Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

scientific article

Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1026413422
P356DOI10.1038/NM.1916
P3181OpenCitations bibliographic resource ID29723
P932PMC publication ID2910579
P698PubMed publication ID19198614
P5875ResearchGate publication ID23986115

P50authorSteven R. ReikenQ114724674
P2093author name stringAlain Lacampagne
Andrew R Marks
Marco Mongillo
Stefan Matecki
Xiaoping Liu
Andrew M Bellinger
Christian Carlson
Lisa Rothman
P2860cites workSerum CK, calcium, magnesium, and oxidative phosphorylation in mdx mouse muscular dystrophyQ67938640
Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylationQ74016180
Ca2+-independent phospholipase A2 enhances store-operated Ca2+ entry in dystrophic skeletal muscle fibersQ80153311
Uncontrolled calcium sparks act as a dystrophic signal for mammalian skeletal muscleQ81657096
PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing heartsQ22254160
Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophyQ24307833
Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failureQ24530067
Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacityQ24649499
Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippersQ24678432
Rescue of dystrophic muscle through U7 snRNA-mediated exon skippingQ28291830
iNOS expression in dystrophinopathies can be reduced by somatic gene transfer of dystrophin or utrophinQ28344971
Association of dystrophin-related protein with dystrophin-associated proteins in mdx mouse muscleQ28510608
Dystrophin: the protein product of the Duchenne muscular dystrophy locusQ29618077
rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice.Q30602105
Alteration in calcium handling at the subcellular level in mdx myotubes.Q31456406
Cysteine-3635 is responsible for skeletal muscle ryanodine receptor modulation by NOQ33944345
Function and genetics of dystrophin and dystrophin-related proteins in muscleQ34120764
Pharmacological strategies for muscular dystrophyQ35128906
A nitric oxide synthase transgene ameliorates muscular dystrophy in mdx miceQ36294012
PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: defective regulation in heart failureQ36325042
Increased calcium influx in dystrophic muscleQ36530501
Sarcolemma-localized nNOS is required to maintain activity after mild exerciseQ36987100
Neuronal nitric oxide synthase and dystrophin-deficient muscular dystrophyQ37387484
Heregulin ameliorates the dystrophic phenotype in mdx miceQ37533952
alpha1-syntrophin gene disruption results in the absence of neuronal-type nitric-oxide synthase at the sarcolemma but does not induce muscle degenerationQ38329382
Intracellular calcium accumulation in Duchenne dystrophy and other myopathies: a study of 567,000 muscle fibers in 114 biopsiesQ39486051
Studies of sarcolemmal integrity in myopathic muscleQ39498832
Coupled gating between individual skeletal muscle Ca2+ release channels (ryanodine receptors)Q41018951
Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding proteinQ41467443
Involvement of TRPC in the abnormal calcium influx observed in dystrophic (mdx) mouse skeletal muscle fibersQ41882302
Overexpression of a calpastatin transgene in mdx muscle reduces dystrophic pathologyQ44159151
Increased activity of calcium leak channels in myotubes of Duchenne human and mdx mouse originQ44177784
Nitric oxide, NOC-12, and S-nitrosoglutathione modulate the skeletal muscle calcium release channel/ryanodine receptor by different mechanisms. An allosteric function for O2 in S-nitrosylation of the channelQ44267719
Duchenne muscular dystrophy: deficiency of dystrophin at the muscle cell surfaceQ44350613
S-glutathionylation decreases Mg2+ inhibition and S-nitrosylation enhances Ca2+ activation of RyR1 channelsQ44550513
Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse.Q45140549
Increased protein degradation results from elevated free calcium levels found in muscle from mdx miceQ46266620
Effects of S-glutathionylation and S-nitrosylation on calmodulin binding to triads and FKBP12 binding to type 1 calcium release channels.Q46584340
Calcium entry through stretch-inactivated ion channels in mdx myotubesQ46603395
Calpains are activated in necrotic fibers from mdx dystrophic miceQ49165175
Evidence ofmdx mouse skeletal muscle fragility in vivo by eccentric running exerciseQ58109283
p66ShcAand Oxidative Stress Modulate Myogenic Differentiation and Skeletal Muscle Regeneration after Hind Limb IschemiaQ62236571
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectDystrophinQ412285
Dystrophin, muscular dystrophyQ14864296
negative regulation of peptidyl-cysteine S-nitrosylationQ21115225
FK506 binding protein 1aQ21498441
Ryanodine receptor 1, skeletal muscleQ21980348
P304page(s)325-30
P577publication date2009-03-01
P1433published inNature MedicineQ1633234
P1476titleHypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle
P478volume15

Reverse relations

cites work (P2860)
Q93000816A Mechanism for Statin-Induced Susceptibility to Myopathy
Q41147415A TGF-β pathway associated with cancer cachexia
Q39310989A change of heart: oxidative stress in governing muscle function?
