Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

scientific article published on July 22, 1982

Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1056/NEJM198207223070401
P953full work available at URLhttp://www.nejm.org/doi/pdf/10.1056/NEJM198207223070401
P698PubMed publication ID6283349

P50authorEdward StinsonQ55610560
P2093author name stringM. E. Billingham
D. C. Harrison
E. B. Stinson
M. R. Bristow
R. Ginsburg
K. Lurie
W. S. Sageman
W. Minobe
R. S. Cubicciotti
P2860cites workMolecular PharmacologyQ1943386
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Impairment of autonomically mediated heart rate control in patients with cardiac dysfunctionQ28329525
Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sitesQ34505907
Distribution and function of beta-adrenoceptors in different chambers of the canine heartQ36096502
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Receptor Occupancy and Tissue ResponseQ59058013
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Role of endocrine factors in chronic congestive heart failure, with emphasis on catecholaminesQ72130561
Histamine receptors in the human heartQ72429362
Decreased Lymphocyte Beta-Adrenergic-Receptor Density in Patients with Heart Failure and Tolerance to the Beta-Adrenergic Agonist PirbuterolQ72478128
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P433issue4
P407language of work or nameEnglishQ1860
P304page(s)205-211
P577publication date1982-07-01
1982-07-22
P1433published inThe New England Journal of MedicineQ582728
P1476titleDecreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts
Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts
P478volume307

Reverse relations

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Q37399543Evaluating presynaptic and postsynaptic innervation in heart failure
Q71328286Evaluating the efficacy of new inotropic agents
Q43201901Evaluation of cardiac beta 1‐adrenergic sensitivity with dobutamine in healthy volunteers
Q50758578Evidence against a role of nitric oxide in the indirect negative inotropic-effect of M-cholinoceptor stimulation in human ventricular myocardium.
Q68085554Evidence against spare or uncoupled beta-adrenoceptors in the human heart
Q40713714Evidence for functional presynaptic alpha-2 adrenoceptors and their down-regulation in human heart failure
Q77802837Evidence of phenotypic alteration as a cause of systolic dysfunction in the failing heart
Q77738058Evolving therapeutic concepts and imaging in ischemic cardiomyopathy
Q24650383Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice
Q71959367Expression of adenylyl cyclase and G-protein beta subunit in end-stage human heart failure
Q35821927Expression of dihydropyridine receptor (Ca2+ channel) and calsequestrin genes in the myocardium of patients with end-stage heart failure
Q35112394Extended-Release Metoprolol Succinate in Chronic Heart Failure
Q26739009Fatty old hearts: role of cardiac lipotoxicity in age-related cardiomyopathy
Q28325222Felodipine: A New Dihydropyridine Calcium-Channel Antagonist
Q71329908Fish oil and other nutritional adjuvants for treatment of congestive heart failure
Q36043165Flow Cytometric Quantification of Peripheral Blood Cell β-Adrenergic Receptor Density and Urinary Endothelial Cell-Derived Microparticles in Pulmonary Arterial Hypertension
Q41265608Force relaxation and thin filament protein phosphorylation during acute myocardial ischemia
Q46086271Force-frequency relations in the failing rabbit heart and responses to adrenergic stimulation
Q68146280Force-frequency relationship and inotropic stimulation in the nonfailing and failing human myocardium: implications for the medical treatment of heart failure
Q33938713Functional consequences of altering myocardial adrenergic receptor signaling
Q42512027Functional properties of the rat phosphatase 1alpha promoter
Q50132075Functions of PDE3 Isoforms in Cardiac Muscle
Q33810086G alpha(q)-mediated activation of GRK2 by mechanical stretch in cardiac myocytes: the role of protein kinase C.
Q37184794G protein betagamma subunits as targets for small molecule therapeutic development
Q35135090G protein coupled receptor kinases as therapeutic targets in cardiovascular disease
Q33604042G protein-coupled Receptor Kinase 2 as a Therapeutic Target for Heart Failure
Q37881660G protein-coupled receptor kinases in normal and failing myocardium
Q33639685G protein-coupled receptors in cardiac biology: old and new receptors
Q42528309G proteins, adenylyl cyclase and related phosphoproteins in the developing rat heart
Q35660111GRK2 and β-arrestins in cardiovascular disease: Something old, something new.
Q37783642GRK2 as a novel gene therapy target in heart failure.
Q35218715Gene interventions in the beta-adrenergic system for treating heart failure
Q36944623Gene therapy in heart failure
Q37310450Gene therapy to treat cardiovascular disease
Q36698991Gene transfer for congestive heart failure: update 2013.
Q95823497Genetic and phenotypic targeting of β-adrenergic signaling in heart failure
Q34016827Haemodynamic response to dopexamine hydrochloride in postinfarction heart failure: lack of tolerance after continuous infusion
Q38186583Heart failure-specific changes in protein kinase signalling.
Q34325932Heart rate variability in chronic heart failure
Q57422785Heart rhythms, ventricular arrhythmias,and death in chronic heart failure
Q39828490Heart transplantation
Q73476808Hemodynamic and clinical effects of oral levodopa in children with congestive heart failure
Q72695879Hemodynamic effects of the novel cardiotonic drug simendan: echocardiographic assessment in healthy volunteers
Q71959363Hemodynamic predictors of early intolerance and long-term effects of propranolol in dilated cardiomyopathy
Q54092891Hemodynamic responses during leg press exercise in patients with chronic congestive heart failure.
