Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis

scientific article published on 19 June 2006

Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SJ.BJP.0706812
P932PMC publication ID1752015
P698PubMed publication ID16783407
P5875ResearchGate publication ID7001242

P50authorBruce N CronsteinQ50056922
Michael PillingerQ50129009
C MontesinosQ70475973
Allison B. ReissQ38323575
P2093author name stringMichael A Schwarzschild
Herman Yee
Scott L Friedman
Jiang-Fan Chen
Patricia Fernandez
Edwin S L Chan
Avani Desai
David L Delano
P2860cites workMolecular action of methotrexate in inflammatory diseasesQ24534771
Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damageQ28214799
Receptors for purines and pyrimidinesQ28283941
A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injuryQ28510918
A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in miceQ28594915
Histological grading and staging of chronic hepatitisQ29619625
Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitisQ29619627
Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protectionQ30307082
Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1.Q45240162
Risk factors for development of lethal sequelae after hepatitis B virus infection in humansQ45795601
Coffee and tea consumption are associated with a lower incidence of chronic liver disease in the United StatesQ46847687
Adenosine partially prevents cirrhosis induced by carbon tetrachloride in ratsQ46972258
Tuberculous peritonitis: a study comparing cirrhotic and noncirrhotic patients.Q54734068
A new physiological function for adenosine: regulation of superoxide anion productionQ57731184
Role of Adenosine A1 and A2A Receptors in the Alcohol Withdrawal SyndromeQ60440924
Sirius red histophotometry and spectrophotometry of sections in the assessment of the collagen content of liver tissue and its application in growing rat liverQ68718624
Possible role of cell redox state on collagen metabolism in carbon tetrachloride-induced cirrhosis as evidenced by adenosine administration to ratsQ72062105
Suppression of lipopolysaccharide-stimulated release of tumor necrosis factor by adenosine: evidence for A2 receptors on rat Kupffer cellsQ72431009
Coffee, tea, and mortalityQ72691558
Coffee, alcohol, and the liverQ73029270
Anti-arthritic effect of methotrexate: is it really mediated by adenosine?Q73422815
Adenosine deaminase isoenzymes and neopterin in liver cirrhosisQ73579256
Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expressionQ77753654
Absence of the adenosine A(2A) receptor or its chronic blockade decrease ethanol withdrawal-induced seizures in miceQ31882968
Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapyQ33706858
Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injuryQ33822590
The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.Q33909650
Mechanisms of alcoholic liver injuryQ33911617
The role and regulation of adenosine in the central nervous systemQ34205330
Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cellsQ34538916
Activation of hepatic stellate cells--a key issue in liver fibrosisQ34565618
Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors.Q35747902
Adenosine: a physiological modulator of superoxide anion generation by human neutrophils.Q36349017
Wound healing is accelerated by agonists of adenosine A2 (G alpha s-linked) receptorsQ36380776
Modulation of human dermal fibroblast extracellular matrix metabolism by the lymphokine leukoregulinQ36529940
Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB.Q37208648
Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cellsQ37443977
An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro.Q38311930
Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis.Q38333252
Turnover of adenosine in plasma of human and dog bloodQ39525884
Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathwayQ39793259
Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotidesQ39797150
Determination of hydroxyprolineQ39967323
Th1 cytokines regulate adenosine receptors and their downstream signaling elements in human microvascular endothelial cells.Q40628587
Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis.Q40681279
Inflammatory cytokines regulate function and expression of adenosine A(2A) receptors in human monocytic THP-1 cells.Q40779392
Ethanol-induced activation of adenine nucleotide turnover. Evidence for a role of acetateQ40926286