Q37761772A rapid approach for the detection, quantification, and discovery of novel sulfenic acid or S-nitrosothiol modified proteins using a biotin-switch method.
Q89842749AMPK Complex Activation Promotes Sarcolemmal Repair in Dysferlinopathy
Q40390266Ablation of the cardiac ryanodine receptor phospho-site Ser2808 does not alter the adrenergic response or the progression to heart failure in mice. Elimination of the genetic background as critical variable
Q26852587Abnormal Ca(2+) cycling in failing ventricular myocytes: role of NOS1-mediated nitroso-redox balance
Q36422465Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy.
Q37805925Acute effects of reactive oxygen and nitrogen species on the contractile function of skeletal muscle.
Q38838750Age-induced oxidative stress: how does it influence skeletal muscle quantity and quality?
Q42483409Age-related regulation of excitation-contraction coupling in rat heart
Q37601041Alterations in mitochondrial function as a harbinger of cardiomyopathy: lessons from the dystrophic heart
Q34335939Altered cross-bridge properties in skeletal muscle dystrophies
Q35116100Altered myocardial calcium cycling and energetics in heart failure--a rational approach for disease treatment
Q36837270Altered sarcoplasmic reticulum calcium cycling--targets for heart failure therapy
Q33589145Androgen receptors in muscle fibers induce rapid loss of force but not mass: implications for spinal bulbar muscular atrophy.
Q90005528Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights
Q35977425Antioxidants protect calsequestrin-1 knockout mice from halothane- and heat-induced sudden death
Q39424672Are Antioxidants a Potential Therapy for FSHD? A Review of the Literature
Q91957452Assays for Modulators of Ryanodine Receptor (RyR)/Ca2+ Release Channel Activity for Drug Discovery for Skeletal Muscle and Heart Diseases
Q35997011Assessment of muscle mass and strength in mice
Q47709918Association of FK506 binding proteins with RyR channels - effect of CLIC2 binding on sub-conductance opening and FKBP binding.
Q91627122Blockade of IGF2R improves muscle regeneration and ameliorates Duchenne muscular dystrophy
Q35915888Blockage of the Ryanodine Receptor via Azumolene Does Not Prevent Mechanical Ventilation-Induced Diaphragm Atrophy
Q39302913Ca2+ Release Channels Join the 'Resolution Revolution'.
Q39493909Ca2+ cycling and new therapeutic approaches for heart failure
Q46308630Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in skeletal and cardiac muscle
Q27001582Ca2+-dependent regulations and signaling in skeletal muscle: from electro-mechanical coupling to adaptation
Q90194088Calcium Mechanisms in Limb-Girdle Muscular Dystrophy with CAPN3 Mutations
Q36497155Calcium cycling proteins and heart failure: mechanisms and therapeutics
Q37072276Calcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia.
Q64105856Cancer- and Chemotherapy-Induced Musculoskeletal Degradation
Q38493236Cancer-associated muscle weakness: What's bone got to do with it?
Q92825511Cardiac Pathophysiology and the Future of Cardiac Therapies in Duchenne Muscular Dystrophy
Q38103213Cardiac and respiratory dysfunction in Duchenne muscular dystrophy and the role of second messengers.
Q36736081Cardiac phenotype of Duchenne Muscular Dystrophy: insights from cellular studies
Q35048166Catecholamine-independent heart rate increases require Ca2+/calmodulin-dependent protein kinase II.
Q91986708Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity
Q42720847Comparison of Reductive Ligation-Based Detection Strategies for Nitroxyl (HNO) and S-Nitrosothiols
Q38751812Coupling of excitation to Ca2+ release is modulated by dysferlin.
