scholarly article | Q13442814 |
P356 | DOI | 10.1016/S1054-3589(10)59001-X |
P953 | full work available at URL | https://europepmc.org/articles/pmc3023997?pdf=render |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20933197/?tool=EBI | ||
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20933197/pdf/?tool=EBI | ||
https://europepmc.org/articles/PMC3023997 | ||
https://europepmc.org/articles/PMC3023997?pdf=render | ||
https://doi.org/10.1016/s1054-3589(10)59001-x | ||
P932 | PMC publication ID | 3023997 |
P698 | PubMed publication ID | 20933197 |
P5875 | ResearchGate publication ID | 47382408 |
P50 | author | Alexander Kushnir | Q91848335 |
P2093 | author name string | Andrew R. Marks | |
P2860 | cites work | Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a | Q22010899 |
PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts | Q22254160 | ||
FK506 binding protein associated with the calcium release channel (ryanodine receptor) | Q24292729 | ||
PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex | Q24295192 | ||
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy | Q24295360 | ||
Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias | Q24296752 | ||
Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak | Q24296910 | ||
Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release | Q24299281 | ||
The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure | Q24299296 | ||
Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction | Q24302344 | ||
Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle | Q24308714 | ||
Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes | Q24315860 | ||
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias | Q24337832 | ||
Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure | Q24530067 | ||
mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module | Q24535019 | ||
Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans | Q24608179 | ||
Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity | Q24649499 | ||
Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers | Q24678432 | ||
K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association | Q24684879 | ||
Coordinated movement of cytoplasmic and transmembrane domains of RyR1 upon gating | Q27331094 | ||
Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium | Q28140574 | ||
FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death | Q28183817 | ||
Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia | Q28201561 | ||
FKBP12 binding modulates ryanodine receptor channel gating | Q28208762 | ||
Localization of the 12.6-kDa FK506-binding protein (FKBP12.6) binding site to the NH2-terminal domain of the cardiac Ca2+ release channel (ryanodine receptor) | Q28215774 | ||
Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic reticulum membrane | Q28248323 | ||
Cellular basis of triggered arrhythmias in heart failure | Q28251279 | ||
Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death | Q28278262 | ||
Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation | Q28282018 | ||
Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum | Q28293449 | ||
Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice | Q28504805 | ||
Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel | Q28506475 | ||
Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytes | Q28512354 | ||
FKBP12.6 disruption impairs glucose-induced insulin secretion | Q28584782 | ||
FKBP12.6-knockout mice display hyperinsulinemia and resistance to high-fat diet-induced hyperglycemia | Q28592360 | ||
Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice | Q30481900 | ||
Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice | Q30488460 | ||
Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor. | Q30494293 | ||
Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure | Q30495045 | ||
Arrhythmic disorder mapped to chromosome 1q42-q43 causes malignant polymorphic ventricular tachycardia in structurally normal hearts | Q33145152 | ||
Luminal loop of the ryanodine receptor: a pore-forming segment? | Q33546213 | ||
Flux regulation of cardiac ryanodine receptor channels | Q33590295 | ||
Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass. | Q33618629 | ||
Heterogeneity of Ca2+ gating of skeletal muscle and cardiac ryanodine receptors | Q33906996 | ||
Modulation of ryanodine receptor by luminal calcium and accessory proteins in health and cardiac disease | Q34008193 | ||
Sarcoplasmic reticulum lumenal Ca2+ has access to cytosolic activation and inactivation sites of skeletal muscle Ca2+ release channel | Q34017877 | ||
