Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice (scientific article published on 20 October 2017)

Intracellular calcium and myosin isoform transitions. Calcineurin and calcium-calmodulin kinase pathways regulate preferential activation of the IIa myosin heavy chain promoter

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Enhanced Ca2+ transport and muscle relaxation in skeletal muscle from sarcolipin-null mice

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Association of dystrophin-related protein with dystrophin-associated proteins in mdx mouse muscle

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A micropeptide encoded by a putative long noncoding RNA regulates muscle performance

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Cardiac specific expression of threonine 5 to alanine mutant sarcolipin results in structural remodeling and diastolic dysfunction

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Metabolic dysfunction and altered mitochondrial dynamics in the utrophin-dystrophin deficient mouse model of duchenne muscular dystrophy

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Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2

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Hsp72 preserves muscle function and slows progression of severe muscular dystrophy

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Dystrophin: the protein product of the Duchenne muscular dystrophy locus

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An intronic LINE-1 element insertion in the dystrophin gene aborts dystrophin expression and results in Duchenne-like muscular dystrophy in the corgi breed

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Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals.

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Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload.

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SERCA pump isoforms: their role in calcium transport and disease

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Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle

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Decreased sarcolipin protein expression and enhanced sarco(endo)plasmic reticulum Ca2+ uptake in human atrial fibrillation

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SERCA2a gene transfer improves electrocardiographic performance in aged mdx mice

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Selective Connexin43 Inhibition Prevents Isoproterenol-Induced Arrhythmias and Lethality in Muscular Dystrophy Mice

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AAV micro-dystrophin gene therapy alleviates stress-induced cardiac death but not myocardial fibrosis in >21-m-old mdx mice, an end-stage model of Duchenne muscular dystrophy cardiomyopathy.

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Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice

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Diaphragm displays early and progressive functional deficits in dysferlin-deficient mice

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Emerging drugs for Duchenne muscular dystrophy

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Pseudotyped adeno-associated virus 2/9-delivered CCL11 shRNA alleviates lung inflammation in an allergen-sensitized mouse model

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Muscle damage in mdx (dystrophic) mice: role of calcium and reactive oxygen species.

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Progress in gene therapy of dystrophic heart disease

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Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin-free skeletal muscle

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Differential expression of sarcolipin protein during muscle development and cardiac pathophysiology

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Cardiac expression of a mini-dystrophin that normalizes skeletal muscle force only partially restores heart function in aged Mdx mice.

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Pathways of abnormal stress-induced Ca2+ influx into dystrophic mdx cardiomyocytes

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Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism

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Increased sarcolipin expression and adrenergic drive in humans with preserved left ventricular ejection fraction and chronic isolated mitral regurgitation.

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Impairment of cardiac autonomic function in patients with Duchenne muscular dystrophy: Relationship to myocardial and respiratory function

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An error in dystrophin mRNA processing in golden retriever muscular dystrophy, an animal homologue of Duchenne muscular dystrophy

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Changes in intracellular ionized Ca concentration associated with muscle fiber type transformation

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The sarcoplasmic reticulum calcium pump is functionally altered in dystrophic muscle

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Corticosteroids decrease mRNA levels of SERCA pumps, whereas they increase sarcolipin mRNA in the rat diaphragm

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Expression of excitation-contraction coupling proteins during muscle differentiation

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Down-regulation of sarcolipin mRNA expression in chronic atrial fibrillation

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Intraperitoneal AAV9-shRNA inhibits target expression in neonatal skeletal and cardiac muscles

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Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management

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Calcium and the damage pathways in muscular dystrophy

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Review of Duchenne Muscular Dystrophy (DMD) for the Pediatricians in the Community

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Cardiac Assessment in Duchenne and Becker Muscular Dystrophies

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Pathophysiology and therapy of cardiac dysfunction in Duchenne muscular dystrophy

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Sarcolipin: A Key Thermogenic and Metabolic Regulator in Skeletal Muscle

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Dominant-negative inhibition of Ca2+ influx via TRPV2 ameliorates muscular dystrophy in animal models

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Synaptic abnormalities of mice lacking toll-like receptor (TLR)-9.

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Post-transcriptional downregulation of sarcolipin mRNA by triiodothyronine in the atrial myocardium.

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Insect cells as a factory to produce adeno-associated virus type 2 vectors

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Reduction in intracellular calcium levels inhibits myoblast differentiation

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Overexpression of SERCA1a in the mdx diaphragm reduces susceptibility to contraction-induced damage

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Involvement of the dihydropyridine receptor and internal Ca2+ stores in myoblast fusion

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Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation

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Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy

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Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides

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Sarcoplasmic reticulum function in slow- and fast-twitch skeletal muscles from mdx mice

Q44113196

Duchenne muscular dystrophy: deficiency of dystrophin at the muscle cell surface

Q44350613

Muscle genome-wide expression profiling during disease evolution in mdx mice.

Q44471658

Increased sarcolipin expression and decreased sarco(endo)plasmic reticulum Ca2+ uptake in skeletal muscles of mouse models of Duchenne muscular dystrophy

Q44826878

Fast-twitch skeletal muscles of dystrophic mouse pups are resistant to injury from acute mechanical stress

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Intrathecal shRNA-AAV9 inhibits target protein expression in the spinal cord and dorsal root ganglia of adult mice

Q45879078

Abnormalities in intracellular Ca2+ regulation contribute to the pathomechanism of Tako-Tsubo cardiomyopathy.

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Effect of cyclopiazonic acid, an inhibitor of the sarcoplasmic reticulum Ca-ATPase, on skeletal muscles from normal and mdx mice

Q46545610

P275

Creative Commons Attribution 4.0 International

copyrighted

describes a project that uses

ImageJ

Q1659584

P433

issue

P407

language of work or name

English

Q1860

P921

main subject

Duchenne muscular dystrophy

Q1648484

P304

page(s)

1068

P577

publication date

2017-10-20

P1433

published in

Nature Communications

Q573880

P1476

title

Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice

P478

volume

Reverse relations

cites work (P2860)

Q96110672	Activation of sarcolipin expression and altered calcium cycling in LMNA cardiomyopathy
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Q90194088	Calcium Mechanisms in Limb-Girdle Muscular Dystrophy with CAPN3 Mutations
Q92825511	Cardiac Pathophysiology and the Future of Cardiac Therapies in Duchenne Muscular Dystrophy
Q90911734	Dietary salt promotes cognitive impairment through tau phosphorylation
Q89782554	Dysregulation of Calcium Handling in Duchenne Muscular Dystrophy-Associated Dilated Cardiomyopathy: Mechanisms and Experimental Therapeutic Strategies
Q89606643	Effect of sarcolipin-mediated cell transdifferentiation in sarcopenia-associated skeletal muscle fibrosis
Q58612995	Enhancing atrial specific gene expression using a calsequestrin cis-regulatory module 4 with a sarcolipin promoter
Q90270633	Exosomes Could Offer New Options to Combat the Long-Term Complications Inflicted by Gestational Diabetes Mellitus
Q57191111	Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness
Q92937460	Single SERCA2a Therapy Ameliorated Dilated Cardiomyopathy for 18 Months in a Mouse Model of Duchenne Muscular Dystrophy
Q64284712	Targeting angiogenesis in Duchenne muscular dystrophy
Q96614443	Troponin T amino acid mutation (ΔK210) knock-in mice as a neonatal dilated cardiomyopathy model

P819	ADS bibcode	2017NatCo...8.1068V
P356	DOI	10.1038/S41467-017-01146-7
P932	PMC publication ID	5648780
P698	PubMed publication ID	29051551