Adenosine; a physiologic modulator of superoxide anion generation by human neutrophils. Adenosine acts via an A2 receptor on human neutrophils.Q41361630
Hepatic adenosine in rats fed ethanol: effect of acute hyperoxia or hypoxiaQ41375390
Ethanol increases extracellular adenosine by inhibiting adenosine uptake via the nucleoside transporter.Q41744358
Hepatotoxicity of Long-Term Methotrexate Therapy for PsoriasisQ42235362
The effect of drinking coffee and smoking cigarettes on the risk of cirrhosis associated with alcohol consumption. A case-control study. Provincial Group for the Study of Chronic Liver DiseaseQ43038426
A therapeutic strategy to prevent morphine dependence and tolerance by coadministration of cAMP-related reagents with morphine.Q43070596
The use of adenosine deaminase as a diagnostic tool for peritoneal tuberculosisQ43683388
Coffee, caffeine, and the risk of liver cirrhosisQ43737586
Adenosine reverses a preestablished CCl4-induced micronodular cirrhosis through enhancing collagenolytic activity and stimulating hepatocyte cell proliferation in ratsQ43755015
Does coffee protect against liver cirrhosis?Q43795142
Regulation of glycogen metabolism in hepatocytes through adenosine receptors. Role of Ca2+ and cAMP.Q43915720
Effect of endotoxin pretreatment on hepatic stellate cell response to ethanol and acetaldehyde.Q43923523
Adenosine A2A receptor agonists promote more rapid wound healing than recombinant human platelet-derived growth factor (Becaplermin gel).Q43950010
Regulation of endothelin-A receptor sensitivity by cyclic adenosine monophosphate in rat hepatic stellate cellsQ44151762
A3 adenosine receptor knockout mice are protected against ischemia- and myoglobinuria-induced renal failureQ44185781
The A2A receptor mediates an endogenous regulatory pathway of cytokine expression in THP-1 cellsQ44215015
Low ethanol sensitivity and increased ethanol consumption in mice lacking adenosine A2A receptors.Q44228562
Caffeine reduces hypnotic effects of alcohol through adenosine A2A receptor blockadeQ44628396
P4510describes a project that usesImageQuantQ112270642
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectliver cirrhosisQ147778
P304page(s)1144-1155
P577publication date2006-06-19
P1433published inBritish Journal of PharmacologyQ919631
P1476titleAdenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis
P478volume148

Reverse relations

cites work (P2860)
Q38588143A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives
Q24652486A2A receptors in inflammation and injury: lessons learned from transgenic animals
Q43677765Absence of the adenosine A(2A) receptor attenuates hypertrophic scarring in mice
Q36312718Activated hepatic stellate cells upregulate transcription of ecto-5'-nucleotidase/CD73 via specific SP1 and SMAD promoter elements
Q37707427Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb.
Q42582009Adenine induces differentiation of rat hepatic stellate cells
Q34853017Adenosine 2A receptor antagonist prevented and reversed liver fibrosis in a mouse model of ethanol-exacerbated liver fibrosis
Q37503660Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3.
Q33783389Adenosine A(1) receptors regulate bone resorption in mice: adenosine A(1) receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone loss in adenosine A(1) receptor-knockout mice
Q33765783Adenosine A(2A) receptors promote collagen production by a Fli1- and CTGF-mediated mechanism.
Q47102657Adenosine A2A Receptor Deletion Blocks the Beneficial Effects of Lactobacillus reuteri in Regulatory T-Deficient Scurfy Mice
Q37468682Adenosine A2A receptor (A2AR) is a fine-tune regulator of the collagen1:collagen3 balance
Q82237362Adenosine A2A receptor activation stimulates collagen production in sclerodermic dermal fibroblasts either directly and through a cross-talk with the cannabinoid system
Q35190917Adenosine A2A receptor blockade or deletion diminishes fibrocyte accumulation in the skin in a murine model of scleroderma, bleomycin-induced fibrosis.
Q36385392Adenosine A2A receptor plays an important role in radiation-induced dermal injury
Q34686068Adenosine A2A receptors play an active role in mouse bone marrow-derived mesenchymal stem cell development.
Q50197688Adenosine A2a Receptor Blockade Diminishes Wnt/β-Catenin Signaling in a Murine Model of Bleomycin-Induced Dermal Fibrosis.
