Protective immunity against Clostridium difficile toxin A induced by oral immunization with a live, attenuated Vibrio cholerae vector strain

scientific article published on July 1997

Protective immunity against Clostridium difficile toxin A induced by oral immunization with a live, attenuated Vibrio cholerae vector strain is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID175412
P698PubMed publication ID9199470

P2093author name stringS B Calderwood
E T Ryan
R N Smith
P A Carroll
J R Butterton
T I Crean
P2860cites workClostridium difficile: its disease and toxinsQ24617347
Effects of Clostridium difficile toxins A and B in rabbit small and large intestine in vivo and on cultured cells in vitroQ24651060
Evidence that glutamic acid 167 is an active-site residue of Shiga-like toxin IQ24651553
Molecular characterization of the Clostridium difficile toxin A geneQ24656092
Human antibody response to Clostridium difficile toxin A in relation to clinical course of infectionQ24676013
Involvement of Ras-related Rho proteins in the mechanisms of action of Clostridium difficile toxin A and toxin BQ24682858
Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine developmentQ28485732
Emergence of a new cholera pandemic: molecular analysis of virulence determinants in Vibrio cholerae O139 and development of a live vaccine prototypeQ30420490
TolC, an Escherichia coli outer membrane protein required for hemolysin secretion.Q33644353
Superior efficacy of secreted over somatic antigen display in recombinant Salmonella vaccine induced protection against listeriosisQ33749862
Release of a chimeric protein into the medium from Escherichia coli using the C-terminal secretion signal of haemolysinQ33929641
Duration of infection-derived immunity to choleraQ70831304
Duplication and amplification of toxin genes in Vibrio choleraeQ71063547
Use of the Vibrio cholerae irgA gene as a locus for insertion and expression of heterologous antigens in cholera vaccine strainsQ72746081
Intestinal immune responses in humans. Oral cholera vaccination induces strong intestinal antibody responses and interferon-gamma production and evokes local immunological memoryQ34225394
Treatment with intravenously administered gamma globulin of chronic relapsing colitis induced by Clostridium difficile toxinQ34880915
Heterologous antigen expression in Vibrio cholerae vector strainsQ35423953
Potential for reacquisition of cholera enterotoxin genes by attenuated Vibrio cholerae vaccine strain CVD 103-HgR.Q35777337
Studies with Vibrio cholerae in the ligated loop of the rabbit intestineQ36152434
CTX genetic element encodes a site-specific recombination system and an intestinal colonization factor.Q36262564
Protective humoral response against pneumococcal infection in mice elicited by recombinant bacille Calmette-Guérin vaccines expressing pneumococcal surface protein A.Q36364180
Effect of iron limitation on growth, siderophore production, and expression of outer membrane proteins of Vibrio choleraeQ36384898
Effect of toxin A and B of Clostridium difficile on rabbit ileum and colonQ36492515
Localization of two epitopes recognized by monoclonal antibody PCG-4 on Clostridium difficile toxin AQ36946424
Toxin A of Clostridium difficile binds to the human carbohydrate antigens I, X, and YQ36958780
Identification of p60 antibodies in human sera and presentation of this listerial antigen on the surface of attenuated salmonellae by the HlyB-HlyD secretion systemQ36972525
Determinants of immunogenicity and mechanisms of protection by virulent and mutant Vibrio cholerae O1 in rabbitsQ36992532
Immunization of adult hamsters against Clostridium difficile-associated ileocecitis and transfer of protection to infant hamstersQ37008939
Cell surface binding site for Clostridium difficile enterotoxin: evidence for a glycoconjugate containing the sequence Gal alpha 1-3Gal beta 1-4GlcNAcQ37025852
Role of cholera toxin in enteric colonization by Vibrio cholerae O1 in rabbitsQ37031718
Successful colonization and immunization of adult rabbits by oral inoculation with Vibrio cholerae O1.Q37107796
Positive transcriptional regulation of an iron-regulated virulence gene in Vibrio choleraeQ37395794
Salmonella strain secreting active listeriolysin changes its intracellular localization.Q39823317
Protective immunity to Shiga-like toxin I following oral immunization with Shiga-like toxin I B-subunit-producing Vibrio cholerae CVD 103-HgR.Q39824053
Transport of hemolysin across the outer membrane of Escherichia coli requires two functionsQ39975513
Antigenic cross-reactivity and functional inhibition by antibodies to Clostridium difficile toxin A, Streptococcus mutans glucan-binding protein, and a synthetic peptideQ40151748
Protection against experimental pseudomembranous colitis in gnotobiotic mice by use of monoclonal antibodies against Clostridium difficile toxin A.Q40153023
Nucleotide sequence of Clostridium difficile toxin A.Q40515226
Clostridium difficile colitisQ40679117
Clostridium difficile diarrhea: pathogenesis, epidemiology, and treatmentQ40685731
Strategies for the induction of immune responses at mucosal surfaces making use of cholera toxin B subunit as immunogen, carrier, and adjuvant.Q40762647
Nosocomial acquisition of Clostridium difficile infectionQ41877583
Genetic fusion of a non-toxic heat-stable enterotoxin-related decapeptide antigen to cholera toxin B-subunitQ41877655
Clostridium difficile toxin A carries a C-terminal repetitive structure homologous to the carbohydrate binding region of streptococcal glycosyltransferasesQ42631108
Epidemiology of antibiotic-associated colitis; isolation of Clostridium difficile from the hospital environmentQ43325209
Human colonic aspirates containing immunoglobulin A antibody to Clostridium difficile toxin A inhibit toxin A-receptor bindingQ43808227
Synthesis in Vibrio cholerae and secretion of hepatitis B virus antigens fused to Escherichia coli heat-labile enterotoxin subunit B.Q44726634
An Escherichia coli hemolysin transport system-based vector for the export of polypeptides: export of Shiga-like toxin IIeB subunit by Salmonella typhimurium aroA.Q47960715
Insertion of a HIV-1-neutralizing epitope in a surface-exposed internal region of the cholera toxin B-subunitQ54191083
Safety, immunogenicity, and efficacy of recombinant live oral cholera vaccines, CVD 103 and CVD 103-HgR.Q54378370
Change in the cellular localization of alkaline phosphatase by alteration of its carboxy-terminal sequence.Q54702999
Analysis of the haemolysin secretion system by PhoA-HlyA fusion proteins.Q54706314
The carboxy-terminal region of haemolysin 2001 is required for secretion of the toxin from Escherichia coli.Q54775082
Development of a live, oral, attenuated vaccine against El Tor choleraQ57924437
Initial clinical studies of CVD 112 Vibrio cholerae O139 live oral vaccine: safety and efficacy against experimental challengeQ57924808
Prevention of clindamycin-induced colitis in hamsters by Clostridium sordellii antitoxinQ67464421
The effects of Clostridium difficile crude toxins and toxin A on ileal and colonic loops in immune and non-immune rabbitsQ69149128
Acquisition of Clostridium difficile from the hospital environmentQ69826873
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectVibrio choleraeQ160821
attenuated vaccineQ1810913
Clostridium difficileQ310543
immunizationQ1415366
P304page(s)2941-2949
P577publication date1997-07-01
P1433published inInfection and ImmunityQ6029193
P1476titleProtective immunity against Clostridium difficile toxin A induced by oral immunization with a live, attenuated Vibrio cholerae vector strain
P478volume65