When calcium turns arrhythmogenic: intracellular calcium handling during the development of hypertrophy and heart failure | Q34137466 | ||
Topology of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum (RyR1). | Q34165350 | ||
Regulation of the cardiac ryanodine receptor channel by luminal Ca2+ involves luminal Ca2+ sensing sites | Q34169533 | ||
Mechanism of calmodulin inhibition of cardiac sarcoplasmic reticulum Ca2+ release channel (ryanodine receptor) | Q34184776 | ||
A model of the putative pore region of the cardiac ryanodine receptor channel | Q34187307 | ||
Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure | Q34241246 | ||
Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression | Q34270987 | ||
Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. | Q34312242 | ||
Defective regulation of interdomain interactions within the ryanodine receptor plays a key role in the pathogenesis of heart failure | Q34427871 | ||
Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure. | Q34514645 | ||
Ryanodine receptor calcium release channels | Q34882627 | ||
JTV-519, a novel cardioprotective agent, improves the contractile recovery after ischaemia-reperfusion in coronary perfused guinea-pig ventricular muscles | Q35042356 | ||
The potential role of Ca2+ for electrical cell-to-cell uncoupling and conduction block in myocardial tissue | Q35220767 | ||
Altered function and regulation of cardiac ryanodine receptors in cardiac disease | Q35601819 | ||
Role of gap junctions in the propagation of the cardiac action potential | Q35749980 | ||
Calstabin deficiency, ryanodine receptors, and sudden cardiac death | Q35874314 | ||
Internal structure and visualization of transmembrane domains of the RyR1 calcium release channel by cryo-EM. | Q35902619 | ||
A mechanism for sudden infant death syndrome (SIDS): stress-induced leak via ryanodine receptors | Q35904783 | ||
Ca2+/calmodulin kinase II increases ryanodine binding and Ca2+-induced sarcoplasmic reticulum Ca2+ release kinetics during beta-adrenergic stimulation | Q36099179 | ||
ADENOSINE TRIPHOSPHATE-LINKED CONCENTRATION OF CALCIUM IONS IN A PARTICULATE FRACTION OF RABBIT MUSCLE | Q36185236 | ||
Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology | Q36433663 | ||
Modulation of the ryanodine receptor and intracellular calcium | Q36824050 | ||
Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation. | Q36851847 | ||
Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes. | Q36968487 | ||
Adrenergic regulation of cardiac contractility does not involve phosphorylation of the cardiac ryanodine receptor at serine 2808 | Q37120202 | ||
Calmodulin kinase II is required for fight or flight sinoatrial node physiology | Q37153688 | ||
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. | Q37170829 | ||
Stress synchronizes calcium release and promotes SR calcium leak | Q43177720 | ||
CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation | Q43199827 | ||
Altered intracellular Ca2+ regulation in chronic rat heart failure | Q43226825 | ||
Increased Ca(2+) leak and spatiotemporal coherence of Ca(2+) release in cardiomyocytes during beta-adrenergic stimulation. | Q43245413 | ||
A mechanism of ryanodine receptor modulation by FKBP12/12.6, protein kinase A, and K201. | Q43297281 | ||
beta-Adrenergic stimulation synchronizes intracellular Ca(2+) release during excitation-contraction coupling in cardiac myocytes | Q43590602 | ||
beta-adrenergic receptor blockers restore cardiac calcium release channel (ryanodine receptor) structure and function in heart failure | Q43815707 | ||
beta-Adrenergic stimulation modulates ryanodine receptor Ca(2+) release during diastolic depolarization to accelerate pacemaker activity in rabbit sinoatrial nodal cells | Q43851351 | ||
Protein kinase A phosphorylation of the ryanodine receptor does not affect calcium sparks in mouse ventricular myocytes | Q43893181 | ||
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes | Q43901717 | ||
Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy | Q43926526 | ||
A novel cardioprotective agent, JTV-519, is abolished by nitric oxide synthase inhibitor on myocardial metabolism in ischemia-reperfused rabbit hearts | Q44016071 | ||
A new cardioprotective agent, JTV519, improves defective channel gating of ryanodine receptor in heart failure | Q44217762 | ||
Abnormal Ca2+ release, but normal ryanodine receptors, in canine and human heart failure | Q44232551 | ||
FKBP12.6-mediated stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure | Q44292820 | ||