Q48859170Adenosine Increases Hepatic Artery Flow in Liver Transplant Recipients: A Pilot Study
Q39004042Adenosine and adenosine receptors in the pathogenesis and treatment of rheumatic diseases
Q35085245Adenosine in fibrosis.
Q35085307Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibition
Q28295173Adenosine inhibits renin release from juxtaglomerular cells via an A1 receptor-TRPC-mediated pathway
Q30432457Adenosine receptor A2A deficiency in leukocytes increases arterial neointima formation in apolipoprotein E-deficient mice
Q88788960Adenosine receptor distribution in Rhesus monkey ocular tissue
Q35263957Adenosine receptors and fibrosis: a translational review
Q29346491Adenosine receptors as drug targets--what are the challenges?
Q37565195Adenosine receptors in wound healing, fibrosis and angiogenesis.
Q41971814Adenosine signaling contributes to ethanol-induced fatty liver in mice.
Q34035228Adenosine signaling during acute and chronic disease states
Q92486062Adenosinergic Signaling in Liver Fibrosis
Q46341987An Elf2-like transcription factor acts as repressor of the mouse ecto-5'-nucleotidase gene expression in hepatic myofibroblasts
Q43153947Anti-metabolic syndrome effects of adenosine ingestion in stroke-prone spontaneously hypertensive rats fed a high-fat diet
Q35370819Antilipogenic and anti-inflammatory activities of Codonopsis lanceolata in mice hepatic tissues after chronic ethanol feeding
Q40092383Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9.
Q28080872Beneficial and detrimental role of adenosine signaling in diseases and therapy
Q44147553Blocking adenosine A2A receptor reduces peritoneal fibrosis in two independent experimental models.
Q92707925CD73 Promotes Glioblastoma Pathogenesis and Enhances Its Chemoresistance via A2B Adenosine Receptor Signaling
Q48140668Caffeine ameliorates hemodynamic derangements and portosystemic collaterals in cirrhotic rats.
Q35135195Caffeine inhibits the activation of hepatic stellate cells induced by acetaldehyde via adenosine A2A receptor mediated by the cAMP/PKA/SRC/ERK1/2/P38 MAPK signal pathway
Q33938555Caffeine, a drug for all seasons.
Q51125370Cancer chemoprevention by an adenosine derivative in a model of cirrhosis-hepatocellular carcinoma induced by diethylnitrosamine in rats.
Q37776184Cell Death and Fibrogenesis
Q33569405Cellular mechanisms of tissue fibrosis. 6. Purinergic signaling and response in fibroblasts and tissue fibrosis
Q85394166Chronic caffeine intake increases androgenic stimuli, epithelial cell proliferation and hyperplasia in rat ventral prostate
Q40068043Coffee Consumption and Risk of Biliary Tract Cancers and Liver Cancer: A Dose-Response Meta-Analysis of Prospective Cohort Studies
Q30473375Current status of novel antifibrotic therapies in patients with chronic liver disease
Q37960072Design and application of locally delivered agonists of the adenosine A(2A) receptor
Q39572713Ecto-5'-nucleotidase/CD73 knockdown increases cell migration and mRNA level of collagen I in a hepatic stellate cell line
Q46246600Effect of unfiltered coffee on carbon tetrachloride-induced liver injury in rats
Q64107472Effects of Caffeine Treatment on Hepatopulmonary Syndrome in Biliary Cirrhotic Rats
Q37768335Evolving challenges in hepatic fibrosis
Q41675213Extracellular adenosine controls NKT-cell-dependent hepatitis induction
Q34135461Genetic deletion of the adenosine A2A receptor confers postnatal development of relative myopia in mice
Q34387063Hepatic stellate cells and liver fibrosis
Q29616840Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver
Q47829842Hepatoprotective Effect of Low Doses of Caffeine on CCl4-Induced Liver Damage in Rats.