Q40179166Hemodynamics in hypertension and heart failure
Q71870050Heterotrimeric G proteins in heart disease
Q36822662Hibernating myocardium in post-ischaemic heart failure: pathophysiology, identification and revascularisation
Q47327873High-dose epinephrine improves outcome from pediatric cardiac arrest
Q49389901Histamine H2 Receptor Polymorphisms, Myocardial Transcripts, and Heart Failure (from the Multi-Ethnic Study of Atherosclerosis and Beta-Blocker Effect on Remodeling and Gene Expression Trial).
Q24568237Histone deacetylase signaling in cardioprotection
Q47671855Human SERCA2a levels correlate inversely with age in senescent human myocardium
Q37427881Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state
Q71945620Hypertrophic cardiomyopathy: A desensitized cardiac \-adrenergic system in the presence of normal plasma catecholamine concentrations
Q39702719Hypocalcemia and hypophosphatemia in acutely ill patients.
Q37509834Hypoxia sensing through β-adrenergic receptors
Q37222188Imaging left ventricular remodeling: targeting the neurohumoral axis
Q74143829Imaging of cardiac neuronal and receptor function
Q36267057Imaging of metabolism and autonomic innervation of the heart by positron emission tomography.
Q42077100Immune modulation of cardiac cell function
Q44223785Impact of age on myocardial uptake of ¹²³I-mIBG in older adult subjects without coronary heart disease
Q39692006Impact of aging on cardiac sympathetic innervation measured by 123I-mIBG imaging in patients with systolic heart failure
Q41155058Impaired Inotropic Responses to Adrenergic Stimulation Following Aortic Constriction: Role of Oxidation Product of Catecholamines
Q60182009Impaired β-adrenergic responsiveness accentuates dysfunctional excitation-contraction coupling in an ovine model of tachypacing-induced heart failure
Q34118813Impairment of diastolic function by shortened filling period in severe left ventricular disease
Q33999920Importance of neuroendocrine activation in chronic heart failure. Impact on treatment strategies
Q70463340Improved method for autoradiographic localization of beta-adrenoceptors using photoaffinity labelling
Q41321446Improved myocardial oxygen utilization following propranolol infusion in adolescents with postburn hypermetabolism
Q35540748Improvement of cardiac contractile function by peptide-based inhibition of NF-κB in the utrophin/dystrophin-deficient murine model of muscular dystrophy
Q78108722In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function
Q33936885In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction
Q36329813Incomplete reversal of β‐adrenoceptor desensitization in human and guinea‐pig cardiomyocytes by cyclic nucleotide phosphodiesterase inhibitors
Q34557266Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart
Q77535879Increased expression of constitutive nitric oxide synthase III, but not inducible nitric oxide synthase II, in human heart failure
Q34567917Increased fat and skeletal muscle beta-adrenergic receptors but unaltered metabolic and hemodynamic sensitivity to epinephrine in vivo in experimental human thyrotoxicosis
Q34119551Increased production of nitric oxide in coronary arteries during congestive heart failure
Q38677735Induction of cardiac dysfunction in developing and adult zebrafish by chronic isoproterenol stimulation
Q60908782Influence of Beta-1 Adrenergic Receptor Genotype on Cardiovascular Response to Exercise in Healthy Subjects
Q68778873Influence of cardiovascular diseases upon the results of the cardiovascular reflex tests in diabetic and nondiabetic subjects
Q35100887Inhibition of Na+/H+-exchanger with sabiporide attenuates the downregulation and uncoupling of the myocardial beta-adrenoceptor system in failing rabbit hearts.
Q37078266Inhibition of angiotensin II Gq signaling augments beta-adrenergic receptor mediated effects in a renal artery stenosis model of high blood pressure
Q43708435Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy
Q39904074Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure
Q42487361Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor
Q73646188Inotropes in the beta-blocker era
Q42253213Inotropic and electrophysiological effects of BDF 9148, a congener of DPI 201-106, in guinea-pig atria and papillary muscles
Q35756777Inotropic response to DPI 201-106 in the failing human heart
Q73597633Inotropic responses to isoproterenol in congestive heart failure subsequent to myocardial infarction in rats
Q40487973Inotropic support of the critically ill patient. A review of the agents
Q39562288Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.
Q64767181Interactions between the autonomic nervous system and tachycardias in man
Q41918298Interstitial remodeling in beta1-adrenergic receptor transgenic mice
Q38389875Intracoronary Gene Transfer of Adenylyl Cyclase 6 in Patients With Heart Failure: A Randomized Clinical Trial
Q64381002Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance
Q35811171Intracoronary infusion of dobutamine to patients with and without severe congestive heart failure. Dose-response relationships, correlation with circulating catecholamines, and effect of phosphodiesterase inhibition
Q73591216Intranuclear mitochondria in human myocardial cells
Q36157352Intrathecal fentanyl blockade of afferent neural feedback from skeletal muscle during exercise in heart failure patients: Influence on circulatory power and pulmonary vascular capacitance
Q37221593Intravenous Followed by X-ray Fused with MRI-Guided Transendocardial Mesenchymal Stem Cell Injection Improves Contractility Reserve in a Swine Model of Myocardial Infarction.
Q41675685Iodine 123-labeled metaiodobenzylguanidine imaging in heart disease
Q38908301Is Heart Rate a Norepiphenomenon in Heart Failure?
Q35415155Is inotropic therapy for heart failure an unfulfilled promise?
Q34275369Is paradoxical pharmacology a strategy worth pursuing?
Q72403094Is the alpha adrenergic receptor density increased in intact thrombocytes in non-isometric trained athletes?
