Evidence that glutamic acid 167 is an active-site residue of Shiga-like toxin I

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Evidence that glutamic acid 167 is an active-site residue of Shiga-like toxin I is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1988PNAS...85.2568H
P356DOI10.1073/PNAS.85.8.2568
P932PMC publication ID280038
P698PubMed publication ID3357883
P5875ResearchGate publication ID19798200

P50authorR. John CollierQ2123854
P2093author name stringJ J Mekalanos
S B Calderwood
C J Hovde
P2860cites workTwo toxin-converting phages from Escherichia coli O157:H7 strain 933 encode antigenically distinct toxins with similar biologic activitiesQ24646436
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectorsQ26778475
2 New M13 vectors for cloningQ27861042
The association between idiopathic hemolytic uremic syndrome and infection by verotoxin-producing Escherichia coliQ33457864
RNA N-glycosidase activity of ricin A-chain. Mechanism of action of the toxic lectin ricin on eukaryotic ribosomesQ34163395
Vero response to a cytotoxin of Escherichia coliQ34177128
Nucleotide sequence of the Shiga-like toxin genes of Escherichia coliQ34633814
Nucleotide sequence and promoter mapping of the Escherichia coli Shiga-like toxin operon of bacteriophage H-19B.Q36265701
Iron regulation of Shiga-like toxin expression in Escherichia coli is mediated by the fur locusQ36269210
Exotoxin A of Pseudomonas aeruginosa: substitution of glutamic acid 553 with aspartic acid drastically reduces toxicity and enzymatic activityQ36270771
Shigella dysenteriae 1 cytotoxin: periplasmic protein releasable by polymyxin B and osmotic shock.Q36342126
Pathogenesis of Shigella diarrhea. IX. Simplified high yield purification of Shigella toxin and characterization of subunit composition and function by the use of subunit-specific monoclonal and polyclonal antibodies.Q36349737
Shiga-like cytotoxin production by enteropathogenic Escherichia coli serogroupsQ37040666
Purification and characterization of a Shigella dysenteriae 1-like toxin produced by Escherichia coliQ37112219
Tinkering with enzymes: what are we learning?Q39656946
Release of Shiga toxin from Shigella dysenteriae 1 by polymyxin B.Q40184317
Preferential codon usage in prokaryotic genes: the optimal codon-anticodon interaction energy and the selective codon usage in efficiently expressed genesQ40244862
Dysentery in pigs associated with cystic enlargement of submucosal glands in the large intestineQ40797842
Nucleotide sequence analysis of the structural genes for Shiga-like toxin I encoded by bacteriophage 933J from Escherichia coliQ42657348
Ribosome-inhibiting proteins, retroviral reverse transcriptases, and RNase H share common structural elementsQ45244947
Cholera toxin transcriptional activator toxR is a transmembrane DNA binding proteinQ48350458
Subunit structure of Shigella cytotoxin.Q50938170
Affinity labeling of the active sites in the sucrase-isomaltase complex from small intestine.Q54263161
The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.Q54408348
Diphtheria toxin. Effect of substituting aspartic acid for glutamic acid 148 on ADP-ribosyltransferase activity.Q54793009
The three-dimensional structure of ricin at 2.8 AQ68962681
Production of Shigella dysenteriae type 1-like cytotoxin by Escherichia coliQ71454940
The cytotoxic activity of Shigella toxin. Evidence for catalytic inactivation of the 60 S ribosomal subunitQ71855282
Escherichia coli O157:H7 strains associated with haemorrhagic colitis in the United States produce a Shigella dysenteriae 1 (SHIGA) like cytotoxinQ72548803
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)2568-72
P577publication date1988-04-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleEvidence that glutamic acid 167 is an active-site residue of Shiga-like toxin I
P478volume85

