
Effect of antiproliferative flavonoids on ascorbic acid accumulation in human colon adenocarcinoma cellsQ73494873
Induction of apoptosis by flavones, flavonols (3-hydroxyflavones) and isoprenoid-substituted flavonoids in human oral tumor cell linesQ73686460
Flavonoids suppress androgen-independent human prostate tumor proliferationQ73846530
Anti-tumor effect of methanol extracts from red and white winesQ73889813
Flavonoid-mediated tumor growth suppression demonstrated by in vivo studyQ73890235
Synthesis and antitumour activity of new derivatives of flavone-8-acetic acid (FAA). Part 4: Variation of the basic structureQ74048845
Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potentialQ74081784
Genistein inactivates bcl-2, delays the G2/M phase of the cell cycle, and induces apoptosis of human breast adenocarcinoma MCF-7 cellsQ74450949
Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB 468: induction of G1 arrest through an increase in Cip1/p21 concomitant with a decrease in kinase activity of cyclin-dependent kinases and associatedQ74490610
Contribution of caffeine and flavanols in the induction of hepatic Phase II activities by green teaQ77291834
Promoter activation and following induction of the p21/WAF1 gene by flavone is involved in G1 phase arrest in A549 lung adenocarcinoma cellsQ77518989
Silybin and its bioavailable phospholipid complex (IdB 1016) potentiate in vitro and in vivo the activity of cisplatinQ77741937
Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug developmentQ78049595
Gene expression of angiogenic factors correlates with metastatic potential of prostate cancer cellsQ80408127
Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cellsQ95810045
Polyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional SignificanceQ56610830
INDUCTION OF RAT HEPATIC AND INTESTINAL GLUTATHIONE S-TRANSFERASES AND GLUTATHIONE BY DIETARY NATURALLY-OCCURRING ANTICARCINOGENSQ56701072
Wine Antioxidant Polyphenols Inhibit the Proliferation of Human Prostate Cancer Cell LinesQ58239713
trans-Bis(3-aminoflavone-κ2N,O)bis(perchlorato-κO)copper(II), a new potential antitumour agentQ60642469
Plasma pharmacokinetics of the antitumour agents 5,6-dimethylxanthenone-4-acetic acid, xanthenone-4-acetic acid and flavone-8-acetic acid in miceQ68033249
Inverse relationship of epidermal growth factor receptor and HER2/neu gene expression in human renal cell carcinomaQ68091627
Mutant p53, EGF receptor and c-erbB-2 expression in human breast cancerQ68329499
Dietary agents in cancer prevention: flavonoids and isoflavonoids.Q34386003
Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450.Q34501881
Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: implications for prostate cancer interventionQ36397666
Soy intake and cancer risk: a review of the in vitro and in vivo dataQ36737007
Flavone 8-acetic acid: our current understanding of its mechanism of action in solid tumoursQ38671961
Anticancer effects of the flavonoid diosmetin on cell cycle progression and proliferation of MDA-MB 468 breast cancer cells due to CYP1 activation.Q39855044
Isolated flavonoids against mammary tumour cells LM2.Q39867997
Downregulation of androgen receptor expression by luteolin causes inhibition of cell proliferation and induction of apoptosis in human prostate cancer cells and xenograftsQ40050221
Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cellsQ40162481
Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolinQ40244807
Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3).Q40286264
Mono- or di-fluorinated analogues of flavone-8-acetic acid: synthesis and in vitro biological activity.Q40427393
Induction of apoptosis by flavopiridol unrelated to cell cycle arrest in germ cell tumour derived cell linesQ40427567
A new flavone glycoside and other constituents from Carduus crispus.Q40440712
Anti-tumour effects of nobiletin, a citrus flavonoid, on gastric cancer include: antiproliferative effects, induction of apoptosis and cell cycle deregulationQ40527746
Proanthocyanidins from grape seeds inhibit expression of matrix metalloproteinases in human prostate carcinoma cells, which is associated with the inhibition of activation of MAPK and NF kappa B.Q40595966
The flavonoids. A class of semi-essential food components: their role in human nutritionQ40621696
Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin.Q40779802
Quercetin-induced apoptosis in the monoblastoid cell line U937 in vitro and the regulation of heat shock proteins expressionQ40825003
Effect of tea polyphenols on growth of oral squamous carcinoma cells in vitroQ40835508