Q40599753Is there a role for positive inotropic agents in congestive heart failure: focus on mortality
Q73862565Ischemic versus idiopathic cardiomyopathy: differing neurohumoral profiles despite comparable peak oxygen uptake
Q34978520Isoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compounds
Q36594157Isolated neonatal rat papillary muscles: a new model to translate neonatal rat myocyte signaling into contractile mechanics
Q24320070Junctin and the histidine-rich Ca2+ binding protein: potential roles in heart failure and arrhythmogenesis
Q44293671Kidney function in heart failure
Q34212291Kinetics of cardiac muscle contraction and relaxation are linked and determined by properties of the cardiac sarcomere.
Q77111366L-type calcium current in human ventricular myocytes at a physiological temperature from children with tetralogy of Fallot
Q44582053Lack of inverse agonistic activity of nebivolol, its D- and L-enantiomers and of in vivo metabolized nebivolol in human myocardium
Q59684598Lack of tolerance development during chronic ibopamine administration to patients with congestive heart failure
Q43788597Left ventricular inotropic reserve and right ventricular function predict increase of left ventricular ejection fraction after beta-blocker therapy in nonischemic cardiomyopathy
Q53698175Left ventricular remodelling in chronic primary mitral regurgitation: implications for medical therapy.
Q54668862Length dependence of force generation exhibit similarities between rat cardiac myocytes and skeletal muscle fibres.
Q45236710Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure
Q48747845Levosimendan improves diastolic and systolic function in failing human myocardium.
Q52066587Linear and non-linear 24 h heart rate variability in chronic heart failure.
Q51740622Long-Term Caloric Restriction Improves Cardiac Function, Remodeling, Adrenergic Responsiveness, and Sympathetic Innervation in a Model of Postischemic Heart Failure.
Q44136289Long-term (2 year) beneficial effects of beta-adrenergic blockade with bucindolol in patients with idiopathic dilated cardiomyopathy
Q42276633Long-term Treatment With Angiotensin I–Converting Enzyme Inhibitors Attenuates the Loss of Cardiac β-Adrenoceptor Responses in Rats With Chronic Heart Failure
Q38734731Long-term intravenous inotropes in low-output terminal heart failure?
Q34569359Loss of high affinity cardiac beta adrenergic receptors in dogs with heart failure
Q37209626Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice
Q36899686Low-level vagus nerve stimulation upregulates small conductance calcium-activated potassium channels in the stellate ganglion
Q34531254MIBG imaging
Q44389057MIBG imaging for selecting heart failure patients for defibrillator therapy: a first step
Q73902331MIC trial: metoprolol in patients with mild to moderate heart failure: effects on ventricular function and cardiopulmonary exercise testing
Q69495372Management of arrhythmias in heart failure
Q34443742Managing heart failure with immunomodulatory agents
Q72540245Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene
Q41669348Mechanism of action of beta-blocking agents in heart failure
Q67708830Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle preparations
Q39310132Mechanisms of SR calcium release in healthy and failing human hearts
Q41259301Mechanisms of beta-adrenergic receptor desensitization: from molecular biology to heart failure
Q40094154Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors
Q38303661Mechanisms of positive inotropic effects
Q33866666Mechanisms of regulation and function of G-protein-coupled receptor kinases
Q40444197Mechanisms, diagnosis, and treatment of diastolic heart failure
Q33558612Medical management of congestive heart failure.
Q77802846Medical therapy of chronic heart failure. Role of ACE inhibitors and beta-blockers
Q71126004Meta-analysis of the use of low-dose beta-adrenergic blocking therapy in idiopathic or ischemic dilated cardiomyopathy
Q42475549Method-related effects of adenovirus-mediated LacZ and SERCA1 gene transfer on contractile behavior of cultured failing human cardiomyocytes.
Q43656945Metoprolol attenuates postischemic depressed myocardial function in papillary muscles isolated from normal and postinfarction rat hearts
Q71514097Metoprolol in dilated cardiomyopathy: is it possible to identify factors predictive of improvement? The Heart Muscle Disease Study Group
Q33748197Mice lacking the Cβ subunit of PKA are resistant to angiotensin II-induced cardiac hypertrophy and dysfunction
Q34794475MicroRNA let-7 establishes expression of beta2-adrenergic receptors and dynamically down-regulates agonist-promoted down-regulation
Q24653709MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths
Q36634010Mild metabolic acidosis impairs the β-adrenergic response in isolated human failing myocardium.
Q54089909Milrinone therapy in catecholamine-dependent critically ill patients with heart failure.
Q34357125Mitigation of beta 1- and/or beta 2-adrenoceptor function in human heart failure
Q34272692Mitral valve reconstruction in the patient with heart failure
Q73290155Mitral valve repair in heart failure
Q30433804Modeling cardiac β-adrenergic signaling with normalized-Hill differential equations: comparison with a biochemical model
Q30371695Modeling the effects of β1-adrenergic receptor blockers and polymorphisms on cardiac myocyte Ca2+ handling.
Q28255887Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes
Q51749399Moderate Continuous Aerobic Exercise Training Improves Cardiomyocyte Contractility in Β1 Adrenergic Receptor Knockout Mice.
Q34150128Modification of beta-adrenoceptor signal transduction pathway by genetic manipulation and heart failure
Q71867473Modulation of Left and Right Ventricular β-Adrenergic Receptors From Spontaneously Hypertensive Rats With Left Ventricular Hypertrophy and Failure
Q36848480Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.