Reverse relations

cites work (P2860)
Q46528787A Cell-Based Fluorescent Assay to Detect the Activity of AB Toxins that Inhibit Protein Synthesis
Q35104239A system for production and rapid purification of large amounts of the Shiga toxin/Shiga-like toxin I B subunit
Q36957798An enzymatic mutant of Shiga-like toxin II variant is a vaccine candidate for edema disease of swine
Q33529309An evolved ribosome-inactivating protein targets and kills human melanoma cells in vitro and in vivo
Q33719498Analysis of Escherichia coli O157:H7 survival in ovine or bovine manure and manure slurry.
Q36104552Analysis of the complexity of gene regulation by fur in Vibrio cholerae
Q34007607Antiviral activity of shiga toxin 1: suppression of bovine leukemia virus-related spontaneous lymphocyte proliferation
Q34531637Antiviral activity of shiga toxin requires enzymatic activity and is associated with increased permeability of the target cells
Q35380050Avirulence of rough mutants of Shigella flexneri: requirement of O antigen for correct unipolar localization of IcsA in the bacterial outer membrane
Q33267808Characterisation of saporin genes: in vitro expression and ribosome inactivation
Q36543943Characterization of Escherichia coli O157:H7 and other Shiga toxin-producing E. coli serotypes isolated from sheep.
Q33991926Characterization of the major control region of Vibrio cholerae bacteriophage K139: immunity, exclusion, and integration.
Q34166278Charged and hydrophobic surfaces on the a chain of shiga-like toxin 1 recognize the C-terminal domain of ribosomal stalk proteins
Q68090249Cloning and sequencing of a Shiga-like toxin II-related gene from Escherichia coli O157:H7 strain 7279
Q36215407Cloning and sequencing of a Shiga-like toxin type II variant from Escherichia coli strain responsible for edema disease of swine
Q35548775Coexpression of the B subunit of Shiga toxin 1 and EaeA from enterohemorrhagic Escherichia coli in Vibrio cholerae vaccine strains
Q34500172Comparison of Xenorhabdus bovienii bacterial strain genomes reveals diversity in symbiotic functions.
Q37424949Conserved Arginines at the P-Protein Stalk Binding Site and the Active Site Are Critical for Ribosome Interactions of Shiga Toxins but Do Not Contribute to Differences in the Affinity of the A1 Subunits for the Ribosome
Q33754052Construction and characterization of an isogenic slt-ii deletion mutant of enterohemorrhagic Escherichia coli.
Q54645159Construction of mutant genes for a non-toxic verotoxin 2 variant (VT2vp1) of Escherichia coli and characterization of purified mutant toxins.
Q52668818Decreased STEC shedding by cattle following passive and active vaccination based on recombinant Escherichia coli Shiga toxoids.
Q34003042Development of a DeltaglnA balanced lethal plasmid system for expression of heterologous antigens by attenuated vaccine vector strains of Vibrio cholerae
Q33767533Disruption of an internal membrane-spanning region in Shiga toxin 1 reduces cytotoxicity
Q41770295Diverse phage-encoded toxins in a protective insect endosymbiont
Q26858938Do the A subunits contribute to the differences in the toxicity of Shiga toxin 1 and Shiga toxin 2?
Q82754354Enhanced immunogenicity of a novel Stx2Am-Stx1B fusion protein in a mice model of enterohemorrhagic Escherichia coli O157:H7 infection
Q36527889Escherichia coli O157:H7 in microbial flora of sheep
Q39480986Establishment of recombinant hybrid-IgG/IgA immunoglobulin specific for Shiga toxin.
Q39454929Evaluation of biological safety in vitro and immunogenicity in vivo of recombinant Escherichia coli Shiga toxoids as candidate vaccines in cattle
Q60311719Exploiting retrograde transport of Shiga-like toxin 1 for the delivery of exogenous antigens into the MHC class I presentation pathway
Q24672377Exploring steric constraints on protein mutations using MAGE/PROBE
Q33991131Functional analysis of a rickettsial OmpA homology domain of Shigella flexneri icsA.
Q48220960Genetic and Immunological Analysis of a Novel Variant of Shiga Toxin 1 from Bovine Escherichia coli Strains and Development of Bead‐ELISA to Detect the Variant Toxin
Q35423953Heterologous antigen expression in Vibrio cholerae vector strains
Q34663367Identification of amino acids critical for the cytotoxicity of Shiga toxin 1 and 2 in Saccharomyces cerevisiae