In vitro evaluation of newly developed chalcone analogues in human cancer cellsQ40846107
The inhibitory effect of curcumin, genistein, quercetin and cisplatin on the growth of oral cancer cells in vitroQ40864077
Signal pathways involved in apigenin inhibition of growth and induction of apoptosis of human anaplastic thyroid cancer cells (ARO).Q40907122
Effect of antioxidants on androgen-induced AP-1 and NF-kappaB DNA-binding activity in prostate carcinoma cellsQ40940877
Increased UDP-glucuronosyltransferase activity and decreased prostate specific antigen production by biochanin A in prostate cancer cells.Q41035469
The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines.Q41075336
Interaction with type II estrogen binding sites and antiproliferative activity of tamoxifen and quercetin in human non-small-cell lung cancerQ41102292
Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cellsQ41500347
NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules.Q41545817
NF-kappaB activation: the I kappaB kinase revealed?Q41639488
Growth inhibitory effects of flavonoids in human thyroid cancer cell linesQ41663672
Overexpression of epidermal growth factor and insulin-like growth factor-I receptors and autocrine stimulation in human esophageal carcinoma cellsQ41688902
Cellular growth response to epidermal growth factor in colon carcinoma cells with an amplified epidermal growth factor receptor derived from a familial adenomatous polyposis patientQ41693276
Effect of catechins and citrus flavonoids on invasion in vitro.Q41703296
Chemopreventive effects of diosmin and hesperidin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary-bladder carcinogenesis in male ICR miceQ42448104
Chemoprevention of 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis by the dietary flavonoids chalcone, 2-hydroxychalcone, and quercetinQ42526345
Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats by flavonoids diosmin and hesperidin, each alone and in combination.Q42528835
Cellular DNA breakage by soy isoflavone genistein and its methylated structural analogue biochanin A.Q43278707
Suppression by flavonoids of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells: structure-activity relationshipQ43505665
Phytoestrogen interaction with estrogen receptors in human breast cancer cellsQ43548451
Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1.Q43588630
Inhibitory effect of silibinin on ligand binding to erbB1 and associated mitogenic signaling, growth, and DNA synthesis in advanced human prostate carcinoma cellsQ43603245
Inhibition of environmental estrogen-induced proliferation of human breast carcinoma MCF-7 cells by flavonoidsQ43712657
Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matriQ43893142
Synthesis and aromatase inhibitory activity of flavanonesQ43948084
A comparative study of growth-inhibitory effects of isoflavones and their metabolites on human breast and prostate cancer cell lines.Q44204714
Stimulation of macrophage tumouricidal activity by 5,6-dimethyl-xanthenone-4-acetic acid, a potent analogue of the antitumour agent flavone-8-acetic acidQ44262858
Inhibitory effect of Perilla leaf extract and luteolin on mouse skin tumor promotionQ44388910
Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogensQ44517404
Discovering novel quercetin-3-O-amino acid-esters as a new class of Src tyrosine kinase inhibitorsQ46223745
Activation of tumor-associated macrophages by the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid induces an effective CD8+ T-cell-mediated antitumor immune response in murine models of lung cancer and mesotheliomaQ46853209
Estimates of the worldwide incidence of 25 major cancers in 1990.Q50638996
Molecular mechanisms in the antiproliferative action of quercetin.Q51107593
Suppression by apigenin of peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats.Q53392573
Comparative chemopreventive mechanisms of green tea, black tea and selected polyphenol extracts measured by in vitro bioassays.Q53415588
Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin.Q53443691
Antioxidant and antipromotional effects of the soybean isoflavone genistein.Q53467259
Isozyme- and species-specific susceptibility of cDNA-expressed CYP1A P-450s to different flavonoids.Q53472909
Mechanisms involved in the chemoprevention of flavonoids.Q53788134
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)1-12
P577publication date2011-01-01
P1433published inPharmacognosy ReviewsQ7180783
P1476titleFlavonoids: A versatile source of anticancer drugs
P478volume5

Reverse relations

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