Molecular Basis of Calmodulin Binding to Cardiac Muscle Ca2+ Release Channel (Ryanodine Receptor) | Q44411401 | ||
Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure. | Q44438480 | ||
Sorcin inhibits calcium release and modulates excitation-contraction coupling in the heart | Q44489717 | ||
Downregulated FKBP12.6 expression and upregulated endothelin signaling contribute to elevated diastolic calcium and arrhythmogenesis in rat cardiomyopathy produced by l-thyroxin | Q44579102 | ||
Stoichiometric phosphorylation of cardiac ryanodine receptor on serine 2809 by calmodulin-dependent kinase II and protein kinase A. | Q44599963 | ||
Modulation of excitation-contraction coupling by isoproterenol in cardiomyocytes with controlled SR Ca2+ load and Ca2+ current trigger | Q44728656 | ||
Beyond Bowditch: the convergence of cardiac chronotropy and inotropy | Q44862851 | ||
Regulation of cardiac excitation-contraction coupling by sorcin, a novel modulator of ryanodine receptors. | Q45264048 | ||
Inactivation of calcium current in bull-frog atrial myocytes | Q46361178 | ||
Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure. | Q46404548 | ||
Defective cardiac ryanodine receptor regulation during atrial fibrillation | Q46455370 | ||
Effects of S-glutathionylation and S-nitrosylation on calmodulin binding to triads and FKBP12 binding to type 1 calcium release channels. | Q46584340 | ||
Conditional FKBP12.6 overexpression in mouse cardiac myocytes prevents triggered ventricular tachycardia through specific alterations in excitation-contraction coupling. | Q46672517 | ||
Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts | Q46786268 | ||
Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure | Q46790561 | ||
Unique phosphorylation site on the cardiac ryanodine receptor regulates calcium channel activity. | Q48707184 | ||
Primary structure and functional expression from cDNA of the cardiac ryanodine receptor/calcium release channel | Q48887625 | ||
Plant insecticides; ryanodine, a new alkaloid from Ryania speciosa Vahl | Q49227497 | ||
Effects of a novel cardioprotective drug, JTV-519, on membrane currents of guinea pig ventricular myocytes. | Q51461343 | ||
Modulation of CICR has no maintained effect on systolic Ca2+: simultaneous measurements of sarcoplasmic reticulum and sarcolemmal Ca2+ fluxes in rat ventricular myocytes. | Q52082843 | ||
Cytoplasmic Ca2+ inhibits the ryanodine receptor from cardiac muscle. | Q52518164 | ||
Redox sensitivity of the ryanodine receptor interaction with FK506-binding protein. | Q52575969 | ||
The immunophilin FK506-binding protein modulates Ca2+ release channel closure in rat heart. | Q53970618 | ||
Characterization of an exchange reaction between soluble FKBP-12 and the FKBP.ryanodine receptor complex. Modulation by FKBP mutants deficient in peptidyl-prolyl isomerase activity. | Q54014128 | ||
A further Contribution regarding the influence of the different Constituents of the Blood on the Contraction of the Heart | Q58717709 | ||
Calmodulin kinase II inhibition protects against structural heart disease | Q59975125 | ||
Increasing Ryanodine Receptor Open Probability Alone Does Not Produce Arrhythmogenic Calcium Waves | Q60182017 | ||
Two structural configurations of the skeletal muscle calcium release channel | Q61685354 | ||
The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes | Q64377082 | ||
Regulation of the Cardiac Ryanodine Receptor by Protein Kinase-Dependent Phosphorylation1 | Q67915244 | ||
Ryanodine activation and inhibition of the Ca2+ release channel of sarcoplasmic reticulum | Q68960736 | ||
Rapid calcium release from cardiac sarcoplasmic reticulum vesicles is dependent on Ca2+ and is modulated by Mg2+, adenine nucleotide, and calmodulin | Q68985664 | ||
Phosphorylation of the cardiac ryanodine receptor by cAMP-dependent protein kinase | Q69428331 | ||
Effects of rapamycin on ryanodine receptor/Ca(2+)-release channels from cardiac muscle | Q71089460 | ||
Selective binding of FKBP12.6 by the cardiac ryanodine receptor | Q71246114 | ||
Neurohormonal activation and exercise function in patients with severe heart failure and patients with left ventricular assist system. A comparative study | Q72313353 | ||
The ryanodine receptor from canine heart sarcoplasmic reticulum is associated with a novel FK-506 binding protein | Q72748127 | ||
Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts | Q72933722 | ||
The electrical constants of Purkinje fibres | Q72990538 | ||
Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca(2+) leak through ryanodine receptor in heart failure | Q73108723 | ||