Q26770423Critical Role of Intracellular RyR1 Calcium Release Channels in Skeletal Muscle Function and Disease
Q39225878Dantrolene enhances antisense-mediated exon skipping in human and mouse models of Duchenne muscular dystrophy
Q87368518Dihydropyridine receptors actively control gating of ryanodine receptors in resting mouse skeletal muscle fibres
Q38480698Drug Discovery of Therapies for Duchenne Muscular Dystrophy
Q24336808Dysfunctional ryanodine receptors in the heart: new insights into complex cardiovascular diseases
Q89782554Dysregulation of Calcium Handling in Duchenne Muscular Dystrophy-Associated Dilated Cardiomyopathy: Mechanisms and Experimental Therapeutic Strategies
Q98185959Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling
Q38257886Dysregulation of calcium homeostasis in muscular dystrophies.
Q53636857Dystrophic cardiomyopathy: role of TRPV2 channels in stretch-induced cell damage.
Q37111473Dystrophin restoration therapy improves both the reduced excitability and the force drop induced by lengthening contractions in dystrophic mdx skeletal muscle
Q44882443Editorial for "Methods for analysis of nitric oxide signalling by S-nitrosylation".
Q28535427Effect of Calstabin1 depletion on calcium transients and energy utilization in muscle fibers and treatment opportunities with RyR1 stabilizers
Q35051963Effects of Dantrolene Therapy on Disease Phenotype in Dystrophin Deficient mdx Mice.
Q35690856Endpoint measures in the mdx mouse relevant for muscular dystrophy pre-clinical studies
Q30512833Enhancing muscle membrane repair by gene delivery of MG53 ameliorates muscular dystrophy and heart failure in δ-Sarcoglycan-deficient hamsters.
Q36048495Enzymatic mechanisms regulating protein S-nitrosylation: implications in health and disease
Q34800076Ethanol enhances carbachol-induced protease activation and accelerates Ca2+ waves in isolated rat pancreatic acini
Q41902894Excess SMAD signaling contributes to heart and muscle dysfunction in muscular dystrophy
Q36258000Excess TGF-β mediates muscle weakness associated with bone metastases in mice
Q42046918Excitation-Contraction Coupling Alterations in Myopathies
Q90603132Exploiting Peptidomimetics to Synthesize Compounds That Activate Ryanodine Receptor Calcium Release Channels
Q43146405Extinguishing intracellular calcium leak: a promising antiarrhythmic approach
Q42005319FKBP12.6 activates RyR1: investigating the amino acid residues critical for channel modulation
Q41683737Fixing ryanodine receptor Ca leak - a novel therapeutic strategy for contractile failure in heart and skeletal muscle.
Q46060420Fixing the leak
Q36309327Focal but reversible diastolic sheet dysfunction reflects regional calcium mishandling in dystrophic mdx mouse hearts.
Q38412593GSNOR Deficiency Enhances In Situ Skeletal Muscle Strength, Fatigue Resistance, and RyR1 S-Nitrosylation Without Impacting Mitochondrial Content and Activity
Q28085320Genetic evidence in the mouse solidifies the calcium hypothesis of myofiber death in muscular dystrophy
Q34059173Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy
Q34409213Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging
Q34792390High throughput screening in duchenne muscular dystrophy: from drug discovery to functional genomics
Q28591442Hsp72 preserves muscle function and slows progression of severe muscular dystrophy
Q38554891Human sports drug testing by mass spectrometry
Q37657529Hyperactive adverse mechanical stress responses in dystrophic heart are coupled to transient receptor potential canonical 6 and blocked by cGMP-protein kinase G modulation.
Q39120000Hyperthermic seizures and aberrant cellular homeostasis in Drosophila dystrophic muscles.
Q34121401Impaired S-nitrosylation of the ryanodine receptor caused by xanthine oxidase activity contributes to calcium leak in heart failure
Q36033118Increased resting intracellular calcium modulates NF-κB-dependent inducible nitric-oxide synthase gene expression in dystrophic mdx skeletal myotubes
Q44826878Increased sarcolipin expression and decreased sarco(endo)plasmic reticulum Ca2+ uptake in skeletal muscles of mouse models of Duchenne muscular dystrophy
Q34542698Inflammatory monocytes promote progression of Duchenne muscular dystrophy and can be therapeutically targeted via CCR2.