Q41609763Molecular and cellular prospects for repair, augmentation, and replacement of the failing heart
Q77730225Molecular and functional mechanisms of right ventricular adaptation in chronic pulmonary hypertension
Q34032476Molecular aspects and gene therapy prospects for diastolic failure
Q42345701Molecular imaging in heart failure patients
Q38241365Molecular imaging to predict ventricular arrhythmia in heart failure
Q36984198Molecule specific effects of PKA-mediated phosphorylation on rat isolated heart and cardiac myofibrillar function
Q42190835Myocardial Function With Reduced Expression of the Sodium-Calcium Exchanger
Q33750874Myocardial G protein-coupled receptor kinases: implications for heart failure therapy
Q36828757Myocardial beta adrenoceptors and left ventricular function in hypertrophic cardiomyopathy
Q33892916Myocardial beta-adrenergic receptor function during the development of pacing-induced heart failure
Q41188796Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice
Q71270504Myocardial beta-adrenoceptor density and plasma catecholamines in syndrome X
Q68238168Myocardial beta-adrenoceptor density and the distribution of beta 1- and beta 2-adrenoceptor subpopulations in children with congenital heart disease
Q53601215Myocardial beta-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[11C]CGP12388.
Q38282980Myocardial beta-adrenoceptor function and regulation in heart failure: implications for therapy
Q71237109Myocardial catecholamines in hypertrophic and dilated (congestive) cardiomyopathy: a biopsy study
Q41700817Myocardial contractile reserve on dobutamine echocardiography predicts late spontaneous improvement in cardiac function in patients with recent onset idiopathic dilated cardiomyopathy
Q44008848Myocardial contractile reserve under low doses of dobutamine and improvement of left ventricular ejection fraction with treatment by carvedilol.
Q71518858Myocardial defect detected by 123I-BMIPP scintigraphy and left ventricular dysfunction in patients with idiopathic dilated cardiomyopathy
Q68745118Myocardial energetics and efficiency in patients with idiopathic cardiomyopathy: response to dobutamine and amrinone
Q73769848Myocardial function in hearts with transgenic overexpression of the G protein-coupled receptor kinase 5
Q44563021Myocardial gene expression of matched hibernating and control tissue from patients with ischemic left ventricular dysfunction
Q34119456Myocardial gene transfer
Q35872400Myocardial hypertrophy, cardiac beta-adrenoceptors and adenylate cyclase activity during sinoaortic denervation in dogs.
Q79759787Myocardial pre-synaptic sympathetic function correlates with glucose uptake in the failing human heart
Q55080592Myocardial remodeling and susceptibility to ventricular tachycardia in a model of chronic epilepsy.
Q33825289Myocyte contractile dysfunction with hypertrophy and failure: relevance to cardiac surgery
Q37357150Myofibrillar calcium sensitivity of isometric tension is increased in human dilated cardiomyopathies: role of altered beta-adrenergically mediated protein phosphorylation
Q36593277Myofibrillar remodeling in cardiac hypertrophy, heart failure and cardiomyopathies
Q24561412Myosin heavy chain gene expression in human heart failure
Q72970854N-isopropyl-p-iodoamphetamine receptors in normal and cancerous tissue of the human lung
Q28345779Nebivolol, bucindolol, metoprolol and carvedilol are devoid of intrinsic sympathomimetic activity in human myocardium
Q37470858Negative impact of β-arrestin-1 on post-myocardial infarction heart failure via cardiac and adrenal-dependent neurohormonal mechanisms
Q34173595Neural control of blood flow during exercise in human metabolic syndrome
Q39649942Neuroendocrine manifestations of congestive heart failure
Q38973209Neurohormonal activation in heart failure with reduced ejection fraction
Q38365094Neurohumoral activation in congestive heart failure: a double-edged sword?
Q58790122New Insights in Cardiac β-Adrenergic Signaling During Heart Failure and Aging
Q27011866New SPECT and PET radiopharmaceuticals for imaging cardiovascular disease
Q41724223New developments in cardiovascular adrenergic receptor pharmacology: molecular mechanisms and clinical relevance
Q34782396New molecular insights into heart failure and cardiomyopathy: potential strategies and therapies
Q37822833New perspectives regarding β(2) -adrenoceptor ligands in the treatment of asthma
Q36515530New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy
Q34687109Newer positive inotropic agents in the treatment of chronic cardiac failure. Current status and future directions
Q85302130Non-classical regulation of β1- and β 2-adrenoceptor-mediated inotropic responses in rat heart ventricle by the G protein Gi
Q34327056Noncanonical EF-hand motif strategically delays Ca2+ buffering to enhance cardiac performance
Q35595409Noncoordinate regulation of cardiac Gs protein and beta-adrenergic receptors by a physiological stimulus, chronic dynamic exercise
Q67673943Noninvasive Exploration of Cardiac Arrhythmias
Q34544890Novel iodinated tracers, MIBG and BMIPP, for nuclear cardiology
Q54977622Novel paradigms governing β1-adrenergic receptor trafficking in primary adult rat cardiac myocytes.
Q41856322Novel strategies for the treatment of heart failure
Q36244456Outpatient Dobutamine Therapy: The Rhyme and the Riddle
Q35665407Outpatient management of congestive heart failure
Q37381474Overexpression of myocardial Gsalpha prevents full expression of catecholamine desensitization despite increased beta-adrenergic receptor kinase
Q77400619Overexpression of nerve growth factor in the heart alters ion channel activity and beta-adrenergic signalling in an adult transgenic mouse
Q37941174PDE3 inhibition in dilated cardiomyopathy
Q42155453PDE4 in the human heart - major player or little helper?