Reverse relations

cites work (P2860)
Q34484003A Cholera Conjugate Vaccine Containing O-specific Polysaccharide (OSP) of V. cholerae O1 Inaba and Recombinant Fragment of Tetanus Toxin Heavy Chain (OSP:rTTHc) Induces Serum, Memory and Lamina Proprial Responses against OSP and Is Protective in Mic
Q36255845A chimeric protein comprising the glucosyltransferase and cysteine proteinase domains of toxin B and the receptor binding domain of toxin A induces protective immunity against Clostridium difficile infection in mice and hamsters
Q36211064A chimeric toxin vaccine protects against primary and recurrent Clostridium difficile infection
Q38208794Antibodies for treatment of Clostridium difficile infection
Q28547242Biochemical and Immunological Characterization of Truncated Fragments of the Receptor-Binding Domains of C. difficile Toxin A
Q34003042Development of a DeltaglnA balanced lethal plasmid system for expression of heterologous antigens by attenuated vaccine vector strains of Vibrio cholerae
Q37427354Enhanced mucosal delivery of antigen with cell wall mutants of lactic acid bacteria
Q35896020Enteric pathogens as vaccine vectors for foreign antigen delivery
Q34403586Evaluation in mice of a conjugate vaccine for cholera made from Vibrio cholerae O1 (Ogawa) O-specific polysaccharide
Q37002887Exploiting cholera vaccines as a versatile antigen delivery platform
Q33866797Immunogenicity of a Salmonella typhimurium aroA aroD vaccine expressing a nontoxic domain of Clostridium difficile toxin A.
Q34003489In vitro and in vivo analyses of constitutive and in vivo-induced promoters in attenuated vaccine and vector strains of Vibrio cholerae
Q34000827In vivo expression and immunoadjuvancy of a mutant of heat-labile enterotoxin of Escherichia coli in vaccine and vector strains of Vibrio cholerae
Q36136940Induction of immune responses in mice after intragastric administration of Lactobacillus casei producing porcine parvovirus VP2 protein
Q36396899Intrarectal instillation of Clostridium difficile toxin A triggers colonic inflammation and tissue damage: development of a novel and efficient mouse model of Clostridium difficile toxin exposure
Q30307170Management and Prevention of Clostridium difficile-Associated Diarrhea
Q34006339Mucosal immune responses and protection against tetanus toxin after intranasal immunization with recombinant Lactobacillus plantarum
Q34003405Optimizing the germfree mouse model for in vivo evaluation of oral Vibrio cholerae vaccine and vector strains
Q41222915Protective antibody responses against Clostridium difficile elicited by a DNA vaccine expressing the enzymatic domain of toxin B.
Q37036112Protective efficacy induced by recombinant Clostridium difficile toxin fragments
Q33584866Recombinant Clostridium difficile toxin fragments as carrier protein for PSII surface polysaccharide preserve their neutralizing activity
Q39512161Recombinant Staphylococcus strains as live vectors for the induction of neutralizing anti-diphtheria toxin antisera.
Q35923218Recombinant lipoprotein-based vaccine candidates against C. difficile infections
Q55042601Sublingual Adjuvant Delivery by a Live Attenuated Vibrio cholerae-Based Antigen Presentation Platform.
Q34009439Targeting of nasal mucosa-associated antigen-presenting cells in vivo with an outer membrane protein A derived from Klebsiella pneumoniae
Q38244134The host immune response to Clostridium difficile infection
Q34832263The protective effect of recombinant Lactococcus lactis oral vaccine on a Clostridium difficile-infected animal model
Q35913487Transcutaneous immunization with Clostridium difficile toxoid A induces systemic and mucosal immune responses and toxin A-neutralizing antibodies in mice
Q37386803Transcutaneous immunization with a synthetic hexasaccharide-protein conjugate induces anti-Vibrio cholerae lipopolysaccharide responses in mice
Q40899692Vaccination against Clostridium difficile using toxin fragments: Observations and analysis in animal models
Q38196682Vaccines against Clostridium difficile

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