Q35620166Investigation of ribosome binding by the Shiga toxin A1 subunit, using competition and site-directed mutagenesis
Q54323381Large-scale preparation of Shiga toxin 2 in Escherichia coli for toxoid vaccine antigen production.
Q36973773Mapping the minimal contiguous gene segment that encodes functionally active Shiga-like toxin II
Q36103964Minimum domain of the Shiga toxin A subunit required for enzymatic activity
Q35626584Molecular cloning of an apoptosis-inducing protein, pierisin, from cabbage butterfly: possible involvement of ADP-ribosylation in its activity
Q36165342Mutational analysis of the Shiga toxin and Shiga-like toxin II enzymatic subunits
Q33897718NADP and NAD utilization in Haemophilus influenzae
Q33950279NadN and e (P4) are essential for utilization of NAD and nicotinamide mononucleotide but not nicotinamide riboside in Haemophilus influenzae
Q39896145Novel cell-based method to detect Shiga toxin 2 from Escherichia coli O157:H7 and inhibitors of toxin activity
Q35552261Oral immunization with attenuated vaccine strains of Vibrio cholerae expressing a dodecapeptide repeat of the serine-rich Entamoeba histolytica protein fused to the cholera toxin B subunit induces systemic and mucosal antiamebic and anti-V. cholerae
Q24550740Pathogenesis and diagnosis of Shiga toxin-producing Escherichia coli infections
Q33369261Polymerase chain reaction for diagnosis of enterohemorrhagic Escherichia coli infection and hemolytic-uremic syndrome
Q35060348Production of hybrid-IgG/IgA plantibodies with neutralizing activity against Shiga toxin 1.
Q33377371Protection against Shiga toxin-producing Escherichia coli infection by transcutaneous immunization with Shiga toxin subunit B
Q35551627Protective immunity against Clostridium difficile toxin A induced by oral immunization with a live, attenuated Vibrio cholerae vector strain
Q24567536Ribosome inactivation by ricin A chain: a sensitive method to assess the activity of wild-type and mutant polypeptides
Q40647546Role of arginine 180 and glutamic acid 177 of ricin toxin A chain in enzymatic inactivation of ribosomes
Q40651036Role of glutamic acid 177 of the ricin toxin A chain in enzymatic inactivation of ribosomes
Q40646196Selection and characterization of ricin toxin A-chain mutations in Saccharomyces cerevisiae
Q27021676Shiga Toxin (Stx) Classification, Structure, and Function
Q26752966Shiga Toxins as Multi-Functional Proteins: Induction of Host Cellular Stress Responses, Role in Pathogenesis and Therapeutic Applications
Q34715023Shiga toxin 1 triggers a ribotoxic stress response leading to p38 and JNK activation and induction of apoptosis in intestinal epithelial cells
Q34140727Shigella flexneri surface protein IcsA is sufficient to direct actin-based motility
Q38776306Strategies for the development of vaccines for typhoid fever, shigellosis, and cholera
Q92153341Structural and Functional Characterization of Stx2k, a New Subtype of Shiga Toxin 2
Q34451464Synthesis of an Aminooxy Derivative of the Trisaccharide Globotriose Gb3
Q27730899The N-glycosidase mechanism of ribosome-inactivating proteins implied by crystal structures of alpha-momorcharin
Q54648744The role of tyrosine-114 in the enzymatic activity of the Shiga-like toxin I A-chain.
Q34288923The use of Shiga-like toxin 1 in cancer therapy
Q33719947Transcriptional analysis of genes encoding Shiga toxin 2 and its variants in Escherichia coli
Q36191893Transcriptional regulation by iron of a Vibrio cholerae virulence gene and homology of the gene to the Escherichia coli fur system
Q33376138Treatment and prevention of enterohemorrhagic Escherichia coli infection and hemolytic uremic syndrome
Q39927930Unipolar localization and ATPase activity of IcsA, a Shigella flexneri protein involved in intracellular movement
Q35461166Vaccination with genetically modified Shiga-like toxin IIe prevents edema disease in swine
Q40782927Vero toxins (Shiga-like toxins) produced by enterohemorrhagic Escherichia coli (verocytotoxin-producing E. coli).
Q35968495Vibrio cholerae fur mutations associated with loss of repressor activity: implications for the structural-functional relationships of fur.

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