Q36707428Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy.
Q34485229Intense resistance exercise induces early and transient increases in ryanodine receptor 1 phosphorylation in human skeletal muscle
Q37011991Interactions between sarco-endoplasmic reticulum and mitochondria in cardiac and skeletal muscle - pivotal roles in Ca²⁺ and reactive oxygen species signaling
Q48112565Intracellular calcium release channels: an update.
Q39791357Investigation of the in vitro metabolism of the emerging drug candidate S107 for doping-preventive purposes
Q37452338Latent TGF-beta-binding protein 4 modifies muscular dystrophy in mice
Q24295360Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy
Q37181836Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation
Q40120301Leaky ryanodine receptors delay the activation of store overload-induced Ca2+ release, a mechanism underlying malignant hyperthermia-like events in dystrophic muscle
Q42149020Leaky ryanodine receptors in β-sarcoglycan deficient mice: a potential common defect in muscular dystrophy.
Q36202652Lipogenesis mitigates dysregulated sarcoplasmic reticulum calcium uptake in muscular dystrophy
Q26799652Malignant hyperthermia: a review
Q33911293Mapping the ryanodine receptor FK506-binding protein subunit using fluorescence resonance energy transfer
Q34985557Mass spectrometric analysis and mutagenesis predict involvement of multiple cysteines in redox regulation of the skeletal muscle ryanodine receptor ion channel complex
Q89480969Mechanical factors tune the sensitivity of mdx muscle to eccentric strength loss and its protection by antioxidant and calcium modulators
Q28383415Mechanism-based triarylphosphine-ester probes for capture of endogenous RSNOs
Q39100152Mechanisms Explaining Muscle Fatigue and Muscle Pain in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a Review of Recent Findings.
Q33950716Mechanisms of muscle weakness in muscular dystrophy
Q38102887Methods for detection and characterization of protein S-nitrosylation
Q33647871Microarchitecture is severely compromised but motor protein function is preserved in dystrophic mdx skeletal muscle
Q28393648Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity
Q34627089Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle
Q35213316Mitochondrial calcium uptake regulates rapid calcium transients in skeletal muscle during excitation-contraction (E-C) coupling
Q35447198Modifications of skeletal muscle ryanodine receptor type 1 and exercise intolerance in heart failure.
Q52605494Modulation of contractile apparatus Ca2+ sensitivity and disruption of excitation-contraction coupling by S-nitrosoglutathione in rat muscle fibres.
Q89985565Molecular regulation of skeletal muscle mass and the contribution of nitric oxide: A review
Q34720150Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins
Q41688477Muscle Weakness in Rheumatoid Arthritis: The Role of Ca2+ and Free Radical Signaling.
Q86291937Muscular dystrophies
Q51781252NO may prompt calcium leakage in dystrophic muscle.
Q57292416Nanoscale remodeling of ryanodine receptor cluster size underlies cerebral microvascular dysfunction in Duchenne muscular dystrophy
Q36394350Nanospan, an alternatively spliced isoform of sarcospan, localizes to the sarcoplasmic reticulum in skeletal muscle and is absent in limb girdle muscular dystrophy 2F.
Q35986842Naproxcinod shows significant advantages over naproxen in the mdx model of Duchenne Muscular Dystrophy
Q43289460Negative modulation of inositol 1,4,5-trisphosphate type 1 receptor expression prevents dystrophin-deficient muscle cells death
Q47983739Neuromuscular diseases in children: a practical approach
Q28390869Neuronal nitric oxide synthase is dislocated in type I fibers of myalgic muscle but can recover with physical exercise training
Q46585617Nicorandil, a Nitric Oxide Donor and ATP-Sensitive Potassium Channel Opener, Protects Against Dystrophin-Deficient Cardiomyopathy
Q35069506Nifedipine treatment reduces resting calcium concentration, oxidative and apoptotic gene expression, and improves muscle function in dystrophic mdx mice
Q38153038Nitric Oxide-Induced Calcium Release: Activation of Type 1 Ryanodine Receptor, a Calcium Release Channel, through Non-Enzymatic Post-Translational Modification by Nitric Oxide
Q37309661Nitric Oxide-induced Activation of the Type 1 Ryanodine Receptor Is Critical for Epileptic Seizure-induced Neuronal Cell Death.
