α-Actinin-3: why gene loss is an evolutionary gain

scientific article published on 15 January 2015

α-Actinin-3: why gene loss is an evolutionary gain is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PGEN.1004908
P932PMC publication ID4295838
P698PubMed publication ID25590140
P5875ResearchGate publication ID270964310

P50authorNiklas IvarssonQ42476977
Hakan WesterbladQ44578418
P2093author name stringHåkan Westerblad
Niklas Ivarsson
P2860cites workHypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscleQ24308714
Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacityQ24649499
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1Q28131760
Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humansQ28513670
Calsequestrin content and SERCA determine normal and maximal Ca2+ storage levels in sarcoplasmic reticulum of fast- and slow-twitch fibres of ratQ28572127
The variant call format and VCFtoolsQ29614172
Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy.Q34083138
ACTN3 allele frequency in humans covaries with global latitudinal gradientQ34566418
Deficiency of a skeletal muscle isoform of α-actinin (α-actinin-3) in merosin-positive congenital muscular dystrophyQ57394329
Increased activity of citrate synthase in human skeletal muscle after a single bout of prolonged exerciseQ73947051
Calcium induces increases in peroxisome proliferator-activated receptor gamma coactivator-1alpha and mitochondrial biogenesis by a pathway leading to p38 mitogen-activated protein kinase activationQ80292775
ACTN3 (R577X) genotype is associated with fiber type distributionQ81234651
Altered Ca2+ kinetics associated with α-actinin-3 deficiency may explain positive selection for ACTN3 null allele in human evolutionQ34973567
Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging.Q36949333
ACTN3 genotype influences muscle performance through the regulation of calcineurin signaling.Q37200853
PGC-1 coactivators and skeletal muscle adaptations in health and diseaseQ37265277
Nonshivering thermogenesis protects against defective calcium handling in muscleQ37693532
Nonshivering thermogenesis and its adequate measurement in metabolic studiesQ37823045
The role of in vivo Ca²⁺ signals acting on Ca²⁺-calmodulin-dependent proteins for skeletal muscle plasticityQ37930824
Increased fatigue resistance linked to Ca2+-stimulated mitochondrial biogenesis in muscle fibres of cold-acclimated miceQ42476920
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectgene lossQ115957864
P304page(s)e1004908
P577publication date2015-01-15
P1433published inPLOS GeneticsQ1893441
P1476titleα-Actinin-3: why gene loss is an evolutionary gain
P478volume11

Reverse relations

cites work (P2860)
Q39134408ACTN3 X-allele carriers had greater levels of muscle damage during a half-ironman.
Q38982708ACTN3 genotype influences exercise-induced muscle damage during a marathon competition.

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