Q22254160PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts
Q27671474Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility
Q36623426Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction
Q35146909Pathogenetic basis of myocardial dysfunction and amenability to reversal
Q71694107Pathophysiologic significance of left ventricular hypertrophy in dilated cardiomyopathy
Q40905686Pathophysiology and treatment of circulatory shock.
Q30315815Pathophysiology of Heart Failure
Q40780795Perspectives on therapy of cardiovascular diseases with coenzyme Q10 (ubiquinone).
Q35033114Perturbed atrial calcium handling in an ovine model of heart failure: potential roles for reductions in the L-type calcium current
Q36459142Pharmacogenetics of the human beta-adrenergic receptors
Q44617780Pharmacokinetics and hemodynamic effects of the phosphodiesterase III inhibitor saterinone in patients with chronic heart failure
Q40905723Pharmacologic cardiovascular support.
Q72666125Pharmacologic management of heart failure: neurohormonal agents
Q39765399Pharmacologic management of the critically ill patient in the perioperative period--emphasis on the sepsis syndrome.
Q40926069Pharmacology and inotropic potential of forskolin in the human heart
Q51554788Phosphodiesterase 2: anti-adrenergic friend or hypertrophic foe in heart disease?
Q37106060Phosphodiesterase 4 inhibition but not beta-adrenergic stimulation suppresses tumor necrosis factor-alpha release in peripheral blood mononuclear cells in septic shock
Q28327140Phosphodiesterase III inhibition or adrenoreceptor stimulation: Milrinone as an alternative to dobutamine in the treatment of severe heart failure
Q38682363Phosphodiesterase inhibition by new cardiotonic agents: mechanism of action and possible clinical relevance in the therapy of congestive heart failure
Q40347242Phospholamban-mediated stimulation of Ca2+ uptake in sarcoplasmic reticulum from normal and failing hearts
Q41062629Phosphotransfer reactions as a means of G protein activation
Q52090035Physical activity decreases the number of beta-adrenergic receptors on human lymphocytes.
Q71870128Physician use of beta-adrenergic blocking therapy: a changing perspective
Q28085424Physiological Implications of Myocardial Scar Structure
Q38136643Physiology and pharmacology of the cardiovascular adrenergic system
Q35045865Plasma membrane‐associated nucleoside diphosphate kinase (nm23) in the heart is regulated by β‐adrenergic signaling
Q71807495Positive and Negative Inotropic Effects of dl -Sotalol and d -Sotalol in Failing and Nonfailing Human Myocardium Under Physiological Experimental Conditions
Q46577023Positive inotropic effects of the calcium channel activator Bay K 8644 on guinea-pig and human isolated myocardium
Q45197917Positive inotropic stimulation in the normal and insufficient human myocardium
Q28293706Positive inotropic therapy: an update and new agents
Q77213473Potential risk of beta-blockade withdrawal in congestive heart failure due to abrupt autonomic changes
Q37362466Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes
Q80695335Pre- and post-synaptic sympathetic function in human hibernating myocardium
Q28345978Prediction of contractile reserve by cyclic variation of integrated backscatter of the myocardium in patients with chronic left ventricular dysfunction
Q35366928Predictive value of dobutamine echocardiography and positron emission tomography in identifying hibernating myocardium in patients with postischaemic heart failure.
Q60922430Prenatal Stress: Molecular Mechanisms and Cardiovascular Disease
Q24656335Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction
Q48008599Preserved Frank-Starling mechanism in human end stage heart failure
Q35023632Preserved cardiac function despite marked impairment of cAMP generation
Q85179679Presynaptic stimulus-release and postsynaptic compensatory changes in mice lacking the N-type calcium channel α1B-subunit
Q40160776Primary and secondary cardioneuropathies and their functional significance
Q70728586Proceedings of a symposium: Calcium metabolism and calcium channel blockers for understanding and treating hypertension
Q69718847Proceedings of the British Pharmacological Society. Leeds, 12th-14th July 1989. Abstracts
Q36757784Prognostic Value of Lymphocyte G Protein-Coupled Receptor Kinase-2 Protein Levels in Patients With Heart Failure
Q36391033Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.
Q26830145Prospects for gene transfer for clinical heart failure
Q34505964Protein kinase A catalytic subunit isoform PRKACA; History, function and physiology
Q50792575Protein kinase C regulation of cardiac calcium channels expressed in Xenopus oocytes.