Q38196172Nitric oxide synthase regulation of cardiac excitation-contraction coupling in health and disease
Q40514382Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function
Q41566729Nitric oxide-induced calcium release: activation of type 1 ryanodine receptor by endogenous nitric oxide
Q36150149Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness
Q35027817Nitrosative stress elicited by nNOSµ delocalization inhibits muscle force in dystrophin-null mice
Q41834889Nitrosative stress in human skeletal muscle attenuated by exercise countermeasure after chronic disuse.
Q28072269Nutraceuticals and Their Potential to Treat Duchenne Muscular Dystrophy: Separating the Credible from the Conjecture
Q47404613Osteolytic Breast Cancer Causes Skeletal Muscle Weakness in an Immunocompetent Syngeneic Mouse Model
Q46262861Oxidative stress, NF-κB and the ubiquitin proteasomal pathway in the pathology of calpainopathy
Q34213979Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4
Q84043011Passive stretch reduces calpain activity through nitric oxide pathway in unloaded soleus muscles
Q36169155Patient-Specific Human Induced Pluripotent Stem Cell Model Assessed with Electrical Pacing Validates S107 as a Potential Therapeutic Agent for Catecholaminergic Polymorphic Ventricular Tachycardia
Q39410461Pharmacological therapeutics targeting the secondary defects and downstream pathology of Duchenne muscular dystrophy
Q48219682Physiology and pathophysiology of excitation-contraction coupling: the functional role of ryanodine receptor
Q35974809Porcine models of muscular dystrophy
Q35020178Protein S-nitrosylation in health and disease: a current perspective
Q43279398Protein denitrosylation: enzymatic mechanisms and cellular functions.
Q34171097Proteomic identification of S-nitrosylated Golgi proteins: new insights into endothelial cell regulation by eNOS-derived NO.
Q37676955Proteomic profiling of x-linked muscular dystrophy
Q37166776Quantitative site-specific reactivity profiling of S-nitrosylation in mouse skeletal muscle using cysteinyl peptide enrichment coupled with mass spectrometry
Q30576097Rapamycin nanoparticles target defective autophagy in muscular dystrophy to enhance both strength and cardiac function
Q42452644Reciprocal amplification of ROS and Ca(2+) signals in stressed mdx dystrophic skeletal muscle fibers.
Q64447696Recovery of respiratory function in mdx mice co-treated with neutralizing interleukin-6 receptor antibodies and urocortin-2
Q26774782Redox Characterization of Functioning Skeletal Muscle
Q39059046Redox Control of Skeletal Muscle Regeneration.
Q42380533Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice
Q35033112Regulation of Ryanodine Receptor Ion Channels Through Posttranslational Modifications
Q42663223Regulation of myocyte contraction via neuronal nitric oxide synthase: role of ryanodine receptor S-nitrosylation
Q55000730Repurposing Dantrolene for Long-Term Combination Therapy to Potentiate Antisense-Mediated DMD Exon Skipping in the mdx Mouse.
Q47959400Respiratory muscle contractile inactivity induced by mechanical ventilation in piglets leads to leaky ryanodine receptors and diaphragm weakness
Q28078420Review of RyR1 pathway and associated pathomechanisms
Q89459214Role of defective Ca2+ signaling in skeletal muscle weakness: Pharmacological implications
Q28511926Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction
Q89532069RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays
Q58600210Ryanodine Receptor 1-Related Myopathies: Diagnostic and Therapeutic Approaches
Q52339083Ryanodine Receptor Calcium Leak in Circulating B-Lymphocytes as a Biomarker in Heart Failure.
Q49721336Ryanodine Receptor Structure and Function in Health and Disease
Q47665947Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy
Q36279483Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease
Q33912937Ryanodine receptor channelopathies
Q36394470Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise.
Q28508488Ryanodine receptor leak mediated by caspase-8 activation leads to left ventricular injury after myocardial ischemia-reperfusion
Q37687548Ryanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction.
Q36949333Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging.