Q42747703How does coffee prevent liver fibrosis? Biological plausibility for recent epidemiological observations
Q35528026Hyaluronan fragments promote inflammation by down-regulating the anti-inflammatory A2a receptor
Q26752304Hypoxia-inducible factors as molecular targets for liver diseases
Q35560040I drink for my liver, Doc: emerging evidence that coffee prevents cirrhosis.
Q33694628Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling
Q39623703Interferon-gamma inhibits adenosine A2A receptor function in hepatic stellate cells by STAT1-mediated repression of adenylyl cyclase
Q29619336Mechanisms of hepatic fibrogenesis
Q38581885Mechanistic review of drug-induced steatohepatitis
Q89559208Metabolomic biomarkers are associated with mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis
Q89748484Methotrexate and its mechanisms of action in inflammatory arthritis
Q47725430Methotrexate modulates the expression of MMP-1 and type 1 collagen in dermal fibroblast
Q38945736Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation
Q43144564Methotrexate--how does it really work?
Q37791059Methylxanthines, Inflammation, and Cancer: Fundamental Mechanisms
Q37628490Molecular Bases Underlying the Hepatoprotective Effects of Coffee.
Q55082101Monitoring methotrexate-induced liver fibrosis in patients with psoriasis: utility of transient elastography.
Q39523639New role of the human equilibrative nucleoside transporter 1 (hENT1) in epithelial-to-mesenchymal transition in renal tubular cells.
Q35079069Nrf2 and Snail-1 in the prevention of experimental liver fibrosis by caffeine.
Q34979922Obesity, diabetes mellitus, and liver fibrosis
Q37326848Part I: Liver function in oncology: biochemistry and beyond
Q36691126Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine
Q37358974Protective Effects of Adenosine Receptor Agonist in a Cirrhotic Liver Resection Model
Q42367885Purinergic Signalling: Therapeutic Developments
Q34008598Purinergic receptors in gastrointestinal inflammation
Q90429521Purinergic signaling in hepatic disease
Q36385326Purinergic signaling in scarring
Q38165746Purinergic signalling in the liver in health and disease
Q36296620Recovery of the Cell Cycle Inhibition in CCl(4)-Induced Cirrhosis by the Adenosine Derivative IFC-305.
Q28742066Renal effects of the novel selective adenosine A1 receptor blocker SLV329 in experimental liver cirrhosis in rats
Q49680083Risk factors for abnormal hepatic enzyme elevation by methotrexate treatment in patients with rheumatoid arthritis: A hospital based-cohort study.
Q38268013SEURAT-1 liver gold reference compounds: a mechanism-based review
Q30440124Suppression of inflammatory and immune responses by the A(2A) adenosine receptor: an introduction
Q38710133Systematic review with meta-analysis: coffee consumption and the risk of cirrhosis
Q33639481Targeting Adenosine Receptors for the Treatment of Cardiac Fibrosis
Q35625864The Value of Circulating Nogo-B for Evaluating Hepatic Functional Reserve in Patients with Cirrhosis
Q30436868The adenosine a2a receptor inhibits matrix-induced inflammation in a novel fashion
Q96230894The adenosine pathway in immuno-oncology
Q37524827The adenosinergic immunomodulatory drugs
Q46837128The antiviral drug tenofovir, an inhibitor of Pannexin-1-mediated ATP release, prevents liver and skin fibrosis by downregulating adenosine levels in the liver and skin.
Q46842154The cardioprotective effects of L-carnitine on rat cardiac injury, apoptosis, and oxidative stress caused by amethopterin
Q52733589The ectonucleotidase ENTPD1/CD39 limits biliary injury and fibrosis in mouse models of sclerosing cholangitis.
Q38233128The role of adenosine receptors A2A and A2B signaling in renal fibrosis
Q37677794Transcriptomic effects of adenosine 2A receptor deletion in healthy and endotoxemic murine myocardium
Q24644038Treating lung inflammation with agonists of the adenosine A2A receptor: promises, problems and potential solutions

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