Q71343626Protein phosphorylation in isolated trabeculae from nonfailing and failing human hearts
Q72587901Pulmonary Oedema Associated with β2-Sympathomimetic Treatment of Premature Labour
Q74154356QT interval lengthening in cardiac disease relates more to left ventricular systolic dysfunction than to autonomic function
Q50929427Quantitation of myosin in muscle
Q64123698Quantitative temporal analysis of protein dynamics in cardiac remodeling
Q34390058RAAS and adrenergic genes in heart failure: Function, predisposition and survival implications
Q34130282Rapid desensitization of neonatal rat liver beta-adrenergic receptors. A role for beta-adrenergic receptor kinase
Q38196174Reactive oxygen species and excitation-contraction coupling in the context of cardiac pathology
Q41452822Recent advances in knowledge about beta-adrenergic receptors: application to clinical cardiology
Q41522913Recent advances in nuclear cardiology in the study of coronary artery disease
Q37615740Recent developments in the treatment of congestive heart failure
Q37233904Recent in vitro findings of negative inotropy of pantoprazole did not translate into clinically relevant effects on left ventricular function in healthy volunteers
Q70118159Receptor binding of propranolol is the missing link between plasma concentration kinetics and the effect-time course in man
Q36390543Receptor function in heart failure
Q81105970Receptor function reserve: a new parameter for disease detection
Q37369510Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice
Q35872448Reduced alpha 1- and beta 2-adrenoceptor-mediated positive inotropic effects in human end-stage heart failure
Q33909731Reduced beta 1 receptor messenger RNA abundance in the failing human heart
Q35553783Reduced beta-adrenergic receptor activation decreases G-protein expression and beta-adrenergic receptor kinase activity in porcine heart
Q33641335Reduced force production during low blood flow to the heart correlates with altered troponin I phosphorylation
Q73368325Reduced length-dependent cross-bridge recruitment in skinned fiber preparations of human failing myocardium
Q43876768Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity
Q46954786Reduced sarcoplasmic reticulum Ca(2+) load mediates impaired contractile reserve in right ventricular pressure overload
Q46600650Reduced troponin I phosphorylation and increased Ca(2+)-dependent ATP-consumption in triton X-skinned fiber preparations from Galphaq overexpressor mice
Q70856648Reduction in lymphocyte beta-adrenergic receptor density in infants and children with heart failure secondary to congenital heart disease
Q41084763Regional distribution of ?1- and ?2-adrenoceptors in the failing and nonfailing human heart
Q34070572Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family
Q33782643Regulation of cardiac contractility by Rab4-modulated beta2-adrenergic receptor recycling
Q38354732Regulation of cardiac β1-adrenergic receptor transcription during the developmental transition
Q36816705Regulation of cellular oxidative stress and apoptosis by G protein-coupled receptor kinase-2; The role of NADPH oxidase 4
Q33538026Regulation of fibre contraction in a rat model of myocardial ischemia
Q36506527Regulation of mitochondrial oxidative stress by β-arrestins in cultured human cardiac fibroblasts
Q43703673Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors
Q68242266Relation between myocardial beta-adrenergic receptor and left ventricular function in patients with left ventricular volume overload due to chronic mitral regurgitation with or without aortic regurgitation
Q44439743Relation of cardiac sympathetic innervation to proinflammatory cytokine levels in patients with heart failure secondary to idiopathic dilated cardiomyopathy
Q71972392Relation of iodine-123 metaiodobenzylguanidine myocardial scintigraphy to endomyocardial biopsy findings in patients with dilated cardiomyopathy
Q45005481Relations between beta-adrenoceptor occupancy and increases of contractile force and adenylate cyclase activity induced by catecholamines in human ventricular myocardium. Acute desensitization and comparison with feline ventricle
Q67900217Relationship between adenylate cyclase activity and regional myocardial energetics in experimental left ventricular hypertrophy
Q35887484Relationship between beta-adrenoceptors and calcium channels in human ventricular myocardium
Q50055043Relationship of left ventricular global longitudinal strain with cardiac autonomic denervation as assessed by 123I-mIBG scintigraphy in patients with heart failure with reduced ejection fraction submitted to cardiac resynchronization therapy : Asses
Q70061445Relative attenuation of sympathetic drive during exercise in patients with congestive heart failure
Q28295123Removal of the N-terminal extension of cardiac troponin I as a functional compensation for impaired myocardial beta-adrenergic signaling
Q67506285Renal beta-adrenoceptors in thyroxine-treated rats
Q40976394Renal denervation improves cardiac function in rats with chronic heart failure: Effects on expression of β-adrenoceptors
Q57778967Renal effects of low-dose dopamine in patients with sepsis syndrome or septic shock treated with catecholamines
Q72034159Response of Failing Canine and Human Heart Cells to β 2 -Adrenergic Stimulation
Q36637020Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer
Q33876021Reversal of impaired myocardial beta-adrenergic receptor signaling by continuous-flow left ventricular assist device support
Q37964927Reverse remodeling in heart failure--mechanisms and therapeutic opportunities
Q26746907Review of novel therapeutic targets for improving heart failure treatment based on experimental and clinical studies
Q46276226Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress
Q41715870Role of cytokines in heart failure
Q35818139Role of intact cardiac nerves and reflex mechanisms in desensitization to catecholamines in conscious dogs
Q35106474Role of nonglycosidic inotropic agents: indications, ethics, and limitations
Q38820202Role of protein phosphatase inhibitor-1 in cardiac beta adrenergic pathway
Q70880316Role of spectral measures of heart rate variability as markers of disease progression in patients with chronic congestive heart failure not treated with angiotensin-converting enzyme inhibitors
Q35762284Role of substrate and triggers in the genesis of cardiac alternans, from the myocyte to the whole heart: implications for therapy
Q54378532Role of the beta 2 adrenoceptor in mediating positive inotropic activity in the failing heart and its relation to the hemodynamic actions of dopexamine hydrochloride.
Q33912937Ryanodine receptor channelopathies
Q37248371Ryanodine receptor-mediated arrhythmias and sudden cardiac death.
Q28240412S100A1 in human heart failure: lack of recovery following left ventricular assist device support
Q92904259Salbutamol modifies the neuromuscular junction in a mouse model of ColQ myasthenic syndrome
Q44279875Sarcolemmal beta-adrenoceptors determined in rat ventricular heart biopsies with (-)-[3H]CGP-12177.
Q37200169Sarcomere length dependence of power output is increased after PKA treatment in rat cardiac myocytes
Q71665345Sarcoplasmic reticulum Ca2+ATPase and phospholamban mRNA and protein levels in end-stage heart failure due to ischemic or dilated cardiomyopathy
Q48008693Sarcoplasmic reticulum in heart failure: central player or bystander?