Q38054907Ryanodine receptor patents
Q37705608Ryanodine receptor studies using genetically engineered mice
Q38217975Ryanodine receptors: physiological function and deregulation in Alzheimer disease.
Q34024377Ryanodine receptors: structure, expression, molecular details, and function in calcium release.
Q36079230S-Nitrosylation of cardiac ion channels
Q37592652S-nitrosation and ubiquitin-proteasome system interplay in neuromuscular disorders
Q33862264S-nitrosoglutathione reductase deficiency-induced S-nitrosylation results in neuromuscular dysfunction.
Q51759239S-nitrosylation drives cell senescence and aging in mammals by controlling mitochondrial dynamics and mitophagy.
Q36497166S-nitrosylation: integrator of cardiovascular performance and oxygen delivery
Q35789210Sarcoplasmic reticulum Ca2+ permeation explored from the lumen side in mdx muscle fibers under voltage control
Q33827719Sildenafil increases muscle protein synthesis and reduces muscle fatigue.
Q92937460Single SERCA2a Therapy Ameliorated Dilated Cardiomyopathy for 18 Months in a Mouse Model of Duchenne Muscular Dystrophy
Q50063914Single-channel recordings of RyR1 at microsecond resolution in CMOS-suspended membranes.
Q42918124Site-specific modification of calmodulin Ca2+ affinity tunes the skeletal muscle ryanodine receptor activation profile
Q33602302Skeletal muscle Ca(2+) mishandling: Another effect of bone-to-muscle signaling
Q36820423Skeletal muscle function during exercise-fine-tuning of diverse subsystems by nitric oxide
Q92371092Small calcium leaks, big muscle adaptations
Q35250678Special article: Future directions in malignant hyperthermia research and patient care
Q34562748Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the 1,4-benzothiazepine derivative S107
Q44929041Stress and muscular dystrophy: a genetic screen for dystroglycan and dystrophin interactors in Drosophila identifies cellular stress response components
Q44740208Stress-induced increase in skeletal muscle force requires protein kinase A phosphorylation of the ryanodine receptor
Q57656681Structural Details of the Ryanodine Receptor Calcium Release Channel and Its Gating Mechanism
Q34451822Structure of a mammalian ryanodine receptor
Q37938337Sub-cellular targeting of constitutive NOS in health and disease
Q34028253Subcellular Ca2+ signaling in the heart: the role of ryanodine receptor sensitivity
Q37885158Targeting ryanodine receptors for anti-arrhythmic therapy
Q39120074The Role of TGFβ in Bone-Muscle Crosstalk
Q34505314The Ryanodine Receptor in Cardiac Physiology and Disease
Q27665591The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule
Q37946876The dystrophin-glycoprotein complex in the prevention of muscle damage
Q51625827The effect of taurine and β-alanine supplementation on taurine transporter protein and fatigue resistance in skeletal muscle from mdx mice.
Q91105830The panniculus carnosus muscle: A novel model of striated muscle regeneration that exhibits sex differences in the mdx mouse
Q38104503The physiological response of protease inhibition in dystrophic muscle
Q33630112The stress protein/chaperone Grp94 counteracts muscle disuse atrophy by stabilizing subsarcolemmal neuronal nitric oxide synthase.
Q47350159Transient receptor potential channel 6 regulates abnormal cardiac S-nitrosylation in Duchenne muscular dystrophy
Q52756417Treating pediatric neuromuscular disorders: The future is now.
Q28484851Treatment with a nitric oxide-donating NSAID alleviates functional muscle ischemia in the mouse model of Duchenne muscular dystrophy
Q35340211Triadopathies: an emerging class of skeletal muscle diseases
Q28573445Upregulation of the CaV 1.1-ryanodine receptor complex in a rat model of critical illness myopathy
Q54960330Very Low Volume High-Intensity Interval Exercise Is More Effective in Young Than Old Women.
Q35236912Whole body periodic acceleration is an effective therapy to ameliorate muscular dystrophy in mdx mice
Q33955159iNOS ablation does not improve specific force of the extensor digitorum longus muscle in dystrophin-deficient mdx4cv mice
Q39310461nNOS regulation of skeletal muscle fatigue and exercise performance
Q64073142nNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis
Q35543033α-Actinin-3: why gene loss is an evolutionary gain