Altered interaction of FKBP12.6 with ryanodine receptor as a cause of abnormal Ca(2+) release in heart failure | Q73131028 | ||
The effect of Ca(2+)-calmodulin-dependent protein kinase II on cardiac excitation-contraction coupling in ferret ventricular myocytes | Q73397043 | ||
Anti-ischemic effect of a novel cardioprotective agent, JTV519, is mediated through specific activation of delta-isoform of protein kinase C in rat ventricular myocardium | Q73466472 | ||
Decreased sarcoplasmic reticulum calcium content is responsible for defective excitation-contraction coupling in canine heart failure | Q73635731 | ||
Modulation of cardiac ryanodine receptors by sorcin | Q73735619 | ||
Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations | Q74016176 | ||
Evidence for Ca(2+) activation and inactivation sites on the luminal side of the cardiac ryanodine receptor complex | Q74113980 | ||
Cardiac resting and action potentials recorded with an intracellular electrode | Q75897378 | ||
ON THE MECHANISM OF CALCIUM TRANSPORT ACROSS THE MEMBRANE OF THE SARCOPLASMIC RETICULUM | Q76657051 | ||
CARDIAC MYOSIN B AND CALCIUM IONS | Q76780916 | ||
Cellular mechanisms of atrial contractile dysfunction caused by sustained atrial tachycardia | Q77142334 | ||
[The calcium pump of the "relaxing granules" of muscle and its dependence on ATP-splitting.] | Q78872490 | ||
On the role of calcium in the activity of adenosine 5'-triphosphate hydrolysis by actomyosin | Q79298811 | ||
Contributions to the physiology of the isolated heart: The consumption of dextrose by mammalian cardiac muscle | Q80321851 | ||
Intact beta-adrenergic response and unmodified progression toward heart failure in mice with genetic ablation of a major protein kinase A phosphorylation site in the cardiac ryanodine receptor | Q80838591 | ||
The Action of Ryanodine on the Contractile Process in Striated Muscle | Q80924617 | ||
The role of calmodulin kinase II in myocardial physiology and disease | Q37192039 | ||
Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor | Q37355318 | ||
Role of ryanodine receptor as a Ca²(+) regulatory center in normal and failing hearts | Q37376855 | ||
Beta-adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel | Q37379759 | ||
Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor. | Q37393446 | ||
Localization of PKA phosphorylation site, Ser(2030), in the three-dimensional structure of cardiac ryanodine receptor. | Q37468661 | ||
Three-dimensional localization of serine 2808, a phosphorylation site in cardiac ryanodine receptor | Q37485713 | ||
Sudden infant death syndrome in mice with an inherited mutation in RyR2. | Q37486353 | ||
Localization of Ca2+ release channels with ryanodine in junctional terminal cisternae of sarcoplasmic reticulum of fast skeletal muscle | Q37536168 | ||
Atrial remodeling and atrial fibrillation: mechanisms and implications. | Q37609710 | ||
Ryanodine receptor studies using genetically engineered mice | Q37705608 | ||
Cardiac channel molecular autopsy for sudden unexpected death in epilepsy | Q38417008 | ||
The pharmacology of ryanodine | Q39978858 | ||
Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store overload-induced Ca2+ release. | Q40095184 | ||
Protein kinase A phosphorylation at serine-2808 of the cardiac Ca2+-release channel (ryanodine receptor) does not dissociate 12.6-kDa FK506-binding protein (FKBP12.6). | Q40600647 | ||
Characterization of Recombinant Skeletal Muscle (Ser-2843) and Cardiac Muscle (Ser-2809) Ryanodine Receptor Phosphorylation Mutants | Q40628200 | ||
Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity | Q40817461 | ||
Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure. | Q40928544 | ||
Coupled gating between individual skeletal muscle Ca2+ release channels (ryanodine receptors) | Q41018951 | ||
Cellular functions of immunophilins | Q41075701 | ||
Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein | Q41467443 | ||
Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor | Q42622044 | ||
Rapid adaptation of cardiac ryanodine receptors: modulation by Mg2+ and phosphorylation | Q43027230 | ||
P407 | language of work or name | English | Q1860 |
P921 | main subject | physiology | Q521 |
electrical conduction system of the heart | Q72711 | ||
heart contraction | Q5165683 | ||
P304 | page(s) | 1-30 | |
P577 | publication date | 2010-01-01 | |
P1433 | published in | Advances in Pharmacology | Q15753809 |
P1476 | title | The ryanodine receptor in cardiac physiology and disease | |
The Ryanodine Receptor in Cardiac Physiology and Disease | |||
P478 | volume | 59 |
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