Q33919826Selection, design and evaluation of new radioligands for PET studies of cardiac adrenoceptors
Q43688881Selective improvement in Seattle Heart Failure Model risk stratification using iodine-123 meta-iodobenzylguanidine imaging
Q35755691Selective regulation of beta 1- and beta 2-adrenoceptors in the human heart by chronic beta-adrenoceptor antagonist treatment
Q39148010Selective updates on mechanisms of action of positive inotropic agents
Q51183535Selective upregulation of beta1-adrenergic receptors and dephosphorylation of troponin I in end-stage heart failure patients supported by ventricular assist devices.
Q38138743Sepsis and the trauma patient.
Q60922459Sex-Related Effects of Prenatal Stress on Region-Specific Expression of Monoamine Oxidase A and β Adrenergic Receptors in Rat Hearts
Q34407902Short-term erythropoietin treatment does not substantially modulate monocyte transcriptomes of patients with combined heart and renal failure
Q28318119Significance of adaptation mechanisms in adriamycin induced congestive heart failure
Q41974755Simultaneous adrenal and cardiac g-protein-coupled receptor-gβγ inhibition halts heart failure progression
Q34077136Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure
Q36416038Some aspects of heart beta adrenoceptor function
Q33951980Soybean oil increases SERCA2a expression and left ventricular contractility in rats without change in arterial blood pressure
Q37868990Specific PI3K isoform modulation in heart failure: lessons from transgenic mice
Q72966236Spectral analysis of heart rate variability in the sepsis syndrome
Q54413506Static exercise with congestive heart failure and the response to vasodilating drugs.
Q35517542Stem and progenitor cell therapy for pulmonary arterial hypertension: effects on the right ventricle (2013 Grover Conference Series).
Q53867970Structure-Activity Relationships of Histamine H2-Agonists, a New Class of Positive Inotropic Drugs
Q41340211Sugemule-3 Protects against Isoprenaline-induced Cardiotoxicity In vitro
Q72591001Sulfinpyrazone increases the number of β-adrenoceptors on intact human lymphocytes
Q54395813Sustained hemodynamic improvement during long-term therapy with levodopa in heart failure: role of plasma catecholamines.
Q36085348Sustaining cardiac claudin-5 levels prevents functional hallmarks of cardiomyopathy in a muscular dystrophy mouse model.
Q35561947Switching Between Beta Blockers in Heart Failure Patients: Rationale and Practical Considerations
Q34097170Symbolic analysis detects alterations of cardiac autonomic modulation in congestive heart failure rats
Q89247755Sympathetic drive stimulating diastolic dysfunction?
Q72736313Sympathetic nervous system activation in postextrasystolic potentiation: role of catecholamine release in enhancement of ventricular function
Q35171874Sympathetic nervous system activity and ventricular tachyarrhythmias: recent advances.
Q70046494Systemic and regional vascular effects of atrial natriuretic peptide in a rat model of chronic heart failure
Q40605722Systemic inflammatory response syndrome: septic shock
Q36302132Systems biology and biomechanical model of heart failure
Q34150582Tachybradycardia in the isolated canine right atrium induced by chronic sympathetic stimulation and pacemaker current inhibition.
Q24322049Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts
Q36522556Targeted inhibition of phosphoinositide 3-kinase activity as a novel strategy to normalize beta-adrenergic receptor function in heart failure
Q34460199Targeting G protein-coupled receptor kinases (GRKs) in Heart Failure
Q38153376Targeting cardiac β-adrenergic signaling via GRK2 inhibition for heart failure therapy
Q35763705Targeting cardiomyocyte Ca2+ homeostasis in heart failure
Q38974127Targeting β3-Adrenergic Receptors in the Heart: Selective Agonism and β-Blockade.
Q40091746The Beta-Adrenergic Receptor in Heart Failure
Q36422577The Frank-Starling mechanism involves deceleration of cross-bridge kinetics and is preserved in failing human right ventricular myocardium
Q42817034The Gordon Wilson Lecture: neurohormonal signaling pathways that link cardiac growth and death.
Q37385715The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure
Q34505314The Ryanodine Receptor in Cardiac Physiology and Disease
Q39654047The altered pharmacokinetics and pharmacodynamics of drugs commonly used in critically ill patients
Q35888279The anti-adrenergic effect of adenosine and its blockade by pertussis toxin: a comparative study in myocytes isolated from guinea-pig, rat and failing human hearts
Q34495307The cardiorenal syndrome: a review
Q37074843The cardiovascular physiologic actions of urocortin II: acute effects in murine heart failure
Q37219835The choice of inotropes following cardiopulmonary bypass Pro: Amrinone is a first-choice inotrope following cardiopulmonary bypass
Q47687870The continuing evolution of cardiac troponin I biomarker analysis: from protein to proteoform
Q36288169The cytoskeleton and related proteins in the human failing heart
Q90411083The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling
Q34443749The dilemma of late-stage heart failure. Rationale for chronic parenteral inotropic support
Q34402982The effect of orthotopic transplantation on total, beta 1‐ and beta 2‐ adrenoceptors in the human heart
Q73862796The effect of salbutamol on skeletal muscle in chronic heart failure
Q38185200The effectiveness of inotropic agents in isolated cardiac preparations from the human heart
Q43960922The effects of dobutamine on cardiac sympathetic activity in patients with congestive heart failure
Q30250314The expanding GRK interactome: Implications in cardiovascular disease and potential for therapeutic development
Q39469516The functional importance of beta 1 and beta 2 adrenoceptors in the human heart
Q35826772The functional significance of genetic variation within the beta-adrenoceptor
Q35754928The influence of atherosclerosis on the mechanical responses of human isolated coronary arteries to substance P, isoprenaline and noradrenaline
Q93662281The inotropic effects of dopamine and its precursor levodopa on isolated human ventricular myocardium
Q38365789The management of heart failure and the scope for new therapies: what role for xamoterol?
Q42858896The new HNO donor, 1-nitrosocyclohexyl acetate, increases contractile force in normal and β-adrenergically desensitized ventricular myocytes
Q46711826The positive inotropic response to milrinone in isolated human and guinea pig myocardium
Q37555074The role of CaMKII regulation of phospholamban activity in heart disease
Q39511387The role of exercise testing in chronic heart failure
Q33824143The role of inflammatory mediators in chronic heart failure: cytokines, nitric oxide, and endothelin-1.
Q36819632The role of the adrenergic system in the heart: Regulation of contractility by cardiac adrenoceptors
Q69617275The search of an ideal oral positive inotropic agent
Q40650773The temporal hormesis of drug therapies
Q39493510The treatment of heart failure--what next?
Q44387849The use of amrinone and norepinephrine for inotropic support during emergence from cardiopulmonary bypass
Q38215931The use of angiotensin-converting enzyme inhibitors in congestive heart failure
Q38281750The war against heart failure: the Lancet lecture
Q36551979Therapy of idiopathic dilated cardiomyopathy with chronic β-adrenergic blockade
Q36014089Thr164Ile polymorphism of beta2-adrenergic receptor negatively modulates cardiac contractility: implications for prognosis in patients with idiopathic dilated cardiomyopathy
Q38248810Time and technology will tell: the pathophysiologic basis of neurohormonal modulation in heart failure
Q42083736Time course and extent of alpha 1-adrenoceptor density changes in rat heart after beta-adrenoceptor blockade
Q46413734Time to re-think the use of dobutamine in sepsis
Q36003934Tissue response selectivity of calcium antagonists is not due to heterogeneity of [3H]-nitrendipine binding sites
Q40921182Tracer norepinephrine kinetics in coronary circulation of patients with heart failure secondary to chronic pressure and volume overload
Q34099660Transcriptional regulation by cAMP in the heart
Q40489196Treating relentlessly progressive congestive heart failure: what next?
Q51790187Treatment of low cardiac output after aortocoronary artery bypass surgery using a combination of norepinephrine and amrinone.
Q36970435Treatment of mild congestive heart failure. The potential for new drugs to reduce the risks
Q45081695Twenty-four-hour spectral analysis of heart rate variability in congestive heart failure secondary to coronary artery disease
Q34281889Type 1 phosphatase, a negative regulator of cardiac function
Q71807622Unchanged Protein Levels of SERCA II and Phospholamban but Reduced Ca 2+ Uptake and Ca 2+ -ATPase Activity of Cardiac Sarcoplasmic Reticulum From Dilated Cardiomyopathy Patients Compared With Patients With Nonfailing Hearts
Q44314798Upregulation of beta 1-adrenergic receptors in ovariectomized rat hearts
Q42490123Upregulation of the alpha1-adrenoceptor-induced phosphoinositide and inotropic response in hypothyroid rat heart.
Q40475658Use of beta-adrenoceptor blockers in patients with congestive heart failure
Q40094984Use of catecholamines in pediatrics
Q72933726What Is Wrong with the Failing Heart?
Q74315537What are we actually measuring by Doppler tissue imaging?
Q77296406Why does the myocardium fail? Insights from basic science
Q69375741Xamoterol and the failing heart
Q39472615Xamoterol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use.
Q70171113[Beta-adrenergic receptors and plasma catecholamine behavior in trained and untrained athletes]
Q54109231[Early hemodynamic effects of olprinone hydrochloride after coronary artery bypass grafting]
Q79242495[On the function of beta3-adrenoceptors in the human heart: signal transduction, inotropic effect and therapeutic prospects]
Q54420542[Regional blood flow in congestive cardiac failure and inhibition of angiotensin converting enzyme].
Q43670404beta(1)-Adrenoceptor antibodies induce positive inotropic response in isolated cardiomyocytes
Q35768797beta-Adrenergic modulation of the inwardly rectifying potassium channel in isolated human ventricular myocytes. Alteration in channel response to beta-adrenergic stimulation in failing human hearts
Q34057925beta-adrenergic mechanisms in cardiac diseases: a perspective
Q37771890betaARKct: a therapeutic approach for improved adrenergic signaling and function in heart disease
Q37235097β-Adrenergic receptor antagonism in mice: a model for pediatric heart disease.
Q33828730β-Adrenergic receptor subtype signaling in heart: from bench to bedside
Q98291427β-Blocker Doses and Heart Rate in Patients with Heart Failure: Results from the National Norwegian Heart Failure Registry
Q37453620β-adrenergic receptor responsiveness in aging heart and clinical implications
Q51831879β1-Blockade Prevents Post-Ischemic Myocardial Decompensation Via β3AR-Dependent Protective Sphingosine-1 Phosphate Signaling.
Q38266154β1-adrenergic receptor and sphingosine-1-phosphate receptor 1 (S1PR1) reciprocal downregulation influences cardiac hypertrophic response and progression to heart failure: protective role of S1PR1 cardiac gene therapy
Q44591642β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure
Q34634348β₂ AR agonists in treatment of chronic heart failure: long path to translation